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BR112015022763A2 - sensores de oxigênio - Google Patents

sensores de oxigênio

Info

Publication number
BR112015022763A2
BR112015022763A2 BR112015022763A BR112015022763A BR112015022763A2 BR 112015022763 A2 BR112015022763 A2 BR 112015022763A2 BR 112015022763 A BR112015022763 A BR 112015022763A BR 112015022763 A BR112015022763 A BR 112015022763A BR 112015022763 A2 BR112015022763 A2 BR 112015022763A2
Authority
BR
Brazil
Prior art keywords
sensors
oxygen sensors
oxygen
dyes
polymers
Prior art date
Application number
BR112015022763A
Other languages
English (en)
Other versions
BR112015022763A8 (pt
Inventor
Helton Kristen
Wisniewski Natalie
Gamsey Soya
Mcmillan William
Original Assignee
Profusa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Profusa Inc filed Critical Profusa Inc
Publication of BR112015022763A2 publication Critical patent/BR112015022763A2/pt
Publication of BR112015022763A8 publication Critical patent/BR112015022763A8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552Details of sensors specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036Porphyrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0073Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form semi-solid, gel, hydrogel, ointment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006Palladium compounds
    • C07F15/0066Palladium compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/497Physical analysis of biological material of gaseous biological material, e.g. breath
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40Animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/18Metal complexes
    • C09K2211/185Metal complexes of the platinum group, i.e. Os, Ir, Pt, Ru, Rh or Pd
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/902Oxidoreductases (1.)
    • G01N2333/904Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

resumo patente de invenção: "sensores de oxigênio". a presente invenção refere-se a sensores, polímeros e corantes luminescentes de detecção de oxigênio que compreendem esses sensores e métodos de uso desses sensores e sistemas.
BR112015022763A 2013-03-14 2014-03-13 sensor para detectar um analito BR112015022763A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784925P 2013-03-14 2013-03-14
PCT/US2014/026183 WO2014160258A1 (en) 2013-03-14 2014-03-13 Oxygen sensors

Publications (2)

Publication Number Publication Date
BR112015022763A2 true BR112015022763A2 (pt) 2017-07-18
BR112015022763A8 BR112015022763A8 (pt) 2019-11-26

Family

ID=51569283

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022763A BR112015022763A8 (pt) 2013-03-14 2014-03-13 sensor para detectar um analito

Country Status (8)

Country Link
US (6) US9375494B2 (pt)
EP (3) EP2970318B1 (pt)
JP (3) JP6244004B2 (pt)
CN (2) CN108852368B (pt)
AU (2) AU2014243988B2 (pt)
BR (1) BR112015022763A8 (pt)
CA (1) CA2904127C (pt)
WO (1) WO2014160258A1 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
CN110604585B (zh) 2010-10-06 2023-04-18 普罗弗萨股份有限公司 组织整合性传感器
FI2872877T3 (fi) 2012-07-10 2023-08-18 Massachusetts Gen Hospital Järjestelmä ja menetelmä kohteen pinnan tarkkailemiseksi ja hoitamiseksi
EP3763292A1 (en) 2013-03-14 2021-01-13 Profusa, Inc. Method and device for correcting optical signals
EP2970318B1 (en) 2013-03-14 2018-11-21 Profusa, Inc. Oxygen sensors comprising a polymer and a luminescent dye
EP3777656A1 (en) 2013-06-06 2021-02-17 Profusa, Inc. Apparatus for detecting optical signals from implanted sensors
WO2016041067A1 (en) * 2014-09-15 2016-03-24 Klox Technologies Inc. Emissive polymeric matrices
CA2996053A1 (en) 2015-09-02 2017-03-09 Metronom Health, Inc. Systems and methods for continuous health monitoring using an opto-enzymatic analyte sensor
DE102015014526A1 (de) 2015-11-11 2017-05-11 Giesecke & Devrient Gmbh Sicherheitspigment, lumineszierendes Polymerharz und Verfahren zum Herstellen desselben
US20190000361A1 (en) * 2015-12-09 2019-01-03 The Texas A&M University System Implantable biosensors
US10324058B2 (en) 2016-04-28 2019-06-18 Medtronic Minimed, Inc. In-situ chemistry stack for continuous glucose sensors
WO2017210841A1 (en) 2016-06-06 2017-12-14 University Of Washington Nanoparticle transducer sensors and methods of use thereof
US10662333B2 (en) 2016-06-17 2020-05-26 Profusa, Inc. NIR long lifetime indicator molecule
CA3034347A1 (en) 2016-08-22 2018-03-01 Fernando Patolsky Methods and systems for detecting bioanalytes
CA3034348A1 (en) * 2016-08-22 2018-03-01 Ramot At Tel-Aviv University Ltd. Method and system for subcutaneous sensing
WO2018119204A1 (en) * 2016-12-21 2018-06-28 Profusa, Inc. Polymerizable near-ir dyes
CN108968976B (zh) 2017-05-31 2022-09-13 心脏起搏器股份公司 具有化学传感器的植入式医疗设备
CA3066768A1 (en) 2017-06-29 2019-01-03 Profusa, Inc. Multi-analyte sensing tissue-integrating sensors
US12004853B2 (en) 2017-07-26 2024-06-11 Cardiac Pacemakers, Inc. Systems and methods for disambiguation of posture
CN109381195B (zh) 2017-08-10 2023-01-10 心脏起搏器股份公司 包括电解质传感器融合的系统和方法
CN109419515B (zh) 2017-08-23 2023-03-24 心脏起搏器股份公司 具有分级激活的可植入化学传感器
CN109864746B (zh) * 2017-12-01 2023-09-29 心脏起搏器股份公司 用于医学装置的多模式分析物传感器
CN109864747B (zh) * 2017-12-05 2023-08-25 心脏起搏器股份公司 多模式分析物传感器光电子接口
WO2019194875A2 (en) * 2017-12-28 2019-10-10 Profusa, Inc. Oxidase-based sensors and methods of using
AU2018395387A1 (en) * 2017-12-28 2020-07-16 Profusa, Inc. System and method for analyzing biochemical sensor data
KR20210040953A (ko) 2018-06-27 2021-04-14 프로퓨사 인코퍼레이티드 근적외선 글루코스 센서
JP2021530266A (ja) 2018-06-29 2021-11-11 プロフサ,インコーポレイテッド 積層型センサー及び使用方法
CN109035688B (zh) * 2018-08-06 2021-01-08 山东师范大学 基于磷光的氧浓度声光报警器
WO2020037269A2 (en) * 2018-08-17 2020-02-20 The Regents Of The University Of California Composite matrix for analyte biosensors
GB2577770B (en) 2019-07-25 2020-10-21 Oxford Optronix Solutions Ltd Method for detection of bacteria
CA3147294A1 (en) 2019-08-20 2021-02-25 Profusa, Inc. Optical filter device, system, and method for improved optical rejection of out-of-band wavelengths
US11998330B2 (en) 2021-01-29 2024-06-04 Medtronic Minimed, Inc. Interference rejection membranes useful with analyte sensors
WO2023172612A2 (en) * 2022-03-08 2023-09-14 Trustees Of Tufts College Silk chromophore composite materials for in situ oxygen sensing
US20250067712A1 (en) * 2023-07-18 2025-02-27 Mohamed Magdy Ibrahim Oxygen Sensing Composition and Method of Use

