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AR248136A1 - Procedimiento e intermediarios para la preparacion de 5 5 5 5 5 - Google Patents

Procedimiento e intermediarios para la preparacion de 5 5 5 5 5

Info

Publication number
AR248136A1
AR248136A1 AR89315705A AR31570589A AR248136A1 AR 248136 A1 AR248136 A1 AR 248136A1 AR 89315705 A AR89315705 A AR 89315705A AR 31570589 A AR31570589 A AR 31570589A AR 248136 A1 AR248136 A1 AR 248136A1
Authority
AR
Argentina
Prior art keywords
fluor
compound
procedure
preparation
methylsulphinyl
Prior art date
Application number
AR89315705A
Other languages
English (en)
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Application granted granted Critical
Publication of AR248136A1 publication Critical patent/AR248136A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE 5-FLUOR-2-¡¡(4-CICLOPROPILMETOXI-2- PIRIDINIL)METIL¿SULFINIL¿-1H-BENCIMIDAZOL (COMPUESTO I) Y SALES FISIOLOGICAMENTE ACEPTABLES DEL MISMO, ASI COMO SUS ENANTIOMEROS OPTICOS, QUE COMPRENDE LA ETAPA DE OXIDACION DE 5-FLUOR-2-¡¡(4-CICLOPROPILMETOXI-2- PIRIDINIL)METIL¿TIO¿-1H-BENCIMIDAZOL, DESPUES DE LO CUAL EL COMPUESTO I ASI OBTENIDO, SI SE DESEA, SE CONVIERTE EN UNA SAL O EN UN ISOMERO OPTICO PURO.
AR89315705A 1988-12-22 1989-12-18 Procedimiento e intermediarios para la preparacion de 5 5 5 5 5 AR248136A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE19888804629A SE8804629D0 (sv) 1988-12-22 1988-12-22 New therapeutically active compounds

Publications (1)

Publication Number Publication Date
AR248136A1 true AR248136A1 (es) 1995-06-30

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89315705A AR248136A1 (es) 1988-12-22 1989-12-18 Procedimiento e intermediarios para la preparacion de 5 5 5 5 5

Country Status (32)

Country Link
US (2) US5008278A (es)
EP (1) EP0449940B1 (es)
JP (1) JP2793906B2 (es)
KR (1) KR910700249A (es)
CN (1) CN1028231C (es)
AR (1) AR248136A1 (es)
AT (1) ATE127799T1 (es)
AU (1) AU634741B2 (es)
BG (1) BG60102B2 (es)
CA (1) CA2005986C (es)
DD (2) DD296078A5 (es)
DE (1) DE68924273T2 (es)
DK (1) DK170800B1 (es)
EG (1) EG19303A (es)
FI (2) FI913035A0 (es)
GR (1) GR1002252B (es)
HR (1) HRP920831A2 (es)
HU (2) HU205927B (es)
IE (1) IE894048L (es)
IL (1) IL92798A0 (es)
LT (2) LT3980B (es)
LV (1) LV10187B (es)
NZ (1) NZ231872A (es)
PH (1) PH27400A (es)
PL (1) PL161150B1 (es)
PT (1) PT92648B (es)
RO (1) RO110494B1 (es)
RU (2) RU2073676C1 (es)
SE (1) SE8804629D0 (es)
WO (1) WO1990006925A1 (es)
YU (1) YU46806B (es)
ZA (2) ZA899795B (es)

