BG63694B1 - Инхибитори на аполипопротеин-в синтеза - Google Patents

Инхибитори на аполипопротеин-в синтеза Download PDF

Info

Publication number: BG63694B1
Authority: BG; Bulgaria
Prior art keywords: alkyl; amino; formula; substituted; cis
Prior art date: 1994-10-27

Application number

BG101402A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG101402A (en

Inventor

Jan Heeres

Leo Backx

Robert HENDRICKX

DER EYCKEN Luc VAN

CHAFFOY DE COURCELLES Didier DE

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-27

Filing date

1997-04-10

Publication date

2002-09-30

1995-05-31 Priority claimed from US08/455,304 external-priority patent/US5521186A/en

1997-04-10 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1997-10-31 Publication of BG101402A publication Critical patent/BG101402A/xx

2002-09-30 Publication of BG63694B1 publication Critical patent/BG63694B1/bg

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BG101402A 1994-10-27 1997-04-10 Инхибитори на аполипопротеин-в синтеза BG63694B1 (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94203120		1994-10-27
US08/455,304 US5521186A (en)	1994-10-27	1995-05-31	Apolipoprotein-β synthesis inhibitors
PCT/EP1995/004111 WO1996013499A1 (en)	1994-10-27	1995-10-19	Apolipoprotein-b synthesis inhibitors

Publications (2)

Publication Number	Publication Date
BG101402A BG101402A (en)	1997-10-31
BG63694B1 true BG63694B1 (bg)	2002-09-30

Family

ID=26136684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG101402A BG63694B1 (bg)	1994-10-27	1997-04-10	Инхибитори на аполипопротеин-в синтеза

Country Status (30)

