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BE868868A - 1-thienyl- et furyl-2,3,4,5-tetrahydro-1h-3-benzazepines substituees - Google Patents

1-thienyl- et furyl-2,3,4,5-tetrahydro-1h-3-benzazepines substituees

Info

Publication number
BE868868A
BE868868A BE189177A BE189177A BE868868A BE 868868 A BE868868 A BE 868868A BE 189177 A BE189177 A BE 189177A BE 189177 A BE189177 A BE 189177A BE 868868 A BE868868 A BE 868868A
Authority
BE
Belgium
Prior art keywords
benzazepines
furyl
tetrahydro
thienyl
substituted
Prior art date
Application number
BE189177A
Other languages
English (en)
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of BE868868A publication Critical patent/BE868868A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BE189177A 1977-02-02 1978-07-10 1-thienyl- et furyl-2,3,4,5-tetrahydro-1h-3-benzazepines substituees BE868868A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/764,672 US4111957A (en) 1977-02-02 1977-02-02 Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds

Publications (1)

Publication Number Publication Date
BE868868A true BE868868A (fr) 1979-01-10

Family

ID=25071413

Family Applications (1)

Application Number Title Priority Date Filing Date
BE189177A BE868868A (fr) 1977-02-02 1978-07-10 1-thienyl- et furyl-2,3,4,5-tetrahydro-1h-3-benzazepines substituees

Country Status (6)

Country Link
US (1) US4111957A (fr)
JP (2) JPS5395989A (fr)
BE (1) BE868868A (fr)
DE (1) DE2804285A1 (fr)
FR (2) FR2379534A1 (fr)
GB (1) GB1599705A (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352754A (en) * 1976-11-17 1982-10-05 Smithkline Corporation 3-Thienylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
ZA792785B (en) * 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
US4282146A (en) * 1978-11-20 1981-08-04 Pennwalt Corporation Preparation of 1,2,4,5-tetrahydro-7-alkoxy-(and 7,8-dialkoxy)-3H,3-benzazepines and 3-substituted derivatives thereof from the corresponding phenethylamines
US4255445A (en) * 1980-03-07 1981-03-10 Smithkline Corporation 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
US4769368A (en) * 1986-02-10 1988-09-06 Smithkline Beckman Corporation 2,3,4,8,9,9A-Hexahydro-4-aryl-1H-indeno(1,7-CD)azepines
DK67489D0 (da) * 1989-02-14 1989-02-14 Novo Industri As Nye benzazepinderivater
JPH03153111A (ja) * 1989-11-09 1991-07-01 Murata Mfg Co Ltd 弾性表面波発振器
GB9903671D0 (en) * 1999-02-17 1999-04-14 Cenes Ltd Dopamine D-1 receptor agonist compounds
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
WO2005003096A1 (fr) * 2003-06-17 2005-01-13 Arena Pharmaceuticals, Inc. Derives de benzazepine et methodes de prophylaxie ou de traitement de maladies associees au recepteur 5ht2c
EP2332919A3 (fr) 2003-06-17 2011-10-19 Arena Pharmaceuticals, Inc. Procédés de préparation de 3-benzazepines
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
ES2332009T3 (es) 2004-12-21 2010-01-22 Arena Pharmaceuticals, Inc. Formas cristalinas de hidrocloruro de (r)-8-cloro-1-metil-2,3,4,5-tetrahidro-1h-3-benzazepina.
EA015012B1 (ru) * 2004-12-23 2011-04-29 Арена Фармасьютикалз, Инк. Композиция, содержащая фентермин и избирательный агонист рецептора 5ht, и ее применение
EP2471779A1 (fr) 2006-04-03 2012-07-04 Arena Pharmaceuticals, Inc. Procédé de résolution d'un mélange de (R)- et (S)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1H-3-benzazépine
SG177128A1 (en) * 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
JP4933325B2 (ja) * 2007-03-29 2012-05-16 原田工業株式会社 接続端子構造
US8822727B2 (en) * 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
EA201390335A1 (ru) 2010-09-01 2013-09-30 Арена Фармасьютикалз, Инк. Введение лоркасерина индивидуумам с почечной недостаточностью
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
AU2011296003B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-HT2C agonist useful for weight management
AU2011296014A1 (en) 2010-09-01 2013-04-04 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
JP2015534563A (ja) 2012-10-09 2015-12-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 体重管理の方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines
US3663532A (en) * 1970-03-04 1972-05-16 American Home Prod Benzodiazocines

Also Published As

Publication number Publication date
JPS6341912B2 (fr) 1988-08-19
FR2379534A1 (fr) 1978-09-01
JPS5395989A (en) 1978-08-22
DE2804285C2 (fr) 1988-01-07
GB1599705A (en) 1981-10-07
DE2804285A1 (de) 1978-08-03
US4111957A (en) 1978-09-05
FR2379534B1 (fr) 1981-11-27
FR2383929A1 (fr) 1978-10-13
FR2383929B1 (fr) 1981-07-31
JPS62161764A (ja) 1987-07-17

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SMITHKLINE CORP.

Effective date: 19890731