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TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
DK0723436T3 (da) * 1994-07-08 2001-11-26 Astrazeneca Ab Tabletteret flerenhedsdoseringsform
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19758573C2 (de) * 1997-11-26 2001-03-01 Implex Hear Tech Ag Fixationselement für ein implantierbares Mikrofon
WO1999053918A1 (fr) * 1998-04-20 1999-10-28 Eisai Co., Ltd. Compositions stabilisees contenant des composes du type benzimidazole
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
PT1222922E (pt) 1999-10-20 2007-09-12 Eisai R&D Man Co Ltd Método para estabilizar compostos de benzimidazole.
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
JP2005521662A (ja) * 2002-01-25 2005-07-21 サンタラス インコーポレイティッド プロトンポンプ阻害剤の経粘膜送達
AU2003224781A1 (en) * 2002-03-26 2003-10-13 Dr. Reddy's Laboratories Limited Crystalline forms of rabeprazole sodium
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
WO2004073654A2 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1648416A4 (en) * 2003-07-18 2012-03-28 Santarus Inc PHARMACEUTICAL FORMULATIONS FOR INHIBITING THE ACIDIC ACIDIFICATION AND MANUFACTURING AND USE METHOD
JP2006528182A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 薬学的製剤および酸に起因する消化器疾患の治療法
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
JP5474541B2 (ja) 2006-07-25 2014-04-16 ベクタ・リミテッド 小さいジカルボン酸の誘導体と組み合わせてｐｐｉを用いる胃酸分泌を阻害する組成物および方法
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
CN102209529A (zh) 2008-09-09 2011-10-05 阿斯利康(瑞典)有限公司 将药物组合物递送至有需要的患者的方法
JP2012531409A (ja) 2009-06-25 2012-12-10 アストラゼネカ・アクチエボラーグ Ｎｓａｉｄ関連潰瘍を発症するリスクがある患者の処置方法
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080501A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
EA028049B1 (ru) 2011-12-28 2017-10-31 Поузен Инк. Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты

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SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
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HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
JPS62201884A (ja) * 1986-02-28 1987-09-05 Tokyo Tanabe Co Ltd ベンズイミダゾール誘導体及びその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
NZ222495A (en) * 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
JPH0676323B2 (ja) * 1987-08-28 1994-09-28 東京田辺製薬株式会社 抗潰瘍剤

Also Published As

Publication number Publication date
CN1043713A (zh) 1990-07-11
DK122291D0 (da) 1991-06-21
JPH04502461A (ja) 1992-05-07
AU4817590A (en) 1990-07-10
US5008278A (en) 1991-04-16
LV10187B (en) 1995-04-20
CN1028231C (zh) 1995-04-19
HU205927B (en) 1992-07-28
BG60102B2 (bg) 1993-10-29
HRP920831A2 (en) 1995-12-31
NZ231872A (en) 1992-03-26
KR910700249A (ko) 1991-03-14
LT3980B (en) 1996-06-25
PT92648A (pt) 1990-06-29
HUT57202A (en) 1991-11-28
PL161150B1 (en) 1993-05-31
LTIP1726A (en) 1995-07-25
DE68924273T2 (de) 1996-02-15
DD296078A5 (de) 1991-11-21
RU2042673C1 (ru) 1995-08-27
CA2005986C (en) 1999-08-03
GR1002252B (en) 1996-04-23
DD296079A5 (de) 1991-11-21
WO1990006925A1 (en) 1990-06-28
EP0449940A1 (en) 1991-10-09
FI954768A (fi) 1995-10-06
LT3914B (en) 1996-04-25
RO110494B1 (ro) 1996-01-30
DK170800B1 (da) 1996-01-22
FI954768A0 (fi) 1995-10-06
ATE127799T1 (de) 1995-09-15
LV10187A (lv) 1994-10-20
PT92648B (pt) 1995-09-12
SE8804629D0 (sv) 1988-12-22
PH27400A (en) 1993-06-21
LTIP1721A (en) 1995-07-25
ZA899795B (en) 1990-08-29
YU242689A (en) 1991-04-30
EG19303A (en) 1994-11-30
EP0449940B1 (en) 1995-09-13
RU2073676C1 (ru) 1997-02-20
IE894048L (en) 1990-06-22
DK122291A (da) 1991-06-24
AU634741B2 (en) 1993-03-04
FI913035A0 (fi) 1991-06-20
DE68924273D1 (de) 1995-10-19
HU901084D0 (en) 1991-09-30
IL92798A0 (en) 1990-09-17
YU46806B (sh) 1994-06-10
ZA899794B (en) 1990-08-29
US5039808A (en) 1991-08-13
JP2793906B2 (ja) 1998-09-03
HU205926B (en) 1992-07-28
GR890100838A (el) 1991-03-15
CA2005986A1 (en) 1990-06-22

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