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220036A (en) * 1985-12-16 1993-06-15 Polaroid Corporation Thiolactone dye precursors
DK576187D0 (da) 1987-11-03 1987-11-03 Radiometer As Fremgangsmaade til bestemmelse af oxygenkoncentration
US5242835A (en) * 1987-11-03 1993-09-07 Radiometer A/S Method and apparatus for determining the concentration of oxygen
US4925268A (en) 1988-07-25 1990-05-15 Abbott Laboratories Fiber-optic physiological probes
US6362175B1 (en) 1991-09-20 2002-03-26 The Trustees Of The University Of Pennsylvania Porphyrin compounds for imaging tissue oxygen
JP2533430B2 (ja) * 1992-03-24 1996-09-11 三ツ星ベルト株式会社 色素分子を分散させたポリアミド複合物とその製造方法
US5487885A (en) * 1992-12-21 1996-01-30 Biophysica, Inc. Sunblocking polymers and their formulation
US5837865A (en) * 1993-10-15 1998-11-17 Trustees Of The University Of Pennsylvania Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen
JP2883824B2 (ja) 1993-11-07 1999-04-19 科学技術振興事業団 ボロン酸基を有する発蛍光性化合物
JP3321288B2 (ja) 1994-04-25 2002-09-03 日本ペイント株式会社 近赤外光重合性組成物
ATE278801T1 (de) 1995-11-22 2004-10-15 Medtronic Minimed Inc Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor
WO1998003512A1 (en) 1996-07-22 1998-01-29 Novartis Ag Process for the preparation of platinum or palladium benzoporphyrins and platinum or palladium cyclohexenoporphyrins, intermediates, and an oxygen sensor comprising platinum or palladium cyclohexenoporphyrin
US6274086B1 (en) 1996-12-16 2001-08-14 The Trustees Of The University Of Pennsylvania Apparatus for non-invasive imaging oxygen distribution in multi-dimensions
US6485703B1 (en) 1998-07-31 2002-11-26 The Texas A&M University System Compositions and methods for analyte detection
US6013122A (en) 1998-08-18 2000-01-11 Option Technologies, Inc. Tattoo inks
BR0007720B1 (pt) 1999-01-25 2014-04-08 Univ Duke Porfirinas substituídas e método de proteção de células contra toxicidade induzida por oxidante
US6858403B2 (en) 1999-05-11 2005-02-22 M-Biotech, Inc. Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide
US6366793B1 (en) 1999-09-10 2002-04-02 Beckman Coulter, Inc. Minimally invasive methods for measuring analtes in vivo
US6682938B1 (en) 1999-09-15 2004-01-27 The Regents Of The University Of California Glucose sensing molecules having selected fluorescent properties
DK1557422T3 (da) 2000-08-04 2014-01-20 Senseonics Inc Detektering af analytter i vandige miljøer
GB0025147D0 (en) 2000-10-13 2000-11-29 Torsana Diabetes Diagnostics A Optical sensor for in situ measurement of analytes
EP1221465A1 (en) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
US20020127626A1 (en) 2001-01-05 2002-09-12 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone
US6800451B2 (en) 2001-01-05 2004-10-05 Sensors For Medicine And Science, Inc. Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone
US20020119581A1 (en) 2001-01-05 2002-08-29 Daniloff George Y. Detection of analytes
JP2003261464A (ja) 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法
AU2003220547A1 (en) 2003-03-28 2004-11-23 Terumo Corporation Of Japan Solid-phase saccharide sensing compounds
EP1620076A4 (en) 2003-04-25 2010-08-25 Kos Life Sciences Inc HIGH SUPERPOREOUS HYDROGEL FORMATION
US7358094B2 (en) 2003-05-01 2008-04-15 Bell Michael L Sensor system for saccharides
WO2005032418A2 (en) 2003-10-01 2005-04-14 University Of Washington Novel porous biomaterials
US8029765B2 (en) * 2003-12-24 2011-10-04 Masimo Laboratories, Inc. SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
EP1804059A2 (en) 2004-05-21 2007-07-04 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
JP4691333B2 (ja) 2004-07-23 2011-06-01 テルモ株式会社 糖類測定用蛍光モノマー化合物、糖類測定用蛍光センサー物質および体内埋め込み用の糖類測定用センサー
EP1619229B1 (en) 2004-07-23 2007-04-11 Terumo Kabushiki Kaisha Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor
JP4691345B2 (ja) 2004-10-07 2011-06-01 テルモ株式会社 糖類測定用蛍光モノマー化合物、糖類測定用蛍光センサー物質および体内埋め込み用の糖類測定用センサー
US20070036682A1 (en) 2005-08-15 2007-02-15 Honeywell International Inc. Microoptic glucose detector
EP1934211B1 (en) 2005-09-02 2017-01-11 Visen Medical, Inc. Biocompatible n, n-disubstituted sulfonamide-containing fluorescent dye labels
GB0522796D0 (en) 2005-11-08 2005-12-14 Smart Holograms Ltd Novel boronate complex and its use in a glucose sensor
US7417164B2 (en) 2006-07-25 2008-08-26 Glumetrics Inc. Fluorescent dyes for use in glucose sensing
GB0615211D0 (en) 2006-07-31 2006-09-06 Ge Healthcare Uk Ltd Asymmetric flouro-substituted polymethine dyes
KR101492849B1 (ko) 2006-11-30 2015-02-12 센세오닉스, 인코포레이티드 산화 저항성 지시약 분자
US8785624B2 (en) 2007-06-13 2014-07-22 University Of Southern California Organic photosensitive optoelectronic devices with nonplanar porphyrins
