BG102959A - Бензоксазинонови антагонисти на допаминов d долу 4 рецептор - Google Patents
Бензоксазинонови антагонисти на допаминов d долу 4 рецепторInfo
- Publication number
- BG102959A BG102959A BG102959A BG10295998A BG102959A BG 102959 A BG102959 A BG 102959A BG 102959 A BG102959 A BG 102959A BG 10295998 A BG10295998 A BG 10295998A BG 102959 A BG102959 A BG 102959A
- Authority
- BG
- Bulgaria
- Prior art keywords
- domamine
- benzooxazinon
- antagonists
- receptor
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретението се отнася до съединения с формула Iили II, в които R1 и R2 означават поотделно водород или С1-С6 алкил, Х е N или СН и R3 е фенил, нафтил, хетероарил, заместен фенил, заместен нафтил или заместен хетероарил, като всеки заместител е избран поотделно от халоген, С1-С6 алкокси, С1-С6 алкил, -CN, -CF3 или сулфонамидо. Изобретението се отнася и до техни фармацевтично приемливи соли, естери, амиди и пролекарства.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1838396P | 1996-05-29 | 1996-05-29 | |
| US4020897P | 1997-03-06 | 1997-03-06 | |
| PCT/US1997/008524 WO1997045419A1 (en) | 1996-05-29 | 1997-05-20 | Benzoxazinone dopamine d4 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG102959A true BG102959A (bg) | 1999-08-31 |
| BG64049B1 BG64049B1 (bg) | 2003-11-28 |
Family
ID=26691052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102959A BG64049B1 (bg) | 1996-05-29 | 1998-11-26 | Бензоксазинонови антагонисти на допаминов d долу 4 рецептор |
Country Status (37)
| Country | Link |
|---|---|
| EP (1) | EP0906294B1 (bg) |
| JP (1) | JP2000511534A (bg) |
| KR (1) | KR20000016151A (bg) |
| CN (1) | CN1074764C (bg) |
| AR (1) | AR008372A1 (bg) |
| AT (1) | ATE231846T1 (bg) |
| AU (1) | AU731104B2 (bg) |
| BG (1) | BG64049B1 (bg) |
| BR (1) | BR9709630A (bg) |
| CA (1) | CA2253406A1 (bg) |
| CO (1) | CO4940505A1 (bg) |
| CZ (1) | CZ384698A3 (bg) |
| DE (1) | DE69718786T2 (bg) |
| DK (1) | DK0906294T3 (bg) |
| EA (1) | EA001486B1 (bg) |
| EE (1) | EE03686B1 (bg) |
| ES (1) | ES2191180T3 (bg) |
| GE (1) | GEP20012389B (bg) |
| HK (1) | HK1019737A1 (bg) |
| HN (1) | HN1997000075A (bg) |
| HR (1) | HRP970301B1 (bg) |
| HU (1) | HUP9903758A3 (bg) |
| ID (1) | ID17266A (bg) |
| IL (1) | IL126895A (bg) |
| NO (1) | NO312296B1 (bg) |
| NZ (1) | NZ332737A (bg) |
| PA (1) | PA8431101A1 (bg) |
| PE (1) | PE69398A1 (bg) |
| PL (1) | PL330195A1 (bg) |
| PT (1) | PT906294E (bg) |
| RO (1) | RO120845B1 (bg) |
| SI (1) | SI0906294T1 (bg) |
| SK (1) | SK282703B6 (bg) |
| SV (1) | SV1997000047A (bg) |
| TW (1) | TW542833B (bg) |
| UY (1) | UY24569A1 (bg) |
| WO (1) | WO1997045419A1 (bg) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177422B1 (en) | 1996-05-29 | 2001-01-23 | Warner-Lambert Company | Benzoxazinone dopamine D4 receptor antagonists |
| GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| US6177566B1 (en) | 1998-06-30 | 2001-01-23 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands |
| JP2002519346A (ja) * | 1998-06-30 | 2002-07-02 | ニューロゲン コーポレイション | １−（ベンゾチアゾール−２−イル）−４−（１−フェニルメチル）ピペラジン：ドーパミン受容体サブタイプ特異リガンド |
| EP1091949A2 (en) * | 1998-06-30 | 2001-04-18 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands |
| US6291463B1 (en) | 1998-06-30 | 2001-09-18 | Neurogen Corporation | 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands |
| DE19844291A1 (de) * | 1998-09-18 | 2000-03-23 | Schering Ag | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| CZ20031163A3 (cs) * | 2000-10-26 | 2004-04-14 | Smithkline Beecham P. L. C. | Deriváty benzoxazinonu, způsob jejich přípravy, jejich použití a farmaceutický prostředek, který je obsahuje |
