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YU47700B - Interferoni i postupak za njihovo dobivanje - Google Patents

Interferoni i postupak za njihovo dobivanje

Info

Publication number
YU47700B
YU47700B YU162281A YU162281A YU47700B YU 47700 B YU47700 B YU 47700B YU 162281 A YU162281 A YU 162281A YU 162281 A YU162281 A YU 162281A YU 47700 B YU47700 B YU 47700B
Authority
YU
Yugoslavia
Prior art keywords
leukocyte interferon
mature human
human leukocyte
producing
dna strand
Prior art date
Application number
YU162281A
Other languages
English (en)
Other versions
YU162281A (en
Inventor
D.V.N. Goeddel
S. Pestka
Original Assignee
F. Hoffmann-La Roche & Co. Ag.
Genen-Tech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU47700(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by F. Hoffmann-La Roche & Co. Ag., Genen-Tech, Inc. filed Critical F. Hoffmann-La Roche & Co. Ag.
Priority to SI8111622A priority Critical patent/SI8111622B/sl
Publication of YU162281A publication Critical patent/YU162281A/xx
Priority to HRP-1622/81A priority patent/HRP930291A2/xx
Publication of YU47700B publication Critical patent/YU47700B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

INTERFERONI I POSTUPAK ZA NJIHOVO DOBIVANJE postupak za dobivanje mikroorganizama, koji su sposobni za proizvodnju polipeptida sa aminokiselinskim nizom jednog zrelog humanog leukocitnog interferona bez predhodnog niza, naznačen time, što se jedan mikroorganizam sa replikabilnim eksprimirajućim vektorom, koji sadrži DNK-niz koji kodira za jedan zreli humani leukocitni interferon bez prethodnog niza, transformiše i kultiviše. Prijava sadrži još 10 zavisnih zahteva. Postupak za dobivanje polipeptida sa aminokiselinskim nizom jednog zrelog humanog leukocitnog interferona bez prethodnog niza i bez glikozil-grupa, naznačen time, što se kultura jednog mikroorganizma, koja je transformisana sa jednim replikabilnim vektorom sposobnim za eksprimiranje takvog peptida, dovodi do eksprimiranja i što se izoluje polipeptid. Prijava sadrži još 14 zavisnih zahteva. Postupak za dobivanje replikabilnog vektora koji je sposoban da u jednom mikroorganizmu proizvede eksprimiranje polipeptida sa aminokiselinskim nizom zrelog humanog leukocitnog interferona, n aznačen time, što se jedan prvi DNK niz koji kodira za pomenuti polipeptid operativno povezuje sa jednim drugim DNK nizom koji sadrži za eksprimiranje potrebne kodove. Prijava sadrži još 15 zavisnih zahteva. Zreli interferon humanih leukocita, proizveden putem bakterija, na značen time, što se sastoji od 165 - 166 aminokiselina i sadrži Cys-Asp-Leu ili Cys-Asn-Leu u položajima 1, 2 i 3, i takav zreli interferon leukocita sa dodatnim ostatkom metionnina na N-ter-minalu. Prijava sadrži još 4 zavisna i 8 nezavisnih zahteva.
YU162281A 1980-07-01 1981-06-30 Interferoni i postupak za njihovo dobivanje YU47700B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8111622A SI8111622B (sl) 1980-07-01 1981-06-30 Interferoni in postopek za njihovo pridobivanje
HRP-1622/81A HRP930291A2 (en) 1980-07-01 1993-03-10 Interferones and process for the preparation thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (2)

Publication Number Publication Date
YU162281A YU162281A (en) 1984-02-29
YU47700B true YU47700B (sh) 1996-01-08

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
YU162281A YU47700B (sh) 1980-07-01 1981-06-30 Interferoni i postupak za njihovo dobivanje

Country Status (36)

