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BR0112092A - 2-aminoalquiltieno[2,3-d]pirimidinas - Google Patents

2-aminoalquiltieno[2,3-d]pirimidinas

Info

Publication number
BR0112092A
BR0112092A BR0112092-1A BR0112092A BR0112092A BR 0112092 A BR0112092 A BR 0112092A BR 0112092 A BR0112092 A BR 0112092A BR 0112092 A BR0112092 A BR 0112092A
Authority
BR
Brazil
Prior art keywords
pyrimidines
treatment
aminoalkylthieno
aminomethylthieno
aminoalkylthene
Prior art date
Application number
BR0112092-1A
Other languages
English (en)
Inventor
Rochus Jonas
Pierre Schelling
Maria Christadler
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0112092A publication Critical patent/BR0112092A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"2-AMINOALQUILTIENO[2,3-d]PIRIMIDINAS". A presente invenção refere-se a 2-aminometiltieno[2,3-d]pirimidinas de fórmula geral (I). Na qual os radicais R^ 1^ a R^ 6^ têm os significados indicado no texto. Os compostos apresentam inibição da fosfodiesterase V e podem ser empregados para o tratamento de condições do sistema cardiovascular e para o tratamento de distúrbios da potência.
BR0112092-1A 2000-06-29 2001-06-28 2-aminoalquiltieno[2,3-d]pirimidinas BR0112092A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10031585A DE10031585A1 (de) 2000-06-29 2000-06-29 2-Aminoalkyl-thieno[2,3-d]pyrimidine
PCT/EP2001/007379 WO2002000664A1 (de) 2000-06-29 2001-06-28 2-aminoalkyl-thieno[2,3-d]pyrimidine

Publications (1)

Publication Number Publication Date
BR0112092A true BR0112092A (pt) 2003-05-06

Family

ID=7647152

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112092-1A BR0112092A (pt) 2000-06-29 2001-06-28 2-aminoalquiltieno[2,3-d]pirimidinas

Country Status (23)

Country Link
US (1) US7259168B2 (pt)
EP (1) EP1294729B1 (pt)
JP (1) JP2004501925A (pt)
KR (1) KR20030010756A (pt)
CN (1) CN1234712C (pt)
AR (1) AR031856A1 (pt)
AT (1) ATE276260T1 (pt)
AU (2) AU2001285785B2 (pt)
BR (1) BR0112092A (pt)
CA (1) CA2410408C (pt)
CZ (1) CZ20024070A3 (pt)
DE (2) DE10031585A1 (pt)
DK (1) DK1294729T3 (pt)
ES (1) ES2227259T3 (pt)
HU (1) HUP0301466A3 (pt)
MX (1) MXPA02012260A (pt)
NO (1) NO20026246D0 (pt)
PL (1) PL358552A1 (pt)
PT (1) PT1294729E (pt)
RU (1) RU2261863C2 (pt)
SK (1) SK17822002A3 (pt)
WO (1) WO2002000664A1 (pt)
ZA (1) ZA200209729B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
BR112015022483A2 (pt) 2013-03-14 2017-07-18 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante
WO2017019537A1 (en) 2015-07-24 2017-02-02 University Of Louisville Research Foundation, Inc. Compounds, compositions, methods for treating diseases, and methods for preparing compounds
WO2019115774A1 (en) * 2017-12-15 2019-06-20 Leo Pharma A/S Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19632423A1 (de) * 1996-08-12 1998-02-19 Merck Patent Gmbh Thienopyrimidine
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE19819023A1 (de) * 1998-04-29 1999-11-04 Merck Patent Gmbh Thienopyrimidine
DE19928146A1 (de) * 1999-06-19 2000-12-21 Merck Patent Gmbh Thienopyrimidine
DE10010612A1 (de) * 2000-03-03 2001-09-27 Merck Patent Gmbh Verwendung von PDE V-Inhibitoren
DE10031584A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
TWI447508B (zh) 2010-04-01 2014-08-01 Delta Electronics Inc 投影裝置以及用於判斷一光點於投影畫面之位置之定位方法

Also Published As

Publication number Publication date
SK17822002A3 (sk) 2003-05-02
NO20026246L (no) 2002-12-27
AR031856A1 (es) 2003-10-08
DK1294729T3 (da) 2005-01-17
ATE276260T1 (de) 2004-10-15
HUP0301466A2 (hu) 2003-11-28
NO20026246D0 (no) 2002-12-27
WO2002000664A1 (de) 2002-01-03
CA2410408A1 (en) 2002-11-26
JP2004501925A (ja) 2004-01-22
US7259168B2 (en) 2007-08-21
DE50103649D1 (de) 2004-10-21
ZA200209729B (en) 2004-03-08
HUP0301466A3 (en) 2005-04-28
EP1294729A1 (de) 2003-03-26
KR20030010756A (ko) 2003-02-05
ES2227259T3 (es) 2005-04-01
CN1439012A (zh) 2003-08-27
EP1294729B1 (de) 2004-09-15
AU8578501A (en) 2002-01-08
AU2001285785B2 (en) 2006-04-13
PL358552A1 (en) 2004-08-09
MXPA02012260A (es) 2003-04-25
RU2261863C2 (ru) 2005-10-10
CN1234712C (zh) 2006-01-04
CA2410408C (en) 2010-06-22
CZ20024070A3 (cs) 2003-04-16
PT1294729E (pt) 2005-01-31
US20040044011A1 (en) 2004-03-04
DE10031585A1 (de) 2002-01-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008.