BR0014851A - Derivados de isoxazolcarboxamida - Google Patents
Derivados de isoxazolcarboxamidaInfo
- Publication number
- BR0014851A BR0014851A BR0014851-2A BR0014851A BR0014851A BR 0014851 A BR0014851 A BR 0014851A BR 0014851 A BR0014851 A BR 0014851A BR 0014851 A BR0014851 A BR 0014851A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- isoxazolcarboxamide
- alkyl
- polyfluoroalkoxy
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
"DERIVADOS DE ISOXAZOLCARBOXAMIDA". Os derivados de isoxazolcarboxamida (I) (R=alquil, poliflúoroalcóxi, OH ou CF~ 3~SO~ 2~O; cada R~ 1~ e R~ 2~ independentemente = H, halogênio, poliflúoroalcóxi ou alcóxi; R~ 3~ = um ou mais substituintes selecionados de H, halogênio, alquil, alcóxi, NO~ 2~, NH~ 2~, NHacil, CN, alcóxicarbonil, carboxamida: R~ 4~ = H, alquil ou aralquil: um n é 0,1 ou 2) e seus N-óxidos e sais farmaceuticamente aceitáveis são dotados com atividade de antagonista adrenérgico e alta seletividade através do receptor adrenérgico <224>~ 1A~ com relação ao receptor 5-HT~ 1A~. Este perfil de atividade sugere o uso destes derivados no tratamento de síndromes obstrutivas do trato urinário inferior, incluindo BPH, sem os efeitos colaterais associados com a presença de hipotensão.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI002173A IT1314191B1 (it) | 1999-10-18 | 1999-10-18 | Derivati isossazolcarbossamidici |
| PCT/EP2000/010144 WO2001029015A2 (en) | 1999-10-18 | 2000-10-16 | Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0014851A true BR0014851A (pt) | 2002-06-11 |
Family
ID=11383797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0014851-2A BR0014851A (pt) | 1999-10-18 | 2000-10-16 | Derivados de isoxazolcarboxamida |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1226131B1 (pt) |
| JP (1) | JP2003512362A (pt) |
| KR (1) | KR20020038944A (pt) |
| CN (1) | CN1139579C (pt) |
| AR (1) | AR029400A1 (pt) |
| AT (1) | ATE256670T1 (pt) |
| AU (1) | AU757614B2 (pt) |
| BR (1) | BR0014851A (pt) |
| CA (1) | CA2385472A1 (pt) |
| DE (1) | DE60007347T2 (pt) |
| DK (1) | DK1226131T3 (pt) |
| ES (1) | ES2210033T3 (pt) |
| HK (1) | HK1044940A1 (pt) |
| HU (1) | HUP0203184A3 (pt) |
| IL (1) | IL148837A0 (pt) |
| IT (1) | IT1314191B1 (pt) |
| MX (1) | MXPA02003432A (pt) |
| MY (1) | MY120400A (pt) |
| NO (1) | NO20021803L (pt) |
| NZ (1) | NZ517884A (pt) |
| PL (1) | PL356990A1 (pt) |
| PT (1) | PT1226131E (pt) |
| RU (1) | RU2002113096A (pt) |
| WO (1) | WO2001029015A2 (pt) |
| ZA (1) | ZA200203942B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101277952B (zh) | 2005-10-11 | 2011-09-28 | 弗·哈夫曼-拉罗切有限公司 | 异*唑衍生物 |
| BRPI0618383A2 (pt) | 2005-11-09 | 2011-08-30 | Hoffmann La Roche | derivados de 3-aril-isoxazol-4-carbonil-benzofurano |
| RU2426731C2 (ru) | 2005-12-23 | 2011-08-20 | Ф. Хоффманн-Ля Рош Аг | Производные арил-изоксазоло-4-ил-оксадиазола |
| ES2371935T3 (es) | 2005-12-27 | 2012-01-11 | F. Hoffmann-La Roche Ag | Derivados de aril-isoxazol-4-il-imidazol. |
| BRPI0706560A2 (pt) | 2006-01-17 | 2011-03-29 | Hoffmann La Roche | derivados de aril-isoxazol-4-il-imidazo [1,2-a] piridina úteis para o tratamento de doença de alzheimer por intermédio de receptores gaba |
| AU2007267183B2 (en) | 2006-05-31 | 2011-10-20 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
| BRPI0814718A2 (pt) | 2007-06-22 | 2015-02-24 | Hoffmann La Roche | Derivados de isoxazol-imidazol |
