[go: up one dir, main page]

BG34336A3 - Method for obtaining derivates of phtalazine-4-yl-acetic acid - Google Patents

Method for obtaining derivates of phtalazine-4-yl-acetic acid

Info

Publication number
BG34336A3
BG34336A3 BG041857A BG4185778A BG34336A3 BG 34336 A3 BG34336 A3 BG 34336A3 BG 041857 A BG041857 A BG 041857A BG 4185778 A BG4185778 A BG 4185778A BG 34336 A3 BG34336 A3 BG 34336A3
Authority
BG
Bulgaria
Prior art keywords
acetic acid
phtalazine
derivates
obtaining
phthalazin
Prior art date
Application number
BG041857A
Other languages
Bulgarian (bg)
English (en)
Inventor
David Brittain
Robin Wood
Original Assignee
Imperial Chemical Industries Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Plc filed Critical Imperial Chemical Industries Plc
Publication of BG34336A3 publication Critical patent/BG34336A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG041857A 1977-12-29 1978-12-26 Method for obtaining derivates of phtalazine-4-yl-acetic acid BG34336A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5414277 1977-12-29

Publications (1)

Publication Number Publication Date
BG34336A3 true BG34336A3 (en) 1983-08-15

Family

ID=10470067

Family Applications (1)

Application Number Title Priority Date Filing Date
BG041857A BG34336A3 (en) 1977-12-29 1978-12-26 Method for obtaining derivates of phtalazine-4-yl-acetic acid

Country Status (31)

