BR112015018701A2 - vaginal ring for dispensing a water soluble polymer, and method for manufacturing a vaginal ring for dispensing a water soluble polymer - Google Patents
vaginal ring for dispensing a water soluble polymer, and method for manufacturing a vaginal ring for dispensing a water soluble polymerInfo
- Publication number
- BR112015018701A2 BR112015018701A2 BR112015018701A BR112015018701A BR112015018701A2 BR 112015018701 A2 BR112015018701 A2 BR 112015018701A2 BR 112015018701 A BR112015018701 A BR 112015018701A BR 112015018701 A BR112015018701 A BR 112015018701A BR 112015018701 A2 BR112015018701 A2 BR 112015018701A2
- Authority
- BR
- Brazil
- Prior art keywords
- water
- soluble polymer
- dispensing
- vaginal ring
- water soluble
- Prior art date
Links
- 229920003169 water-soluble polymer Polymers 0.000 title abstract 7
- 229940044953 vaginal ring Drugs 0.000 title abstract 4
- 239000006213 vaginal ring Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940113118 carrageenan Drugs 0.000 abstract 2
- 235000010418 carrageenan Nutrition 0.000 abstract 2
- 229920001525 carrageenan Polymers 0.000 abstract 2
- 239000000679 carrageenan Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 abstract 2
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229920001971 elastomer Polymers 0.000 abstract 1
- 239000000806 elastomer Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- -1 lambda carrageenan Chemical compound 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000003641 microbiacidal effect Effects 0.000 abstract 1
- 229940124561 microbicide Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/731—Carrageenans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1 / 1 resumo “anel vaginal para dispensaã‡ãƒo de um polã�mero solãšvel em ã�gua, e, mã‰todo para fabricar um anel vaginal para dispensaã‡ãƒo de um polã�mero solãšvel em ã�guaâ€� sã£o descritas composiã§ãµes para inibir transmissã£o de uma infecã§ã£o sexualmente transmissãvel que contãªm um ou mais microbicidas polianiã´nicos, como carragenina, incluindo carragenina lambda, assim como sais de metais solãºveis em ã¡gua e agentes antirretrovirais especificados compreendendo nnrtis e nrtis. tambã©m sã£o descritos mã©todos para fazer e usar as composiã§ãµes. tambã©m sã£o descritos anã©is intravaginais para dispensar compostos solãºveis em ã¡gua, e preferivelmente polãmeros solãºveis em ã¡gua de peso molecular alto a essencialmente uma velocidade de ordem zero. os anã©is incluem uma camada externa de elastã´mero nã£o intumescente em ã¡gua, e preferivelmente polãmero solãºvel em ã¡gua de peso molecular alto e uma camada interna do polãmero solãºvel em ã¡gua, que ã© embutida na camada externa, e um orifãcio atravã©s da camada externa para liberaã§ã£o do mesmo apenas atravã©s deste orifãcio.1/1 overview “vaginal ring for dispensing a water-soluble polymer, and method for making a vaginal ring for dispensing a water-soluble polymer” Compositions for inhibiting transmission of a sexually transmitted infection containing one or more polyanionic microbicides, such as carrageenan, including lambda carrageenan, as well as water-soluble metal salts and antiretroviral agents, are described. specified comprising nnrtis and nrtis. Also described are methods for making and using the compositions. Intravaginal rings for dispensing water-soluble compounds, and preferably water-soluble polymers of high molecular weight at essentially zero order velocity, are also described. the rings include an outer layer of non-water swellable elastomer, and preferably high molecular weight water-soluble polymer and an inner layer of water-soluble polymer, which is embedded in the outer layer, and an orifice through the outer layer for release thereof only through this orifice.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/759,981 US20130150810A1 (en) | 2002-04-30 | 2013-02-05 | Intravaginal ring for the delivery of unique combinations of antimicrobial compositions |