Country	Link
US (1)	US5929075A (sk)
EP (1)	EP0788496B1 (sk)
JP (1)	JP3025907B2 (sk)
KR (1)	KR100227231B1 (sk)
CN (1)	CN1068000C (sk)
AP (1)	AP779A (sk)
AT (1)	ATE198889T1 (sk)
AU (1)	AU697744C (sk)
BG (1)	BG63694B1 (sk)
BR (1)	BR9509436A (sk)
CA (1)	CA2203274C (sk)
CY (1)	CY2256B1 (sk)
CZ (1)	CZ286476B6 (sk)
DE (3)	DE122007000005I2 (sk)
DK (1)	DK0788496T3 (sk)
ES (1)	ES2155535T3 (sk)
FI (1)	FI119548B (sk)
GR (1)	GR3035519T3 (sk)
HR (1)	HRP950532B1 (sk)
HU (1)	HU219862B (sk)
IL (1)	IL115771A (sk)
LU (1)	LU91306I2 (sk)
NO (1)	NO311937B1 (sk)
NZ (1)	NZ295353A (sk)
OA (1)	OA10479A (sk)
PT (1)	PT788496E (sk)
RO (1)	RO118715B1 (sk)
SK (1)	SK281908B6 (sk)
TR (1)	TR199501295A2 (sk)
WO (1)	WO1996013499A1 (sk)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU746890B2 (en) *	1997-11-03	2002-05-02	Janssen Pharmaceutica N.V.	Compositions of lipid lowering agents
EE200000796A (et) *	1998-04-27	2002-06-17	Janssen Pharmaceutica N.V.	Ravimkuulike, selle valmistamismeetod ja farmatseutiline doseerimisvorm, ravimkuulikeste kasutaminefarmatseutilise doseerimisvormi valmistamiseks ning farmatseutiline pakend
CA2355822A1 (en) *	1998-12-22	2000-06-29	Janssen Pharmaceutica N.V.	S-oxide lipid lowering compounds
DE19945982A1 (de)	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) *	2003-12-12	2005-06-16	International Business Machines Corporation	Computer system with LAN-based I/O
AU2005205933B2 (en) *	2004-01-21	2010-02-18	Elanco Animal Health Ireland Limited	Mitratapide oral solution
US7649002B2 (en)	2004-02-04	2010-01-19	Pfizer Inc	(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
CA2562015A1 (en) *	2004-04-09	2005-10-20	Janssen Pharmaceutica Nv	Intermittent dosing regimens of apob secretion/mtp inhibitors for overweith and obese subjects
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
WO2006129193A2 (en) *	2005-05-27	2006-12-07	Pfizer Products Inc.	Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
JP2009503050A (ja) *	2005-08-04	2009-01-29	ファイザー・リミテッド	ピペリジノイル−ピロリジンおよびピペリジノイル−ピペリジン化合物
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
DK1989196T3 (da) *	2006-02-23	2013-04-15	Pfizer Ltd	Piperidinoylpyrrolidiner som melanocortin-type 4-receptoragonister
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
WO2008059335A1 (en)	2006-11-13	2008-05-22	Pfizer Products Inc.	Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
WO2008070496A2 (en)	2006-12-01	2008-06-12	Bristol-Myers Squibb Company	N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US8765979B2 (en)	2007-05-25	2014-07-01	Janssen Pharmaceutica	Synthesis of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3 dioxolane-4-methanol methanesulfonate(ester)
JP5530438B2 (ja) *	2008-08-06	2014-06-25	ファイザー・リミテッド	Ｍｃ４作動薬としてのジアゼピンおよびジアゾカン化合物
WO2011144653A1 (en) *	2010-05-19	2011-11-24	Sandoz Ag	Process for the preparation of chiral triazolones
CN112074505B (zh)	2018-03-08	2024-04-05	因赛特公司	作为PI3K-γ抑制剂的氨基吡嗪二醇化合物
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4218458A (en) *	1978-06-23	1980-08-19	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4313953A (en) *	1978-06-23	1982-02-02	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) *	1981-06-23	1988-08-23	Janssen Pharmaceutica N.V.	N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) *	1983-02-28	1986-10-28	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) *	1985-12-03	1991-11-26	Alfonsus Guilielmus Knaeps	Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl\|-1,3-dioxolan-2-yl\|methyl\|-1h-imidazoles and 1h-1,2,4-triazoles
NZ223799A (en) *	1987-03-25	1989-12-21	Janssen Pharmaceutica Nv	Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (en) *	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) *	1993-03-04	1994-09-26	Cytoven International N.V.	Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) *	1994-10-27	1996-05-28	Janssen Pharmaceutica N.V.	Apolipoprotein-β synthesis inhibitors

