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BR0009281A - Derivados de morfolina, processo de preparação dos mesmos e composições farmacêuticas que os contêm - Google Patents

Derivados de morfolina, processo de preparação dos mesmos e composições farmacêuticas que os contêm

Info

Publication number
BR0009281A
BR0009281A BR0009281-9A BR0009281A BR0009281A BR 0009281 A BR0009281 A BR 0009281A BR 0009281 A BR0009281 A BR 0009281A BR 0009281 A BR0009281 A BR 0009281A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
morpholine derivatives
preparation process
compositions containing
same
Prior art date
Application number
BR0009281-9A
Other languages
English (en)
Other versions
BR0009281B1 (pt
Inventor
Jean Philippe Ducoux
Xavier Emonds-Alt
Patrick Gueule
Vincenzo Proietto
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR0009281A publication Critical patent/BR0009281A/pt
Publication of BR0009281B1 publication Critical patent/BR0009281B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE MORFOLINA, PROCESSO DE PREPARAçãO DOS MESMOS E COMPOSIçõES FARMACêUTICAS QUE OS CONTêM". A invenção refere-se aos compostos de fórmula (I) assim como a seus sais com ácidos minerais ou orgânicos, seus solvatos e/ou seus hidratos, que apresentam uma grande afinidade e uma grande seletividade para os receptores NK~ 1~ humanos da Substância P. A invenção também refere-se ao processo de preparação dos mesmos, aos compostos intermediários de fórmulas (IV), (VI) e (VIII) úteis para a preparação dos mesmos, às composições farmacêuticas que os contêm e à utilização dos mesmos para a fabricação de medicamentos destinados a tratar qualquer patologia na qual a Substância P e/ou os receptores NK~ 1~ humanos estão implicados.
BRPI0009281-9A 1999-03-25 2000-03-21 derivados de morfolina, processo de preparação dos mesmos, composições farmacêuticas que os contêm, uso dos referidos derivados e medicamento. BR0009281B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9903854A FR2791346B3 (fr) 1999-03-25 1999-03-25 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2000/000695 WO2000058292A1 (fr) 1999-03-25 2000-03-21 Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
BR0009281A true BR0009281A (pt) 2002-01-22
BR0009281B1 BR0009281B1 (pt) 2011-05-17

Family

ID=9543720

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0009281-9A BR0009281B1 (pt) 1999-03-25 2000-03-21 derivados de morfolina, processo de preparação dos mesmos, composições farmacêuticas que os contêm, uso dos referidos derivados e medicamento.

Country Status (41)

Country Link
US (1) US6506750B1 (pt)
EP (1) EP1165528B1 (pt)
JP (1) JP3853155B2 (pt)
KR (1) KR100696340B1 (pt)
CN (1) CN100422160C (pt)
AR (1) AR023139A1 (pt)
AT (1) ATE275136T1 (pt)
AU (1) AU756855B2 (pt)
BG (1) BG64623B1 (pt)
BR (1) BR0009281B1 (pt)
CA (1) CA2366829C (pt)
CO (1) CO5160340A1 (pt)
CZ (1) CZ300911B6 (pt)
DE (1) DE60013418T2 (pt)
DK (1) DK1165528T3 (pt)
EE (1) EE04525B1 (pt)
ES (1) ES2226794T3 (pt)
FR (1) FR2791346B3 (pt)
HK (1) HK1042092B (pt)
HR (1) HRP20010704B1 (pt)
HU (1) HUP0201863A3 (pt)
ID (1) ID29871A (pt)
IL (2) IL145041A0 (pt)
IS (1) IS2338B (pt)
ME (2) ME00057B (pt)
MX (1) MXPA01009643A (pt)
NO (1) NO321576B1 (pt)
NZ (1) NZ513674A (pt)
PE (1) PE20001596A1 (pt)
PL (1) PL205318B1 (pt)
PT (1) PT1165528E (pt)
RS (1) RS50085B (pt)
RU (1) RU2222537C2 (pt)
SI (1) SI1165528T1 (pt)
SK (1) SK286977B6 (pt)
TR (1) TR200102639T2 (pt)
TW (1) TW534906B (pt)
UA (1) UA73931C2 (pt)
UY (1) UY26079A1 (pt)
WO (1) WO2000058292A1 (pt)
ZA (1) ZA200106981B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE286897T1 (de) * 2000-11-28 2005-01-15 Smithkline Beecham Plc Morpholinderivate als antagonisten an orexinrezeptoren
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
GB0228787D0 (en) * 2002-12-10 2003-01-15 Pfizer Ltd Morpholine dopamine agonists
ES2312856T3 (es) * 2002-12-13 2009-03-01 Smithkline Beecham Corporation Compuestos heterociclicos como antagonistas de ccr5.
JO2485B1 (en) * 2002-12-23 2009-01-20 شركة جانسين فارماسوتيكا ان. في 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists
JP2007515425A (ja) * 2003-12-22 2007-06-14 シェーリング　コーポレイション 医薬組成物
FR2873373B1 (fr) * 2004-07-23 2006-09-08 Sanofi Synthelabo Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
CN103142569B (zh) * 2013-02-27 2016-01-20 南京医科大学 2,6-二异丙基苯甲酸及其衍生物作为神经保护剂的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ3134U1 (cs) * 1995-01-10 1995-03-17 Pavel Ing. Janda Rotor universálního radiálního ventilátoru
US5780466A (en) * 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
RU2135494C1 (ru) * 1995-12-01 1999-08-27 Санкио Компани Лимитед Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
JP3192631B2 (ja) * 1997-05-28 2001-07-30 三共株式会社 飽和複素環化合物からなる医薬
TR200001622T2 (tr) 1997-12-04 2001-07-23 Sankyo Company Limited Asilatlı Hetero-Alisiklik Türevleri

Also Published As

Publication number Publication date
HRP20010704B1 (en) 2005-04-30
TR200102639T2 (tr) 2002-02-21
PL351317A1 (en) 2003-04-07
KR100696340B1 (ko) 2007-03-20
IL145041A (en) 2010-11-30
UA73931C2 (en) 2005-10-17
DE60013418T2 (de) 2005-09-22
SI1165528T1 (en) 2005-02-28
US6506750B1 (en) 2003-01-14
NZ513674A (en) 2003-05-30
MEP12008A (en) 2010-06-10
FR2791346B3 (fr) 2001-04-27
HK1042092B (zh) 2005-04-22
IS6063A (is) 2001-08-24
CA2366829A1 (fr) 2000-10-05
ID29871A (id) 2001-10-18
WO2000058292A1 (fr) 2000-10-05
IS2338B (is) 2008-02-15
KR20010108381A (ko) 2001-12-07
PL205318B1 (pl) 2010-04-30
ES2226794T3 (es) 2005-04-01
BG64623B1 (bg) 2005-09-30
ME00057B (me) 2010-10-10
CN100422160C (zh) 2008-10-01
NO20014632L (no) 2001-11-26
IL145041A0 (en) 2002-06-30
RU2222537C2 (ru) 2004-01-27
PE20001596A1 (es) 2001-04-01
HRP20010704A2 (en) 2002-08-31
PT1165528E (pt) 2005-01-31
BG105923A (en) 2002-05-31
JP3853155B2 (ja) 2006-12-06
CA2366829C (fr) 2007-05-15
HUP0201863A3 (en) 2003-03-28
EP1165528B1 (fr) 2004-09-01
CZ300911B6 (cs) 2009-09-09
TW534906B (en) 2003-06-01
HK1042092A1 (en) 2002-08-02
DK1165528T3 (da) 2005-01-10
AU756855B2 (en) 2003-01-23
BR0009281B1 (pt) 2011-05-17
AR023139A1 (es) 2002-09-04
CZ20013365A3 (cs) 2002-01-16
EP1165528A1 (fr) 2002-01-02
AU3301600A (en) 2000-10-16
RS50085B (sr) 2009-01-22
EE200100499A (et) 2002-12-16
SK13462001A3 (sk) 2002-05-09
NO20014632D0 (no) 2001-09-24
JP2002540195A (ja) 2002-11-26
YU68201A (sh) 2004-03-12
FR2791346A1 (fr) 2000-09-29
CN1353698A (zh) 2002-06-12
UY26079A1 (es) 2000-10-31
EE04525B1 (et) 2005-08-15
ATE275136T1 (de) 2004-09-15
HUP0201863A2 (hu) 2002-12-28
MXPA01009643A (es) 2002-05-14
NO321576B1 (no) 2006-06-06
ZA200106981B (en) 2002-10-24
SK286977B6 (sk) 2009-08-06
CO5160340A1 (es) 2002-05-30
DE60013418D1 (de) 2004-10-07

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS (FR)

Free format text: ALTERADO DE: SANOFI-SYNTHELABO

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/05/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2259 DE 22-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.