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BG62656B1 - Рекомбинантни антитела за хуманната медицина - Google Patents

Рекомбинантни антитела за хуманната медицина Download PDF

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Publication number
BG62656B1
BG62656B1 BG98411A BG9841194A BG62656B1 BG 62656 B1 BG62656 B1 BG 62656B1 BG 98411 A BG98411 A BG 98411A BG 9841194 A BG9841194 A BG 9841194A BG 62656 B1 BG62656 B1 BG 62656B1
Authority
BG
Bulgaria
Prior art keywords
antibody
human
monkey
antigen
region
Prior art date
Application number
BG98411A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG98411A (bg
Inventor
Roland A. Newman
Nabil Hanna
Ronald W. Raab
Original Assignee
Idec Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27112830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62656(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idec Pharmaceuticals Corporation filed Critical Idec Pharmaceuticals Corporation
Publication of BG98411A publication Critical patent/BG98411A/bg
Publication of BG62656B1 publication Critical patent/BG62656B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BG98411A 1991-07-25 1994-01-24 Рекомбинантни антитела за хуманната медицина BG62656B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73506491A 1991-07-25 1991-07-25
US85628192A 1992-03-23 1992-03-23
PCT/US1992/006194 WO1993002108A1 (en) 1991-07-25 1992-07-24 Recombinant antibodies for human therapy

Publications (2)

Publication Number Publication Date
BG98411A BG98411A (bg) 1995-02-28
BG62656B1 true BG62656B1 (bg) 2000-04-28

Family

ID=27112830

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98411A BG62656B1 (bg) 1991-07-25 1994-01-24 Рекомбинантни антитела за хуманната медицина

Country Status (24)

Country Link
EP (3) EP1715045A3 (no)
JP (1) JP3048640B2 (no)
KR (1) KR0137806B1 (no)
AP (1) AP307A (no)
AT (2) ATE327331T1 (no)
AU (1) AU673499B2 (no)
BG (1) BG62656B1 (no)
BR (1) BR9206313A (no)
CA (1) CA2114015C (no)
CZ (1) CZ289472B6 (no)
DE (2) DE69233011T2 (no)
DK (2) DK1266965T3 (no)
ES (2) ES2196002T3 (no)
FI (1) FI117703B (no)
HU (2) HUT70272A (no)
IL (1) IL102640A0 (no)
MY (1) MY121185A (no)
NO (1) NO318097B1 (no)
NZ (1) NZ243706A (no)
OA (1) OA09879A (no)
PT (1) PT100735B (no)
RO (1) RO116404B1 (no)
SK (2) SK285960B6 (no)
WO (1) WO1993002108A1 (no)

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* Cited by examiner, † Cited by third party
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US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US7192584B2 (en) 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
JP3502093B2 (ja) * 1991-07-15 2004-03-02 ザ・ウエルカム・ファウンデーション・リミテッド 抗体の製造
US6136310A (en) 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
US7744877B2 (en) 1992-11-13 2010-06-29 Biogen Idec Inc. Expression and use of anti-CD20 Antibodies
DE69303494T2 (de) 1992-11-13 1997-01-16 Idec Pharma Corp Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
US5733742A (en) 1993-06-03 1998-03-31 Therapeutic Antibodies Inc. Production of antibody fragments from whole blood
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
ES2151054T3 (es) * 1994-04-26 2000-12-16 Kanebo Ltd Farmaco para el tratamiento de la artritis reumatoide.
KR20040058016A (ko) * 1994-10-25 2004-07-02 글락소 그룹 리미티드 Cd23에 대한 결합제
JP2001506122A (ja) * 1994-12-07 2001-05-15 エフ.ホフマン−ラ ロシュ アーゲー 免疫抑制作用を有するモノクローナル抗体断片
US7153508B2 (en) 1995-06-07 2006-12-26 Biogen Idec Inc. Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4
US7175847B1 (en) 1995-06-07 2007-02-13 Biogen Idec Inc. Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4
US6113898A (en) 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
GB9624038D0 (en) * 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
US6893636B2 (en) 1997-02-20 2005-05-17 Biogen Idec Ma Inc. Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics
US6011138A (en) * 1997-02-20 2000-01-04 Idec Pharmaceuticals Corporation Gamma-1 anti-human CD23 monoclonal antibodies
US7033589B1 (en) 1997-02-20 2006-04-25 Biogen Idec Ma Inc. γ-1 anti-human CD23 monoclonal antibodies and use thereof as therapeutics
ES2230848T3 (es) * 1998-04-28 2005-05-01 Smithkline Beecham Corporation Anticuerpos monoclonales con inmunogenicidad reducida.
GB9809839D0 (en) 1998-05-09 1998-07-08 Glaxo Group Ltd Antibody
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BR9915164A (pt) 1998-11-09 2003-01-07 Idec Pharma Corp Tratamento de malignidades hematológicas associadas com células de tumor circulantes usando anticorpo anti-cd20 quimérico
NZ514914A (en) 1999-05-07 2004-09-24 Genentech Inc Treatment of autoimmune diseases with antagonists which bind to B cell surface markers
US8557244B1 (en) 1999-08-11 2013-10-15 Biogen Idec Inc. Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
JP4762478B2 (ja) 2000-07-03 2011-08-31 キャタレント ファーマ ソリューションズ リミテッド ライアビリティ カンパニー 発現ベクター
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3502093B2 (ja) * 1991-07-15 2004-03-02 ザ・ウエルカム・ファウンデーション・リミテッド 抗体の製造

Also Published As

Publication number Publication date
EP1266965B1 (en) 2006-05-24
PT100735A (pt) 1993-10-29
BR9206313A (pt) 1995-04-11
NO940219L (no) 1994-03-25
JPH06509708A (ja) 1994-11-02
CZ289472B6 (cs) 2002-01-16
MY121185A (en) 2006-01-28
ES2265005T3 (es) 2007-02-01
SK285046B6 (sk) 2006-05-04
AP307A (en) 1994-01-31
BG98411A (bg) 1995-02-28
DE69233011D1 (de) 2003-05-22
WO1993002108A1 (en) 1993-02-04
HU9400201D0 (en) 1994-05-30
EP1715045A3 (en) 2006-12-13
HU211881A9 (en) 1995-12-28
PT100735B (pt) 1999-07-30
EP1715045A2 (en) 2006-10-25
ES2196002T3 (es) 2003-12-16
FI940336A0 (fi) 1994-01-24
JP3048640B2 (ja) 2000-06-05
AU673499B2 (en) 1996-11-14
ATE237638T1 (de) 2003-05-15
EP1266965A2 (en) 2002-12-18
CZ14994A3 (en) 1994-07-13
DE69233628D1 (de) 2006-06-29
SK8894A3 (en) 1994-09-07
NZ243706A (en) 1994-08-26
KR0137806B1 (ko) 1998-04-30
DE69233628T2 (de) 2007-04-26
AU2425592A (en) 1993-02-23
HUT70272A (en) 1995-09-28
IL102640A0 (en) 1993-01-14
DE69233011T2 (de) 2003-11-06
SK285960B6 (sk) 2007-12-06
DK1266965T3 (da) 2006-09-25
EP0605442B1 (en) 2003-04-16
NO318097B1 (no) 2005-01-31
EP0605442A1 (en) 1994-07-13
EP1266965A3 (en) 2003-01-02
FI940336L (fi) 1994-03-10
RO116404B1 (ro) 2001-01-30
CA2114015C (en) 2002-12-10
EP0605442A4 (en) 1995-07-12
AP9200413A0 (en) 1992-07-31
OA09879A (en) 1994-09-15
FI117703B (fi) 2007-01-31
CA2114015A1 (en) 1993-02-04
NO940219D0 (no) 1994-01-21
DK0605442T3 (da) 2003-08-04
ATE327331T1 (de) 2006-06-15

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