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BG42189A3 - Method for preparing of ripe human leucocytic interferon - Google Patents

Method for preparing of ripe human leucocytic interferon

Info

Publication number
BG42189A3
BG42189A3 BG052673A BG5267381A BG42189A3 BG 42189 A3 BG42189 A3 BG 42189A3 BG 052673 A BG052673 A BG 052673A BG 5267381 A BG5267381 A BG 5267381A BG 42189 A3 BG42189 A3 BG 42189A3
Authority
BG
Bulgaria
Prior art keywords
human leukocyte
interferon
leukocyte interferon
coli
transformed
Prior art date
Application number
BG052673A
Other languages
Bulgarian (bg)
English (en)
Inventor
David Norman
Sidney Pestka
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG42189(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of BG42189A3 publication Critical patent/BG42189A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
BG052673A 1980-07-01 1981-06-29 Method for preparing of ripe human leucocytic interferon BG42189A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number Publication Date
BG42189A3 true BG42189A3 (en) 1987-10-15

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
BG052673A BG42189A3 (en) 1980-07-01 1981-06-29 Method for preparing of ripe human leucocytic interferon

Country Status (36)

Country Link
EP (2) EP0043980B1 (fr)
AR (1) AR242833A1 (fr)
AT (3) ATE29727T1 (fr)
AU (1) AU552004B2 (fr)
BG (1) BG42189A3 (fr)
BR (1) BR8104189A (fr)
CH (2) CH657141A5 (fr)
CS (1) CS273152B2 (fr)
DD (3) DD210304A5 (fr)
DE (3) DE3177288T3 (fr)
DK (1) DK173543B1 (fr)
DZ (1) DZ312A1 (fr)
ES (1) ES8207514A1 (fr)
FI (1) FI82712C (fr)
FR (1) FR2486098B1 (fr)
GB (1) GB2079291B (fr)
GE (1) GEP19960519B (fr)
GR (1) GR75714B (fr)
HK (1) HK49285A (fr)
HU (1) HU196457B (fr)
IE (1) IE49255B1 (fr)
IT (1) IT1137272B (fr)
KE (1) KE3534A (fr)
LU (1) LU83461A1 (fr)
MC (1) MC1396A1 (fr)
MY (1) MY8700711A (fr)
NL (1) NL8103151A (fr)
NO (1) NO159392C (fr)
NZ (1) NZ197572A (fr)
PH (1) PH18036A (fr)
PL (3) PL148276B1 (fr)
PT (1) PT73289B (fr)
RO (1) RO87590A (fr)
SE (2) SE465223C5 (fr)
SU (1) SU1414319A3 (fr)
YU (1) YU47700B (fr)

Families Citing this family (50)

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ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NO811118L (no) 1980-04-03 1981-10-05 Biogen Nv Dna-sekvenser, rekombinante dna-molekyler og fremgangsmaate ved fremstilling av polypeptider
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58501543A (ja) * 1981-08-14 1983-09-16 エイ／エス　アルフレツド　ベンツオン ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
EP0088994B1 (fr) * 1982-03-15 1991-06-19 Schering Corporation ADN hybride, composition liante produite à l'aide de celui-ci et procédés pour la mise en oeuvre
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
CA1210714A (fr) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
WO1984003300A1 (fr) * 1983-02-24 1984-08-30 Inst Organicheskogo Sinteza Ak Interferon n humain leucocytaire et son procede d'obtention dans des cellules bacteriennes
EP0165942A1 (fr) * 1983-12-23 1986-01-02 Monash University PRODUCTION D'INTERFERON $g(a) HUMAIN
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (fr) * 1987-11-09 1992-10-20 Toshiya Takano Methode de production de genes etrangers
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (fr) * 1989-09-08 1991-03-21 California Institute Of Biological Research Compositions du ligand cr2 et procede de modulation des fonctions de cellules immunitaires
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
DK0741577T3 (da) * 1994-03-07 2003-02-17 Imperial College Anvendelsen af enterferon, subtype alfa 8, til fremstilling af lægemidler til behandling af virusinfektioner i leveren
ES2161793T3 (es) * 1994-04-09 2001-12-16 Hoffmann La Roche Proceso para la produccion de alfa-interferona.
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
US6299869B1 (en) 1997-12-08 2001-10-09 Genentech, Inc. Human interferon-epsilon: a type I interferon
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
DK1100542T3 (da) 1998-08-06 2005-10-17 Mountain View Pharmaceuticals PEG-uratoxidasekonjugater og anvendelsen heraf
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
AU2888602A (en) * 2000-11-03 2002-05-15 Pbl Biomedical Lab Interferons, uses and compositions related thereto
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
RU2451074C2 (ru) 2005-04-11 2012-05-20 Савиент Фармасьютикалз, Инк. Вариантные формы уратоксидазы и их применение
WO2009090056A2 (fr) * 2008-01-18 2009-07-23 F. Hoffmann-La Roche Ag Purification de polypeptides non glycosylés
NZ597089A (en) 2009-06-25 2014-05-30 Savient Pharmaceuticals Inc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
WO2018087345A1 (fr) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag Polythérapie comprenant un inhibiteur d'un antigène de hbsag, un analogue nucléosidique ou nucléotidique et un interféron

