BR112012000209B8 - glutamic acid heterodimers and their preparation processes - Google Patents
glutamic acid heterodimers and their preparation processesInfo
- Publication number
- BR112012000209B8 BR112012000209B8 BR112012000209A BR112012000209A BR112012000209B8 BR 112012000209 B8 BR112012000209 B8 BR 112012000209B8 BR 112012000209 A BR112012000209 A BR 112012000209A BR 112012000209 A BR112012000209 A BR 112012000209A BR 112012000209 B8 BR112012000209 B8 BR 112012000209B8
- Authority
- BR
- Brazil
- Prior art keywords
- heterodimers
- glutamic acid
- preparation processes
- formula
- benzyl
- Prior art date
Links
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 title abstract 2
- 235000013922 glutamic acid Nutrition 0.000 title abstract 2
- 239000004220 glutamic acid Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
heterodímeros de ácido glutâmico e seus processos de preparação. um processo de fabricação para a preparação de compostos radiorrotulados de fórmula (i) (i), inclui a reação de compostos de fórmula (ii) com uma fonte de radionucleotídeo de um halogênio na presença de um oxidante sob condição acídica, (ii) em que: *l é 123l, 124l, 125l ou 131l; r é alquila inferior, opcionalmente substituída com um ou mais átomos de flúor; q é c(o), o, nr', s, s(o)2, c(o)2, (ch2)p; y é c(o), o, nr', s, s(o)2, c(o)2, (ch2)p; r' é h, c(o), s(o)2, c(o)2; z é h, c1-c4 alquila, benzila, benzila substituída ou trialquilsilila; m é 0, 1, 2, 3, 4 ou 5; n é 0, 1, 2, 3, 4, 5 ou 6; e p é 0, 1, 2, 3, 4, 5 ou 6.glutamic acid heterodimers and their preparation processes. a manufacturing process for preparing radiolabeled compounds of formula (i) (i), includes reacting compounds of formula (ii) with a radionucleotide source of a halogen in the presence of an oxidant under acidic condition, (ii) in that: *l is 123l, 124l, 125l or 131l; r is lower alkyl, optionally substituted with one or more fluorine atoms; q is c(o), o, nr', s, s(o)2, c(o)2, (ch2)p; y is c(o), o, nr', s, s(o)2, c(o)2, (ch2)p; r' is h, c(o), s(o)2, c(o)2; z is h, c1-c4 alkyl, benzyl, substituted benzyl or trialkylsilyl; m is 0, 1, 2, 3, 4 or 5; n is 0, 1, 2, 3, 4, 5 or 6; and p is 0, 1, 2, 3, 4, 5 or 6.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18712009P | 2009-06-15 | 2009-06-15 | |
| US61/187,120 | 2009-06-15 | ||
| PCT/US2010/038645 WO2010147965A2 (en) | 2009-06-15 | 2010-06-15 | Process for production of heterodimers of glutamic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012000209A2 BR112012000209A2 (en) | 2017-07-11 |
| BR112012000209B1 BR112012000209B1 (en) | 2020-10-13 |
| BR112012000209B8 true BR112012000209B8 (en) | 2021-07-27 |
Family
ID=43067201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012000209A BR112012000209B8 (en) | 2009-06-15 | 2010-06-15 | glutamic acid heterodimers and their preparation processes |
| BR112012000210A BR112012000210A2 (en) | 2009-06-15 | 2010-06-15 | process for the production of glutamic acid heterodimers. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012000210A BR112012000210A2 (en) | 2009-06-15 | 2010-06-15 | process for the production of glutamic acid heterodimers. |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US8465725B2 (en) |
| AU (1) | AU2010260195B2 (en) |
| BR (2) | BR112012000209B8 (en) |
| WO (1) | WO2010147965A2 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528499B1 (en) * | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
| ES2847275T3 (en) | 2006-11-08 | 2021-08-02 | Molecular Insight Pharm Inc | Glutamic acid heterodimers |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP3875082A1 (en) | 2012-11-15 | 2021-09-08 | Endocyte, Inc. | Conjugates for treating diseases caused by psma expressing cells |
| US20150110814A1 (en) | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
| JP6908964B2 (en) | 2013-10-18 | 2021-07-28 | ピーエスエムエー ディベロップメント カンパニー，エルエルシー | Combination therapy with PSMA ligand conjugate |
| DK4095130T3 (en) | 2013-10-18 | 2024-04-22 | Novartis Ag | LABELED PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITORS, THEIR USE AS IMAGING AGENTS AND PHARMACEUTICAL AGENTS FOR THE TREATMENT OF PROSTATE CANCER |