| PCT/US2014/014633 WO2014123880A1 (en) | 2013-02-05 | 2014-02-04 | Intravaginal ring for the delivery of unique combinations of antimicrobial compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015018701A2 true BR112015018701A2 (en) | 2017-07-18 |
Family
ID=50114594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015018701A BR112015018701A2 (en) | 2013-02-05 | 2014-02-04 | vaginal ring for dispensing a water soluble polymer, and method for manufacturing a vaginal ring for dispensing a water soluble polymer |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2953629A1 (en) |
| CN (1) | CN105555281A (en) |
| AU (1) | AU2014215459A1 (en) |
| BR (1) | BR112015018701A2 (en) |
| RU (1) | RU2015136769A (en) |
| WO (1) | WO2014123880A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018016651A2 (en) * | 2016-02-17 | 2018-12-26 | Ent Tech Pty Ltd | compositions and methods for treating sinus disease and disorders |
| RU2755130C2 (en) * | 2016-05-12 | 2021-09-13 | Мерк Шарп И Доум Корп. | Drug delivery system for delivery of antiviral drugs |
| CN106474147B (en) * | 2016-10-14 | 2022-07-05 | 上海颉隆投资管理有限公司 | Dressing for preventing and controlling human papilloma virus infection and preparation method thereof |
| BR112021016369A2 (en) * | 2019-02-19 | 2021-10-19 | Particle Sciences Inc. | DISTRIBUTION DEVICE, AND, METHODS FOR PRODUCING THE DRUG DISTRIBUTION DEVICE AND FOR DISTRIBUTING ONE OR MORE ACTIVE PHARMACEUTICAL AGENTS |
| EP4487840A1 (en) * | 2023-07-07 | 2025-01-08 | Sever Pharma Solutions | A three-layered intravaginal ring |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994015624A1 (en) | 1993-01-08 | 1994-07-21 | The Population Council | Use of sulphated polysaccharides for preventing sexually transmitted diseases |
| US5972372A (en) | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| US8367098B2 (en) * | 2002-04-30 | 2013-02-05 | The Population Council, Inc. | Unique combinations of antimicrobial compositions |
| WO2005004837A1 (en) * | 2003-07-10 | 2005-01-20 | Galen (Chemicals) Limited | Intravaginal drug delivery devices |
| CN105581976A (en) * | 2007-06-26 | 2016-05-18 | 沃纳奇尔科特有限责任公司 | Intravaginal drug delivery devices for the delivery of macromolecules and watersoluble drugs |
| CN103327985A (en) | 2010-08-20 | 2013-09-25 | 犹他大学研究基金会 | Devices and methods for intravaginal delivery of drugs and other substances |
| WO2012024461A2 (en) * | 2010-08-20 | 2012-02-23 | Teva Women's Health, Inc. | Intravaginal devices, methods of making, and uses thereof |
| US9078813B2 (en) * | 2010-11-12 | 2015-07-14 | The University Of Utah Research Foundation | Intravaginal devices for controlled delivery of lubricants |
| US9937335B2 (en) * | 2011-06-06 | 2018-04-10 | Oak Crest Institute Of Science | Drug delivery device employing wicking release window |
| KR20140074281A (en) | 2011-07-20 | 2014-06-17 | 패트릭 에프. 카이저 | Intravaginal devices for drug delivery |
-
2014
- 2014-02-04 BR BR112015018701A patent/BR112015018701A2/en not_active IP Right Cessation
- 2014-02-04 EP EP14705007.4A patent/EP2953629A1/en not_active Withdrawn
- 2014-02-04 AU AU2014215459A patent/AU2014215459A1/en not_active Abandoned
- 2014-02-04 RU RU2015136769A patent/RU2015136769A/en not_active Application Discontinuation
- 2014-02-04 WO PCT/US2014/014633 patent/WO2014123880A1/en not_active Ceased
- 2014-02-04 CN CN201480020245.9A patent/CN105555281A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015136769A (en) | 2017-03-13 |
| EP2953629A1 (en) | 2015-12-16 |
| CN105555281A (en) | 2016-05-04 |
| WO2014123880A1 (en) | 2014-08-14 |
| AU2014215459A1 (en) | 2015-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |