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BG104937A - Метод за получаване на (-) - галантамин хидробромид - Google Patents

Метод за получаване на (-) - галантамин хидробромид

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Publication number
BG104937A
BG104937A BG104937A BG10493700A BG104937A BG 104937 A BG104937 A BG 104937A BG 104937 A BG104937 A BG 104937A BG 10493700 A BG10493700 A BG 10493700A BG 104937 A BG104937 A BG 104937A
Authority
BG
Bulgaria
Prior art keywords
galantamine
narvedine
preparation
narvedin
hydrogen bromide
Prior art date
Application number
BG104937A
Other languages
English (en)
Other versions
BG64485B1 (bg
Inventor
Дикран КРИКОРЯН
Стоян ПАРУШЕВ
Пепа МЕЧКАРОВА
Original Assignee
Дикран КРИКОРЯН
Стоян ПАРУШЕВ
Пепа МЕЧКАРОВА
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дикран КРИКОРЯН, Стоян ПАРУШЕВ, Пепа МЕЧКАРОВА filed Critical Дикран КРИКОРЯН
Priority to BG104937A priority Critical patent/BG64485B1/bg
Publication of BG104937A publication Critical patent/BG104937A/bg
Publication of BG64485B1 publication Critical patent/BG64485B1/bg

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до метод за получаване на(-)-галантамин, при който дифенолни производни сеподлагат на окисление с фенилйодозо(III)бис(трифлуорацетат) в полярен разтворител при температура от 0 до -450С в продължение на 10 до 60 min. Полученото нарвединово производно се защитава с етиленгликол и полученият междинен кетал се трансформира в( )-нарведин с висок добив чрез редукция с LiAlH4. Извършва се цялостно превръщане на рацемичния нарведин в (-)-нарведин, чрез използване като зародиши на кристали от (-)-нарведин. Полученият (-)-нарведин се редуцира стереоспецифично до (-)-галантамин с помощта на L-селектрид и при последваща обработка с бромоводородна киселина се получава хидробромидната сол на (-)-галантамин.
BG104937A 2000-11-09 2000-11-09 Метод за получаване на (-) - галантамин хидробромид BG64485B1 (bg)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG104937A BG64485B1 (bg) 2000-11-09 2000-11-09 Метод за получаване на (-) - галантамин хидробромид

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG104937A BG64485B1 (bg) 2000-11-09 2000-11-09 Метод за получаване на (-) - галантамин хидробромид

Publications (2)

Publication Number Publication Date
BG104937A true BG104937A (bg) 2002-06-28
BG64485B1 BG64485B1 (bg) 2005-04-30

Family

ID=3928219

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104937A BG64485B1 (bg) 2000-11-09 2000-11-09 Метод за получаване на (-) - галантамин хидробромид

Country Status (1)

Country Link
BG (1) BG64485B1 (bg)

Also Published As

Publication number Publication date
BG64485B1 (bg) 2005-04-30

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