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (fr) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
CY1346A (en) * 1980-01-08 1987-01-16 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (fr) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Micro-organismes génétiquement modifiés

Also Published As

Publication number Publication date
DE3177288D1 (de) 1992-10-01
EP0211148B2 (fr) 1999-11-24
IT1137272B (it) 1986-09-03
DZ312A1 (fr) 2004-09-13
SE465223C5 (sv) 1998-02-10
GR75714B (fr) 1984-08-02
MY8700711A (en) 1987-12-31
BR8104189A (pt) 1982-03-16
DD210305A5 (de) 1984-06-06
YU47700B (sh) 1996-01-08
YU162281A (en) 1984-02-29
NO812247L (no) 1982-01-04
SE8104093L (sv) 1982-01-02
ES503528A0 (es) 1982-10-01
SE465223B (sv) 1991-08-12
MC1396A1 (fr) 1982-04-27
PL148260B1 (en) 1989-09-30
PL148276B1 (en) 1989-09-30
AU552004B2 (en) 1986-05-22
NZ197572A (en) 1985-07-31
KE3534A (en) 1985-06-07
EP0043980A3 (en) 1982-09-15
PT73289B (en) 1983-05-11
GB2079291A (en) 1982-01-20
ATA290981A (de) 1985-09-15
DK291081A (da) 1982-01-02
FI82712C (fi) 1991-04-10
DE3125706A1 (de) 1982-04-15
NL8103151A (nl) 1982-02-01
FR2486098A1 (fr) 1982-01-08
DD202307A5 (de) 1983-09-07
EP0043980A2 (fr) 1982-01-20
FI812067L (fi) 1982-01-02
DE3177288T2 (de) 1992-12-10
GEP19960519B (en) 1996-07-02
RO87590A (fr) 1986-07-30
PT73289A (en) 1981-07-01
ES8207514A1 (es) 1982-10-01
HK49285A (en) 1985-07-05
IT8122682A0 (it) 1981-07-01
EP0211148A1 (fr) 1987-02-25
DK173543B1 (da) 2001-02-05
ATE79901T1 (de) 1992-09-15
PL148261B1 (en) 1989-09-30
AT380272B (de) 1986-05-12
PL231940A1 (en) 1983-07-18
CH657141A5 (de) 1986-08-15
CS503781A2 (en) 1990-07-12
CH651308A5 (de) 1985-09-13
AU7246281A (en) 1982-01-07
FI82712B (fi) 1990-12-31
GB2079291B (en) 1984-06-13
NO159392C (no) 1988-12-21
ATE29727T1 (de) 1987-10-15
DE3125706C2 (de) 1995-05-24
HU196457B (en) 1988-11-28
DE3176448D1 (en) 1987-10-22
SU1414319A3 (ru) 1988-07-30
DE3177288T3 (de) 2000-03-16
LU83461A1 (de) 1983-04-06
IE811463L (en) 1982-01-01
CS273152B2 (en) 1991-03-12
PH18036A (en) 1985-03-06
DD210304A5 (de) 1984-06-06
NO159392B (no) 1988-09-12
IE49255B1 (en) 1985-09-04
EP0043980B1 (fr) 1987-09-16
FR2486098B1 (fr) 1985-12-27
EP0211148B1 (fr) 1992-08-26
AR242833A1 (es) 1993-05-31

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