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BG45701A3 - Метод за получаване на алфа-хетероциклично заместени толунитрили - Google Patents

Метод за получаване на алфа-хетероциклично заместени толунитрили

Info

Publication number
BG45701A3
BG45701A3 BG081515A BG8151587A BG45701A3 BG 45701 A3 BG45701 A3 BG 45701A3 BG 081515 A BG081515 A BG 081515A BG 8151587 A BG8151587 A BG 8151587A BG 45701 A3 BG45701 A3 BG 45701A3
Authority
BG
Bulgaria
Prior art keywords
alpha
preparing
heterocyclic substituted
tolunitriles
substituted tolunitriles
Prior art date
Application number
BG081515A
Other languages
English (en)
Inventor
Robert Bowman
Ronald Steele
Leslie Browne
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG45701(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BG45701A3 publication Critical patent/BG45701A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Алфа-хетероциклично заместените толунитрили намират приложение в медицината като инхибитори на ароматазата. 3 претенции
BG081515A 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили BG45701A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (1)

Publication Number Publication Date
BG45701A3 true BG45701A3 (bg) 1989-07-14

Family

ID=25274596

Family Applications (4)

Application Number Title Priority Date Filing Date
BG081515A BG45701A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG081514A BG45700A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG078756A BG46598A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Family Applications After (3)

Application Number Title Priority Date Filing Date
BG081514A BG45700A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG078756A BG46598A3 (bg) 1986-03-07 1987-03-05 Метод за получаване на алфа-хетероциклично заместени толунитрили
BG098212A BG61204B2 (bg) 1986-03-07 1993-11-11 Алфа-хетероциклени заместени толунитрили

Country Status (36)

Country Link
US (1) US4749713A (bg)
EP (1) EP0236940B3 (bg)
JP (1) JPH0755930B2 (bg)
KR (1) KR910000482B1 (bg)
AT (1) ATE94873T1 (bg)
BG (4) BG45701A3 (bg)
CA (1) CA1316928C (bg)
CY (1) CY1905A (bg)
CZ (3) CZ279028B6 (bg)
DD (1) DD264432A5 (bg)
DE (2) DE19775016I2 (bg)
DK (1) DK172190B1 (bg)
DZ (1) DZ1055A1 (bg)
ES (1) ES2059317T3 (bg)
FI (1) FI91857C (bg)
HK (1) HK50296A (bg)
HU (1) HU202843B (bg)
IE (1) IE61101B1 (bg)
IL (1) IL81746A (bg)
LU (1) LU90128I2 (bg)
LV (1) LV5769B4 (bg)
MA (1) MA20888A1 (bg)
MC (1) MC1805A1 (bg)
MT (1) MTP998B (bg)
MX (1) MX5496A (bg)
MY (1) MY102428A (bg)
NL (1) NL970011I2 (bg)
NO (2) NO170277C (bg)
PH (1) PH24159A (bg)
PL (2) PL151490B1 (bg)
PT (1) PT84410B (bg)
RO (2) RO101533B1 (bg)
SK (3) SK736887A3 (bg)
SU (3) SU1470184A3 (bg)
TN (1) TNSN87033A1 (bg)
ZA (1) ZA871637B (bg)

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EP0408509B1 (de) * 1989-07-14 1996-03-06 Ciba-Geigy Ag Substituierte Benzonitrile
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
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DE4120107A1 (de) * 1991-06-14 1992-12-17 Schering Ag Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
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JP2000504014A (ja) * 1996-01-30 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
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US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
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US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
KR20030094415A (ko) 2001-05-16 2003-12-11 노파르티스 아게 Ν-｛5-[4-(4-메틸-피페라지노-메틸)-벤조일아미도]-2-메틸페닐｝-4-(3-피리딜)-2-피리미딘-아민 및 화학치료제를포함하는 배합물
CN1325482C (zh) * 2001-12-11 2007-07-11 埃默里大学 双(氰基苯基)甲基－三唑在预防乳腺癌中的用途
ATE345790T1 (de) * 2002-07-30 2006-12-15 Novartis Pharma Gmbh Kombination von einem aromatasehemmer mit einem bisphosphonat
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BRPI0417407A (pt) * 2003-12-15 2007-04-03 Theramex derivados de 1-n-fenil-amino-1h-imidazol e composições farmacêuticas contendo estes
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US9150524B2 (en) 2010-08-27 2015-10-06 Generics [Uk] Limited Pure intermediate
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ES2900829T3 (es) 2013-08-14 2022-03-18 Novartis Ag Terapia combinada para el tratamiento del cáncer
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JP2022504388A (ja) 2018-10-08 2022-01-13 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｐｉ３ｋアルファ阻害剤およびメトホルミンを用いたがんの処置方法
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Also Published As

Publication number Publication date
DZ1055A1 (fr) 2004-09-13
MTP998B (en) 1987-08-21
HK50296A (en) 1996-03-29
ZA871637B (en) 1987-10-28
DK172190B1 (da) 1997-12-22
LU90128I2 (fr) 1997-10-06
EP0236940B3 (en) 2011-03-23
PL151490B1 (en) 1990-09-28
EP0236940A2 (en) 1987-09-16
IE870575L (en) 1987-09-07
PT84410A (en) 1987-04-01
NO170277B (no) 1992-06-22
CA1316928C (en) 1993-04-27
RO101533B1 (en) 1992-06-25
IE61101B1 (en) 1994-10-05
FI870903A0 (fi) 1987-03-02
CS8707368A2 (en) 1991-02-12
MX5496A (es) 1993-12-01
BG46598A3 (bg) 1990-01-15
NL970011I2 (nl) 1997-09-01
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
MY102428A (en) 1992-06-30
IL81746A0 (en) 1987-10-20
SU1577695A3 (ru) 1990-07-07
SK736787A3 (en) 1998-06-03
DE3787480T2 (de) 1994-02-24
TNSN87033A1 (fr) 1990-01-01
EP0236940A3 (en) 1989-10-18
US4749713A (en) 1988-06-07
DK117687A (da) 1987-09-08
RO101532B1 (en) 1992-11-03
BG45700A3 (bg) 1989-07-14
AU6976887A (en) 1987-09-10
SK279102B6 (sk) 1998-06-03
PT84410B (pt) 1989-10-04
NO870937L (no) 1987-09-08
BG61204B2 (bg) 1997-02-28
LV5769A4 (lv) 1996-12-20
SK151287A3 (en) 1998-06-03
CS8701512A2 (en) 1991-02-12
CZ279028B6 (en) 1994-11-16
LV5769B4 (lv) 1997-04-20
NO1998010I1 (no) 1998-03-04
MC1805A1 (fr) 1987-12-22
ATE94873T1 (de) 1993-10-15
PL264460A1 (en) 1988-07-21
SK279101B6 (sk) 1998-06-03
SK279103B6 (sk) 1998-06-03
JPS62212369A (ja) 1987-09-18
DD264432A5 (de) 1989-02-01
ES2059317T3 (es) 1994-11-16
FI91857C (fi) 1994-08-25
DE3787480D1 (de) 1993-10-28
FI91857B (fi) 1994-05-13
SU1549478A3 (ru) 1990-03-07
PL152025B1 (en) 1990-10-31
KR870008851A (ko) 1987-10-21
CZ279026B6 (en) 1994-11-16
NO170277C (no) 1992-09-30
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
DK117687D0 (da) 1987-03-06
CS8707367A2 (en) 1991-02-12
AU604011B2 (en) 1990-12-06
SK736887A3 (en) 1998-06-03
JPH0755930B2 (ja) 1995-06-14
DE19775016I2 (de) 2002-02-21
CY1905A (en) 1987-03-05
EP0236940B1 (en) 1993-09-22
PH24159A (en) 1990-03-22
FI870903A (fi) 1987-09-08
MA20888A1 (fr) 1987-10-01
NL970011I1 (nl) 1997-05-01
KR910000482B1 (ko) 1991-01-25
IL81746A (en) 1992-02-16
CZ279027B6 (en) 1994-11-16

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