Country Link
EP (2) EP0043980B1 (sh)
AR (1) AR242833A1 (sh)
AT (3) ATE29727T1 (sh)
AU (1) AU552004B2 (sh)
BG (1) BG42189A3 (sh)
BR (1) BR8104189A (sh)
CH (2) CH657141A5 (sh)
CS (1) CS273152B2 (sh)
DD (3) DD210304A5 (sh)
DE (3) DE3177288T3 (sh)
DK (1) DK173543B1 (sh)
DZ (1) DZ312A1 (sh)
ES (1) ES8207514A1 (sh)
FI (1) FI82712C (sh)
FR (1) FR2486098B1 (sh)
GB (1) GB2079291B (sh)
GE (1) GEP19960519B (sh)
GR (1) GR75714B (sh)
HK (1) HK49285A (sh)
HU (1) HU196457B (sh)
IE (1) IE49255B1 (sh)
IT (1) IT1137272B (sh)
KE (1) KE3534A (sh)
LU (1) LU83461A1 (sh)
MC (1) MC1396A1 (sh)
MY (1) MY8700711A (sh)
NL (1) NL8103151A (sh)
NO (1) NO159392C (sh)
NZ (1) NZ197572A (sh)
PH (1) PH18036A (sh)
PL (3) PL148276B1 (sh)
PT (1) PT73289B (sh)
RO (1) RO87590A (sh)
SE (2) SE465223C5 (sh)
SU (1) SU1414319A3 (sh)
YU (1) YU47700B (sh)

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EP0165942A1 (en) * 1983-12-23 1986-01-02 Monash University PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
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US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
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FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
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DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
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Also Published As

Publication number Publication date
DE3177288D1 (de) 1992-10-01
EP0211148B2 (en) 1999-11-24
IT1137272B (it) 1986-09-03
DZ312A1 (fr) 2004-09-13
SE465223C5 (sv) 1998-02-10
GR75714B (sh) 1984-08-02
MY8700711A (en) 1987-12-31
BR8104189A (pt) 1982-03-16
BG42189A3 (en) 1987-10-15
DD210305A5 (de) 1984-06-06
YU162281A (en) 1984-02-29
NO812247L (no) 1982-01-04
SE8104093L (sv) 1982-01-02
ES503528A0 (es) 1982-10-01
SE465223B (sv) 1991-08-12
MC1396A1 (fr) 1982-04-27
PL148260B1 (en) 1989-09-30
PL148276B1 (en) 1989-09-30
AU552004B2 (en) 1986-05-22
NZ197572A (en) 1985-07-31
KE3534A (en) 1985-06-07
EP0043980A3 (en) 1982-09-15
PT73289B (en) 1983-05-11
GB2079291A (en) 1982-01-20
ATA290981A (de) 1985-09-15
DK291081A (da) 1982-01-02
FI82712C (fi) 1991-04-10
DE3125706A1 (de) 1982-04-15
NL8103151A (nl) 1982-02-01
FR2486098A1 (fr) 1982-01-08
DD202307A5 (de) 1983-09-07
EP0043980A2 (en) 1982-01-20
FI812067L (fi) 1982-01-02
DE3177288T2 (de) 1992-12-10
GEP19960519B (en) 1996-07-02
RO87590A (ro) 1986-07-30
PT73289A (en) 1981-07-01
ES8207514A1 (es) 1982-10-01
HK49285A (en) 1985-07-05
IT8122682A0 (it) 1981-07-01
EP0211148A1 (en) 1987-02-25
DK173543B1 (da) 2001-02-05
ATE79901T1 (de) 1992-09-15
PL148261B1 (en) 1989-09-30
AT380272B (de) 1986-05-12
PL231940A1 (en) 1983-07-18
CH657141A5 (de) 1986-08-15
CS503781A2 (en) 1990-07-12
CH651308A5 (de) 1985-09-13
AU7246281A (en) 1982-01-07
FI82712B (fi) 1990-12-31
GB2079291B (en) 1984-06-13
NO159392C (no) 1988-12-21
ATE29727T1 (de) 1987-10-15
DE3125706C2 (de) 1995-05-24
HU196457B (en) 1988-11-28
DE3176448D1 (en) 1987-10-22
SU1414319A3 (ru) 1988-07-30
DE3177288T3 (de) 2000-03-16
LU83461A1 (de) 1983-04-06
IE811463L (en) 1982-01-01
CS273152B2 (en) 1991-03-12
PH18036A (en) 1985-03-06
DD210304A5 (de) 1984-06-06
NO159392B (no) 1988-09-12
IE49255B1 (en) 1985-09-04
EP0043980B1 (en) 1987-09-16
FR2486098B1 (fr) 1985-12-27
EP0211148B1 (en) 1992-08-26
AR242833A1 (es) 1993-05-31

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