1995
- 1995-10-19 RO RO97-00812A patent/RO118715B1/ro unknown
- 1995-10-19 DE DE122007000005C patent/DE122007000005I2/de active Active
- 1995-10-19 NZ NZ295353A patent/NZ295353A/en not_active IP Right Cessation
- 1995-10-19 DE DE1995619995 patent/DE122007000005I1/de active Pending
- 1995-10-19 JP JP8514288A patent/JP3025907B2/ja not_active Expired - Fee Related
- 1995-10-19 WO PCT/EP1995/004111 patent/WO1996013499A1/en active IP Right Grant
- 1995-10-19 EP EP95937804A patent/EP0788496B1/en not_active Expired - Lifetime
- 1995-10-19 AT AT95937804T patent/ATE198889T1/de active
- 1995-10-19 CZ CZ19971198A patent/CZ286476B6/cs not_active IP Right Cessation
- 1995-10-19 SK SK507-97A patent/SK281908B6/sk not_active IP Right Cessation
- 1995-10-19 BR BR9509436A patent/BR9509436A/pt not_active IP Right Cessation
- 1995-10-19 HU HU9701956A patent/HU219862B/hu not_active IP Right Cessation
- 1995-10-19 KR KR1019970702662A patent/KR100227231B1/ko not_active IP Right Cessation
- 1995-10-19 DK DK95937804T patent/DK0788496T3/da active
- 1995-10-19 DE DE69519995T patent/DE69519995T2/de not_active Expired - Lifetime
- 1995-10-19 ES ES95937804T patent/ES2155535T3/es not_active Expired - Lifetime
- 1995-10-19 US US08/817,247 patent/US5929075A/en not_active Expired - Lifetime
- 1995-10-19 PT PT95937804T patent/PT788496E/pt unknown
- 1995-10-19 CA CA002203274A patent/CA2203274C/en not_active Expired - Fee Related
- 1995-10-19 AP APAP/P/1997/000968A patent/AP779A/en active
- 1995-10-19 CN CN95195885A patent/CN1068000C/zh not_active Expired - Fee Related
- 1995-10-19 AU AU38680/95A patent/AU697744C/en not_active Ceased
- 1995-10-20 TR TR95/01295A patent/TR199501295A2/xx unknown
- 1995-10-26 IL IL11577195A patent/IL115771A/xx not_active IP Right Cessation
- 1995-10-27 HR HR950532A patent/HRP950532B1/xx not_active IP Right Cessation
1997
- 1997-04-10 BG BG101402A patent/BG63694B1/bg unknown
- 1997-04-24 NO NO19971895A patent/NO311937B1/no not_active IP Right Cessation
- 1997-04-25 FI FI971784A patent/FI119548B/fi not_active IP Right Cessation
- 1997-04-25 OA OA60997A patent/OA10479A/en unknown
2001
- 2001-03-05 GR GR20010400359T patent/GR3035519T3/el unknown
2002
- 2002-01-04 CY CY0200004A patent/CY2256B1/xx unknown
2007
- 2007-01-17 LU LU91306C patent/LU91306I2/fr unknown

Also Published As

Publication number	Publication date
EP0788496A1 (en)	1997-08-13
EP0788496B1 (en)	2001-01-24
NO971895D0 (no)	1997-04-24
DE69519995T2 (de)	2001-08-23
CY2256B1 (en)	2003-07-04
CA2203274C (en)	2002-02-19
SK281908B6 (sk)	2001-09-11
CN1068000C (zh)	2001-07-04
NO971895L (no)	1997-04-24
FI119548B (fi)	2008-12-31
CA2203274A1 (en)	1996-05-09
ATE198889T1 (de)	2001-02-15
LU91306I2 (fr)	2007-03-19
DE122007000005I1 (de)	2007-04-26
NO311937B1 (no)	2002-02-18
US5929075A (en)	1999-07-27
WO1996013499A1 (en)	1996-05-09
HU219862B (hu)	2001-08-28
AU697744C (en)	2002-08-22
IL115771A0 (en)	1996-01-19
IL115771A (en)	2000-02-29
BG101402A (en)	1997-10-31
HRP950532B1 (en)	2001-06-30
CZ286476B6 (en)	2000-04-12
JP3025907B2 (ja)	2000-03-27
AP9700968A0 (en)	1997-04-30
DK0788496T3 (da)	2001-06-18
HUT77360A (hu)	1998-03-30
CN1161695A (zh)	1997-10-08
RO118715B1 (ro)	2003-09-30
NZ295353A (en)	1998-08-26
TR199501295A2 (tr)	1996-06-21
AU697744B2 (en)	1998-10-15
AP779A (en)	1999-11-03
DE122007000005I2 (de)	2008-04-24
SK50797A3 (en)	1998-04-08
JPH09511759A (ja)	1997-11-25
KR100227231B1 (ko)	1999-11-01
FI971784A (fi)	1997-04-25
ES2155535T3 (es)	2001-05-16
GR3035519T3 (en)	2001-06-29
BR9509436A (pt)	1998-01-06
DE69519995D1 (en)	2001-03-01
MX9703074A (es)	1997-07-31
CZ119897A3 (cs)	1998-03-18
AU3868095A (en)	1996-05-23
PT788496E (pt)	2001-07-31
OA10479A (en)	2002-04-09
FI971784A0 (fi)	1997-04-25
HRP950532A2 (en)	1997-08-31