Country Link
US (2) US4251528A (de)
EP (1) EP0002895B1 (de)
JP (2) JPS5495582A (de)
AT (1) AT365581B (de)
AU (1) AU516264B2 (de)
BG (1) BG34336A3 (de)
CA (1) CA1107732A (de)
CS (1) CS241015B2 (de)
CY (1) CY1219A (de)
DD (1) DD141021A5 (de)
DE (1) DE2861170D1 (de)
DK (1) DK151253C (de)
ES (1) ES476496A1 (de)
FI (1) FI64357C (de)
GR (1) GR65303B (de)
HK (1) HK22484A (de)
HU (1) HU182585B (de)
IE (1) IE47592B1 (de)
IL (1) IL56099A0 (de)
IN (1) IN150196B (de)
IT (1) IT1110885B (de)
MY (1) MY8500359A (de)
NO (1) NO154346C (de)
NZ (1) NZ189034A (de)
PH (1) PH15435A (de)
PL (1) PL118443B1 (de)
PT (1) PT68956A (de)
SG (1) SG68683G (de)
SU (3) SU1087075A3 (de)
YU (3) YU41607B (de)
ZW (1) ZW24978A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
CA1143733A (en) * 1979-07-31 1983-03-29 Masao Yoshida Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
EP0222576B1 (de) * 1985-11-07 1992-03-18 Pfizer Inc. Heterocyclische Oxophthalazinylessigsäure
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
US5011840A (en) * 1986-11-24 1991-04-30 Pfizer Inc. Imidazolidinedione derivatives in diabetes treatment
GB8704569D0 (en) * 1987-02-26 1987-04-01 Ici America Inc Therapeutic agent
US4868301A (en) * 1987-06-09 1989-09-19 Pfizer Inc. Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0315249A1 (de) * 1987-11-02 1989-05-10 Merck & Co. Inc. Phthalazinessigsäure-Zusammensetzung und Tablette
DK607188A (da) * 1987-11-02 1989-06-22 Merck & Co Inc Tablet indeholdende en phthalazineddikesyreforbindelse
US4880928A (en) * 1987-12-21 1989-11-14 Merck & Co., Inc. Process for the preparation of 3-((4-bromo-2-fluorophenyl)methyl)-3,4-dihydro-4-oxo-1-phthalazine-acetic acid
US4940791A (en) * 1988-02-29 1990-07-10 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel hydrazine containing intermediate
US4904782A (en) * 1988-02-29 1990-02-27 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
US4954629A (en) * 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
EP0397930A1 (de) * 1989-05-18 1990-11-22 Merck & Co. Inc. Verfahren zur Herstellung von 3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazin-Essigsäure
FR2647676A1 (fr) * 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
WO1991009019A1 (en) * 1989-12-15 1991-06-27 Pfizer Inc. Substituted oxophthalazinyl acetic acids and analogs thereof
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
FR2682108B1 (fr) * 1991-10-07 1994-01-07 Lipha Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant.
CA2145640C (en) * 1992-09-28 2001-01-30 Banavara L. Mylari Substituted pyrimidines for control of diabetic complications
CA2147504A1 (en) * 1992-11-02 1994-05-11 Prasun K. Chakravarty Substituted phthalazinones as neurotensin antagonists
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
JPH09506068A (ja) * 1993-07-26 1997-06-17 藤沢薬品工業株式会社 悪液質治療のためのオキソフタラジン類
US6696407B1 (en) 1997-03-21 2004-02-24 The Regents Of The University Of California Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
AU6473898A (en) * 1997-03-21 1998-10-20 Regents Of The University Of California, The Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors
IL131659A (en) * 1997-04-15 2005-07-25 Csir Pharmaceutical compositions having appetite suppressant activity
ID27884A (id) * 1998-03-31 2001-05-03 Inst For Pharm Discovery Inc Asam-asam indolealkanoat yang disubstitusikan.
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
AU2002215160A1 (en) * 2000-11-30 2002-06-11 Pfizer Products Inc. Combination of gaba agonists and aldose reductase inhibitors
DE60204611T2 (de) 2001-02-28 2006-05-11 Pfizer Products Inc., Groton Sulfonyl-pyridazinon-derivate zur Verwendung als Aldose-reduktase-inhibitoren
JP2004528319A (ja) * 2001-03-30 2004-09-16 ファイザー・プロダクツ・インク ピリダジノンアルドースレダクダーゼ阻害物質
JP2004528344A (ja) * 2001-04-30 2004-09-16 ファイザー・プロダクツ・インク アルドースレダクターゼ阻害薬とシクロオキシゲナーゼ−２阻害薬の併用
AU761191B2 (en) 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
US20050209237A1 (en) * 2002-04-30 2005-09-22 Brazzell Romulus K Method for decreasing capillary permeability in the retina
AU2003256926A1 (en) * 2002-07-26 2004-02-16 The Institutes For Pharmaceutical Discovery, Llc Substituted indolealkanoic acids derivative and formulations containing same for use in treatment of diabetic complications
US7572910B2 (en) * 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
JP4838582B2 (ja) * 2004-12-27 2011-12-14 岐阜プラスチック工業株式会社 台車用本体
ES2371393T3 (es) 2007-03-12 2011-12-30 Zadec Aps Extracto antidiabético de rooibos.
US8273746B2 (en) * 2007-03-23 2012-09-25 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibitors
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
AU2011348074B2 (en) 2010-12-23 2016-04-28 The Board Of Regents Of The University Of Texas System Methods for treating COPD
WO2014093988A2 (en) * 2012-12-14 2014-06-19 Phusis Therapeutics, Inc. Methods and compositions for inhibiting cnksr1
CA2983260C (en) 2015-04-20 2024-01-23 Phusis Therapeutics, Inc. Sulfonamide compounds, compositions and methods for inhibiting cnksr1
US12090142B2 (en) 2018-02-22 2024-09-17 Board Of Regents, The University Of Texas System Combination therapy for the treatment of cancer
CN112789149B (zh) * 2018-10-04 2023-06-06 日东电工株式会社 耐热脱模片和热压接方法
JP6751974B1 (ja) * 2019-10-16 2020-09-09 株式会社コバヤシ 離型フィルム及び離型フィルムの製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833579A (en) * 1935-11-11 1974-09-03 Inoue Michiro 4-carbamoyl phthalazones
JPS5116430B2 (de) * 1971-08-05 1976-05-24
GB1398549A (en) * 1972-11-06 1975-06-25 Boots Co Ltd Phthalazine derivatives and their use in pharmaceutical compo sitions
AR205004A1 (es) * 1973-10-30 1976-03-31 Ishikawa M Procedimiento para preparar derivados de 6,8-dialquil-7-alcoxi-carbonil-4-hidroximetil-1-ftalazona y la 7,8-lactona
DE2451117A1 (de) * 1973-10-31 1975-05-22 Boots Co Ltd Therapeutisch wirksame verbindungen
IE43079B1 (en) * 1975-03-20 1980-12-17 Ici Ltd Quinolone derivatives
GB1502312A (en) 1975-03-20 1978-03-01 Ici Ltd Quinolone derivatives
JPS5214788A (en) * 1975-07-21 1977-02-03 Fuji Photo Film Co Ltd Process for preparing phthalazinone and its derivatives
NL7702763A (nl) * 1976-03-18 1977-09-20 Takio Shimamoto En Masayuki Is Werkwijze voor de bereiding van thromboxaan- -antagonisten en van preparaten die deze stof- fen bevatten.
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4293553A (en) * 1978-08-11 1981-10-06 Masayuki Ishikawa 1-Phthalazone derivatives, and use thereof