| SG10201803618RA (en) | 2013-11-14 | 2018-06-28 | Endocyte Inc | Compounds for positron emission tomography |
| US20150147339A1 (en) | 2013-11-15 | 2015-05-28 | Psma Development Company, Llc | Biomarkers for psma targeted therapy for prostate cancer |
| AU2015315465B2 (en) | 2014-09-08 | 2019-08-29 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in PSMA-targeted radionuclide therapy of prostate cancer |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| MX2020010813A (en) | 2018-04-17 | 2021-01-08 | Endocyte Inc | Methods of treating cancer. |
| CN111072653A (en) * | 2019-12-26 | 2020-04-28 | 浙江工业大学 | A kind of method for directly synthesizing 1,3-dithioindolizine compounds from substituted 2-aryl indolizines |
| WO2021202376A1 (en) | 2020-03-30 | 2021-10-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for blocking uptake of prostate-specific membrane antigen (psma)-targeted radionuclides by exocrine organs |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800457A (en) | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
| US2730456A (en) | 1953-06-30 | 1956-01-10 | Ncr Co | Manifold record material |
| US2730457A (en) | 1953-06-30 | 1956-01-10 | Ncr Co | Pressure responsive record materials |
| US3527789A (en) | 1967-10-06 | 1970-09-08 | Shell Oil Co | Production of poly(lower)alkyl alkenepolycarboxylates |
| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US4272398A (en) | 1978-08-17 | 1981-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Microencapsulation process |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| JPS6131056A (en) | 1984-07-25 | 1986-02-13 | K Baiorojikaru Sci Lab:Kk | Preparation of processed soybean food |
| US4925673A (en) | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| JP2608550B2 (en) | 1986-10-17 | 1997-05-07 | 株式会社 片山化学工業研究所 | Corrosion protection method for soft water boiler |
| US4888136A (en) | 1988-05-02 | 1989-12-19 | Witco Corporation | New flame retardant compositions of matter and cellulosic products containing same |
| TW353663B (en) | 1991-04-06 | 1999-03-01 | Hoechst Ag | Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process |
| JP3051497B2 (en) | 1991-05-17 | 2000-06-12 | 株式会社第一ラジオアイソトープ研究所 | Radiodiagnostic agent using technetium complex of sulfanilamide derivative |
| US6359120B1 (en) | 1991-10-29 | 2002-03-19 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia-localizing moiety |
| NZ244613A (en) | 1991-10-29 | 1996-05-28 | Bracco International B V Subst | A ligand containing a hypoxia-localising moiety, preparation thereof; a kit (optionally multivial) for preparing a metal complex containing the ligand |
| IT1270260B (en) | 1994-06-21 | 1997-04-29 | Zambon Spa | PHOSPHONIC ACID DERIVATIVES FOR METALLOPEPTIDASE INHIBITIVE ACTIVITIES |
| US6011021A (en) | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
| JP2856098B2 (en) | 1995-04-11 | 1999-02-10 | 日本製紙株式会社 | Thermal recording sheet |
| US5795877A (en) | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
| US5824662A (en) | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
| US6046180A (en) | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
| US5672592A (en) | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
| US5902817A (en) | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
| US6071965A (en) | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
| US5962521A (en) | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
| CZ60499A3 (en) | 1996-09-27 | 1999-08-11 | Guilford Pharmaceuticals Inc. | PREPARATION ACTING UPON NAALADases, METHODS OF TREATING GLUTAMATE ABNORMALITY AND PROCESSES FOR INFLUENCING NEURONAL ACTIVITY IN ANIMALS |
| ZA983930B (en) | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| NZ507032A (en) | 1998-03-19 | 2003-06-30 | Pharmacia & Upjohn | 1,3,4-thiadiazoles useful for the treatment of herpes and cytomegalovirus infections |
| WO2000064911A1 (en) | 1999-04-28 | 2000-11-02 | Georgetown University | Ligands for metabotropic glutamate receptors |
| US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
| US6228888B1 (en) | 1999-07-01 | 2001-05-08 | Guilford Pharmaceuticals Inc. | Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors |
| CN1630517A (en) | 2001-05-24 | 2005-06-22 | 吴羽化学工业株式会社 | CXCR4-antagonistic drugs composed of nitrogen-containing compound |
| DE10135355C1 (en) | 2001-07-20 | 2003-04-17 | Schering Ag | Conjugates of macrocyclic metal complexes with biomolecules and their use in the preparation of NMR and radiodiagnostic agents and radiotherapy |
| US20030100594A1 (en) | 2001-08-10 | 2003-05-29 | Pharmacia Corporation | Carbonic anhydrase inhibitor |
| JP4303595B2 (en) | 2001-12-21 | 2009-07-29 | 透 小池 | Zinc complexes capable of trapping substances with anionic substituents |
| PT1472541E (en) | 2002-01-10 | 2009-12-21 | Univ Johns Hopkins | Imaging agents and methods of imaging naaladase of psma |
| ES2559764T3 (en) | 2002-03-11 | 2016-02-15 | Molecular Insight Pharmaceuticals, Inc. | Technetium dipyridine complexes, and methods of use thereof |
| CN100528846C (en) | 2002-09-11 | 2009-08-19 | 株式会社吴羽 | Amine compounds and use thereof |
| EP2594265B1 (en) | 2002-11-26 | 2015-10-28 | Institute Of Virology | Ca ix-specific inhibitors |
| US7833734B2 (en) | 2002-11-26 | 2010-11-16 | Institute Of Virology Of The Slovak Academy Of Sciences | CA IX-specific inhibitors |
| US7291631B2 (en) | 2003-04-11 | 2007-11-06 | Genzyme Corporation | CXCR4 chemokine receptor binding compounds |
| US7682601B2 (en) | 2003-04-15 | 2010-03-23 | Mallinckrodt Inc. | Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes |
| JP2007513928A (en) | 2003-12-12 | 2007-05-31 | オサケユイチア ユバンティア ファーマ リミティド | Somatostatin receptor subtype 1 (SSTR1) active compounds and their use in therapy |
| EP1718342A4 (en) | 2004-02-12 | 2009-07-22 | Molecular Insight Pharm Inc | Technetium-and rhenium-bis(heteroaryl) complexes, and methods of use thereof |
| GB0421308D0 (en) * | 2004-09-24 | 2004-10-27 | Amersham Plc | Enzyme inhibitor imaging agents |
| WO2008059489A2 (en) | 2006-11-13 | 2008-05-22 | Spectrum Dynamics Llc | Radioimaging applications of and novel formulations of teboroxime |
| WO2006080993A1 (en) | 2004-12-08 | 2006-08-03 | Purdue Research Foundation | Novel cationic metal complex radiopharmaceuticals |
| US20060155021A1 (en) | 2005-01-13 | 2006-07-13 | Lenges Christian P | Coating compositions containing rheology control agents |
| US7741510B2 (en) | 2005-01-13 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Rheology control agents |
| WO2006093991A1 (en) | 2005-03-02 | 2006-09-08 | The Cleveland Clinic Foundation | Compounds which bind psma and uses thereof |
| CA2606477C (en) | 2005-04-27 | 2013-05-28 | Siemens Medical Solutions Usa, Inc. | In situ click chemistry method for screening high affinity molecular imaging probes |
| US8871720B2 (en) * | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| FR2890657B1 (en) | 2005-09-15 | 2007-11-09 | Commissariat Energie Atomique | PROCESS FOR OBTAINING COMPLEXES OF HIGHLY LUMINESCENT LANTHANIDES |
| US8926945B2 (en) | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| PL1961744T3 (en) | 2005-11-18 | 2013-09-30 | Ono Pharmaceutical Co | Basic group-containing compound and use thereof |
| EP1981635A1 (en) | 2006-02-06 | 2008-10-22 | Ciba Holding Inc. | Use of metal complex compounds as oxidation catalysts |
| US8618122B2 (en) | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| CN101472895A (en) | 2006-06-20 | 2009-07-01 | 石原产业株式会社 | Pest control agent containing novel pyridyl-methanamine derivative or salt thereof |
| WO2008016006A1 (en) | 2006-07-31 | 2008-02-07 | Ono Pharmaceutical Co., Ltd. | Compound having cyclic group bound thereto through spiro binding and use thereof |
| CN101594886A (en) | 2006-08-29 | 2009-12-02 | 分子制药洞察公司 | Be coupled to and be used for the irradiation image part that the peptidase bound fraction of the tissue of peptidase and organ is expressed in imaging |
| ES2847275T3 (en) | 2006-11-08 | 2021-08-02 | Molecular Insight Pharm Inc | Glutamic acid heterodimers |
| JP2010523599A (en) | 2007-04-05 | 2010-07-15 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | Development of molecular imaging probe for carbonic anhydrase-IX using click chemistry |
| WO2009076434A1 (en) | 2007-12-12 | 2009-06-18 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of integrin vla-4 |
