BE903828R - TRIAZOLOPYRIMIDINES AND THEIR PREPARATION PROCESS. - Google Patents
TRIAZOLOPYRIMIDINES AND THEIR PREPARATION PROCESS.Info
- Publication number
- BE903828R BE903828R BE0/215989A BE215989A BE903828R BE 903828 R BE903828 R BE 903828R BE 0/215989 A BE0/215989 A BE 0/215989A BE 215989 A BE215989 A BE 215989A BE 903828 R BE903828 R BE 903828R
- Authority
- BE
- Belgium
- Prior art keywords
- alkyl
- branched
- linear
- triazolopyrimidines
- preparation process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
s-Triazolo-(1,5a)-pyrimidines répondant à la formule I où R2 et R3 = H, alkyle en C2-C3 ou halogène, R4 = alkyle linéaire ou ramifié en C4.C9, aralkyle éventuellement substitué, 2,5-dioxaheptyle ou 3-oxaheptyle, R5 = H, alkyle en C1-C3, hydroxyéthyle ou hydroxypropyle, R6 et R7 = H, alkyle linéaire ou ramifié en C1-C5 ou éléments d'un noyau cycloaliphatique, les substituants en position 5 et 7 pouvant etre échangés. Ces dérivés présentent des propriétés thérapeutiques intéressantes dans le domaine de l'inhibition de l'agrégation des thrombocytes, ils influencent le métabolisme du calcium, et autres, associé à une faible toxicité.s-Triazolo- (1,5a) -pyrimidines corresponding to formula I where R2 and R3 = H, C2-C3 or halogenated alkyl, R4 = linear or branched C4.C9 alkyl, optionally substituted aralkyl, 2,5- dioxaheptyl or 3-oxaheptyl, R5 = H, C1-C3 alkyl, hydroxyethyl or hydroxypropyl, R6 and R7 = H, linear or branched C1-C5 alkyl or elements of a cycloaliphatic ring, the substituents in positions 5 and 7 being able to be exchanged. These derivatives have interesting therapeutic properties in the field of inhibition of thrombocyte aggregation, they influence the metabolism of calcium, and others, associated with low toxicity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD84262043A DD228811A1 (en) | 1984-04-17 | 1984-04-17 | PROCESS FOR THE PREPARATION OF NEW TRIAZOLOPYRIMIDINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE903828R true BE903828R (en) | 1986-04-01 |
Family
ID=5556238
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/214861A BE902218A (en) | 1984-04-17 | 1985-04-17 | TRIAZOLOPYRIMIDINES, AND THEIR PREPARATION PROCESS. |
| BE0/215989A BE903828R (en) | 1984-04-17 | 1985-12-10 | TRIAZOLOPYRIMIDINES AND THEIR PREPARATION PROCESS. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/214861A BE902218A (en) | 1984-04-17 | 1985-04-17 | TRIAZOLOPYRIMIDINES, AND THEIR PREPARATION PROCESS. |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS60224692A (en) |
| AT (1) | AT391866B (en) |
| BE (2) | BE902218A (en) |
| CH (1) | CH669196A5 (en) |
| DD (1) | DD228811A1 (en) |
| DE (1) | DE3512629C2 (en) |
| ES (1) | ES8706682A1 (en) |
| FR (1) | FR2562895B1 (en) |
| GB (1) | GB2157684B (en) |
| LT (1) | LT2594B (en) |
| MD (1) | MD59C2 (en) |
| NL (1) | NL8501111A (en) |
| SE (1) | SE466104B (en) |
| SU (1) | SU1468423A3 (en) |
| YU (1) | YU47167B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11987583B2 (en) | 2017-03-24 | 2024-05-21 | Piksci Inc. | Fused triazolo-pyrimidine compounds having useful pharmaceutical application |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| PT757984E (en) * | 1995-08-08 | 2003-02-28 | Ono Pharmaceutical Co | UTEIS HYDROXAMIC ACID DERIVATIVES TO INHIBIT GELATINASE |
