BR112014027841A2 - derivado de pirazola e o uso do mesmo para fins médicos - Google Patents
derivado de pirazola e o uso do mesmo para fins médicos Download PDFInfo
- Publication number
- BR112014027841A2 BR112014027841A2 BR112014027841A BR112014027841A BR112014027841A2 BR 112014027841 A2 BR112014027841 A2 BR 112014027841A2 BR 112014027841 A BR112014027841 A BR 112014027841A BR 112014027841 A BR112014027841 A BR 112014027841A BR 112014027841 A2 BR112014027841 A2 BR 112014027841A2
- Authority
- BR
- Brazil
- Prior art keywords
- medical purposes
- pyrazole
- present
- derived
- constipation
- Prior art date
Links
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 206010010774 Constipation Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 150000003217 pyrazoles Chemical class 0.000 abstract 2
- LREHMKLEOJAVMQ-TXKDOCKMSA-N 2,2-dimethyl-3-[3-[3-methyl-4-[[5-propan-2-yl-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1h-pyrazol-4-yl]methyl]phenoxy]propylamino]propanamide Chemical compound C=1C=C(OCCCNCC(C)(C)C(N)=O)C=C(C)C=1CC1=C(C(C)C)NN=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O LREHMKLEOJAVMQ-TXKDOCKMSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
resumo derivado de pirazola e o uso do mesmo para fins médicos a presente invenção proporciona derivados de pirazola, o uso dos mesmos para fins médicos e assim por diante. mais particularmente, a presente invenção se refere a produtos farmacêuticos úteis para a prevenção ou o tratamento de constipa-ção, que compreende como um ingrediente ativo 3-(3-{4-[3-(ß-d-glicopiranosiloxi)-5-isopropil-1h-pirazol-4-ilmetil]-3-metilfenoxi}propilamino)-2,2-dimetilpropionamida, ou um sal farmaceuticamente aceitável do mesmo. os produtos farmacêuticos da pre-sente invenção exercem um efeito de aumentar a frequência do movimento dos in-testinos ou semelhante, e são úteis para a prevenção ou o tratamento de constipa-ção.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-105847 | 2012-05-07 | ||
| JP2012105847 | 2012-05-07 | ||
| PCT/JP2013/062755 WO2013168671A1 (ja) | 2012-05-07 | 2013-05-02 | ピラゾール誘導体及びその医薬用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112014027841A2 true BR112014027841A2 (pt) | 2017-06-27 |
| BR112014027841A8 BR112014027841A8 (pt) | 2021-09-28 |
| BR112014027841B1 BR112014027841B1 (pt) | 2022-08-09 |
Family
ID=49550709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014027841-5A BR112014027841B1 (pt) | 2012-05-07 | 2013-05-02 | Uso de derivados de pirazola na fabricação de um fármaco para prevenir ou tratar constipação |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9273085B2 (pt) |
| EP (1) | EP2848254B1 (pt) |
| JP (2) | JP5663699B2 (pt) |
| KR (1) | KR101868991B1 (pt) |
| CN (1) | CN104284665B (pt) |
| AU (1) | AU2013258566B2 (pt) |
| BR (1) | BR112014027841B1 (pt) |
| CA (1) | CA2872002C (pt) |
| DK (1) | DK2848254T3 (pt) |
| ES (1) | ES2601127T3 (pt) |
| HK (1) | HK1204773A1 (pt) |
| MX (1) | MX359988B (pt) |
| PL (1) | PL2848254T3 (pt) |
| PT (1) | PT2848254T (pt) |
| RU (1) | RU2602739C2 (pt) |
| WO (1) | WO2013168671A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3400944T3 (da) | 2010-11-04 | 2020-10-12 | Albireo Ab | Ibat-inhibitorer til behandling af leversygdomme |
| JP5663699B2 (ja) * | 2012-05-07 | 2015-02-04 | キッセイ薬品工業株式会社 | ピラゾール誘導体及びその医薬用途 |
| EP2952206B1 (en) | 2013-02-04 | 2018-10-24 | Taisho Pharmaceutical Co., Ltd. | Prophylactic or therapeutic drug for constipation |
| WO2015199146A1 (ja) * | 2014-06-25 | 2015-12-30 | 味の素株式会社 | 固形製剤及びその安定化方法 |
| CN106659726A (zh) | 2014-06-25 | 2017-05-10 | Ea制药株式会社 | 固体制剂及其着色防止或着色减少方法 |
| CN112469407B (zh) | 2018-03-28 | 2024-10-01 | 阿沃林特有限公司 | 用于治疗餐后低血糖症的方法 |
| ES2942443T3 (es) | 2018-06-05 | 2023-06-01 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores de ácidos biliares |