| GB0203804D0 (en) | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
| GB0209244D0 (en) * | 2002-04-23 | 2002-06-05 | Glaxo Group Ltd | Compounds |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
| CN100455573C (zh) * | 2005-11-11 | 2009-01-28 | 华东理工大学 | 一种制备1,4-苯并噁唑嗪-3-酮化合物的微波合成方法 |
| KR200482995Y1 (ko) | 2015-08-19 | 2017-03-23 | 이현진 | 물 공급부를 구비하는 얼음 트레이 |
| AU2022261029A1 (en) * | 2021-04-23 | 2023-10-19 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| WO2023207283A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Compounds as parp1 inhibitiors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
| EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
| DE69321126D1 (de) * | 1992-08-06 | 1998-10-22 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrol-derivate als dopamin-d3-rezeptor-antagonisten |
-
1997
- 1997-05-20 JP JP09542647A patent/JP2000511534A/ja not_active Ceased
- 1997-05-20 BR BR9709630A patent/BR9709630A/pt not_active Application Discontinuation
- 1997-05-20 EA EA199800987A patent/EA001486B1/ru not_active IP Right Cessation
- 1997-05-20 SI SI9730482T patent/SI0906294T1/xx unknown
- 1997-05-20 HU HU9903758A patent/HUP9903758A3/hu unknown
- 1997-05-20 DE DE69718786T patent/DE69718786T2/de not_active Expired - Fee Related
- 1997-05-20 PT PT97925651T patent/PT906294E/pt unknown
- 1997-05-20 WO PCT/US1997/008524 patent/WO1997045419A1/en not_active Application Discontinuation
- 1997-05-20 AT AT97925651T patent/ATE231846T1/de not_active IP Right Cessation
- 1997-05-20 AU AU30727/97A patent/AU731104B2/en not_active Ceased
- 1997-05-20 EE EE9800417A patent/EE03686B1/xx not_active IP Right Cessation
- 1997-05-20 DK DK97925651T patent/DK0906294T3/da active
- 1997-05-20 IL IL12689597A patent/IL126895A/en not_active IP Right Cessation
- 1997-05-20 GE GEAP19974623A patent/GEP20012389B/en unknown
- 1997-05-20 CZ CZ983846A patent/CZ384698A3/cs unknown
- 1997-05-20 PL PL97330195A patent/PL330195A1/xx unknown
- 1997-05-20 ES ES97925651T patent/ES2191180T3/es not_active Expired - Lifetime
- 1997-05-20 RO RO98-01622A patent/RO120845B1/ro unknown
- 1997-05-20 KR KR1019980709719A patent/KR20000016151A/ko not_active Application Discontinuation
- 1997-05-20 EP EP97925651A patent/EP0906294B1/en not_active Expired - Lifetime
- 1997-05-20 SK SK1627-98A patent/SK282703B6/sk unknown
- 1997-05-20 NZ NZ332737A patent/NZ332737A/en unknown
- 1997-05-20 CA CA002253406A patent/CA2253406A1/en not_active Abandoned
- 1997-05-20 CN CN97195015A patent/CN1074764C/zh not_active Expired - Fee Related
- 1997-05-22 HN HN1997000075A patent/HN1997000075A/es unknown
- 1997-05-27 AR ARP970102249A patent/AR008372A1/es unknown
- 1997-05-28 ID IDP971778A patent/ID17266A/id unknown
- 1997-05-28 UY UY24569A patent/UY24569A1/es not_active Application Discontinuation
- 1997-05-28 CO CO97029474A patent/CO4940505A1/es unknown
- 1997-05-28 PA PA19978431101A patent/PA8431101A1/es unknown
- 1997-05-28 SV SV1997000047A patent/SV1997000047A/es not_active Application Discontinuation
- 1997-05-28 PE PE1997000432A patent/PE69398A1/es not_active Application Discontinuation
- 1997-05-28 TW TW086107221A patent/TW542833B/zh active
- 1997-05-29 HR HR970301A patent/HRP970301B1/xx not_active IP Right Cessation
-
1998
- 1998-11-26 BG BG102959A patent/BG64049B1/bg unknown
- 1998-11-27 NO NO19985531A patent/NO312296B1/no not_active IP Right Cessation
-
1999
- 1999-10-28 HK HK99104867A patent/HK1019737A1/xx not_active IP Right Cessation
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