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BG28049A3 - Метод за получаване на 2-бром-6-флуор-n-2-имидазолиди-нилиден- бензамин и неговите присъединителни с киселина соли - Google Patents

Метод за получаване на 2-бром-6-флуор-n-2-имидазолиди-нилиден- бензамин и неговите присъединителни с киселина соли

Info

Publication number
BG28049A3
BG28049A3 BG036775A BG3677577A BG28049A3 BG 28049 A3 BG28049 A3 BG 28049A3 BG 036775 A BG036775 A BG 036775A BG 3677577 A BG3677577 A BG 3677577A BG 28049 A3 BG28049 A3 BG 28049A3
Authority
BG
Bulgaria
Prior art keywords
benzamine
imdazolidinilidene
fluor
bromine
acid
Prior art date
Application number
BG036775A
Other languages
English (en)
Inventor
Helmut Staehle
Herbert Koeppe
Werner Kummer
Wolfgang Hoefke
Original Assignee
C.H.Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H.Boehringer Sohn filed Critical C.H.Boehringer Sohn
Publication of BG28049A3 publication Critical patent/BG28049A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electric Clocks (AREA)

Abstract

Метод за получаване на 2-бром-6-флуор-n-2имидазолидинилиден-бензамин и неговите присъединителни с киселина соли, характеризиращ се с това, че изотиокарбамид с обща формула..... Патентните претенции са формулирани в 4 точки.
BG036775A 1976-07-03 1977-07-01 Метод за получаване на 2-бром-6-флуор-n-2-имидазолиди-нилиден- бензамин и неговите присъединителни с киселина соли BG28049A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2630060A DE2630060C2 (de) 1976-07-03 1976-07-03 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
BG28049A3 true BG28049A3 (bg) 1980-02-25

Family

ID=5982175

Family Applications (1)

Application Number Title Priority Date Filing Date
BG036775A BG28049A3 (bg) 1976-07-03 1977-07-01 Метод за получаване на 2-бром-6-флуор-n-2-имидазолиди-нилиден- бензамин и неговите присъединителни с киселина соли

Country Status (32)

Country Link
US (1) US4166859A (bg)
JP (1) JPS6026108B2 (bg)
AT (1) AT354436B (bg)
AU (1) AU507260B2 (bg)
BE (1) BE856395A (bg)
BG (1) BG28049A3 (bg)
CA (1) CA1088550A (bg)
CH (2) CH633273A5 (bg)
CS (1) CS204005B2 (bg)
DD (1) DD132965A5 (bg)
DE (1) DE2630060C2 (bg)
DK (1) DK146281C (bg)
ES (4) ES460351A1 (bg)
FI (1) FI64146C (bg)
FR (1) FR2356642B1 (bg)
GB (1) GB1575147A (bg)
GR (1) GR63636B (bg)
HU (1) HU180429B (bg)
IE (1) IE45109B1 (bg)
IL (1) IL52433A (bg)
LU (1) LU77679A1 (bg)
MX (1) MX4841E (bg)
NL (2) NL188643C (bg)
NO (2) NO145951C (bg)
NZ (1) NZ184539A (bg)
PH (1) PH14572A (bg)
PL (1) PL102918B1 (bg)
PT (1) PT66756B (bg)
SE (1) SE431871B (bg)
SU (2) SU680644A3 (bg)
YU (1) YU161977A (bg)
ZA (1) ZA773979B (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2806811A1 (de) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben
DE2806775A1 (de) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
US4644007A (en) * 1981-11-20 1987-02-17 Alcon Laboratories, Inc. 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
DE3437694A1 (de) * 1984-10-15 1986-04-17 Boehringer Ingelheim Vetmedica GmbH, 6507 Ingelheim Verwendung einer substanz als sedativum
US4587257A (en) * 1984-12-14 1986-05-06 Alcon Laboratories, Inc. Control of ocular bleeding using clonidine derivatives
JPH0317363Y2 (bg) * 1986-11-19 1991-04-12
US5441339A (en) * 1992-10-22 1995-08-15 Prince Corporation Vehicle light
WO2005000818A1 (en) 2003-06-27 2005-01-06 Warner-Lambert Company Llc 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
CN115784896A (zh) * 2022-11-24 2023-03-14 山东诚创蓝海医药科技有限公司 一种2-溴-6-氟苯胺的制备方法
CN116063184B (zh) * 2022-12-28 2025-01-28 浙江车头制药股份有限公司 一种2-溴-6-氟苯胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770874B2 (de) * 1968-07-12 1977-09-15 Veb Arzneimittelwerk Dresden, Ddr 8122 Radebeul Verfahren zur herstellung von 2-(2,6- dichlorphenylamino)-imidazolin-2
BE787683A (fr) * 1971-08-20 1973-02-19 Boehringer Sohn Ingelheim 2-phenylimino-imidazolidines, leurs sels d'addition avec des acides et procedes pour les fabriquer
DE2446758C3 (de) * 1974-10-01 1979-01-04 C.H. Boehringer Sohn, 6507 Ingelheim 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie
DE2542702C2 (de) * 1975-09-25 1983-11-10 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur Herstellung von 1-Benzoyl-2-(2,6-dichlorphenylamino)-2-imidazolin

Also Published As

Publication number Publication date
AU507260B2 (en) 1980-02-07
ES460351A1 (es) 1978-08-16
CS204005B2 (en) 1981-03-31
NL930111I2 (nl) 1995-04-03
NO145951C (no) 1982-06-30
GB1575147A (en) 1980-09-17
NL188643C (nl) 1992-08-17
DK296477A (da) 1978-01-04
PH14572A (en) 1981-09-24
BE856395A (fr) 1978-01-02
NO145951B (no) 1982-03-22
SU680644A3 (ru) 1979-08-15
NL930111I1 (nl) 1993-10-18
DD132965A5 (de) 1978-11-22
FI64146C (fi) 1983-10-10
FR2356642A1 (fr) 1978-01-27
YU161977A (en) 1983-01-21
NZ184539A (en) 1980-03-05
LU77679A1 (bg) 1978-09-14
DE2630060A1 (de) 1978-01-12
SE431871B (sv) 1984-03-05
NO1994024I1 (no) 1994-11-25
NL7707308A (nl) 1978-01-05
FI771972A (bg) 1978-01-04
IE45109L (en) 1978-01-03
ES466851A1 (es) 1978-10-01
CH633275A5 (de) 1982-11-30
PL199298A1 (pl) 1978-03-28
DK146281C (da) 1984-01-30
IE45109B1 (en) 1982-06-16
NL188643B (nl) 1992-03-16
DK146281B (da) 1983-08-22
GR63636B (en) 1979-11-27
PL102918B1 (pl) 1979-05-31
FR2356642B1 (fr) 1985-07-19
AT354436B (de) 1979-01-10
ES466850A1 (es) 1978-10-01
JPS6026108B2 (ja) 1985-06-21
NO772329L (no) 1978-01-03
DE2630060C2 (de) 1984-04-19
US4166859A (en) 1979-09-04
PT66756A (de) 1977-08-01
CA1088550A (en) 1980-10-28
CH633273A5 (de) 1982-11-30
AU2662077A (en) 1979-01-04
PT66756B (de) 1979-06-07
IL52433A (en) 1980-09-16
HU180429B (en) 1983-03-28
ES466852A1 (es) 1978-10-01
JPS535164A (en) 1978-01-18
ZA773979B (en) 1979-03-28
SU665800A3 (ru) 1979-05-30
IL52433A0 (en) 1977-10-31
FI64146B (fi) 1983-06-30
SE7707689L (sv) 1978-01-04
MX4841E (es) 1982-10-28
ATA438777A (de) 1979-06-15

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