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BR112017008945A2 - Anticorpos anti-cs1 e conjugados fármaco- anticorpo - Google Patents

Anticorpos anti-cs1 e conjugados fármaco- anticorpo

Info

Publication number
BR112017008945A2
BR112017008945A2 BR112017008945A BR112017008945A BR112017008945A2 BR 112017008945 A2 BR112017008945 A2 BR 112017008945A2 BR 112017008945 A BR112017008945 A BR 112017008945A BR 112017008945 A BR112017008945 A BR 112017008945A BR 112017008945 A2 BR112017008945 A2 BR 112017008945A2
Authority
BR
Brazil
Prior art keywords
antibodies
antibody conjugates
pharmaceutical
bind
drug
Prior art date
Application number
BR112017008945A
Other languages
English (en)
Inventor
K Kim Han
C Gish Kurt
Naumovski Louie
Original Assignee
Abbvie Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Biotherapeutics Inc filed Critical Abbvie Biotherapeutics Inc
Publication of BR112017008945A2 publication Critical patent/BR112017008945A2/pt

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
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  • Medicinal Chemistry (AREA)
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  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Hematology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
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  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a presente invenção refere-se a anticorpos e conjugados fármaco-anticorpo que se ligam a cs1 humano e seus usos para tratar indivíduos diagnosticados com neoplasia de células plasmáticas, por exemplo, mieloma múltiplo.
BR112017008945A 2014-10-31 2015-10-30 Anticorpos anti-cs1 e conjugados fármaco- anticorpo BR112017008945A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462073824P 2014-10-31 2014-10-31
PCT/US2015/058389 WO2016070089A2 (en) 2014-10-31 2015-10-30 Anti-cs1 antibodies and antibody drug conjugates

Publications (1)

Publication Number Publication Date
BR112017008945A2 true BR112017008945A2 (pt) 2018-01-16

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BR112017008945A BR112017008945A2 (pt) 2014-10-31 2015-10-30 Anticorpos anti-cs1 e conjugados fármaco- anticorpo

Country Status (10)

Country Link
US (2) US10011657B2 (pt)
EP (1) EP3212668B1 (pt)
JP (2) JP2017537893A (pt)
AU (1) AU2015339012B2 (pt)
BR (1) BR112017008945A2 (pt)
CA (1) CA2966005C (pt)
ES (1) ES2832711T3 (pt)
IL (1) IL251938A0 (pt)
SG (1) SG11201703446RA (pt)
WO (1) WO2016070089A2 (pt)

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BR112017008575B1 (pt) 2014-10-29 2021-07-13 Bicyclerd Limited Ligantes de peptídeos bicíclicos específicos a mt1-mmp, conjugado de fármaco, processo para preparação de um conjugado de fármaco e composição farmacêutica
RS62352B1 (sr) * 2015-06-29 2021-10-29 Bristol Myers Squibb Co Imunoterapijski režimi doziranja koji obuhvataju pomalidomid i anti-cs1 antitelo za lečenje kancera
CN108884160B (zh) 2015-10-30 2023-02-03 恩比伊治疗股份公司 抗ror1抗体
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
PE20191102A1 (es) 2016-09-14 2019-08-23 Abbvie Biotherapeutics Inc Anticuerpos anti-pd-1 y sus usos
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
WO2018141959A1 (en) * 2017-02-06 2018-08-09 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
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