| JP2001322933A (en) | 2000-05-15 | 2001-11-20 | Ucb Sa | Cd40 signal blocker |
| US8186931B2 (en) | 2006-08-17 | 2012-05-29 | Steven Borntrager | Powered hand truck |
| MD4246C1 (en) * | 2012-03-12 | 2014-03-31 | Иван ПРИДА | Barrel for aging alcoholic products |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD61269A (en) * | ||||
| DE61269C (en) * | 1891-04-01 | 1892-03-23 | J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 | Washing machine |
| CH569734A5 (en) * | 1967-07-01 | 1975-11-28 | Hydrierwerk Rodleben Veb | 5-and 7-basically subst s-triazolo 1 5-a pyrimidines |
| DE1720004A1 (en) * | 1968-03-08 | 1971-05-19 | Hydrierwerk Rodleben Veb | Process for the preparation of s-triazolo (1.5-a) pyrimidines which are substituted in the 5- and 7-positions by basic groups |
-
1984
- 1984-04-17 DD DD84262043A patent/DD228811A1/en not_active IP Right Cessation
- 1984-11-09 JP JP59235364A patent/JPS60224692A/en active Granted
-
1985
- 1985-04-05 AT AT0105085A patent/AT391866B/en not_active IP Right Cessation
- 1985-04-06 DE DE3512629A patent/DE3512629C2/en not_active Expired - Fee Related
- 1985-04-15 SE SE8501835A patent/SE466104B/en not_active IP Right Cessation
- 1985-04-15 GB GB08509561A patent/GB2157684B/en not_active Expired
- 1985-04-16 CH CH1624/85A patent/CH669196A5/en not_active IP Right Cessation
- 1985-04-16 NL NL8501111A patent/NL8501111A/en active Search and Examination
- 1985-04-16 YU YU64185A patent/YU47167B/en unknown
- 1985-04-16 SU SU853884102A patent/SU1468423A3/en active
- 1985-04-16 ES ES542269A patent/ES8706682A1/en not_active Expired
- 1985-04-17 FR FR8505831A patent/FR2562895B1/en not_active Expired
- 1985-04-17 BE BE0/214861A patent/BE902218A/en not_active IP Right Cessation
- 1985-12-10 BE BE0/215989A patent/BE903828R/en not_active IP Right Cessation
-
1993
- 1993-09-28 LT LTRP1203A patent/LT2594B/en not_active IP Right Cessation
-
1994
- 1994-02-15 MD MD94-0068A patent/MD59C2/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11987583B2 (en) | 2017-03-24 | 2024-05-21 | Piksci Inc. | Fused triazolo-pyrimidine compounds having useful pharmaceutical application |
Also Published As
| Publication number | Publication date |
|---|---|
| BE902218A (en) | 1985-08-16 |
| GB2157684B (en) | 1987-11-11 |
| SE8501835L (en) | 1985-10-18 |
| ES542269A0 (en) | 1987-07-01 |
| JPS60224692A (en) | 1985-11-09 |
| ATA105085A (en) | 1990-06-15 |
| SU1468423A3 (en) | 1989-03-23 |
| NL8501111A (en) | 1985-11-18 |
| MD59B1 (en) | 1994-08-31 |
| AT391866B (en) | 1990-12-10 |
| CH669196A5 (en) | 1989-02-28 |
| GB8509561D0 (en) | 1985-05-22 |
| FR2562895B1 (en) | 1988-10-07 |
| JPH0455193B2 (en) | 1992-09-02 |
| DD228811A1 (en) | 1985-10-23 |
| LT2594B (en) | 1994-03-25 |
| ES8706682A1 (en) | 1987-07-01 |
| GB2157684A (en) | 1985-10-30 |
| FR2562895A1 (en) | 1985-10-18 |
| YU64185A (en) | 1992-09-07 |
| YU47167B (en) | 1995-01-31 |
| SE8501835D0 (en) | 1985-04-15 |
| DE3512629C2 (en) | 1995-07-06 |
| MD59C2 (en) | 1995-01-31 |
| SE466104B (en) | 1991-12-16 |
| DE3512629A1 (en) | 1986-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: VEB DEUTSCHES HYDIERWERK ROLDIEBEN Effective date: 20000430 |