BG42675A3 - Method for preparing of 20- amino- macrolidic derivatives - Google Patents

Method for preparing of 20- amino- macrolidic derivatives

Info

Publication number: BG42675A3
Authority: BG; Bulgaria
Prior art keywords: derivatives; macrolidic; amino; preparing; lactenocin
Prior art date: 1982-09-13

Application number

BG062310A

Other languages

Bulgarian (bg)

English (en)

Inventor

Manuel Debono

Herbert Kirst

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-13

Filing date

1983-09-08

Publication date

1988-01-15

1983-09-08 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

1988-01-15 Publication of BG42675A3 publication Critical patent/BG42675A3/xx

Links

QRPHLEPFYLNRDA-NLGRAQRVSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,1 Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O QRPHLEPFYLNRDA-NLGRAQRVSA-N 0.000 abstract 1
CFMSCYSETWZXRS-UHFFFAOYSA-N Lactenocin Natural products O=CCC1CC(C)C(=O)C=CC(C)=CC(COC2C(C(O)C(O)C(C)O2)OC)C(CC)OC(=O)CC(O)C(C)C1OC1OC(C)C(O)C(N(C)C)C1O CFMSCYSETWZXRS-UHFFFAOYSA-N 0.000 abstract 1
229930194936 Tylosin Natural products 0.000 abstract 1
239000004182 Tylosin Substances 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
244000052616 bacterial pathogen Species 0.000 abstract 1
CFMSCYSETWZXRS-SNPFKJFCSA-N lactenocin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@@H]1[C@H]([C@@H](O)[C@@H](O)[C@@H](C)O1)OC)CC)C1O[C@@H](C)[C@@H](O)[C@@H](N(C)C)[C@@H]1O CFMSCYSETWZXRS-SNPFKJFCSA-N 0.000 abstract 1
UFUYRGNJTFAODM-HQCAVAADSA-N macrocin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](O)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 UFUYRGNJTFAODM-HQCAVAADSA-N 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 abstract 1
229960004059 tylosin Drugs 0.000 abstract 1
235000019375 tylosin Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Fodder In General (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BG062310A 1982-09-13 1983-09-08 Method for preparing of 20- amino- macrolidic derivatives BG42675A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41724782A	1982-09-13	1982-09-13

Publications (1)

Publication Number	Publication Date
BG42675A3 true BG42675A3 (en)	1988-01-15

Family

ID=23653182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG062310A BG42675A3 (en)	1982-09-13	1983-09-08	Method for preparing of 20- amino- macrolidic derivatives

Country Status (34)

Country	Link
EP (1)	EP0103465B1 (nl)
JP (1)	JPS5973598A (nl)
KR (1)	KR850000961B1 (nl)
AR (1)	AR241595A1 (nl)
AT (1)	AT381707B (nl)
AU (1)	AU561147B2 (nl)
BG (1)	BG42675A3 (nl)
CA (1)	CA1243310A (nl)
CS (1)	CS259862B2 (nl)
CY (1)	CY1417A (nl)
DD (1)	DD210284A5 (nl)
DE (1)	DE3366097D1 (nl)
DK (1)	DK153555C (nl)
EG (1)	EG16287A (nl)
ES (2)	ES8604596A1 (nl)
FI (1)	FI73222C (nl)
GB (1)	GB2127017B (nl)
GR (1)	GR79067B (nl)
HK (1)	HK21888A (nl)
HU (1)	HU194271B (nl)
IE (1)	IE55916B1 (nl)
IL (1)	IL69666A (nl)
LU (1)	LU90240I2 (nl)
MY (1)	MY8700756A (nl)
NL (1)	NL950001I2 (nl)
NZ (1)	NZ205501A (nl)
PH (1)	PH23242A (nl)
PL (2)	PL142304B1 (nl)
PT (1)	PT77335B (nl)
RO (1)	RO89235A (nl)
SG (1)	SG99287G (nl)
SU (1)	SU1375135A3 (nl)
UA (1)	UA6045A1 (nl)
ZA (1)	ZA836741B (nl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59181294A (ja) *	1983-03-30	1984-10-15	Satoshi Omura	抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法
US4921947A (en) *	1986-03-31	1990-05-01	Eli Lilly And Company	Process for preparing macrolide derivatives
EP0262903A3 (en) *	1986-09-29	1988-11-02	Eli Lilly And Company	New acyl derivatives of 20-modified tylosin and desmycosin compounds
US4820694A (en) *	1986-09-29	1989-04-11	Eli Lilly And Company	Modifications of 3-O-demethylmycinose in macrocin and lactenocin
US5354708A (en) *	1992-06-04	1994-10-11	Taskar Nikhil R	Method of nitrogen doping of II-VI semiconductor compounds during epitaxial growth using an amine
TW226373B (nl) *	1992-07-15	1994-07-11	Pfizer
ES2076107B1 (es) *	1993-09-20	1996-04-01	Pfizer	Derivados de antibioticos macrolidos de anillos de 16 miembros.
AU3121095A (en) *	1994-09-22	1996-04-09	Pfizer Inc.	Antibiotic macrolides
EP0778283A3 (en) *	1995-12-05	1998-01-28	Pfizer Inc.	Antibiotic macrolides
US6605599B1 (en)	1997-07-08	2003-08-12	Bristol-Myers Squibb Company	Epothilone derivatives
US6034070A (en) *	1998-03-02	2000-03-07	Eli Lilly And Company	Treatment of viral disease in swine
EP2019112A1 (en)	2007-07-26	2009-01-28	Intervet International BV	Macrolide solid-state forms
KR101538599B1 (ko)	2006-07-28	2015-07-21	인터벳 인터내셔널 비.브이.	마크롤라이드 합성 방법
US8350059B2 (en) *	2007-12-07	2013-01-08	Eisai R&D Management Co., Ltd.	Intermediates and methods for making zearalenone macrolide analogs
KR102307218B1 (ko) *	2013-05-23	2021-10-05	바이엘 애니멀 헬스 게엠베하	틸로신 유도체 및 그의 제조 방법
CN103880903B (zh) *	2014-03-21	2016-06-15	烟台万润药业有限公司	一种泰乐菌素类大环内酯及其衍生物的制备方法
CN117304241B (zh) *	2023-11-30	2024-03-01	中国农业科学院饲料研究所	一种大环内酯类化合物及其制备方法与应用
CN117510561B (zh) *	2023-11-30	2024-04-02	中国农业科学院饲料研究所	一种泰乐菌素衍生物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE32839B1 (en) *	1967-12-04	1973-12-28	Lilly Co Eli	Urea-antibiotic adducts and process for preparing the same
US4279896A (en) *	1980-06-23	1981-07-21	Schering Corporation	Novel 20-imino macrolide antibacterial agents
JPS58146595A (ja) *	1982-02-25	1983-09-01	Satoshi Omura	マクロライド系抗生物質

