BE640160A - - Google Patents

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Publication number: BE640160A
Authority: BE; Belgium
Prior art keywords: indicated; desc; page number; clms page; residue
Prior art date

Application number

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English (en)

French (fr)

Publication of BE640160A publication Critical patent/BE640160A/fr

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150000001875 compounds Chemical class 0.000 claims description 21
150000003839 salts Chemical class 0.000 claims description 11
239000011780 sodium chloride Substances 0.000 claims description 11
-1 alkyl groups Ion Chemical class 0.000 claims description 10
238000000034 method Methods 0.000 claims description 10
238000002360 preparation method Methods 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 6
238000006243 chemical reaction Methods 0.000 claims description 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
239000000463 material Substances 0.000 claims description 3
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 2
229940091292 Alo Drugs 0.000 claims description 2
230000001034 aminogenic Effects 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
239000003814 drug Substances 0.000 claims description 2
125000005059 halophenyl group Chemical group 0.000 claims description 2
229910052760 oxygen Inorganic materials 0.000 claims description 2
239000001301 oxygen Substances 0.000 claims description 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 2
229940093912 Gynecological Sulfonamides Drugs 0.000 claims 2
125000004432 carbon atoms Chemical group C* 0.000 claims 2
229940079867 intestinal antiinfectives Sulfonamides Drugs 0.000 claims 2
229940005938 ophthalmologic antiinfectives Sulfonamides Drugs 0.000 claims 2
150000003456 sulfonamides Chemical class 0.000 claims 2
229940026752 topical Sulfonamides Drugs 0.000 claims 2
101710032514 ACTI Proteins 0.000 claims 1
101710007561 ALDH3A1 Proteins 0.000 claims 1
241000270299 Boa Species 0.000 claims 1
235000017399 Caesalpinia tinctoria Nutrition 0.000 claims 1
101710004932 ECU01_0460 Proteins 0.000 claims 1
241000272168 Laridae Species 0.000 claims 1
241000143392 Oar Species 0.000 claims 1
ZGUGWUXLJSTTMA-UHFFFAOYSA-N Promazinum Chemical compound C1=CC=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZGUGWUXLJSTTMA-UHFFFAOYSA-N 0.000 claims 1
240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
241000388430 Tara Species 0.000 claims 1
240000006365 Vitis vinifera Species 0.000 claims 1
235000014787 Vitis vinifera Nutrition 0.000 claims 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
235000009754 grape Nutrition 0.000 claims 1
235000012333 grape Nutrition 0.000 claims 1
229910052736 halogen Inorganic materials 0.000 claims 1
125000001475 halogen functional group Chemical group 0.000 claims 1
150000002367 halogens Chemical class 0.000 claims 1
229910052739 hydrogen Inorganic materials 0.000 claims 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
239000001257 hydrogen Substances 0.000 claims 1
125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 23
UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 22
239000000243 solution Substances 0.000 description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
239000000155 melt Substances 0.000 description 13
239000000047 product Substances 0.000 description 11
HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
239000003921 oil Substances 0.000 description 9
239000011541 reaction mixture Substances 0.000 description 8
238000003756 stirring Methods 0.000 description 8
238000001816 cooling Methods 0.000 description 7
XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
238000004587 chromatography analysis Methods 0.000 description 6
238000002844 melting Methods 0.000 description 6
239000000203 mixture Substances 0.000 description 6
239000002244 precipitate Substances 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
229920002472 Starch Polymers 0.000 description 5
239000002253 acid Substances 0.000 description 5
239000007795 chemical reaction product Substances 0.000 description 5
238000001914 filtration Methods 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
238000010992 reflux Methods 0.000 description 4
YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical compound OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 4
WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 4
FDDDEECHVMSUSB-UHFFFAOYSA-N Sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
125000000217 alkyl group Chemical group 0.000 description 3
WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
230000000875 corresponding Effects 0.000 description 3
239000000706 filtrate Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
239000007858 starting material Substances 0.000 description 3
229960001663 sulfanilamide Drugs 0.000 description 3
239000000725 suspension Substances 0.000 description 3
YJISHJVIRFPGGN-UHFFFAOYSA-N 5-[5-[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxy-6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 YJISHJVIRFPGGN-UHFFFAOYSA-N 0.000 description 2
241000283014 Dama Species 0.000 description 2