| MX2010005753A (es) | 2007-12-04 | 2010-06-15 | Hoffmann La Roche | Derivados de isoxazolo-pirazina. |
| US7902201B2 (en) | 2007-12-04 | 2011-03-08 | Hoffmann-La Roche Inc. | Isoxazolo-pyrazine derivatives |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
| TW201033201A (en) | 2009-02-19 | 2010-09-16 | Hoffmann La Roche | Isoxazole-isoxazole and isoxazole-isothiazole derivatives |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| US20100280019A1 (en) | 2009-04-30 | 2010-11-04 | Roland Jakob-Roetne | Isoxazoles |
| CN102414206B (zh) | 2009-05-05 | 2014-11-05 | 霍夫曼-拉罗奇有限公司 | 异*唑-吡啶衍生物 |
| KR101384829B1 (ko) | 2009-05-05 | 2014-04-15 | 에프. 호프만-라 로슈 아게 | 이속사졸-피라졸 유도체 |
| US8410104B2 (en) | 2009-05-05 | 2013-04-02 | Hoffmann-La Roche Inc. | Pyridazines |
| AU2010244551A1 (en) | 2009-05-05 | 2011-12-01 | F. Hoffmann-La Roche Ag | Isoxazole-thiazole derivatives as GABA A receptor inverse agonists for use in the treatment of cognitive disorders |
| KR101354416B1 (ko) | 2009-05-07 | 2014-02-19 | 에프. 호프만-라 로슈 아게 | 감마-아미노부티르산 조절제로서 이속사졸-피리딘 유도체 |
| US8785435B2 (en) | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
| CN113121540B (zh) * | 2020-01-15 | 2024-01-26 | 鲁南制药集团股份有限公司 | 一种西格列汀游离碱的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
| IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
-
1999
- 1999-10-18 IT IT1999MI002173A patent/IT1314191B1/it active
-
2000
- 2000-10-10 MY MYPI20004718A patent/MY120400A/en unknown
- 2000-10-16 DK DK00992436T patent/DK1226131T3/da active
- 2000-10-16 DE DE60007347T patent/DE60007347T2/de not_active Expired - Fee Related
- 2000-10-16 KR KR1020027004663A patent/KR20020038944A/ko not_active Application Discontinuation
- 2000-10-16 AT AT00992436T patent/ATE256670T1/de not_active IP Right Cessation
- 2000-10-16 RU RU2002113096/04A patent/RU2002113096A/ru not_active Application Discontinuation
- 2000-10-16 CA CA002385472A patent/CA2385472A1/en not_active Abandoned
- 2000-10-16 WO PCT/EP2000/010144 patent/WO2001029015A2/en active IP Right Grant
- 2000-10-16 NZ NZ517884A patent/NZ517884A/en unknown
- 2000-10-16 AU AU28347/01A patent/AU757614B2/en not_active Ceased
- 2000-10-16 ES ES00992436T patent/ES2210033T3/es not_active Expired - Lifetime
- 2000-10-16 HU HU0203184A patent/HUP0203184A3/hu unknown
- 2000-10-16 EP EP00992436A patent/EP1226131B1/en not_active Expired - Lifetime
- 2000-10-16 BR BR0014851-2A patent/BR0014851A/pt not_active IP Right Cessation
- 2000-10-16 PT PT00992436T patent/PT1226131E/pt unknown
- 2000-10-16 PL PL00356990A patent/PL356990A1/xx not_active Application Discontinuation
- 2000-10-16 MX MXPA02003432A patent/MXPA02003432A/es not_active Application Discontinuation
- 2000-10-16 IL IL14883700A patent/IL148837A0/xx unknown
- 2000-10-16 JP JP2001531815A patent/JP2003512362A/ja active Pending
- 2000-10-16 CN CNB008143226A patent/CN1139579C/zh not_active Expired - Fee Related
- 2000-10-18 AR ARP000105475A patent/AR029400A1/es not_active Application Discontinuation
-
2002
- 2002-04-17 NO NO20021803A patent/NO20021803L/no not_active Application Discontinuation
- 2002-05-17 ZA ZA200203942A patent/ZA200203942B/en unknown
- 2002-08-13 HK HK02105918.6A patent/HK1044940A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1226131T3 (da) | 2004-04-19 |
| AU2834701A (en) | 2001-04-30 |
| AR029400A1 (es) | 2003-06-25 |
