BR0101518A - Polinucleotìdeo, vetor, célula hospedeira,polipeptìdeo, método para produzir ml-236b,ml-236b, método para fabricar pravastatina, e,anticorpo - Google Patents
Polinucleotìdeo, vetor, célula hospedeira,polipeptìdeo, método para produzir ml-236b,ml-236b, método para fabricar pravastatina, e,anticorpoInfo
- Publication number
- BR0101518A BR0101518A BR0101518-4A BR0101518A BR0101518A BR 0101518 A BR0101518 A BR 0101518A BR 0101518 A BR0101518 A BR 0101518A BR 0101518 A BR0101518 A BR 0101518A
- Authority
- BR
- Brazil
- Prior art keywords
- polynucleotide
- polypeptide
- antibody
- vector
- host cell
- Prior art date
Links
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title abstract 3
- 229960002965 pravastatin Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 5
- 244000005700 microbiome Species 0.000 abstract 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229930001119 polyketide Natural products 0.000 abstract 1
- 125000000830 polyketide group Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/385—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Penicillium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
"POLINUCLEOTìDEO VETOR, CéLULA HOSPEDEIRA,POLIPEPTìDEO, MéTODO PARA PRODUZIR ML-236B,ML-236B, MéTODO PARA FABRICAR PRAVASTATINA, E,ANTICORPO". O ML-236B é um inibidor de HMG-CoA redutase eútil na preparação de um outro tal inibidor, pravastatina. Apreparação de ML-236B usando-se um microorganismo queproduza ML-236B é intensificada usando-se um polinucleotídeoque codifica um gene relacionado ao agrupamento do policetídeosintase que ocorre em tal microorganismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000116591 | 2000-04-18 | ||
| JP2000117458 | 2000-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0101518A true BR0101518A (pt) | 2001-11-13 |
Family
ID=26590305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0101518-4A BR0101518A (pt) | 2000-04-18 | 2001-04-18 | Polinucleotìdeo, vetor, célula hospedeira,polipeptìdeo, método para produzir ml-236b,ml-236b, método para fabricar pravastatina, e,anticorpo |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US7056710B2 (pt) |
| EP (1) | EP1149919B1 (pt) |
| KR (1) | KR100632174B1 (pt) |
| CN (1) | CN1325959B (pt) |
| AR (1) | AR034550A1 (pt) |
| AT (1) | ATE373101T1 (pt) |
| AU (1) | AU783319B2 (pt) |
| BR (1) | BR0101518A (pt) |
| CA (1) | CA2342397C (pt) |
| CY (1) | CY1106985T1 (pt) |
| CZ (1) | CZ20011367A3 (pt) |
| DE (1) | DE60130394T2 (pt) |
| DK (1) | DK1149919T3 (pt) |
| ES (1) | ES2293966T3 (pt) |
| HU (1) | HUP0101569A3 (pt) |
| IL (1) | IL142619A (pt) |
| MX (1) | MXPA01003913A (pt) |
| NO (1) | NO328653B1 (pt) |
| NZ (1) | NZ511166A (pt) |
| PL (1) | PL202457B1 (pt) |
| PT (1) | PT1149919E (pt) |
| RU (1) | RU2236463C2 (pt) |
| TW (1) | TWI312807B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100048938A1 (en) * | 2006-06-22 | 2010-02-25 | Marco Alexander Van Den Berg | Fermentation of pravastatin |
| EP2334781A1 (en) * | 2008-09-24 | 2011-06-22 | DSM IP Assets B.V. | Improved statin production |
| WO2010069914A1 (en) * | 2008-12-19 | 2010-06-24 | Dsm Ip Assets B.V. | Statin transcription regulators |
