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BG60102B2 - Метод за получаване на 5-флуор-2(((4-циклопропил- метокси-2-пиридинил)метил)тионил)-1н-бензимидазол - Google Patents

Метод за получаване на 5-флуор-2(((4-циклопропил- метокси-2-пиридинил)метил)тионил)-1н-бензимидазол

Info

Publication number
BG60102B2
BG60102B2 BG094659A BG9465991A BG60102B2 BG 60102 B2 BG60102 B2 BG 60102B2 BG 094659 A BG094659 A BG 094659A BG 9465991 A BG9465991 A BG 9465991A BG 60102 B2 BG60102 B2 BG 60102B2
Authority
BG
Bulgaria
Prior art keywords
cyclopropylmethoxy
thionyl
fluoro
methyl
pyridyl
Prior art date
Application number
BG094659A
Other languages
English (en)
Inventor
Arne Braendstroem
Per Lindberg
Gunnel Sunden
Original Assignee
Aktiebolaget Haessle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Haessle filed Critical Aktiebolaget Haessle
Publication of BG60102B2 publication Critical patent/BG60102B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

(57) 5-флуор-2(((4-циклопропилметокси-2-пиридинил)метил)тионил)-1Н-бензимидазол и неговите физиологично приемливи соли, както междинни продукти и фармацевтични състави, които съдържат съединението като активен ингредиент, и употребата им в медицината.@@ 1 претенция
BG094659A 1988-12-22 1991-06-19 Метод за получаване на 5-флуор-2(((4-циклопропил- метокси-2-пиридинил)метил)тионил)-1н-бензимидазол BG60102B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds

Publications (1)

Publication Number Publication Date
BG60102B2 true BG60102B2 (bg) 1993-10-29

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
BG094659A BG60102B2 (bg) 1988-12-22 1991-06-19 Метод за получаване на 5-флуор-2(((4-циклопропил- метокси-2-пиридинил)метил)тионил)-1н-бензимидазол

Country Status (32)

Country Link
US (2) US5008278A (bg)
EP (1) EP0449940B1 (bg)
JP (1) JP2793906B2 (bg)
KR (1) KR910700249A (bg)
CN (1) CN1028231C (bg)
AR (1) AR248136A1 (bg)
AT (1) ATE127799T1 (bg)
AU (1) AU634741B2 (bg)
BG (1) BG60102B2 (bg)
CA (1) CA2005986C (bg)
DD (2) DD296078A5 (bg)
DE (1) DE68924273T2 (bg)
DK (1) DK170800B1 (bg)
EG (1) EG19303A (bg)
FI (2) FI913035A0 (bg)
GR (1) GR1002252B (bg)
HR (1) HRP920831A2 (bg)
HU (2) HU205927B (bg)
IE (1) IE894048L (bg)
IL (1) IL92798A0 (bg)
LT (2) LT3980B (bg)
LV (1) LV10187B (bg)
NZ (1) NZ231872A (bg)
PH (1) PH27400A (bg)
PL (1) PL161150B1 (bg)
PT (1) PT92648B (bg)
RO (1) RO110494B1 (bg)
RU (2) RU2073676C1 (bg)
SE (1) SE8804629D0 (bg)
WO (1) WO1990006925A1 (bg)
YU (1) YU46806B (bg)
ZA (2) ZA899795B (bg)

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JP2006528182A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 薬学的製剤および酸に起因する消化器疾患の治療法
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
JP5474541B2 (ja) 2006-07-25 2014-04-16 ベクタ・リミテッド 小さいジカルボン酸の誘導体と組み合わせてｐｐｉを用いる胃酸分泌を阻害する組成物および方法
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
CN102209529A (zh) 2008-09-09 2011-10-05 阿斯利康(瑞典)有限公司 将药物组合物递送至有需要的患者的方法
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Also Published As

Publication number Publication date
CN1043713A (zh) 1990-07-11
DK122291D0 (da) 1991-06-21
JPH04502461A (ja) 1992-05-07
AU4817590A (en) 1990-07-10
US5008278A (en) 1991-04-16
LV10187B (en) 1995-04-20
CN1028231C (zh) 1995-04-19
HU205927B (en) 1992-07-28
HRP920831A2 (en) 1995-12-31
NZ231872A (en) 1992-03-26
KR910700249A (ko) 1991-03-14
LT3980B (en) 1996-06-25
PT92648A (pt) 1990-06-29
HUT57202A (en) 1991-11-28
PL161150B1 (en) 1993-05-31
LTIP1726A (en) 1995-07-25
DE68924273T2 (de) 1996-02-15
DD296078A5 (de) 1991-11-21
RU2042673C1 (ru) 1995-08-27
CA2005986C (en) 1999-08-03
GR1002252B (en) 1996-04-23
DD296079A5 (de) 1991-11-21
WO1990006925A1 (en) 1990-06-28
EP0449940A1 (en) 1991-10-09
FI954768A (fi) 1995-10-06
LT3914B (en) 1996-04-25
RO110494B1 (ro) 1996-01-30
DK170800B1 (da) 1996-01-22
FI954768A0 (fi) 1995-10-06
ATE127799T1 (de) 1995-09-15
LV10187A (lv) 1994-10-20
PT92648B (pt) 1995-09-12
SE8804629D0 (sv) 1988-12-22
PH27400A (en) 1993-06-21
LTIP1721A (en) 1995-07-25
ZA899795B (en) 1990-08-29
YU242689A (en) 1991-04-30
EG19303A (en) 1994-11-30
AR248136A1 (es) 1995-06-30
EP0449940B1 (en) 1995-09-13
RU2073676C1 (ru) 1997-02-20
IE894048L (en) 1990-06-22
DK122291A (da) 1991-06-24
AU634741B2 (en) 1993-03-04
FI913035A0 (fi) 1991-06-20
DE68924273D1 (de) 1995-10-19
HU901084D0 (en) 1991-09-30
IL92798A0 (en) 1990-09-17
YU46806B (sh) 1994-06-10
ZA899794B (en) 1990-08-29
US5039808A (en) 1991-08-13
JP2793906B2 (ja) 1998-09-03
HU205926B (en) 1992-07-28
GR890100838A (el) 1991-03-15
CA2005986A1 (en) 1990-06-22

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