| CR20210027A (es) | 2018-06-20 | 2021-04-29 | Albireo Ab | Formulación farmacéutica de odevixibat |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| PE20212251A1 (es) | 2019-02-06 | 2021-11-24 | Albireo Ab | Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| JP2023504644A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| JP2023504643A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| ES2973549T3 (es) | 2019-12-04 | 2024-06-20 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores de los ácidos biliares |
| EP4188541B1 (en) | 2020-08-03 | 2024-12-25 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| EP4243831A1 (en) | 2020-11-12 | 2023-09-20 | Albireo AB | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| JP2024500309A (ja) | 2020-12-04 | 2024-01-09 | アルビレオ エービー | ベンゾチア（ジ）アゼピン化合物および胆汁酸モジュレータとしてのその使用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004137245A (ja) | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
| AU2007243466B2 (en) * | 2006-04-26 | 2012-01-19 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them |
| ES2548578T3 (es) * | 2007-12-27 | 2015-10-19 | Kissei Pharmaceutical Co., Ltd. | Monosebacato de un derivado de pirazol |
| ES2385185T3 (es) | 2008-04-16 | 2012-07-19 | Kissei Pharmaceutical Co., Ltd. | Hemifumarato de un derivado de pirazol |
| AR087701A1 (es) | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
| JP5663699B2 (ja) * | 2012-05-07 | 2015-02-04 | キッセイ薬品工業株式会社 | ピラゾール誘導体及びその医薬用途 |
-
2013
- 2013-05-02 JP JP2014514708A patent/JP5663699B2/ja active Active
- 2013-05-02 CA CA2872002A patent/CA2872002C/en active Active
- 2013-05-02 AU AU2013258566A patent/AU2013258566B2/en active Active
- 2013-05-02 PT PT137877148T patent/PT2848254T/pt unknown
- 2013-05-02 CN CN201380024202.3A patent/CN104284665B/zh active Active
- 2013-05-02 US US14/399,093 patent/US9273085B2/en active Active
- 2013-05-02 EP EP13787714.8A patent/EP2848254B1/en active Active
- 2013-05-02 ES ES13787714.8T patent/ES2601127T3/es active Active
- 2013-05-02 DK DK13787714.8T patent/DK2848254T3/en active
- 2013-05-02 BR BR112014027841-5A patent/BR112014027841B1/pt active IP Right Grant
- 2013-05-02 RU RU2014149181/15A patent/RU2602739C2/ru active
- 2013-05-02 MX MX2014013696A patent/MX359988B/es active IP Right Grant
- 2013-05-02 PL PL13787714T patent/PL2848254T3/pl unknown
- 2013-05-02 WO PCT/JP2013/062755 patent/WO2013168671A1/ja active Application Filing
- 2013-05-02 KR KR1020147033887A patent/KR101868991B1/ko active Active
-
2014
- 2014-12-04 JP JP2014245645A patent/JP6105546B2/ja active Active
-
2015
- 2015-06-05 HK HK15105374.8A patent/HK1204773A1/xx unknown
-
2016
- 2016-01-14 US US14/995,489 patent/US9694027B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013168671A1 (ja) | 2013-11-14 |
| JP6105546B2 (ja) | 2017-03-29 |
| BR112014027841B1 (pt) | 2022-08-09 |
| ES2601127T3 (es) | 2017-02-14 |
| AU2013258566B2 (en) | 2017-03-16 |
| KR101868991B1 (ko) | 2018-06-19 |
| KR20150013671A (ko) | 2015-02-05 |
| US20160129031A1 (en) | 2016-05-12 |
| EP2848254B1 (en) | 2016-08-03 |
| US20150141631A1 (en) | 2015-05-21 |
| EP2848254A1 (en) | 2015-03-18 |
| DK2848254T3 (en) | 2016-10-31 |
| US9273085B2 (en) | 2016-03-01 |
| BR112014027841A8 (pt) | 2021-09-28 |
| CA2872002C (en) | 2019-01-15 |
| RU2014149181A (ru) | 2016-06-27 |
| EP2848254A4 (en) | 2015-07-15 |
| RU2602739C2 (ru) | 2016-11-20 |
| MX2014013696A (es) | 2015-02-05 |
| CA2872002A1 (en) | 2013-11-14 |
| JPWO2013168671A1 (ja) | 2016-01-07 |
| JP2015083580A (ja) | 2015-04-30 |
| PT2848254T (pt) | 2016-10-05 |
| PL2848254T3 (pl) | 2017-03-31 |
| CN104284665A (zh) | 2015-01-14 |
| AU2013258566A1 (en) | 2014-11-27 |
| JP5663699B2 (ja) | 2015-02-04 |
| MX359988B (es) | 2018-10-18 |
| CN104284665B (zh) | 2016-11-16 |
| US9694027B2 (en) | 2017-07-04 |
| HK1204773A1 (en) | 2015-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/05/2013, OBSERVADAS AS CONDICOES LEGAIS |