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BG105923A - Нови морфолинови производни, метод за тяхното получаване и фармацевтични състави, които ги съдържат - Google Patents

Нови морфолинови производни, метод за тяхното получаване и фармацевтични състави, които ги съдържат

Info

Publication number
BG105923A
BG105923A BG105923A BG10592301A BG105923A BG 105923 A BG105923 A BG 105923A BG 105923 A BG105923 A BG 105923A BG 10592301 A BG10592301 A BG 10592301A BG 105923 A BG105923 A BG 105923A
Authority
BG
Bulgaria
Prior art keywords
derivatives
production
pharmaceutical preparations
preparations containing
novel morpholine
Prior art date
Application number
BG105923A
Other languages
English (en)
Other versions
BG64623B1 (bg
Inventor
Jean Ducoux
Xavier Edmonds-Alt
Patrick Gueule
Vincenzo Proietto
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of BG105923A publication Critical patent/BG105923A/bg
Publication of BG64623B1 publication Critical patent/BG64623B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до съединения с формула, в която значенията на заместителите са посочени в описанието, и до техни соли с минерални или органични киселини, солвати и/или хидрати, които проявяват силен афинитет и висока степен на селективност по отношение на човешки NK1 рецептори на веществото Р. Изобретението се отнася и до метод за тяхнотополучаване, до междинни съединения с формули IV, VI и VIII, посочени в описанието, които са полезниза получаването им, до фармацевтични състави, съдържащи тези съединения, и до тяхното използване за получаване на лекарствени средства за лечение навсички патологии, включващи веществото Р и NK1 човешки рецептори.
BG105923A 1999-03-25 2001-09-19 Нови морфолинови производни, метод за тяхното получаване и фармацевтични състави, които ги съдържат BG64623B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9903854A FR2791346B3 (fr) 1999-03-25 1999-03-25 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
BG105923A true BG105923A (bg) 2002-05-31
BG64623B1 BG64623B1 (bg) 2005-09-30

Family

ID=9543720

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105923A BG64623B1 (bg) 1999-03-25 2001-09-19 Нови морфолинови производни, метод за тяхното получаване и фармацевтични състави, които ги съдържат

Country Status (41)

Country Link
US (1) US6506750B1 (bg)
EP (1) EP1165528B1 (bg)
JP (1) JP3853155B2 (bg)
KR (1) KR100696340B1 (bg)
CN (1) CN100422160C (bg)
AR (1) AR023139A1 (bg)
AT (1) ATE275136T1 (bg)
AU (1) AU756855B2 (bg)
BG (1) BG64623B1 (bg)
BR (1) BR0009281B1 (bg)
CA (1) CA2366829C (bg)
CO (1) CO5160340A1 (bg)
CZ (1) CZ300911B6 (bg)
DE (1) DE60013418T2 (bg)
DK (1) DK1165528T3 (bg)
EE (1) EE04525B1 (bg)
ES (1) ES2226794T3 (bg)
FR (1) FR2791346B3 (bg)
HK (1) HK1042092B (bg)
HR (1) HRP20010704B1 (bg)
HU (1) HUP0201863A3 (bg)
ID (1) ID29871A (bg)
IL (2) IL145041A0 (bg)
IS (1) IS2338B (bg)
ME (2) ME00057B (bg)
MX (1) MXPA01009643A (bg)
NO (1) NO321576B1 (bg)
NZ (1) NZ513674A (bg)
PE (1) PE20001596A1 (bg)
PL (1) PL205318B1 (bg)
PT (1) PT1165528E (bg)
RS (1) RS50085B (bg)
RU (1) RU2222537C2 (bg)
SI (1) SI1165528T1 (bg)
SK (1) SK286977B6 (bg)
TR (1) TR200102639T2 (bg)
TW (1) TW534906B (bg)
UA (1) UA73931C2 (bg)
UY (1) UY26079A1 (bg)
WO (1) WO2000058292A1 (bg)
ZA (1) ZA200106981B (bg)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE286897T1 (de) * 2000-11-28 2005-01-15 Smithkline Beecham Plc Morpholinderivate als antagonisten an orexinrezeptoren
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
GB0228787D0 (en) * 2002-12-10 2003-01-15 Pfizer Ltd Morpholine dopamine agonists
ES2312856T3 (es) * 2002-12-13 2009-03-01 Smithkline Beecham Corporation Compuestos heterociclicos como antagonistas de ccr5.
JO2485B1 (en) * 2002-12-23 2009-01-20 شركة جانسين فارماسوتيكا ان. في 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists
JP2007515425A (ja) * 2003-12-22 2007-06-14 シェーリング　コーポレイション 医薬組成物
FR2873373B1 (fr) * 2004-07-23 2006-09-08 Sanofi Synthelabo Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
CN103142569B (zh) * 2013-02-27 2016-01-20 南京医科大学 2,6-二异丙基苯甲酸及其衍生物作为神经保护剂的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ3134U1 (cs) * 1995-01-10 1995-03-17 Pavel Ing. Janda Rotor universálního radiálního ventilátoru
US5780466A (en) * 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
RU2135494C1 (ru) * 1995-12-01 1999-08-27 Санкио Компани Лимитед Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
JP3192631B2 (ja) * 1997-05-28 2001-07-30 三共株式会社 飽和複素環化合物からなる医薬
TR200001622T2 (tr) 1997-12-04 2001-07-23 Sankyo Company Limited Asilatlı Hetero-Alisiklik Türevleri

Also Published As

Publication number Publication date
HRP20010704B1 (en) 2005-04-30
TR200102639T2 (tr) 2002-02-21
PL351317A1 (en) 2003-04-07
KR100696340B1 (ko) 2007-03-20
IL145041A (en) 2010-11-30
UA73931C2 (en) 2005-10-17
DE60013418T2 (de) 2005-09-22
SI1165528T1 (en) 2005-02-28
US6506750B1 (en) 2003-01-14
NZ513674A (en) 2003-05-30
MEP12008A (en) 2010-06-10
FR2791346B3 (fr) 2001-04-27
HK1042092B (zh) 2005-04-22
IS6063A (is) 2001-08-24
CA2366829A1 (fr) 2000-10-05
ID29871A (id) 2001-10-18
WO2000058292A1 (fr) 2000-10-05
IS2338B (is) 2008-02-15
KR20010108381A (ko) 2001-12-07
PL205318B1 (pl) 2010-04-30
ES2226794T3 (es) 2005-04-01
BG64623B1 (bg) 2005-09-30
ME00057B (me) 2010-10-10
BR0009281A (pt) 2002-01-22
CN100422160C (zh) 2008-10-01
NO20014632L (no) 2001-11-26
IL145041A0 (en) 2002-06-30
RU2222537C2 (ru) 2004-01-27
PE20001596A1 (es) 2001-04-01
HRP20010704A2 (en) 2002-08-31
PT1165528E (pt) 2005-01-31
JP3853155B2 (ja) 2006-12-06
CA2366829C (fr) 2007-05-15
HUP0201863A3 (en) 2003-03-28
EP1165528B1 (fr) 2004-09-01
CZ300911B6 (cs) 2009-09-09
TW534906B (en) 2003-06-01
HK1042092A1 (en) 2002-08-02
DK1165528T3 (da) 2005-01-10
AU756855B2 (en) 2003-01-23
BR0009281B1 (pt) 2011-05-17
AR023139A1 (es) 2002-09-04
CZ20013365A3 (cs) 2002-01-16
EP1165528A1 (fr) 2002-01-02
AU3301600A (en) 2000-10-16
RS50085B (sr) 2009-01-22
EE200100499A (et) 2002-12-16
SK13462001A3 (sk) 2002-05-09
NO20014632D0 (no) 2001-09-24
JP2002540195A (ja) 2002-11-26
YU68201A (sh) 2004-03-12
FR2791346A1 (fr) 2000-09-29
CN1353698A (zh) 2002-06-12
UY26079A1 (es) 2000-10-31
EE04525B1 (et) 2005-08-15
ATE275136T1 (de) 2004-09-15
HUP0201863A2 (hu) 2002-12-28
MXPA01009643A (es) 2002-05-14
NO321576B1 (no) 2006-06-06
ZA200106981B (en) 2002-10-24
SK286977B6 (sk) 2009-08-06
CO5160340A1 (es) 2002-05-30
DE60013418D1 (de) 2004-10-07

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