1983
- 1983-09-05 IL IL69666A patent/IL69666A/xx not_active IP Right Cessation
- 1983-09-05 AU AU18710/83A patent/AU561147B2/en not_active Expired
- 1983-09-06 NZ NZ205501A patent/NZ205501A/en unknown
- 1983-09-07 PH PH29508A patent/PH23242A/en unknown
- 1983-09-07 GR GR72394A patent/GR79067B/el unknown
- 1983-09-07 AR AR83294140A patent/AR241595A1/es active
- 1983-09-08 UA UA3641764A patent/UA6045A1/uk unknown
- 1983-09-08 CY CY141783A patent/CY1417A/xx unknown
- 1983-09-08 SU SU833641764A patent/SU1375135A3/ru active
- 1983-09-08 BG BG062310A patent/BG42675A3/xx unknown
- 1983-09-08 GB GB08324044A patent/GB2127017B/en not_active Expired
- 1983-09-08 AT AT0320683A patent/AT381707B/de not_active IP Right Cessation
- 1983-09-08 DE DE8383305241T patent/DE3366097D1/de not_active Expired
- 1983-09-08 EP EP83305241A patent/EP0103465B1/en not_active Expired
- 1983-09-09 FI FI833229A patent/FI73222C/fi not_active IP Right Cessation
- 1983-09-09 RO RO83112026A patent/RO89235A/ro unknown
- 1983-09-11 EG EG557/83A patent/EG16287A/xx active
- 1983-09-12 IE IE2131/83A patent/IE55916B1/en not_active IP Right Cessation
- 1983-09-12 CA CA000436451A patent/CA1243310A/en not_active Expired
- 1983-09-12 DK DK413783A patent/DK153555C/da not_active IP Right Cessation
- 1983-09-12 PL PL1983243718A patent/PL142304B1/pl unknown
- 1983-09-12 DD DD83254748A patent/DD210284A5/de unknown
- 1983-09-12 HU HU833167A patent/HU194271B/hu unknown
- 1983-09-12 KR KR1019830004273A patent/KR850000961B1/ko not_active IP Right Cessation
- 1983-09-12 PL PL1983250619A patent/PL142251B1/pl unknown
- 1983-09-12 ZA ZA836741A patent/ZA836741B/xx unknown
- 1983-09-12 ES ES525544A patent/ES8604596A1/es not_active Expired
- 1983-09-13 CS CS836653A patent/CS259862B2/cs unknown
- 1983-09-13 JP JP58169127A patent/JPS5973598A/ja active Granted
- 1983-09-13 PT PT77335A patent/PT77335B/pt unknown
1985
- 1985-10-31 ES ES548472A patent/ES8607336A1/es not_active Expired
1987
- 1987-11-11 SG SG992/87A patent/SG99287G/en unknown
- 1987-12-30 MY MY756/87A patent/MY8700756A/xx unknown
1988
- 1988-03-24 HK HK218/88A patent/HK21888A/xx not_active IP Right Cessation
1995
- 1995-01-10 NL NL950001C patent/NL950001I2/nl unknown
1998
- 1998-05-06 LU LU90240C patent/LU90240I2/fr unknown

