BR0209936A - Composição combinada farmacêutica,e uso de um composto e de um inibidor de cianoguanidina ikk - Google Patents
Composição combinada farmacêutica,e uso de um composto e de um inibidor de cianoguanidina ikkInfo
- Publication number
- BR0209936A BR0209936A BR0209936-5A BR0209936A BR0209936A BR 0209936 A BR0209936 A BR 0209936A BR 0209936 A BR0209936 A BR 0209936A BR 0209936 A BR0209936 A BR 0209936A
- Authority
- BR
- Brazil
- Prior art keywords
- alkoxycarbonyl
- alkoxy
- cyanoguanidine
- inhibitor
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- -1 nitro, sulfo, cyano, amino Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 229940041181 antineoplastic drug Drugs 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSIçãO COMBINADA FARMACêUTICA, E, USOS DE UM COMPOSTO E DE UM INIBIDOR DE CIANOGUANIDINA IKK". Composição farmacêutica que compreende, como uma primeira droga anti-neoplástica, inibidores de cianoguanidina IKK, e em particular compostos da fórmula (I): em que n é 0, 1 ou 2, cada R representa independentemente grupos halogênio, trifluorometila., hidróxi, alquila C~ 1-4~, alcóxi C~ 1-4~, alcoxicarbonila C~ 1-4~, nitro, sulfo, ciano, amino ou carbóxi. Q é um radical hidrocarboneto divalente C~ 4-20~ saturado ou insaturado, reto ou ramificado, X é uma ligação amino, O, S, carbonila, carbonilamino, aminocarbonila, oxicarbonilóxi, oxicarbonila, carbonilóxi, aminocarbonilóxi, aminotiocarbonilóxi, oxicarbonilamino ou oxitiocarbonilamino; A é di (alcóxi C~ 1-4~) fosfinoilóxi, alcoxicarbonila C~ 1-4~, alcoxicarbonilamino C~ 1-4~, anel carbocíclico C~ 3-12~ ou anel heterocarbocíclico C~ 3-12~ opcionalmente substituído por um ou mais R~ 1~; R~ 1~ sendo independentemente selecionado a partir do grupo que consiste de halogênio, trifluorometila, hidróxi, alquila C~ 1-4~, alcóxi C~ 1-4~, alcoxicarbonila C~ 1-4~, nitro, ciano, amino, sulfo, carbóxi, carboxmido, sulfamoíla, ou hidroxialquila C~ 1-4~; em combinação com uma segunda droga anti-neoplástica são providos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29292801P | 2001-05-24 | 2001-05-24 | |
| PCT/DK2002/000351 WO2002094322A2 (en) | 2001-05-24 | 2002-05-24 | Combination medicament for treatment of neoplastic diseases containing cyanoguanidine ikk inhibitors and a second anti-neoplastic drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209936A true BR0209936A (pt) | 2004-04-06 |
Family
ID=23126850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209936-5A BR0209936A (pt) | 2001-05-24 | 2002-05-24 | Composição combinada farmacêutica,e uso de um composto e de um inibidor de cianoguanidina ikk |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20030045515A1 (pt) |
| EP (1) | EP1411984B1 (pt) |
| JP (1) | JP2005508857A (pt) |
| KR (1) | KR20040007607A (pt) |
| CN (1) | CN1516600A (pt) |
| AT (1) | ATE394100T1 (pt) |
| AU (1) | AU2002316795B2 (pt) |
| BR (1) | BR0209936A (pt) |
| CA (1) | CA2449442A1 (pt) |
| CZ (1) | CZ20033189A3 (pt) |
| DE (1) | DE60226446D1 (pt) |
| HU (1) | HUP0400024A3 (pt) |
| IL (1) | IL158821A0 (pt) |
| MX (1) | MXPA03010691A (pt) |
| PL (1) | PL366462A1 (pt) |
| RU (1) | RU2291710C2 (pt) |
| WO (1) | WO2002094322A2 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0309996A (pt) * | 2002-05-17 | 2005-02-22 | Leo Pharma As | Composto, composição farmacêutica, método de tratar ou melhorar doenças ou condições proliferativas, uso de um composto, e, método de tratar ou melhorar doenças inflamatórias |
| AU2003223932A1 (en) * | 2002-05-17 | 2003-12-02 | Leo Pharma A/S | Cyanoguanidine produgs |
| US7253193B2 (en) * | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| WO2004041285A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| AU2003295773A1 (en) * | 2002-11-21 | 2004-06-18 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050075341A1 (en) * | 2003-07-17 | 2005-04-07 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an IKK inhibitor for the treatment of ischemic mediated central nervous system disorders or injury |
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| PE20060748A1 (es) | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
| WO2006066584A1 (en) | 2004-12-22 | 2006-06-29 | Leo Pharma A/S | Novel cyanoguanidine compounds |
| AR055343A1 (es) | 2005-06-30 | 2007-08-22 | Smithkline Beecham Corp | Derivados de indolcarboxamida inhibidores de quinasas ikk2 |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| EP1912646A2 (de) * | 2005-08-04 | 2008-04-23 | Bayer HealthCare AG | KOMBINATIONEN MIT IKK-ß INHIBITOREN |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| JP2011518195A (ja) | 2008-04-21 | 2011-06-23 | オトノミ―，インク． | 耳の疾患と疾病を処置するための耳の製剤と関連する応用 |
| WO2010088842A1 (zh) * | 2009-02-06 | 2010-08-12 | 天津和美生物技术有限公司 | 含有吡啶基氰基胍的药物组合物及其制备和应用 |
| EP2406249A1 (en) | 2009-03-10 | 2012-01-18 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| JP5881705B2 (ja) | 2010-09-03 | 2016-03-09 | フォーマ ティーエム， エルエルシー． | Ｎａｍｐｔの阻害のための新規化合物及び組成物 |
| US10744141B2 (en) | 2015-06-23 | 2020-08-18 | Case Western Reserve University | Compositions and methods for treating cancer |
| WO2018005830A1 (en) | 2016-06-29 | 2018-01-04 | Otonomy, Inc. | Triglyceride otic formulations and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9219472D0 (en) * | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9711119D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711124D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711122D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
-
2002
- 2002-05-21 US US10/151,094 patent/US20030045515A1/en not_active Abandoned
- 2002-05-24 IL IL15882102A patent/IL158821A0/xx unknown
- 2002-05-24 AT AT02745167T patent/ATE394100T1/de not_active IP Right Cessation
- 2002-05-24 KR KR10-2003-7015363A patent/KR20040007607A/ko not_active Application Discontinuation
- 2002-05-24 CN CNA028121880A patent/CN1516600A/zh active Pending
- 2002-05-24 DE DE60226446T patent/DE60226446D1/de not_active Expired - Fee Related
- 2002-05-24 PL PL02366462A patent/PL366462A1/xx not_active Application Discontinuation
- 2002-05-24 RU RU2003137006/15A patent/RU2291710C2/ru not_active IP Right Cessation
- 2002-05-24 HU HU0400024A patent/HUP0400024A3/hu unknown
- 2002-05-24 JP JP2002591038A patent/JP2005508857A/ja not_active Withdrawn
- 2002-05-24 CA CA002449442A patent/CA2449442A1/en not_active Abandoned
- 2002-05-24 WO PCT/DK2002/000351 patent/WO2002094322A2/en active IP Right Grant
- 2002-05-24 BR BR0209936-5A patent/BR0209936A/pt not_active IP Right Cessation
- 2002-05-24 CZ CZ20033189A patent/CZ20033189A3/cs unknown
- 2002-05-24 MX MXPA03010691A patent/MXPA03010691A/es unknown
- 2002-05-24 AU AU2002316795A patent/AU2002316795B2/en not_active Ceased
- 2002-05-24 EP EP02745167A patent/EP1411984B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002316795B2 (en) | 2007-08-02 |
