BG46003A3 - Method for preparing 1- (hydroxistirtl)- 5h- 2, 3- benzodiazepin combinations - Google Patents
Method for preparing 1- (hydroxistirtl)- 5h- 2, 3- benzodiazepin combinationsInfo
- Publication number
- BG46003A3 BG46003A3 BG079835A BG7983587A BG46003A3 BG 46003 A3 BG46003 A3 BG 46003A3 BG 079835 A BG079835 A BG 079835A BG 7983587 A BG7983587 A BG 7983587A BG 46003 A3 BG46003 A3 BG 46003A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- hydroxistirtl
- benzodiazepin
- preparing
- combinations
- polar
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- KTFPBRZYIREQHS-UHFFFAOYSA-N 2H-chromen-2-yl perchlorate Chemical compound Cl(=O)(=O)(=O)OC1OC2=C(C=C1)C=CC=C2 KTFPBRZYIREQHS-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000012404 In vitro experiment Methods 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU862140A HU195788B (en) | 1986-05-21 | 1986-05-21 | Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG46003A3 true BG46003A3 (en) | 1989-09-15 |
Family
ID=10957976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG079835A BG46003A3 (en) | 1986-05-21 | 1987-05-21 | Method for preparing 1- (hydroxistirtl)- 5h- 2, 3- benzodiazepin combinations |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4840948A (sh) |
| JP (1) | JPS6322082A (sh) |
| AT (1) | AT395009B (sh) |
| BE (1) | BE1000573A4 (sh) |
| BG (1) | BG46003A3 (sh) |
| CA (1) | CA1280748C (sh) |
| CH (1) | CH671226A5 (sh) |
| CS (1) | CS262690B2 (sh) |
| DD (1) | DD268943A5 (sh) |
| DE (1) | DE3717080C2 (sh) |
| DK (1) | DK258187A (sh) |
| ES (1) | ES2005582A6 (sh) |
| FI (1) | FI91964C (sh) |
| FR (1) | FR2599034B1 (sh) |
| GB (1) | GB2190677B (sh) |
| HU (1) | HU195788B (sh) |
| IL (1) | IL82613A (sh) |
| IT (1) | IT1205665B (sh) |
| NL (1) | NL8701213A (sh) |
| PL (1) | PL147687B1 (sh) |
| PT (1) | PT84923B (sh) |
| SE (1) | SE468560B (sh) |
| SU (1) | SU1503681A3 (sh) |
| YU (1) | YU46675B (sh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380721A (en) * | 1990-09-10 | 1995-01-10 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| SK283859B6 (sk) * | 1995-02-09 | 2004-03-02 | EGIS Gyógyszergyár Rt. | 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie |
| HU224435B1 (hu) * | 1995-02-09 | 2005-10-28 | EGIS Gyógyszergyár Rt. | Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények |
| EP0726257B1 (en) * | 1995-02-09 | 2001-04-11 | Egis Gyogyszergyar Rt. | 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders, and benzopyrylium intermediates for their preparation |
| ES2111493B1 (es) * | 1996-02-08 | 1999-08-01 | Egyt Gyogyszervegyeszeti Gyar | Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes. |
| HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
| EP1575521A4 (en) * | 2002-12-03 | 2008-04-30 | Vela Acquisition Corp | PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE |
| US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| US6638928B1 (en) | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
| JP2006510634A (ja) * | 2002-12-03 | 2006-03-30 | ヴェラ ファーマスーティカルズ インコーポレイテッド | １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途 |
| US20040224943A1 (en) * | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines |
| US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam |
| HUP0302449A3 (en) * | 2003-08-04 | 2005-06-28 | Egis Gyogyszergyar Nyilvanosan | 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK118660B (da) * | 1966-12-09 | 1970-09-21 | Egyt Gyogyszervegyeszeti Gyar | Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid. |
| HU179018B (en) * | 1978-10-19 | 1982-08-28 | Gyogyszerkutato Intezet | Process for producing new 5h-2,3-benzodiazepine derivatives |
| HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
-
1986
- 1986-05-21 HU HU862140A patent/HU195788B/hu not_active IP Right Cessation
-
1987
- 1987-05-19 CH CH1916/87A patent/CH671226A5/de not_active IP Right Cessation
- 1987-05-20 US US07/051,777 patent/US4840948A/en not_active Expired - Fee Related
- 1987-05-21 PL PL1987265812A patent/PL147687B1/pl unknown
- 1987-05-21 FI FI872255A patent/FI91964C/fi not_active IP Right Cessation
- 1987-05-21 NL NL8701213A patent/NL8701213A/nl not_active Application Discontinuation
- 1987-05-21 SE SE8702120A patent/SE468560B/sv not_active IP Right Cessation
- 1987-05-21 BE BE8700571A patent/BE1000573A4/fr not_active IP Right Cessation
- 1987-05-21 YU YU90687A patent/YU46675B/sh unknown
- 1987-05-21 FR FR8707118A patent/FR2599034B1/fr not_active Expired
- 1987-05-21 IT IT20619/87A patent/IT1205665B/it active
- 1987-05-21 DE DE3717080A patent/DE3717080C2/de not_active Expired - Fee Related
- 1987-05-21 PT PT84923A patent/PT84923B/pt not_active IP Right Cessation
- 1987-05-21 ES ES8701496A patent/ES2005582A6/es not_active Expired
- 1987-05-21 GB GB8712005A patent/GB2190677B/en not_active Expired - Lifetime
- 1987-05-21 SU SU874203194A patent/SU1503681A3/ru active
- 1987-05-21 IL IL82613A patent/IL82613A/xx unknown
- 1987-05-21 CS CS873690A patent/CS262690B2/cs unknown
- 1987-05-21 BG BG079835A patent/BG46003A3/xx unknown
- 1987-05-21 AT AT0130287A patent/AT395009B/de not_active IP Right Cessation
- 1987-05-21 CA CA000537655A patent/CA1280748C/en not_active Expired - Lifetime
- 1987-05-21 JP JP62124992A patent/JPS6322082A/ja active Pending
- 1987-05-21 DK DK258187A patent/DK258187A/da not_active Application Discontinuation
- 1987-05-21 DD DD87303005A patent/DD268943A5/de not_active IP Right Cessation
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