| EP3134098A1 (en) * | 2014-04-23 | 2017-03-01 | Danmarks Tekniske Universitet | Statin resistance and export |
| CN115851654B (zh) * | 2022-11-09 | 2025-02-07 | 江西省农业科学院植物保护研究所 | 一种芦笋茎枯病菌聚酮体合成酶及其编码基因和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS572240A (en) | 1980-06-06 | 1982-01-07 | Sankyo Co Ltd | Ml-236b derivative |
| US5179013A (en) | 1987-02-02 | 1993-01-12 | Sankyo Company, Limited | Cytochrome P-450 enzymes |
| JPH09504436A (ja) | 1993-11-02 | 1997-05-06 | メルク エンド カンパニー インコーポレーテッド | トリオールポリケチドシンターゼをコードするｄｎａ |
| ZA969974B (en) * | 1995-11-29 | 1997-06-17 | Sankyo Co | Actinomycete promoter |
| KR100186758B1 (ko) * | 1996-08-09 | 1999-04-01 | 영진약품공업 주식회사 | 프라바스타틴(pravastatin)전구체의제조방법 |
| US6391583B1 (en) | 1998-12-18 | 2002-05-21 | Wisconsin Alumni Research Foundation | Method of producing antihypercholesterolemic agents |
| AU6475800A (en) | 1999-08-11 | 2001-03-13 | Sankyo Company Limited | Ml-236b biosynthesis-associated dna |
| FR2801648B1 (fr) * | 1999-11-30 | 2002-06-21 | Commissariat Energie Atomique | Injecteur a vapeur haute pression comportant un drain axial |
-
2001
- 2001-04-16 IL IL142619A patent/IL142619A/en not_active IP Right Cessation
- 2001-04-17 CZ CZ20011367A patent/CZ20011367A3/cs unknown
- 2001-04-17 RU RU2001110575/13A patent/RU2236463C2/ru not_active IP Right Cessation
- 2001-04-17 CA CA2342397A patent/CA2342397C/en not_active Expired - Fee Related
- 2001-04-17 US US09/836,705 patent/US7056710B2/en not_active Expired - Fee Related
- 2001-04-17 NO NO20011890A patent/NO328653B1/no not_active IP Right Cessation
- 2001-04-18 EP EP01303527A patent/EP1149919B1/en not_active Expired - Lifetime
- 2001-04-18 MX MXPA01003913A patent/MXPA01003913A/es active IP Right Grant
- 2001-04-18 KR KR1020010020867A patent/KR100632174B1/ko not_active Expired - Fee Related
- 2001-04-18 PT PT01303527T patent/PT1149919E/pt unknown
- 2001-04-18 AR ARP010101821A patent/AR034550A1/es active IP Right Grant
- 2001-04-18 BR BR0101518-4A patent/BR0101518A/pt not_active IP Right Cessation
- 2001-04-18 NZ NZ511166A patent/NZ511166A/xx unknown
- 2001-04-18 TW TW090109340A patent/TWI312807B/zh not_active IP Right Cessation
- 2001-04-18 CN CN011196556A patent/CN1325959B/zh not_active Expired - Fee Related
- 2001-04-18 AT AT01303527T patent/ATE373101T1/de not_active IP Right Cessation
- 2001-04-18 ES ES01303527T patent/ES2293966T3/es not_active Expired - Lifetime
- 2001-04-18 HU HU0101569A patent/HUP0101569A3/hu unknown
- 2001-04-18 AU AU37092/01A patent/AU783319B2/en not_active Ceased
- 2001-04-18 DK DK01303527T patent/DK1149919T3/da active
- 2001-04-18 PL PL347118A patent/PL202457B1/pl not_active IP Right Cessation
- 2001-04-18 DE DE60130394T patent/DE60130394T2/de not_active Expired - Lifetime
-
2005
- 2005-05-11 US US11/127,939 patent/US20050214909A1/en not_active Abandoned
-
2006
- 2006-12-14 US US11/639,130 patent/US20070111293A1/en not_active Abandoned
-
2007
- 2007-11-08 CY CY20071101434T patent/CY1106985T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 13A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2256 DE 01/04/2014. |