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BE781879A - Nouveaux 1,4-dihydropyridines dissymetriques leur procede de preparation et leur application comme medicaments - Google Patents

Nouveaux 1,4-dihydropyridines dissymetriques leur procede de preparation et leur application comme medicaments

Info

Publication number
BE781879A
BE781879A BE781879A BE781879A BE781879A BE 781879 A BE781879 A BE 781879A BE 781879 A BE781879 A BE 781879A BE 781879 A BE781879 A BE 781879A BE 781879 A BE781879 A BE 781879A
Authority
BE
Belgium
Prior art keywords
dissymetrics
dihydropyridines
new
application
preparation process
Prior art date
Application number
BE781879A
Other languages
English (en)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BE781879A publication Critical patent/BE781879A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
BE781879A 1971-04-10 1972-04-10 Nouveaux 1,4-dihydropyridines dissymetriques leur procede de preparation et leur application comme medicaments BE781879A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2117572A DE2117572C3 (de) 1971-04-10 1971-04-10 Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
BE781879A true BE781879A (fr) 1972-10-10

Family

ID=5804434

Family Applications (1)

Application Number Title Priority Date Filing Date
BE781879A BE781879A (fr) 1971-04-10 1972-04-10 Nouveaux 1,4-dihydropyridines dissymetriques leur procede de preparation et leur application comme medicaments

Country Status (27)

Country Link
US (1) US3799936A (fr)
JP (1) JPS5527054B1 (fr)
AT (1) AT316552B (fr)
AU (1) AU459338B2 (fr)
BE (1) BE781879A (fr)
BG (4) BG20106A3 (fr)
CA (1) CA925513A (fr)
CH (2) CH571493A5 (fr)
CS (2) CS177846B2 (fr)
DD (1) DD104519A5 (fr)
DE (1) DE2117572C3 (fr)
DK (1) DK132321C (fr)
ES (1) ES401615A1 (fr)
FI (1) FI55187C (fr)
FR (1) FR2132831B1 (fr)
GB (1) GB1331405A (fr)
HU (1) HU165875B (fr)
IE (1) IE36947B1 (fr)
IL (1) IL39170A (fr)
LU (1) LU65129A1 (fr)
NL (1) NL170140C (fr)
NO (1) NO133711C (fr)
PL (2) PL84571B1 (fr)
RO (2) RO63113A (fr)
SE (1) SE371824B (fr)
SU (2) SU431671A3 (fr)
ZA (1) ZA722355B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210674C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
US3988458A (en) * 1972-03-06 1976-10-26 Bayer Aktiengesellschaft Bicyclic derivatives of 1,4-dihydropyridine 3,5-carboxylic acid esters
US3857849A (en) * 1973-02-28 1974-12-31 Bayer Ag 2-amino-1,4-dihydropyridine derivatives
US3935223A (en) * 1972-03-06 1976-01-27 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
US3917620A (en) * 1972-03-06 1975-11-04 Bayer Ag 2-Amino-4,5-dihydropyridine derivatives
US3887558A (en) * 1972-03-06 1975-06-03 Bayer Ag Process for producing 2,6-diamino -1,4- dihydro-3,5-pyridine-dicarboxylates and derivatives thereof
US3917622A (en) * 1972-03-06 1975-11-04 Bayer Ag 2-Amino-1,4-dihydropyridine derivatives
US4001258A (en) * 1972-03-06 1977-01-04 Bayer Aktiengesellschaft 2-amino-1,4-dihydropyridine derivatives
US3939171A (en) * 1972-03-06 1976-02-17 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
DE2210672C3 (de) * 1972-03-06 1980-03-20 Bayer Ag, 5090 Leverkusen N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DD106832A5 (fr) * 1972-03-06 1974-07-05
US3920823A (en) * 1972-03-06 1975-11-18 Bayer Ag Use of unsymmetrical esters of n-substituted 1,4-dihydropyridine 3,5-dicarboxylic acid as cardio-vascular agents
US3917619A (en) * 1972-03-06 1975-11-04 Bayer Ag 2-Amino-4,5-dihydropyridine derivatives
DE2242786A1 (de) * 1972-08-31 1974-03-14 Bayer Ag Verfahren zur herstellung von neuen 2-amino-1,4-dihydropyridinen mit einer carbonylfunktion sowie ihre verwendung als arzneimittel
US3989708A (en) * 1972-08-31 1976-11-02 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
DK152285C (da) * 1975-07-02 1988-10-10 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater
FR2405937A1 (fr) * 1977-10-14 1979-05-11 Labaz Nouveaux derives de dihydropyridine, leur procede de preparation et leur application
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
SE7910521L (sv) * 1979-12-20 1981-06-21 Haessle Ab Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPS6143165A (ja) * 1984-08-07 1986-03-01 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体の製造法
US5571827A (en) * 1990-03-13 1996-11-05 Sepracor Inc. Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
AU3128693A (en) * 1991-11-18 1993-06-15 G.D. Searle & Co. 2-(4-substituted)phenylmethylene derivatives and methods of use
ES2193148T3 (es) * 1993-12-10 2003-11-01 Bayer Ag 1,4-dihidropiridinas sustituidas con fenilo con actividad cerebral.
EE03192B1 (et) * 1993-12-10 1999-06-15 Bayer Aktiengesellschaft Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine
DE19727350C1 (de) * 1997-06-27 1999-01-21 Bayer Ag Verfahren zur Herstellung von Nifedipin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern

Also Published As

Publication number Publication date
CH571491A5 (fr) 1976-01-15
CS177821B2 (fr) 1977-08-31
BG19374A3 (bg) 1975-06-15
NL170140B (nl) 1982-05-03
NL7204694A (fr) 1972-10-12
AT316552B (de) 1974-07-25
DE2117572A1 (de) 1972-10-19
DD104519A5 (fr) 1974-03-12
SE371824B (fr) 1974-12-02
IE36947B1 (en) 1977-03-30
CS177846B2 (fr) 1977-08-31
US3799936A (en) 1974-03-26
BG19595A3 (fr) 1975-06-25
DK132321C (da) 1976-04-26
FI55187C (fi) 1979-06-11
NO133711B (fr) 1976-03-08
DE2117572C3 (de) 1980-03-20
CA925513A (en) 1973-05-01
IE36947L (en) 1972-10-10
RO63113A (fr) 1978-06-15
FR2132831B1 (fr) 1975-12-26
PL84571B1 (fr) 1976-04-30
GB1331405A (en) 1973-09-26
HU165875B (fr) 1974-12-28
AU4045472A (en) 1973-10-04
FI55187B (fi) 1979-02-28
DE2117572B2 (fr) 1979-06-28
BG20106A3 (bg) 1975-10-30
CH571493A5 (fr) 1976-01-15
NO133711C (fr) 1976-06-16
RO59959A (fr) 1976-06-15
FR2132831A1 (fr) 1972-11-24
ES401615A1 (es) 1975-11-01
SU475771A3 (ru) 1975-06-30
DK132321B (da) 1975-11-24
SU431671A3 (fr) 1974-06-05
NL170140C (nl) 1982-10-01
IL39170A0 (en) 1972-06-28
LU65129A1 (fr) 1972-07-12
BG20353A3 (bg) 1975-11-05
PL92407B1 (fr) 1977-04-30
ZA722355B (en) 1972-12-27
IL39170A (en) 1975-04-25
AU459338B2 (en) 1975-03-05
JPS5527054B1 (fr) 1980-07-17

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: FARBENFABRIKEN BAYER A.G.

Effective date: 19920410