| US8562945B2 (en) | 2008-01-09 | 2013-10-22 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof |
| WO2009089383A2 (en) | 2008-01-09 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase ix |
| RU2011116223A (en) | 2008-09-25 | 2012-10-27 | Моликьюлар Инсайт Фармасьютикалз, Инк. (Us) | SEPRAZE SELECTIVE INHIBITORS |
| US8211402B2 (en) | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer |
| CN102272101A (en) | 2008-12-05 | 2011-12-07 | 分子制药洞察公司 | Ca-ix specific radiopharmaceuticals for the treatment and imaging of cancer |
-
2010
- 2010-06-15 AU AU2010260195A patent/AU2010260195B2/en active Active
- 2010-06-15 BR BR112012000209A patent/BR112012000209B8/en active IP Right Grant
- 2010-06-15 BR BR112012000210A patent/BR112012000210A2/en not_active IP Right Cessation
- 2010-06-15 WO PCT/US2010/038645 patent/WO2010147965A2/en active Application Filing
- 2010-06-15 US US12/815,637 patent/US8465725B2/en active Active
-
2013
- 2013-05-09 US US13/890,912 patent/US9149547B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012000209B1 (en) | 2020-10-13 |
| AU2010260195A1 (en) | 2012-01-19 |
| US20140030188A1 (en) | 2014-01-30 |
| AU2010260195B2 (en) | 2014-11-20 |
| US8465725B2 (en) | 2013-06-18 |
| WO2010147965A2 (en) | 2010-12-23 |
| US20110008253A1 (en) | 2011-01-13 |
| WO2010147965A3 (en) | 2011-07-28 |
| BR112012000210A2 (en) | 2019-09-24 |
| US9149547B2 (en) | 2015-10-06 |
| BR112012000209A2 (en) | 2017-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012000209B8 (en) | glutamic acid heterodimers and their preparation processes | |
| CY1113131T1 (en) | INDOLO PRODUCERS AS S1P1 RECEPTOR RACE | |
| CO6612267A2 (en) | New derivatives of 1,1 dioxide-5 phenyl- 2,3,4-5 tetrahydro-1,4-benzothiazepine and pharmaceutical compositions comprising them | |
| CU20120122A7 (en) | DERIVATIVES 5-ARIL-1,2,4-TRIAZOLONA LINKED TO REPLACED BISARILO | |
| BRPI0618482A2 (en) | nucleobase containing perfluoroalkyl group and process for the production thereof | |
| BRPI0814153B8 (en) | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES AND STARTING COMPOUNDS USEFUL IN THE METHOD | |
| BRPI1013821A8 (en) | substituted pyridines as ccr3 antagonists. | |
| BR112012010186A2 (en) | heteroaryl derivatives containing n as jak3 kinase inhibitors. | |
| BR112015022483A2 (en) | 3-pyrimidin-4-yl-oxazolidin-2-ones as mutant idh inhibitors | |
| EA201490912A1 (en) | DERIVATIVES [1,2,3] TRIAZOLO [4,5-D] Pyrimidine as Agonists of Cannabinoid Receptor 2 | |
| BRPI0514125A (en) | condensed pyridines as kinase inhibitors | |
| UY33337A (en) | SUBSTITUTED DERIVATIVES OF 1H-PIRAZOL [3,4-d] PYRIMIDINE AS INHIBITORS OF PHOSFOINOSITIDE 3-KINASES | |
| CR20140057A (en) | FUNGICIDE COMPOUNDS OF 1- {2- [2-HALO-4- (4-HALOGEN-Phenoxy) -Phenyl] -2-ETOXI-ETIL} -1H- [1,2,4] SUBSTITUTED TRIAZOL | |
| ECSP088623A (en) | DERIVATIVES OF AZEPINOINDOL AS PHARMACEUTICAL AGENTS | |
| UY33241A (en) | ? Tienopyrimidines containing heterocycloalkyl for pharmaceutical compositions ?. | |
| PE20120495A1 (en) | ETHYL 3-CYCLOPENTILAMINO-2,2-DIFLUOR-PROPANOATE AS AN INTERMEDIARY IN THE PREPARATION OF PYRIMIDODIAZEPINES | |
| BR112015012366A2 (en) | cxcr7 antagonists | |
| BR112013021896A2 (en) | serine / threonine kinase inhibitors | |
| BRPI0713190B1 (en) | compound and methods for preparing compounds | |
| BR112015018663A2 (en) | pyridazinone amides derivatives | |
| BR112013023876A2 (en) | pyrroltriazinone derivatives as pi3k inhibitors | |
| MA35434B1 (en) | Amino-quinazolines as kinase inhibitors | |
| BR112012030473A2 (en) | pesticides based on spiroheterocyclic pyrrolidine derivatives | |
| ECSP099806A (en) | OXAZOLIDINONES REPLACED AND ITS USE | |
| MX2016003422A (en) | Imidazo[1,2-a]pyridin-7-amines as imaging tools. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15G | Petition not considered as such [chapter 15.7 patent gazette] | ||
| B151 | Others concerning applications: resolution cancelled [chapter 15.31 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/10/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/06/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |