BG62656B1 - Рекомбинантни антитела за хуманната медицина - Google Patents
Рекомбинантни антитела за хуманната медицина Download PDFInfo
- Publication number
- BG62656B1 BG62656B1 BG98411A BG9841194A BG62656B1 BG 62656 B1 BG62656 B1 BG 62656B1 BG 98411 A BG98411 A BG 98411A BG 9841194 A BG9841194 A BG 9841194A BG 62656 B1 BG62656 B1 BG 62656B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- antibody
- human
- monkey
- antigen
- region
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73506491A | 1991-07-25 | 1991-07-25 | |
US85628192A | 1992-03-23 | 1992-03-23 | |
PCT/US1992/006194 WO1993002108A1 (en) | 1991-07-25 | 1992-07-24 | Recombinant antibodies for human therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
BG98411A BG98411A (bg) | 1995-02-28 |
BG62656B1 true BG62656B1 (bg) | 2000-04-28 |
Family
ID=27112830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG98411A BG62656B1 (bg) | 1991-07-25 | 1994-01-24 | Рекомбинантни антитела за хуманната медицина |
Country Status (24)
Country | Link |
---|---|
EP (3) | EP1715045A3 (no) |
JP (1) | JP3048640B2 (no) |
KR (1) | KR0137806B1 (no) |
AP (1) | AP307A (no) |
AT (2) | ATE327331T1 (no) |
AU (1) | AU673499B2 (no) |
BG (1) | BG62656B1 (no) |
BR (1) | BR9206313A (no) |
CA (1) | CA2114015C (no) |
CZ (1) | CZ289472B6 (no) |
DE (2) | DE69233011T2 (no) |
DK (2) | DK1266965T3 (no) |
ES (2) | ES2196002T3 (no) |
FI (1) | FI117703B (no) |
HU (2) | HUT70272A (no) |
IL (1) | IL102640A0 (no) |
MY (1) | MY121185A (no) |
NO (1) | NO318097B1 (no) |
NZ (1) | NZ243706A (no) |
OA (1) | OA09879A (no) |
PT (1) | PT100735B (no) |
RO (1) | RO116404B1 (no) |
SK (2) | SK285960B6 (no) |
WO (1) | WO1993002108A1 (no) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991002078A1 (en) | 1989-08-07 | 1991-02-21 | Peptide Technology Ltd | Tumour necrosis factor binding ligands |
US20030225254A1 (en) | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
JP3502093B2 (ja) * | 1991-07-15 | 2004-03-02 | ザ・ウエルカム・ファウンデーション・リミテッド | 抗体の製造 |
US6136310A (en) | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
US7744877B2 (en) | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
DE69303494T2 (de) | 1992-11-13 | 1997-01-16 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
US5733742A (en) | 1993-06-03 | 1998-03-31 | Therapeutic Antibodies Inc. | Production of antibody fragments from whole blood |
US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
ES2151054T3 (es) * | 1994-04-26 | 2000-12-16 | Kanebo Ltd | Farmaco para el tratamiento de la artritis reumatoide. |
KR20040058016A (ko) * | 1994-10-25 | 2004-07-02 | 글락소 그룹 리미티드 | Cd23에 대한 결합제 |
JP2001506122A (ja) * | 1994-12-07 | 2001-05-15 | エフ.ホフマン−ラ ロシュ アーゲー | 免疫抑制作用を有するモノクローナル抗体断片 |
US7153508B2 (en) | 1995-06-07 | 2006-12-26 | Biogen Idec Inc. | Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4 |
US7175847B1 (en) | 1995-06-07 | 2007-02-13 | Biogen Idec Inc. | Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4 |
US6113898A (en) | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
US6893636B2 (en) | 1997-02-20 | 2005-05-17 | Biogen Idec Ma Inc. | Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics |
US6011138A (en) * | 1997-02-20 | 2000-01-04 | Idec Pharmaceuticals Corporation | Gamma-1 anti-human CD23 monoclonal antibodies |
US7033589B1 (en) | 1997-02-20 | 2006-04-25 | Biogen Idec Ma Inc. | γ-1 anti-human CD23 monoclonal antibodies and use thereof as therapeutics |
ES2230848T3 (es) * | 1998-04-28 | 2005-05-01 | Smithkline Beecham Corporation | Anticuerpos monoclonales con inmunogenicidad reducida. |
GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
CN101695574A (zh) | 1998-08-11 | 2010-04-21 | 拜奥根Idec公司 | 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法 |
BR9915164A (pt) | 1998-11-09 | 2003-01-07 | Idec Pharma Corp | Tratamento de malignidades hematológicas associadas com células de tumor circulantes usando anticorpo anti-cd20 quimérico |
NZ514914A (en) | 1999-05-07 | 2004-09-24 | Genentech Inc | Treatment of autoimmune diseases with antagonists which bind to B cell surface markers |
US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
JP4762478B2 (ja) | 2000-07-03 | 2011-08-31 | キャタレント ファーマ ソリューションズ リミテッド ライアビリティ カンパニー | 発現ベクター |
AU2001271614B2 (en) * | 2000-07-03 | 2007-05-31 | Catalent Pharma Solutions, Llc | Host cells containing multiple integrating vectors |
EP1299556A2 (en) * | 2000-07-03 | 2003-04-09 | Gala Design, Inc. | Host cells containing multiple integrating vectors |
UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
US20050101012A1 (en) | 2001-03-12 | 2005-05-12 | Gerold Schuler | CD4+CD25+ regulatory T cells from human blood |
EP1241249A1 (en) * | 2001-03-12 | 2002-09-18 | Gerold Schuler | CD4+CD25+regulatory T cells from human blood |
TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
US20040038304A1 (en) | 2002-03-28 | 2004-02-26 | Gala Design, Inc. | Antibody libraries |
US7384738B2 (en) | 2002-03-28 | 2008-06-10 | Bremel Robert D | Retrovirus-based genomic screening |
US8222033B2 (en) | 2002-08-12 | 2012-07-17 | Argos Therapeutics, Inc. | CD4+CD25− T cells and Tr1-like regulatory T cells |
KR20090088973A (ko) | 2002-10-17 | 2009-08-20 | 젠맵 에이/에스 | Cd20에 대한 인간 모노클로날 항체 |
JP2007534305A (ja) * | 2003-11-07 | 2007-11-29 | アムジェン インコーポレイテッド | サル免疫グロブリン配列 |
AU2004291107B2 (en) | 2003-11-14 | 2010-09-30 | Brigham And Women's Hospital, Inc. | Methods of modulating immunity |
NZ550225A (en) | 2004-03-30 | 2010-11-26 | Glaxo Group Ltd | Immunoglobulins that bind oncostatin and inhibit or block interaction between hOSM and pg130 |
US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
EP1919504B1 (en) * | 2005-08-03 | 2013-10-16 | iBio, Inc. | Antibody to bacillus anthracis protective antigen |
MX2008002161A (es) * | 2005-08-15 | 2008-04-22 | Arana Therapeutics Ltd | Anticuerpos quimericos con regiones de primate del nuevo mundo. |
EP1945668A4 (en) * | 2005-08-15 | 2009-07-22 | Arana Therapeutics Ltd | SYNTHETIC ANTIBODIES WITH FRAMEWORK REGIONS OF NEUWELTPRIMATEN |
US7981414B2 (en) * | 2005-12-20 | 2011-07-19 | Cephalon Australia Pty Ltd | Anti-inflammatory dAb |
CN103232540A (zh) | 2006-02-01 | 2013-08-07 | 赛法隆澳大利亚控股有限公司 | 结构域抗体构建体 |
EP2056858B1 (en) | 2006-08-11 | 2014-06-25 | CSL Limited | Treatment of pulmonary disease conditions |
TW200817438A (en) | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
PL2066349T3 (pl) | 2006-09-08 | 2012-09-28 | Medimmune Llc | Humanizowane przeciwciała anty-CD19 i ich zastosowanie w leczeniu nowotworów, transplantacjach i leczeniu chorób autoimmunologicznych |
CA2666682C (en) | 2006-10-19 | 2014-07-08 | Merck & Co., Inc. | Anti-il-13r.alpha.1 antibodies and their uses thereof |
PL2829551T3 (pl) | 2006-10-19 | 2018-04-30 | Csl Limited | Antagonisty przeciwciała o wysokim powinowactwie wobec receptora alfa 1 interleukiny-13 |
TW200902544A (en) | 2007-03-13 | 2009-01-16 | Hoffmann La Roche | Peptide-complement conjugates |
US20090022720A1 (en) | 2007-07-20 | 2009-01-22 | Stephan Fischer | Conjugate of an antibody against CD4 and antifusogenic peptides |
US8637466B2 (en) | 2008-08-11 | 2014-01-28 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
US8415291B2 (en) | 2008-10-31 | 2013-04-09 | Centocor Ortho Biotech Inc. | Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses |
GB2476681B (en) | 2010-01-04 | 2012-04-04 | Argen X Bv | Humanized camelid VH, VK and VL immunoglobulin domains |
TWI689314B (zh) | 2010-11-30 | 2020-04-01 | 建南德克公司 | 低親和力血腦障壁受體抗體及其用途 |
WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
WO2012166555A1 (en) | 2011-05-27 | 2012-12-06 | Nektar Therapeutics | Water - soluble polymer - linked binding moiety and drug compounds |
EP2974976A1 (de) * | 2011-10-31 | 2016-01-20 | Embella GmbH | Einhändig bedienbare verpackung mit doppellasche |
US10940204B2 (en) | 2015-07-31 | 2021-03-09 | Research Institute At Nationwide Children's Hospital | Peptides and antibodies for the removal of biofilms |
EP3365027B1 (en) | 2015-10-14 | 2022-03-30 | Research Institute at Nationwide Children's Hospital | Hu specific antibodies and their use in inhibiting biofilm |
US10465003B2 (en) | 2016-02-05 | 2019-11-05 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes |
US12098188B2 (en) | 2017-01-04 | 2024-09-24 | Research Institute At Nationwide Children's Hospital | Antibody fragments for the treatment of biofilm-related disorders |
AU2018206552B2 (en) | 2017-01-04 | 2024-10-24 | Research Institute At Nationwide Children's Hospital | DNABII vaccines and antibodies with enhanced activity |
CA3052095A1 (en) | 2017-01-30 | 2018-08-02 | Janssen Biotech, Inc. | Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis |
KR20240038148A (ko) | 2017-02-07 | 2024-03-22 | 얀센 바이오테크 인코포레이티드 | 활성 강직성 척추염의 치료를 위한 항-tnf 항체, 조성물, 및 방법 |
EP3595445B1 (en) | 2017-03-15 | 2024-09-04 | The Research Institute at Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
US12161701B2 (en) | 2018-10-05 | 2024-12-10 | Research Institute At Nationwide Children's Hospital | Compositions and methods for enzymatic disruption of bacterial biofilms |
CN113874073A (zh) | 2019-05-23 | 2021-12-31 | 詹森生物科技公司 | 用针对IL-23和TNFα的抗体的联合疗法治疗炎性肠病的方法 |
CN119504987A (zh) | 2019-07-08 | 2025-02-25 | 国家儿童医院研究所 | 破坏生物膜的抗体组合物 |
US12258393B2 (en) | 2020-05-21 | 2025-03-25 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha |
BR112022024745A2 (pt) | 2020-06-04 | 2023-03-07 | Bioinvent Int Ab | Melhora de tolerabilidade de anticorpo associada a administração intravenosa |
KR20230154315A (ko) | 2021-03-09 | 2023-11-07 | 바이오인벤트 인터내셔날 에이비 | 항체의 신규한 조합물 및 이의 용도 |
EP4482860A1 (en) | 2022-02-24 | 2025-01-01 | AbnomX BV | Human-like target-binding proteins |
TW202336033A (zh) | 2022-03-07 | 2023-09-16 | 瑞典商生物創新國際有限公司 | 抗體之新穎組合及用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3502093B2 (ja) * | 1991-07-15 | 2004-03-02 | ザ・ウエルカム・ファウンデーション・リミテッド | 抗体の製造 |
-
1992
- 1992-07-24 EP EP06010708A patent/EP1715045A3/en not_active Withdrawn
- 1992-07-24 ES ES92917108T patent/ES2196002T3/es not_active Expired - Lifetime
- 1992-07-24 NZ NZ243706A patent/NZ243706A/en unknown
- 1992-07-24 CA CA002114015A patent/CA2114015C/en not_active Expired - Fee Related
- 1992-07-24 CZ CZ1994149A patent/CZ289472B6/cs not_active IP Right Cessation
- 1992-07-24 HU HU9400201A patent/HUT70272A/hu unknown
- 1992-07-24 RO RO94-00095A patent/RO116404B1/ro unknown
- 1992-07-24 JP JP5503072A patent/JP3048640B2/ja not_active Expired - Fee Related
- 1992-07-24 DE DE69233011T patent/DE69233011T2/de not_active Expired - Fee Related
- 1992-07-24 ES ES02012106T patent/ES2265005T3/es not_active Expired - Lifetime
- 1992-07-24 EP EP02012106A patent/EP1266965B1/en not_active Revoked
- 1992-07-24 EP EP92917108A patent/EP0605442B1/en not_active Expired - Lifetime
- 1992-07-24 DE DE69233628T patent/DE69233628T2/de not_active Revoked
- 1992-07-24 AT AT02012106T patent/ATE327331T1/de active
- 1992-07-24 AT AT92917108T patent/ATE237638T1/de not_active IP Right Cessation
- 1992-07-24 DK DK02012106T patent/DK1266965T3/da active
- 1992-07-24 SK SK5059-2005A patent/SK285960B6/sk not_active IP Right Cessation
- 1992-07-24 AU AU24255/92A patent/AU673499B2/en not_active Ceased
- 1992-07-24 IL IL102640A patent/IL102640A0/xx not_active IP Right Cessation
- 1992-07-24 KR KR1019940700217A patent/KR0137806B1/ko not_active Expired - Fee Related
- 1992-07-24 DK DK92917108T patent/DK0605442T3/da active
- 1992-07-24 SK SK88-94A patent/SK285046B6/sk not_active IP Right Cessation
- 1992-07-24 BR BR9206313A patent/BR9206313A/pt not_active Application Discontinuation
- 1992-07-24 WO PCT/US1992/006194 patent/WO1993002108A1/en active IP Right Grant
- 1992-07-25 MY MYPI92001327A patent/MY121185A/en unknown
- 1992-07-27 AP APAP/P/1992/000413A patent/AP307A/en active
- 1992-07-27 PT PT100735A patent/PT100735B/pt not_active IP Right Cessation
-
1994
- 1994-01-21 NO NO19940219A patent/NO318097B1/no not_active IP Right Cessation
- 1994-01-24 FI FI940336A patent/FI117703B/fi active IP Right Grant
- 1994-01-24 OA OA60460A patent/OA09879A/en unknown
- 1994-01-24 BG BG98411A patent/BG62656B1/bg unknown
-
1995
- 1995-06-29 HU HU95P/P00595P patent/HU211881A9/hu unknown
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