Also Published As

Publication number Publication date
AU516264B2 (en) 1981-05-28
YU232082A (en) 1983-01-21
CS241015B2 (en) 1986-03-13
FI64357B (fi) 1983-07-29
YU42807B (en) 1988-12-31
AT365581B (de) 1982-01-25
DK151253C (da) 1988-05-16
YU42054B (en) 1988-04-30
PL118443B1 (en) 1981-10-31
MY8500359A (en) 1985-12-31
YU41607B (en) 1987-12-31
NO784397L (no) 1979-07-02
IT1110885B (it) 1986-01-06
IE782337L (en) 1979-06-29
IN150196B (de) 1982-08-14
ATA937678A (de) 1981-06-15
JPS63119469A (ja) 1988-05-24
FI783844A (fi) 1979-06-30
YU232182A (en) 1983-01-21
PT68956A (en) 1979-01-01
FI64357C (fi) 1983-11-10
SU1087075A3 (ru) 1984-04-15
HK22484A (en) 1984-03-23
DK541878A (da) 1979-06-30
IE47592B1 (en) 1984-05-02
SG68683G (en) 1984-08-03
EP0002895A1 (de) 1979-07-11
YU312778A (en) 1983-01-21
EP0002895B1 (de) 1981-10-14
DE2861170D1 (en) 1981-12-24
JPS5495582A (en) 1979-07-28
ES476496A1 (es) 1979-04-16
SU1072803A3 (ru) 1984-02-07
US4393062A (en) 1983-07-12
SU1272984A3 (ru) 1986-11-23
DD141021A5 (de) 1980-04-09
PH15435A (en) 1983-01-18
JPH0262532B2 (de) 1990-12-26
AU4204078A (en) 1979-07-05
CA1107732A (en) 1981-08-25
NZ189034A (en) 1981-11-19
JPS6326110B2 (de) 1988-05-27
US4251528A (en) 1981-02-17
HU182585B (en) 1984-02-28
CY1219A (en) 1984-04-06
IL56099A0 (en) 1979-01-31
IT7852480A0 (it) 1978-12-28
GR65303B (en) 1980-08-01
NO154346C (no) 1986-09-03
DK151253B (da) 1987-11-16
NO154346B (no) 1986-05-26
ZW24978A1 (en) 1980-10-22

Similar Documents

Publication Publication Date Title
BG34336A3 (en) Method for obtaining derivates of phtalazine-4-yl-acetic acid
BG30015A3 (en) Method for obtaining of triphenylalkene derivatives
BG31225A3 (en) Method for obtaining of acilanilid derivatives
BG33286A3 (en) Method for obtaining of 4- hydroxy- 2h- 1, 2- benzothiazin- 3- carboxamid- 1, 1- dioxides
BG34614A3 (en) Method for preparing derivatives of penicillanic acid
BG28703A3 (en) Method of obtaining of momatostatine derivatives
BG31945A3 (en) Method for obtaining of 4- acylamino- phenyl- ethanolamines
BG34338A3 (en) Method for obtaining thiadiazolylcephalosporines
BG32851A3 (en) Method for obtaining of 3, 4, 5, 6- tetrahydro- 2 h- 1- benzoxycin
BG27905A3 (en) Method of obtaining of phospinous acids
BG28700A3 (en) Method of obtaining of alkylendiamine derivatives
BG28072A4 (en) Method of obtaining of 1-substitvated canamyzine derivatives
BG32855A3 (bg) Метод за получаване на 1-оксадетиацефалоспорини
BG34036A3 (en) A method of obtaining propargyl- 2- phenylamino- imidazolines- (2) and their acid salts
BG28713A3 (en) Method of obtaining of 5,11- dihydro- 6h- pyrido (2,3- b) (1,4) benzodiazepine- 6- ons
BG30927A3 (en) Method for obtaining of trans- 4- alpha- phenyl- octahydro- 1h- 2- pyridine
BG31073A3 (en) Method for obtaining of 1, 5- substituated- 2- pyrolidine
BG30175A4 (en) Method of obtaining of pyridon compounds
BG28064A3 (en) Method of obtaining of 2,6-methane-2h-1-benzoxozines
BG35466A3 (en) Method for preparing derivatives of clavulanic acid
BG30021A3 (en) Method for obtaining of imidazoisohinolin- dion
BG32116A3 (en) Method for obtaining of 4- amino- oleandomicine derivatives
BG31947A3 (en) Method for obtaining of acetidine derivatives
BG35032A3 (en) Method for preparing 1, 1, 2- triphenylpropene derivatives
BG33283A3 (en) Method for obtaining of pyridazinylhydrazon