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BR112013004397A2 - método para produzir uma partícula de lipídio, a partícula de lipídio em si e seu uso - Google Patents

método para produzir uma partícula de lipídio, a partícula de lipídio em si e seu uso

Info

Publication number
BR112013004397A2
BR112013004397A2 BR112013004397A BR112013004397A BR112013004397A2 BR 112013004397 A2 BR112013004397 A2 BR 112013004397A2 BR 112013004397 A BR112013004397 A BR 112013004397A BR 112013004397 A BR112013004397 A BR 112013004397A BR 112013004397 A2 BR112013004397 A2 BR 112013004397A2
Authority
BR
Brazil
Prior art keywords
lipid particle
producing
itself
solution
detergent
Prior art date
Application number
BR112013004397A
Other languages
English (en)
Inventor
Grossmann Adelbert
Bader Martin
Baehner Monika
Mohl Silke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112013004397A2 publication Critical patent/BR112013004397A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

método para produzir uma partícula de lipídio, a partícula de lipídio em si e seu uso. é relatado aqui um método para produzir uma partícula de lipídio compreendendo as seguintes etapas i) proporcionar uma primeira solução compreendendo apolipoproteína desnaturada, ii) adicionar a primeira solução para uma segunda solução compreendendo pelo menos dois lipídios e um detergente, mas não a apolipoproteína, e iii) remover o detergente a partir da solução obtida na etapa ii) e, assim, produzir uma partícula de lipídio.
BR112013004397A 2010-08-30 2011-08-25 método para produzir uma partícula de lipídio, a partícula de lipídio em si e seu uso BR112013004397A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10008995 2010-08-30
PCT/EP2011/064600 WO2012028524A2 (en) 2010-08-30 2011-08-25 Method for producing a lipid particle, the lipid particle itself and its use

Publications (1)

Publication Number Publication Date
BR112013004397A2 true BR112013004397A2 (pt) 2017-06-27

Family

ID=44532851

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013004397A BR112013004397A2 (pt) 2010-08-30 2011-08-25 método para produzir uma partícula de lipídio, a partícula de lipídio em si e seu uso

Country Status (9)

Country Link
EP (1) EP2611419A2 (pt)
JP (1) JP2013544488A (pt)
KR (1) KR20130047749A (pt)
CN (1) CN103068368A (pt)
BR (1) BR112013004397A2 (pt)
CA (1) CA2807433A1 (pt)
MX (1) MX2013001541A (pt)
RU (1) RU2013111678A (pt)
WO (1) WO2012028524A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014010092A (es) 2012-02-29 2014-09-16 Hoffmann La Roche Escision enzimatica en columna.
CN103408669B (zh) * 2013-08-01 2016-01-20 江苏泰康生物医药有限公司 Glp-1类似物融合蛋白，及其制备方法和用途
DK3733641T3 (da) 2017-12-28 2024-07-22 Takeda Pharmaceuticals Co Kationiske lipider
TWI825057B (zh) 2017-12-28 2023-12-11 國立大學法人京都大學 標的基因改變用組成物
DE202019003092U1 (de) * 2019-07-24 2020-01-17 Ruth-Maria Korth Test zur Bestimmung von Proteophospholipiden und FIDA-Formeln zur Bestimmung von Schutzfaktoren , die mit Substraten auszugleichen sind
CN112546201A (zh) * 2019-09-26 2021-03-26 中国科学院生物物理研究所 人工脂蛋白颗粒apoA-Ⅳ脂肪体在治疗和/或预防糖尿病中的应用
CN116396358B (zh) * 2023-06-08 2023-08-29 时夕(广州)生物科技有限公司 一种骨靶向纳米脂质颗粒的制备及应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608347A (en) * 1982-04-15 1986-08-26 Bernstam Victor A Compositions, uses and methods creating reverse micelles for the clarification of biological fluids to obtain undistorted assay of analytes following clarification
SE500941C2 (sv) 1989-08-16 1994-10-03 Algy Persson Förfarande och apparat för snittning av ett preparat
DE4192335T1 (de) * 1990-09-18 1993-10-07 Biotech Australia Pty Ltd T-Zell-Epitope
US5652339A (en) * 1993-12-31 1997-07-29 Rotkreuzstiftung Zentrallaboratorium Method of producing reconstituted lipoproteins
US6037323A (en) 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6287590B1 (en) 1997-10-02 2001-09-11 Esperion Therapeutics, Inc. Peptide/lipid complex formation by co-lyophilization
EP0972838B1 (en) 1998-07-15 2004-09-15 Roche Diagnostics GmbH Escherichia coli host/vector system based on antibiotic-free selection by complementation of an auxotrophy
US6291245B1 (en) 1998-07-15 2001-09-18 Roche Diagnostics Gmbh Host-vector system
WO2001079446A2 (en) 2000-04-14 2001-10-25 Hyseq, Inc. Materials and methods relating to lipid metabolism
CN1268641C (zh) * 2000-11-10 2006-08-09 普罗蒂奥制药公司 载脂蛋白类似物
EP1382614A1 (en) * 2002-07-15 2004-01-21 Bayer HealthCare AG Process for the purification of interleukin-4 and its muteins
CA2443365C (en) 2002-11-19 2010-01-12 F. Hoffmann-La Roche Ag Methods for the recombinant production of antifusogenic peptides
PE20050438A1 (es) 2003-10-20 2005-06-14 Esperion Therapeutics Inc Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos
KR20060108739A (ko) * 2003-12-30 2006-10-18 와이어쓰 개선된 내약성을 가지는 면역원성 조성물 중 소수성단백질의 제제
WO2005084642A1 (en) 2004-01-28 2005-09-15 Biodelivery Sciences International, Inc. Apoprotein cochleate compositions
US20060160721A1 (en) * 2004-12-22 2006-07-20 Baylor College Of Medicine Method of plasma lipidation to prevent, inhibit and/or reverse atherosclerosis
WO2006125304A1 (en) 2005-05-25 2006-11-30 Liponex, Inc. Pharmaceutical compositions for treating or preventing coronary artery disease
US8163699B2 (en) 2006-06-01 2012-04-24 Montreal Heart Institute Method for the treatment of valvular disease
FR2915490B1 (fr) * 2007-04-26 2011-10-28 Univ Joseph Fourier Grenoble I Formation de proteoliposomes contenant des proteines membranaires a l'aide d'un systeme de synthese proteique acellulaire
WO2009048961A1 (en) * 2007-10-08 2009-04-16 Anaphore, Inc. Trimeric il-1ra
US8999320B2 (en) * 2008-01-30 2015-04-07 The Rockefeller University Nanoscale bound bilayers, methods of use and production
JP5539962B2 (ja) 2008-04-25 2014-07-02 ノースウェスタン、ユニバーシティ コレステロールを隔離するのに適したナノ構造体

Also Published As

Publication number Publication date
KR20130047749A (ko) 2013-05-08
JP2013544488A (ja) 2013-12-19
EP2611419A2 (en) 2013-07-10
CN103068368A (zh) 2013-04-24
RU2013111678A (ru) 2014-10-10
WO2012028524A3 (en) 2012-11-15
WO2012028524A2 (en) 2012-03-08
CA2807433A1 (en) 2012-03-08
MX2013001541A (es) 2013-03-18

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 6A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)
B15K Others concerning applications: alteration of classification

Ipc: A61K 9/127 (2006.01), A61K 38/47 (2006.01), C07K 1