Also Published As

Publication number	Publication date
AU1871083A (en)	1984-03-22
GB2127017B (en)	1986-01-15
FI833229A0 (fi)	1983-09-09
ATA320683A (de)	1986-04-15
GB2127017A (en)	1984-04-04
PL142304B1 (en)	1987-10-31
DK153555C (da)	1988-12-05
DK153555B (da)	1988-07-25
LU90240I2 (fr)	1998-07-06
IL69666A (en)	1987-10-20
AR241595A1 (es)	1992-09-30
DE3366097D1 (en)	1986-10-16
SU1375135A3 (ru)	1988-02-15
UA6045A1 (uk)	1994-12-29
CY1417A (en)	1988-04-22
IE55916B1 (en)	1991-02-27
NL950001I2 (nl)	1997-05-01
RO89235A (ro)	1986-03-15
HK21888A (en)	1988-03-31
FI73222C (fi)	1987-09-10
DK413783D0 (da)	1983-09-12
AU561147B2 (en)	1987-04-30
PL250619A1 (en)	1985-07-30
IL69666A0 (en)	1983-12-30
FI73222B (fi)	1987-05-29
PT77335B (en)	1986-05-19
NL950001I1 (nl)	1995-02-16
PL142251B1 (en)	1987-10-31
ES525544A0 (es)	1986-02-01
ES548472A0 (es)	1986-06-01
PL243718A1 (en)	1985-04-09
ZA836741B (en)	1984-04-25
JPH021840B2 (nl)	1990-01-12
CA1243310A (en)	1988-10-18
EP0103465B1 (en)	1986-09-10
PT77335A (en)	1983-10-01
DD210284A5 (de)	1984-06-06
AT381707B (de)	1986-11-25
CS259862B2 (en)	1988-11-15
NZ205501A (en)	1985-09-13
KR850000961B1 (ko)	1985-07-02
ES8604596A1 (es)	1986-02-01
EG16287A (en)	1987-04-30
EP0103465A1 (en)	1984-03-21
GB8324044D0 (en)	1983-10-12
FI833229A (fi)	1984-03-14
MY8700756A (en)	1987-12-31
HUT35272A (en)	1985-06-28
CS665383A2 (en)	1988-04-15
DK413783A (da)	1984-03-14
SG99287G (en)	1988-09-23
HU194271B (en)	1988-01-28
ES8607336A1 (es)	1986-06-01
IE832131L (en)	1984-03-13
KR840005734A (ko)	1984-11-15
JPS5973598A (ja)	1984-04-25
GR79067B (nl)	1984-10-02
PH23242A (en)	1989-06-06

Publication	Publication Date	Title
BG42675A3 (en)	1988-01-15	Method for preparing of 20- amino- macrolidic derivatives
ES475854A1 (es)	1980-05-16	Un procedimiento para preparar derivados de glicosido de pleuromutilina
BG44205A3 (en)	1988-10-14	Method for preparing of antibiotic s541
ATE30237T1 (de)	1987-10-15	Epi-derivat von azahomoerythromycin a und zwischenprodukte.
EA199901016A1 (ru)	2000-06-26	9-оксим-производные эритромицина
ATE66001T1 (de)	1991-08-15	Makrolid-antibiotikaderivate.
RO85833A (ro)	1984-11-25	Procedeu pentru prepararea unor derivati de 20-aminotilozina
MX7303E (es)	1988-04-29	Procedimiento microbiologico para la preparacion de derivados de antraciclina
IL57853A (en)	1983-06-15	Sisomycin derivatives,their production and pharmaceutical compositions and fodder containing them
ES2080140T3 (es)	1996-02-01	Derivados de eritromicina.
BE814267A (fr)	1974-10-28	Procede d'isolement de l'antibiotique av-290
ES442505A1 (es)	1977-05-16	Procedimiento de preparacion de la 4-0-n2',6'-diamino-2',3',6' - tridesoxi-alfa, d-ribohexopiranosiln6-0 - n3" - metila-mino-3",4",6"tridesoxi alfa,d-xilohexopiranosiln2-desoxies- treptamina.
IL69093A (en)	1986-09-30	Method for preparing 20-deoxo-23-de(mycinosyloxy)tylosin antibiotics,the novel 20-deoxo-23-de(mycinoslyloxy)tylosin derivatives,their use as intermediates and pharmaceutical compositions containing them
ES8300773A1 (es)	1982-11-01	"un procedimiento para la preparacion de derivados de metoxicefalosporinas".
BG42676A3 (en)	1988-01-15	Method for preparang derivatives of 6- aminoalkyl- penicillanic acid
ES2059791T3 (es)	1994-11-16	Antibiotico a80915 y procedimiento para su produccion.
ES464924A1 (es)	1978-09-01	Un procedimiento para la preparacion de derivados de olean- domicina.
ES2082806T3 (es)	1996-04-01	Derivados quimicos de los antibioticos alfa- y beta-ll-e19020.
GR3003852T3 (nl)	1993-03-16
DE3173571D1 (en)	1986-03-06	Antibiotic s/433, the process for preparing it and its use as an anti-tumor agent
IT8019606A0 (it)	1980-01-31	Antibiotico prodotto per fermentazioni di micro-organismi.