SRTHRWZAMDZJOS-UHFFFAOYSA-N Lithium hydride Chemical compound [H-].[Li+] SRTHRWZAMDZJOS-UHFFFAOYSA-N 0.000 description 2
229940100445 WHEAT STARCH Drugs 0.000 description 2
239000002585 base Substances 0.000 description 2
239000001273 butane Substances 0.000 description 2
ZAFNJMIOTHYJRJ-UHFFFAOYSA-N diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
238000010790 dilution Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
239000008079 hexane Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
230000002829 reduced Effects 0.000 description 2
YXFVVABEGXRONW-UHFFFAOYSA-N toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-Aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 1
BHHGXPLMPWCGHP-UHFFFAOYSA-N 2-Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 description 1
PLWALTDUYKDGRF-UHFFFAOYSA-N 2-phenylbutan-1-amine Chemical compound CCC(CN)C1=CC=CC=C1 PLWALTDUYKDGRF-UHFFFAOYSA-N 0.000 description 1
125000003890 2-phenylbutyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 1
LYUQWQRTDLVQGA-UHFFFAOYSA-N 3-phenylpropan-1-amine Chemical compound NCCCC1=CC=CC=C1 LYUQWQRTDLVQGA-UHFFFAOYSA-N 0.000 description 1
BDZUAWTZJXBMLX-UHFFFAOYSA-N 4-Chlorophenylisobutylamine Chemical compound CCC(N)CC1=CC=C(Cl)C=C1 BDZUAWTZJXBMLX-UHFFFAOYSA-N 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
210000003169 Central Nervous System Anatomy 0.000 description 1
206010011416 Croup infectious Diseases 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
241001331845 Equus asinus x caballus Species 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
JJWLVOIRVHMVIS-UHFFFAOYSA-N Isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 description 1
241000218652 Larix Species 0.000 description 1
235000005590 Larix decidua Nutrition 0.000 description 1
101710035524 MYOT Proteins 0.000 description 1
210000004080 Milk Anatomy 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N Phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
BZKICOFSQOWHPW-UHFFFAOYSA-N ST023535 Chemical compound C=1C(=C2OCCBr)CC(C=3OCCBr)=CC(C4(C)CCCCC4)=CC=3CC(C=3OCCBr)=CC(C4(C)CCCCC4)=CC=3CC(C=3OCCBr)=CC(C4(C)CCCCC4)=CC=3CC2=CC=1C1(C)CCCCC1 BZKICOFSQOWHPW-UHFFFAOYSA-N 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N Silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
210000000952 Spleen Anatomy 0.000 description 1
229940090121 Sulfonylureas for blood glucose lowering Drugs 0.000 description 1
241000009298 Trigla lyra Species 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
230000000240 adjuvant Effects 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N al2o3 Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
239000011260 aqueous acid Substances 0.000 description 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
125000001246 bromo group Chemical group Br* 0.000 description 1
UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
125000001589 carboacyl group Chemical group 0.000 description 1
239000000969 carrier Substances 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
239000002361 compost Substances 0.000 description 1
201000010549 croup Diseases 0.000 description 1
XDTMQSROBMDMFD-UHFFFAOYSA-N cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
OTMSDBZUPAUEDD-UHFFFAOYSA-N ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
235000013305 food Nutrition 0.000 description 1
150000003948 formamides Chemical class 0.000 description 1
238000005755 formation reaction Methods 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxyl anion Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000000670 limiting Effects 0.000 description 1
HPQVWDOOUQVBTO-UHFFFAOYSA-N lithium aluminium hydride Substances [Li+].[Al-] HPQVWDOOUQVBTO-UHFFFAOYSA-N 0.000 description 1
OCZDCIYGECBNKL-UHFFFAOYSA-N lithium;alumanuide Chemical compound [Li+].[AlH4-] OCZDCIYGECBNKL-UHFFFAOYSA-N 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
238000002156 mixing Methods 0.000 description 1
JXYZHMPRERWTPM-UHFFFAOYSA-M morpholine;chloride Chemical compound [Cl-].C1COCCN1 JXYZHMPRERWTPM-UHFFFAOYSA-M 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
230000003533 narcotic Effects 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
230000003287 optical Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000003204 osmotic Effects 0.000 description 1
125000005440 p-toluyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C(*)=O)C([H])([H])[H] 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
235000015108 pies Nutrition 0.000 description 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
235000009991 pite Nutrition 0.000 description 1
244000293655 pite Species 0.000 description 1
239000004033 plastic Substances 0.000 description 1
230000002335 preservative Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000001294 propane Substances 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000001624 sedative Effects 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical compound OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000003760 tallow Substances 0.000 description 1
230000001131 transforming Effects 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BE640160D BE640160A (pt)

Publications (1)

Publication Number	Publication Date
BE640160A true BE640160A (pt)

Family

ID=204194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE640160D BE640160A (pt)

Country Status (1)

Country	Link
BE (1)	BE640160A (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0860428A2 (en) *	1997-02-04	1998-08-26	Eli Lilly And Company	Sulphonamide derivatives
WO2007143822A1 (en) *	2006-06-14	2007-12-21	Methylgene Inc.	Sulfamide and sulfamate derivatives as histone deacetylase inhibitors

0
- BE BE640160D patent/BE640160A/fr unknown

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0860428A2 (en) *	1997-02-04	1998-08-26	Eli Lilly And Company	Sulphonamide derivatives
EP0860428A3 (en) *	1997-02-04	2000-07-19	Eli Lilly And Company	Sulphonamide derivatives
US6303816B1 (en)	1997-02-04	2001-10-16	Eli Lilly And Company	Sulphonamide derivatives
US6596716B2 (en)	1997-02-04	2003-07-22	Eli Lilly And Company	2-propane-sulphonamide derivatives
US7135487B2 (en)	1997-02-04	2006-11-14	Eli Lilly And Company	Sulphonamide derivatives
WO2007143822A1 (en) *	2006-06-14	2007-12-21	Methylgene Inc.	Sulfamide and sulfamate derivatives as histone deacetylase inhibitors

Publication	Publication Date	Title
JP2009528375A (ja)	2009-08-06	代謝障害を処置するための化合物
LU79761A1 (fr)	1980-01-22	Procede de preparation de nouveaux composes de phtalazine et de composition pharmaceutique les contenant
CH643546A5 (fr)	1984-06-15	Procede pour la preparation de derives d'hydantoine.
FR2554814A1 (fr)	1985-05-17	Oxazolidines, procede pour leur preparation et leurs utilisations therapeutiques, notamment dans le traitement de l'obesite et du diabete
EP0025727B1 (fr)	1984-03-28	Dérivés de l'indole, procédé pour leur préparation et médicaments les contenant
FR2479815A1 (fr)	1981-10-09	Derives du cyclohexene
BE1004995A3 (fr)	1993-03-16	Nouveau derive de 5h-benzodiazepine, compositions pharmaceutiques le contenant et procede pour les preparer.
EP0524846A1 (fr)	1993-01-27	Dérivés de 2-(pipéridin-1-y1) éthanol, leur préparation et leur application en thérapeutique
BE640160A (pt)
CA1053679A (fr)	1979-05-01	N-(trifluoromethyl-3-phenyl)-1-propyl-2 glycinate de aminoalkyle
CA2091127A1 (fr)	1993-09-07	Derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BE868004A (fr)	1978-12-11	Derives de carbostyryle, leur procede de preparation et leurs applications en therapeutique
BE660217A (pt)	1965-08-25
BE499947A (pt)
EP0518769B1 (fr)	1994-12-07	Nouveaux dérivés de benzoate d'éthanolamine, leur procédé de préparation et les compositions pharmaceutiques les renfermant
BE503348A (pt)
EP0662081B1 (fr)	1997-03-12	Derives d'ureido-acetamide, leur preparation et les medicaments les contenant
CA2393995C (fr)	2008-06-10	Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BE634833A (pt)
EP0824512B1 (de)	2000-12-20	Synthese von optisch aktivem aminoindanol
FR2738567A1 (fr)	1997-03-14	Derives de alpha-phenylpiperidine-1-propanol, leur preparation et leur application en therapeutique
FR2491471A1 (fr)	1982-04-09	Benzoxazolinones substituees, leur preparation et leur application en therapeutique
LU84680A1 (fr)	1983-11-17	Nouveaux derives de 3-azetidinylethyl-1-phenyl-2-imidazolidinones et leur utilisation comme neuroleptiques
BE682082A (pt)	1966-12-05
EP0088849A1 (fr)	1983-09-21	Isomères lévogyres de composés benzènesulfonamides N-substitués, leur procédé de préparation et compositions pharmaceutiques les contenant

BE640160A - - Google Patents

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