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BE903828R - Triazolopyrimidines et leur procede de preparation. - Google Patents

Triazolopyrimidines et leur procede de preparation.

Info

Publication number
BE903828R
BE903828R BE0/215989A BE215989A BE903828R BE 903828 R BE903828 R BE 903828R BE 0/215989 A BE0/215989 A BE 0/215989A BE 215989 A BE215989 A BE 215989A BE 903828 R BE903828 R BE 903828R
Authority
BE
Belgium
Prior art keywords
alkyl
branched
linear
triazolopyrimidines
preparation process
Prior art date
Application number
BE0/215989A
Other languages
English (en)
Original Assignee
Deutsches Hydierwerk Roldieben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Hydierwerk Roldieben filed Critical Deutsches Hydierwerk Roldieben
Application granted granted Critical
Publication of BE903828R publication Critical patent/BE903828R/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

s-Triazolo-(1,5a)-pyrimidines répondant à la formule I où R2 et R3 = H, alkyle en C2-C3 ou halogène, R4 = alkyle linéaire ou ramifié en C4.C9, aralkyle éventuellement substitué, 2,5-dioxaheptyle ou 3-oxaheptyle, R5 = H, alkyle en C1-C3, hydroxyéthyle ou hydroxypropyle, R6 et R7 = H, alkyle linéaire ou ramifié en C1-C5 ou éléments d'un noyau cycloaliphatique, les substituants en position 5 et 7 pouvant etre échangés. Ces dérivés présentent des propriétés thérapeutiques intéressantes dans le domaine de l'inhibition de l'agrégation des thrombocytes, ils influencent le métabolisme du calcium, et autres, associé à une faible toxicité.
BE0/215989A 1984-04-17 1985-12-10 Triazolopyrimidines et leur procede de preparation. BE903828R (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD84262043A DD228811A1 (de) 1984-04-17 1984-04-17 Verfahren zur herstellung von neuen triazolopyrimidinen

Publications (1)

Publication Number Publication Date
BE903828R true BE903828R (fr) 1986-04-01

Family

ID=5556238

Family Applications (2)

Application Number Title Priority Date Filing Date
BE0/214861A BE902218A (fr) 1984-04-17 1985-04-17 Triazolopyrimidines, et leur procede de preparation.
BE0/215989A BE903828R (fr) 1984-04-17 1985-12-10 Triazolopyrimidines et leur procede de preparation.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE0/214861A BE902218A (fr) 1984-04-17 1985-04-17 Triazolopyrimidines, et leur procede de preparation.

Country Status (15)

Country Link
JP (1) JPS60224692A (fr)
AT (1) AT391866B (fr)
BE (2) BE902218A (fr)
CH (1) CH669196A5 (fr)
DD (1) DD228811A1 (fr)
DE (1) DE3512629C2 (fr)
ES (1) ES8706682A1 (fr)
FR (1) FR2562895B1 (fr)
GB (1) GB2157684B (fr)
LT (1) LT2594B (fr)
MD (1) MD59C2 (fr)
NL (1) NL8501111A (fr)
SE (1) SE466104B (fr)
SU (1) SU1468423A3 (fr)
YU (1) YU47167B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11987583B2 (en) 2017-03-24 2024-05-21 Piksci Inc. Fused triazolo-pyrimidine compounds having useful pharmaceutical application

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
PT757984E (pt) * 1995-08-08 2003-02-28 Ono Pharmaceutical Co Derivados de acido hidroxamico uteis para inibir a gelatinase
JP2001322933A (ja) 2000-05-15 2001-11-20 Ucb Sa Ｃｄ４０シグナル遮断剤
US8186931B2 (en) 2006-08-17 2012-05-29 Steven Borntrager Powered hand truck
MD4246C1 (ro) * 2012-03-12 2014-03-31 Иван ПРИДА Butoi pentru maturarea produselor alcoolice

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD61269A (fr) *
DE61269C (de) * 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Waschmaschine
CH569734A5 (en) * 1967-07-01 1975-11-28 Hydrierwerk Rodleben Veb 5-and 7-basically subst s-triazolo 1 5-a pyrimidines
DE1720004A1 (de) * 1968-03-08 1971-05-19 Hydrierwerk Rodleben Veb Verfahren zur Herstellung von s-Triazolo(1.5-a)pyrimidinen,die in 5- und 7-Stellung durch basische Gruppen substituiert sind

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11987583B2 (en) 2017-03-24 2024-05-21 Piksci Inc. Fused triazolo-pyrimidine compounds having useful pharmaceutical application

Also Published As

Publication number Publication date
BE902218A (fr) 1985-08-16
GB2157684B (en) 1987-11-11
SE8501835L (sv) 1985-10-18
ES542269A0 (es) 1987-07-01
JPS60224692A (ja) 1985-11-09
ATA105085A (de) 1990-06-15
SU1468423A3 (ru) 1989-03-23
NL8501111A (nl) 1985-11-18
MD59B1 (ro) 1994-08-31
AT391866B (de) 1990-12-10
CH669196A5 (de) 1989-02-28
GB8509561D0 (en) 1985-05-22
FR2562895B1 (fr) 1988-10-07
JPH0455193B2 (fr) 1992-09-02
DD228811A1 (de) 1985-10-23
LT2594B (lt) 1994-03-25
ES8706682A1 (es) 1987-07-01
GB2157684A (en) 1985-10-30
FR2562895A1 (fr) 1985-10-18
YU64185A (sh) 1992-09-07
YU47167B (sh) 1995-01-31
SE8501835D0 (sv) 1985-04-15
DE3512629C2 (de) 1995-07-06
MD59C2 (ro) 1995-01-31
SE466104B (sv) 1991-12-16
DE3512629A1 (de) 1986-10-09

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: VEB DEUTSCHES HYDIERWERK ROLDIEBEN

Effective date: 20000430