| EP1226131A2 (en) | 2002-07-31 |
| IL148837A0 (en) | 2002-09-12 |
| ZA200203942B (en) | 2003-01-02 |
| DE60007347T2 (de) | 2004-09-02 |
| HK1044940A1 (zh) | 2002-11-08 |
| PT1226131E (pt) | 2004-05-31 |
| HUP0203184A2 (hu) | 2003-01-28 |
| MY120400A (en) | 2005-10-31 |
| HUP0203184A3 (en) | 2004-12-28 |
| CN1379767A (zh) | 2002-11-13 |
| NZ517884A (en) | 2003-08-29 |
| ITMI992173A1 (it) | 2001-04-18 |
| DE60007347D1 (de) | 2004-01-29 |
| ATE256670T1 (de) | 2004-01-15 |
| NO20021803D0 (no) | 2002-04-17 |
| CA2385472A1 (en) | 2001-04-26 |
| NO20021803L (no) | 2002-06-17 |
| IT1314191B1 (it) | 2002-12-06 |
| ES2210033T3 (es) | 2004-07-01 |
| WO2001029015A3 (en) | 2001-11-01 |
| KR20020038944A (ko) | 2002-05-24 |
| WO2001029015A2 (en) | 2001-04-26 |
| RU2002113096A (ru) | 2003-11-10 |
| ITMI992173A0 (it) | 1999-10-18 |
| EP1226131B1 (en) | 2003-12-17 |
| AU757614B2 (en) | 2003-02-27 |
| CN1139579C (zh) | 2004-02-25 |
| PL356990A1 (en) | 2004-07-12 |
| MXPA02003432A (es) | 2002-08-20 |
| JP2003512362A (ja) | 2003-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0014851A (pt) | Derivados de isoxazolcarboxamida | |
| DE60032482D1 (de) | 5-cyano-2-aminopyrimidine derivate | |
| NO965125D0 (no) | Heterosykliske forbindelser med tachykininreseptor-antagonistaktivitet, deres fremstilling og anvendelse | |
| BR0115609A (pt) | Agentes serotonérgicos | |
| HUP0203677A2 (hu) | Muszkarin receptor antagonista aktivitással rendelkező karbamid vegyületek | |
| MY130803A (en) | New quinuclidine amide derivatives | |
| AU2003301020A8 (en) | Isoquinolinone derivatives and their use as therapeutic agents | |
| BR9811482A (pt) | Derivados de 1-(n-fenilaminoalquil)-piperazina substituìda na posição 2 do anel fenìlico | |
| DE60025189D1 (de) | Cyanopyrrole als progesteronrezeptoragonisten | |
| ATE416767T1 (de) | 5-halo-tryptaminderivate als 5-ht6 und/oder 5-ht7 rezeptorliganden | |
| MXPA06000716A (es) | Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1. | |
| EA199800340A1 (ru) | Производные пиримидина как антагонисты 5нт2с | |
| TR200102489T2 (tr) | 3-Fenilpiridin Türevleri ve bunların NK-1 alıcı antagonistler olarak kullanılması | |
| BR0309463A (pt) | Derivados de 1,2,3,4,7,8-hexaidro-6h-[1,4]diazepino[6,7,1-ij]quinolina como agentes antipsicóticos e antiobesidade | |
| CY1108061T1 (el) | Παραγωγα κιναζολινης ως src αναστολεις κινασης τυροσινης | |
| BR9812340A (pt) | Antagonistas de receptor de vitronectina | |
| TR200101654T2 (tr) | Vitronektin reseptr antagonistleri | |
| BR0209604A (pt) | Derivados de 1-oxa-3,9-diaza-spiro-5,5-undecan-2-onas e seu uso como antagonista do receptor para neuricinina | |
| TR200200969T2 (tr) | Karbonilamino türevlerinin CNS bozukluklarına karşı kullanılması | |
| AU2001261707A1 (en) | Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives | |
| WO2002024661A3 (en) | New n, n'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors | |
| NO20006249L (no) | Acetylkolinforsterkere | |
| NO973340L (no) | Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for behandling eller profylakse av fedme | |
| BR0015120A (pt) | Derivado de benzamidina ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um derivado de benzamidina ou de um sal deste farmaceuticamente aceitável | |
| PT1222183E (pt) | Derivados do benzopirano |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |