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BG104937A - Galantamine substance and method for its preparation - Google Patents

Galantamine substance and method for its preparation

Info

Publication number
BG104937A
BG104937A BG104937A BG10493700A BG104937A BG 104937 A BG104937 A BG 104937A BG 104937 A BG104937 A BG 104937A BG 10493700 A BG10493700 A BG 10493700A BG 104937 A BG104937 A BG 104937A
Authority
BG
Bulgaria
Prior art keywords
galantamine
narvedine
preparation
narvedin
hydrogen bromide
Prior art date
Application number
BG104937A
Other languages
Bulgarian (bg)
Other versions
BG64485B1 (en
Inventor
Дикран КРИКОРЯН
Стоян ПАРУШЕВ
Пепа МЕЧКАРОВА
Original Assignee
Дикран КРИКОРЯН
Стоян ПАРУШЕВ
Пепа МЕЧКАРОВА
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дикран КРИКОРЯН, Стоян ПАРУШЕВ, Пепа МЕЧКАРОВА filed Critical Дикран КРИКОРЯН
Priority to BG104937A priority Critical patent/BG64485B1/en
Publication of BG104937A publication Critical patent/BG104937A/en
Publication of BG64485B1 publication Critical patent/BG64485B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to a method for the preparation of (-)-galantamine, wherein diphenol derivatives are subjected to oxidation with phenyliodozo(III)bis(trifluoracetate) in a polar solvent at temperature ranging from 0 to -45 degrees C for 10 to 60 min. The narvedine derivative produced is protected by ethyleneglycol and the intermediate ketal is transformed into (() -narvedine having high yield by reduction with LiAlH4. Comprehensive conversion of the racemic narvedine into (()-narvedine is made by making use, as nucleus, of crystals of (-)-narvedin. The produced (-)-narvedin is reduced stereospecifically to (-)-galantamine by means of L-selectride and at subsequent treatment with hydrogen bromide thus producing the hydrogen bromide salts of the (-)-galantamine. 4 claims
BG104937A 2000-11-09 2000-11-09 Method for the preparatrion of (-)-galantamine hydrobromide BG64485B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG104937A BG64485B1 (en) 2000-11-09 2000-11-09 Method for the preparatrion of (-)-galantamine hydrobromide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG104937A BG64485B1 (en) 2000-11-09 2000-11-09 Method for the preparatrion of (-)-galantamine hydrobromide

Publications (2)

Publication Number Publication Date
BG104937A true BG104937A (en) 2002-06-28
BG64485B1 BG64485B1 (en) 2005-04-30

Family

ID=3928219

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104937A BG64485B1 (en) 2000-11-09 2000-11-09 Method for the preparatrion of (-)-galantamine hydrobromide

Country Status (1)

Country Link
BG (1) BG64485B1 (en)

Also Published As

Publication number Publication date
BG64485B1 (en) 2005-04-30

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