GB0906318D0 (en) 2009-04-09 2009-05-20 Glysure Ltd Fluorophore and fluorescent sensor compound containing same
US9517023B2 (en) * 2009-06-01 2016-12-13 Profusa, Inc. Method and system for directing a localized biological response to an implant
US9040687B2 (en) 2010-01-22 2015-05-26 Council Of Scientific And Idustrial Research Process for the preparaton of novel porphyrin derivatives and their use as PDT agents and fluorescence probes
ES2524576T3 (es) 2010-01-29 2014-12-10 Nerviano Medical Sciences S.R.L. Derivados de 6,7-dihidroimidazo[1,5-a]pirazin-8(5H)-ona como moduladores de proteína cinasa
FR2958557B1 (fr) 2010-04-07 2014-10-31 Centre Nat Rech Scient Procede de traitement d'effluents comprenant des composes halogenes
US20140148596A1 (en) 2010-04-07 2014-05-29 Cornell University Covalent Organic Frameworks and Methods of Making Same
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
US9515206B2 (en) 2010-08-25 2016-12-06 The University Of South Dakota Electron-deficient fluorous porphyrins and methods of making and their use in organic solar cells
US9447107B2 (en) 2010-09-10 2016-09-20 University Of Southern California Broadly absorbing metalloporphyrin-based multichromophoric arrays for triplet harvesting
CN110604585B (zh) 2010-10-06 2023-04-18 普罗弗萨股份有限公司 组织整合性传感器
MX377462B (es) * 2010-12-28 2025-03-10 Dura Chemicals Inc Aditivos para composiciones liquidas curables.
US9250246B2 (en) 2011-06-29 2016-02-02 Portland State University Near-infrared fluorescent dyes with large stokes shifts
JP5844462B2 (ja) * 2011-07-01 2016-01-20 エンパイア テクノロジー ディベロップメント エルエルシー セルロース系材料を保存するためのパラベン誘導体
US9469941B2 (en) 2011-07-01 2016-10-18 Empire Technology Development Llc Paraben derivatives for preserving cellulosic materials
CA2843950A1 (en) 2011-08-01 2013-02-07 Massachusetts Institute Of Technology Photoluminescent nanostructure-based sensors
JP2013103094A (ja) 2011-11-16 2013-05-30 Sony Corp 測定装置、測定方法、プログラム及び記録媒体
EP2804860B1 (en) 2012-03-02 2016-06-15 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
CN102735667B (zh) 2012-06-28 2014-05-21 南京大学 基于氟硼二吡咯-苯硼酸的荧光传感膜及其制备方法和应用
WO2014041546A1 (en) 2012-09-13 2014-03-20 Ben-Gurion University Of The Negev Research And Development Authority Diagnostic agents with enhanced sensitivity/specificity
US20140088383A1 (en) 2012-09-14 2014-03-27 Senseonics, Incorporated Integrated catalytic protection of oxidation sensitive materials
US9714260B2 (en) 2013-01-07 2017-07-25 The University Of Tokyo Asymmetrical Si rhodamine and rhodol synthesis
US10156573B2 (en) 2013-03-14 2018-12-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Tri-color dual glucose and oxygen sensors and methods of preparing and using them
EP2970318B1 (en) 2013-03-14 2018-11-21 Profusa, Inc. Oxygen sensors comprising a polymer and a luminescent dye
EP3763292A1 (en) 2013-03-14 2021-01-13 Profusa, Inc. Method and device for correcting optical signals
EP2972229B1 (en) 2013-03-15 2017-12-27 Promega Corporation New silicon and germanium dyes for use in genetic identity
EP3777656A1 (en) 2013-06-06 2021-02-17 Profusa, Inc. Apparatus for detecting optical signals from implanted sensors
US9410958B2 (en) 2014-03-25 2016-08-09 The Regents Of The University Of California Alkyne-activated fluorogenic azide compounds and methods of use thereof
JP6618486B2 (ja) 2015-01-27 2019-12-11 テルモ株式会社 センサ挿入装置及びセンサ挿入装置セット
AU2016284813B2 (en) 2015-06-25 2020-12-24 Profusa, Inc. Transcutaneous reader for use with implantable analyte sensors
CN105602276B (zh) 2016-01-30 2017-07-28 苏州大学 可聚合近红外荧光染料单体及其制备方法、用途
US10662333B2 (en) 2016-06-17 2020-05-26 Profusa, Inc. NIR long lifetime indicator molecule
WO2018119204A1 (en) 2016-12-21 2018-06-28 Profusa, Inc. Polymerizable near-ir dyes
JOP20190161A1 (ar) 2016-12-27 2017-06-16 Profusa Inc مستشعرات جلوكوز بطيف قريب من الأشعة تحت الحمراء
MX2019010241A (es) 2017-03-01 2019-12-02 Metronom Health Inc Sensores de analitos y metodos de fabricacion de sensores de analitos.
CA3066768A1 (en) 2017-06-29 2019-01-03 Profusa, Inc. Multi-analyte sensing tissue-integrating sensors
WO2019194875A2 (en) 2017-12-28 2019-10-10 Profusa, Inc. Oxidase-based sensors and methods of using
KR20210040953A (ko) 2018-06-27 2021-04-14 프로퓨사 인코퍼레이티드 근적외선 글루코스 센서

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US20160374601A1 (en) 2016-12-29
BR112015022763A8 (pt) 2019-11-26
US9650566B2 (en) 2017-05-16
EP3797798A1 (en) 2021-03-31
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EP2970318B1 (en) 2018-11-21
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