| MXPA03010691A (es) | 2004-07-01 |
| WO2002094322A3 (en) | 2004-02-26 |
| CZ20033189A3 (cs) | 2004-12-15 |
| ATE394100T1 (de) | 2008-05-15 |
| HUP0400024A3 (en) | 2007-05-29 |
| JP2005508857A (ja) | 2005-04-07 |
| KR20040007607A (ko) | 2004-01-24 |
| EP1411984B1 (en) | 2008-05-07 |
| RU2291710C2 (ru) | 2007-01-20 |
| HUP0400024A2 (hu) | 2004-04-28 |
| PL366462A1 (en) | 2005-02-07 |
| DE60226446D1 (de) | 2008-06-19 |
| US20030045515A1 (en) | 2003-03-06 |
| RU2003137006A (ru) | 2005-04-10 |
| CN1516600A (zh) | 2004-07-28 |
| CA2449442A1 (en) | 2002-11-28 |
| EP1411984A2 (en) | 2004-04-28 |
| IL158821A0 (en) | 2004-05-12 |
| WO2002094322A2 (en) | 2002-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0209936A (pt) | Composição combinada farmacêutica,e uso de um composto e de um inibidor de cianoguanidina ikk | |
| BRPI0418639A (pt) | inibidores de dipeptidil peptidase | |
| BRPI0415960A (pt) | composto ou um sal do mesmo, pró-droga de um composto, agente farmacêutico, inibidor de peptidase, composto ou um sal do mesmo, pró-droga de um composto, agente farmacêutico, inibidor de peptidase, uso de um composto,e, método para produzir um composto | |
| BR0208192A (pt) | Derivados espirotricìclicos e seu uso como inibidores da fosfodiesterase-7. | |
| ES2531660T3 (es) | Compuestos novedosos que tienen actividad inhibidora frente a transportador de glucosa dependiente de sodio | |
| CO5580803A2 (es) | Derivados de piperidin-bencensulfonamida | |
| BR0208907A (pt) | Composto uso de um composto, composição farmacêutica, métodos para a terapia da dor em um animal de sangue quente e para a redução seletiva de uma porção nitro orto para um substituinte amino em um anel fenila ou piridila de um composto. | |
| UY27604A1 (es) | Compuestos químicos. | |
| BR0316081A (pt) | Derivados de 2-piridona como inibidores de elastase de neutrófilo | |
| BRPI0417571A (pt) | 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase | |
| ATE302775T1 (de) | Carbolinderivate | |
| UY28623A1 (es) | Derivados de pirazol y usos de los mismos | |
| BR0013041A (pt) | Composto heterociclico e composição farmacêutica para tratar e prevenir doenças mediadas por cgmp-pde, seu uso e método | |
| BRPI0113162B8 (pt) | compostos ariloxialquilaminas nao-imidazólicos e composição farmacêutica compreendendo os referidos compostos | |
| CO5690551A2 (es) | Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo | |
| BRPI0407591A (pt) | inibidores de transcriptase reversa de não-nucleosìdeo | |
| BRPI0408353A (pt) | composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto | |
| HN2003000062A (es) | Derivados de nicotinamida utiles como inhibidores de pde4 | |
| ATE332903T1 (de) | Kondensierte pyridoindolderivate | |
| ATE300543T1 (de) | Kondensierte pyrazindionderivate als pde5 inhibitore | |
| AR063625A1 (es) | COMPUESTOS HETEROCICLICOS eTILES COMO AGENTES ANTICANCEROSOS | |
| DE60219911D1 (de) | Pyrrolidin-2-on derivate als faktor xa inhibitoren | |
| DK1448562T3 (da) | Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer | |
| BR0317284A (pt) | Inibidores aminocianopiridina de proteìna quinase-2 ativada com proteìna quinase ativada com mitógeno | |
| NO20054787D0 (no) | Indenderivater som farmasotiske midler |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 7A., E 8A. ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |