[go: up one dir, main page]

BE2012C050I2 - - Google Patents

Download PDF

Info

Publication number
BE2012C050I2
BE2012C050I2 BE2012C050C BE2012C050C BE2012C050I2 BE 2012C050 I2 BE2012C050 I2 BE 2012C050I2 BE 2012C050 C BE2012C050 C BE 2012C050C BE 2012C050 C BE2012C050 C BE 2012C050C BE 2012C050 I2 BE2012C050 I2 BE 2012C050I2
Authority
BE
Belgium
Application number
BE2012C050C
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23001755&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2012C050(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Publication of BE2012C050I2 publication Critical patent/BE2012C050I2/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/116Polyvalent bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
BE2012C050C 2001-01-23 2012-11-29 BE2012C050I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26343501P 2001-01-23 2001-01-23
PCT/US2002/001963 WO2002058737A2 (fr) 2001-01-23 2002-01-22 Vaccin meningococcique polyvalent prrepare avec un conjugue de polysaccharide et de proteine

Publications (1)

Publication Number Publication Date
BE2012C050I2 true BE2012C050I2 (fr) 2021-03-23

Family

ID=23001755

Family Applications (3)

Application Number Title Priority Date Filing Date
BE2012C050C BE2012C050I2 (fr) 2001-01-23 2012-11-29
BE2015C077C BE2015C077I2 (fr) 2001-01-23 2015-12-15
BE2022C502C BE2022C502I2 (fr) 2001-01-23 2022-01-06

Family Applications After (2)

Application Number Title Priority Date Filing Date
BE2015C077C BE2015C077I2 (fr) 2001-01-23 2015-12-15
BE2022C502C BE2022C502I2 (fr) 2001-01-23 2022-01-06

Country Status (38)

Country Link
US (9) US8722062B2 (fr)
EP (3) EP2332581B1 (fr)
JP (6) JP2005504718A (fr)
KR (2) KR100947757B1 (fr)
CN (1) CN100556459C (fr)
AP (1) AP1897A (fr)
AU (2) AU2007216743A1 (fr)
BE (3) BE2012C050I2 (fr)
BR (1) BRPI0206672B8 (fr)
CA (1) CA2435681C (fr)
CR (1) CR7035A (fr)
CY (2) CY1113072T1 (fr)
DK (2) DK2332581T3 (fr)
EA (1) EA006947B1 (fr)
EC (1) ECSP034701A (fr)
ES (3) ES2892316T3 (fr)
FR (3) FR12C0072I2 (fr)
GE (1) GEP20053691B (fr)
HR (1) HRP20030598B1 (fr)
HU (2) HU230490B1 (fr)
IL (3) IL157060A0 (fr)
IS (1) IS6881A (fr)
LT (1) LT5177B (fr)
LU (1) LU92108I2 (fr)
LV (1) LV13128B (fr)
MX (2) MXPA03006561A (fr)
NO (1) NO20033816L (fr)
NZ (2) NZ602682A (fr)
OA (1) OA12590A (fr)
PL (1) PL226184B1 (fr)
PT (2) PT1355673E (fr)
RO (1) RO122761B1 (fr)
SI (1) SI21352A (fr)
TN (1) TNSN03041A1 (fr)
UA (1) UA92579C2 (fr)
WO (1) WO2002058737A2 (fr)
YU (1) YU66103A (fr)
ZA (1) ZA200306176B (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
BRPI0206672B8 (pt) 2001-01-23 2021-05-25 Aventis Pasteur composição imunológica, vacina conjugada tetravalente e vacina meningocócica multivalente
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
AU2014218428B2 (en) * 2001-06-20 2016-08-25 Glaxosmithkline Biologicals Sa Capsular polysaccharide solubilisation and combination vaccines
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
GB0302218D0 (en) 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
DE60328481D1 (de) * 2002-05-14 2009-09-03 Novartis Vaccines & Diagnostic Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält
WO2004033623A2 (fr) * 2002-05-16 2004-04-22 Aventis Pasteur, Inc. Fermentation de polysaccharides meningococciques exempte de constituant animal et developpement de banque de semences
AU2003257003A1 (en) * 2002-07-30 2004-02-16 Baxter Healthcare S.A. Chimeric multivalent polysaccharide conjugate vaccines
CA2506090A1 (fr) * 2002-11-14 2004-05-27 Carmen Rosa Soto Rodriguez Procede d'obtention de vaccins conjugues et de compositions vaccinales qui les contiennent.
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
WO2004067030A2 (fr) * 2003-01-30 2004-08-12 Chiron Srl Vaccins injectables contre les multiples serogroupes du meningocoque
US9296795B2 (en) * 2003-03-07 2016-03-29 Wyeth Holdings, Llc. Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
US20050002948A1 (en) * 2003-05-07 2005-01-06 Ryall Robert P. Method of enhanced immunogenicity to meningococcal vaccination
EP1631264B8 (fr) * 2003-06-02 2017-05-24 GlaxoSmithKline Biologicals SA Compositions immunogenes basees sur des microparticules biodegradables comprenant des anatoxines diphtheriques et tetaniques
WO2005000347A1 (fr) * 2003-06-23 2005-01-06 Baxter International Inc. Vaccins contre neisseria meningitidis du groupe y et combinaisons meningococciques desdits vaccins
JP2007516181A (ja) * 2003-06-23 2007-06-21 アヴェンティス パストゥール インコーポレイテッド 髄膜炎菌血清群aおよびcに対する免疫方法
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
CA2885040C (fr) * 2003-10-02 2018-10-30 Novartis Vaccines And Diagnostics S.R.L. Vaccins liquides contre de multiples serogroupes meningococciques
GB0406013D0 (en) * 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
AU2011204789B2 (en) * 2004-04-22 2013-07-11 Glaxosmithkline Biologicals S.A. Immunising against meningococcal serogroup Y using proteins
GB0408978D0 (en) 2004-04-22 2004-05-26 Chiron Srl Meningococcal fermentation for preparing conjugate vaccines
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
SI1740217T1 (sl) 2004-04-30 2011-10-28 Novartis Ag Konjugirano meningokokno cepljenje
GB0409745D0 (en) 2004-04-30 2004-06-09 Chiron Srl Compositions including unconjugated carrier proteins
GB0413868D0 (en) * 2004-06-21 2004-07-21 Chiron Srl Dimensional anlaysis of saccharide conjugates
CN101934077A (zh) * 2004-08-30 2011-01-05 圣诺菲·帕斯图尔公司 多价的脑膜炎球菌产生的多糖-蛋白质偶联物和疫苗
GB0419846D0 (en) * 2004-09-07 2004-10-13 Chiron Srl Vaccine adjuvants for saccharides
EP1791562A4 (fr) * 2004-09-21 2008-07-09 Sanofi Pasteur Inc Conjugues polysaccharide/proteine menogococciques multivalents derivatises et vaccin
GB0428394D0 (en) * 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
GB0505518D0 (en) 2005-03-17 2005-04-27 Chiron Srl Combination vaccines with whole cell pertussis antigen
SG175456A1 (en) 2005-04-18 2011-11-28 Novartis Vaccines & Diagnostic Expressing hepatitis b virus surface antigen for vaccine preparation
MX2007016237A (es) 2005-06-27 2008-03-07 Glaxosmithkline Biolog Sa Composicion inmunogenica.
EP2308505A3 (fr) 2005-09-01 2011-11-30 Novartis Vaccines and Diagnostics GmbH Vaccins multiples comprenant le sérogroupe C de Neisseria meningitidis
US20070065462A1 (en) * 2005-09-21 2007-03-22 Ryall Robert P Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine
BRPI0708849B1 (pt) * 2006-03-17 2022-05-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Métodos para a preparação de conjugados imunogênicos multivalentes complexos, os referidos conjugados, e composições farmacêuticas
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
PT2004225E (pt) * 2006-03-22 2012-05-30 Novartis Ag Regimes para imunização com conjugados meningocócicos
GB0605757D0 (en) 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
US8414899B2 (en) 2006-04-11 2013-04-09 Yeda Research And Development Co. Ltd. Vaccines comprising multimeric HSP60 peptide carriers
US20100203137A1 (en) 2007-06-04 2010-08-12 Mario Contorni Formulation of meningitis vaccines
CA2702871A1 (fr) 2007-10-19 2009-04-23 Novartis Ag Formulations de vaccin meningococcique
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
GB0822633D0 (en) 2008-12-11 2009-01-21 Novartis Ag Formulation
US20100189737A1 (en) 2008-12-17 2010-07-29 Arico Beatrice Meningococcal vaccines including hemoglobin receptor
US8003112B2 (en) * 2009-04-16 2011-08-23 Howard University Meningococcal and pneumococcal conjugate vaccine and method of using same
EP2519265B1 (fr) 2009-12-30 2018-11-14 GlaxoSmithKline Biologicals SA Immunogènes de polysaccharide conjugués à des protéines porteuses de e. coli
EP2547357A1 (fr) 2010-03-18 2013-01-23 Novartis AG Vaccins adjuvantés contre le méningocoque de sérogroupe b
WO2012025873A2 (fr) 2010-08-23 2012-03-01 Wyeth Llc Formulations stables des antigènes rlp2086 de neisseria meningitidis
WO2012031271A1 (fr) 2010-09-04 2012-03-08 Novartis Ag Dosages d'anticorps bactéricides pour évaluer l'immunogénicité et la puissance de vaccins contre le méningocoque constitués de saccharides capsulaires
EP2613806B2 (fr) 2010-09-10 2022-10-26 Wyeth LLC Dérivés non-lipidés des antigènes orf2086 de neisseria meningitidis
CA2860331A1 (fr) 2010-12-24 2012-06-28 Novartis Ag Composes
JP6191082B2 (ja) 2011-03-02 2017-09-06 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム より低用量の抗原および/またはアジュバントを有する混合ワクチン
EP2729178A1 (fr) 2011-07-08 2014-05-14 Novartis AG Procédé de ligature de la tyrosine
AU2012335208B2 (en) 2011-11-07 2017-08-31 Glaxosmithkline Biologicals S.A. Carrier molecule comprising a spr0096 and a spr2021 antigen
CN104159603A (zh) 2012-03-08 2014-11-19 诺华股份有限公司 带有tlr4激动剂的联合疫苗
US10598666B2 (en) 2012-03-08 2020-03-24 Glaxosmithkline Biologicals Sa In vitro potency assay for protein-based meningococcal vaccines
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
US8986710B2 (en) 2012-03-09 2015-03-24 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN102660602B (zh) * 2012-04-17 2015-03-25 江苏康泰生物医学技术有限公司 快速纯化细菌荚膜多糖的方法
SG11201407440WA (en) 2012-05-22 2014-12-30 Novartis Ag Meningococcus serogroup x conjugate
HUE049531T2 (hu) * 2012-08-16 2020-10-28 Pfizer Glikokonjugációs eljárások és kompozíciók
WO2014037472A1 (fr) 2012-09-06 2014-03-13 Novartis Ag Vaccins combinatoires avec méningococcus de sérogroupe b et d/t/p
CN102861326A (zh) * 2012-09-19 2013-01-09 天津康希诺生物技术有限公司 流脑多糖-蛋白质缀合疫苗及制备方法
US20150320852A1 (en) 2012-12-18 2015-11-12 Glaxosmithkline Biologicals Sa Conjugates for protecting against diphtheria and/or tetanus
JP6446377B2 (ja) 2013-03-08 2018-12-26 ファイザー・インク 免疫原性融合ポリペプチド
SG11201506810RA (en) * 2013-03-18 2015-10-29 Glaxosmithkline Biolog Sa Method of treatment
CN105593238B (zh) 2013-07-11 2020-09-08 诺华股份有限公司 使用微生物转谷氨酰胺酶进行赖氨酸特异性化学酶法蛋白质修饰
EP4098276A1 (fr) 2013-09-08 2022-12-07 Pfizer Inc. Compositions utilisables contre neisseria meningitidis et procédés associés
EP3148577B1 (fr) 2014-05-24 2021-01-20 Biological E Limited Nouveau vaccin conjugué méningococcique semi-synthétique
CN107249626A (zh) 2015-02-19 2017-10-13 辉瑞大药厂 脑膜炎奈瑟球菌组合物及其方法
EP3258850B1 (fr) 2015-02-20 2020-06-24 Bayer HealthCare LLC Agent d'imagerie de contraste à fluide à dégagement de gaz dissous
KR20160011136A (ko) 2015-03-25 2016-01-29 한국기계연구원 내식성이 향상된 마그네슘 합금 및 이를 이용하여 제조한 마그네슘 합금 부재의 제조방법
GB201518668D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Immunogenic Comosition
PL3397324T3 (pl) 2015-12-30 2022-10-24 Ascendis Pharma A/S Automatyczny wstrzykiwacz z układem utrzymywania wkładu
KR102204927B1 (ko) 2016-07-25 2021-01-19 에스케이바이오사이언스(주) 피막 다당류-단백질 접합 백신의 품질 평가 방법
EP3506933A2 (fr) 2016-09-02 2019-07-10 GlaxoSmithKline Biologicals SA Vaccins contre neisseria gonorrhoeae
SI3506935T1 (sl) 2016-09-02 2024-06-28 Sanofi Pasteur, Inc. Cepivo proti neisseriji meningitidis
AU2018215585B2 (en) 2017-01-31 2022-03-17 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
WO2019198096A1 (fr) * 2018-04-11 2019-10-17 Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. Composition de vaccin méningococcique tétravalente et son procédé de préparation
WO2020055788A1 (fr) 2018-09-12 2020-03-19 Bayer Healthcare Llc Système de conduite d'une procédure d'injection de fluide
EP3632465A1 (fr) 2018-10-03 2020-04-08 Sanofi Pasteur Inc. Immunisation combinée contre la méningite à méningocoques et le papillomavirus humain
WO2020168146A1 (fr) * 2019-02-14 2020-08-20 University Of Florida Research Foundation, Inc. Vaccin à base de snodgrassella alvi commensale d'abeilles contre neisseriaceae pathogènes
CN110903388B (zh) * 2019-12-03 2024-01-02 兰州生物制品研究所有限责任公司 一种将脑膜炎球菌抗血清去交叉反应的方法
MX2022007326A (es) 2019-12-17 2022-09-23 9286 3620 Quebec Inc Sistemas de suministro oral basados en la formacion in situ de coacervados de proteínas polisacáridos.
KR102610292B1 (ko) 2021-02-10 2023-12-04 에스케이바이오사이언스(주) 스트랩토코커스 뉴모니애 다당류와 운반체 단백질의 접합체 제조 방법
TW202245836A (zh) 2021-02-19 2022-12-01 美商賽諾菲巴斯德公司 重組b型腦膜炎球菌疫苗
WO2023200704A1 (fr) 2022-04-11 2023-10-19 Sanofi Pasteur Inc. Conjugaison protéine-saccharide avec du cyanoborohydrure de sodium
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物
WO2025034954A1 (fr) 2023-08-09 2025-02-13 Bayer Healthcare Llc Dispositif d'administration de gaz noble, cartouche et système de déclenchement d'imagerie fonctionnelle et structurale du poumon

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351761A (en) 1978-05-15 1982-09-28 Research Corporation Purified antigen to test for Neisseria gonorrhoeae antibodies
US4404371A (en) 1981-01-14 1983-09-13 Battelle Memorial Institute Carboxymethylcellulose with carbonate bridges and preparation thereof
US4351762A (en) * 1981-03-10 1982-09-28 Bioresearch, Inc. Rapid, quantitative peptide synthesis using mixed anhydrides
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4902506A (en) 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4619828A (en) 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
EP0109350B1 (fr) 1982-11-10 1991-10-16 Mitsubishi Jukogyo Kabushiki Kaisha Alliage nickel-chrome
US4762713A (en) * 1983-07-05 1988-08-09 The University Of Rochester Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers
US4761283A (en) * 1983-07-05 1988-08-02 The University Of Rochester Immunogenic conjugates
EP0200249B1 (fr) 1985-04-17 1988-10-19 Akzo N.V. Procédé d'application d'une composition de marquage routier
DE3518706A1 (de) 1985-05-24 1986-11-27 Kernforschungszentrum Karlsruhe Gmbh, 7500 Karlsruhe Verfahren zur herstellung von formkoerpern mit verbesserten, isotropen eigenschaften
US4814276A (en) * 1986-04-25 1989-03-21 Becton, Dickinson And Company Selective medium for growth of neisseria
ES2070312T5 (es) 1988-12-19 2003-05-16 American Cyanamid Co Vacuna de proteina de membrana exterior meningococica de clase 1.
US4963534A (en) * 1989-05-19 1990-10-16 Merck & Co., Inc. Process for solubilizing polyanoinic bacterial polysaccharides in aprotic solvents
NZ239643A (en) 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
US5153312A (en) 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
ATE198834T1 (de) 1991-03-12 2001-02-15 Us Health Konjugate bestehend aus polysaccharid und protein
SK18594A3 (en) 1991-08-16 1994-08-10 Merck & Co Inc Method of production of capsular polysacharide without lipid and endotoxine
US5314811A (en) * 1992-07-13 1994-05-24 Merck & Co., Inc. Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
US5422427A (en) 1991-09-17 1995-06-06 The United States Of America As Represented By The United States Department Of Health And Human Services Pneumococcal fimbrial protein A
FR2682388B1 (fr) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.
DE69334297D1 (de) * 1992-05-23 2009-11-12 Glaxosmithkline Biolog Sa Kombinierte Impfstoffe, die Hepatitis B oberfläche Antigen und andere Antigenen enthalten
US5445817A (en) * 1992-08-21 1995-08-29 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines
PL175595B1 (pl) * 1992-08-31 1999-01-29 North American Vaccine Inc Antygenowy/immunogenny koniugat do wytwarzania szczepionki przeciwko infekcji N.meningitidis, sposób wytwarzania antygenowego/immunogennego koniugatu oraz szczepionka przeciwko infekcji N.meningitidis
US20030157129A1 (en) * 1995-06-23 2003-08-21 Smithkline Beecham Biologicals S.A. Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein
SI1090642T1 (sl) 1995-06-07 2008-12-31 Glaxosmithkline Biolog Sa Vakcine, ki obsegajo konjugat polisaharidni antigen-nosilni protein in prosti nosilni protein
US5811102A (en) * 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
SI0833662T2 (sl) 1995-06-23 2011-06-30 Smithkline Beecham Biolog Cepivni sestavek, ki vsebuje polisaharidni konjugirani antigen haemophilus influenzae b adsorbiran na aluminijevem fosfatu
US20020054884A1 (en) * 1995-06-23 2002-05-09 Smithkline Beecham Biologicals, Sa Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate
US6248334B1 (en) * 1997-01-08 2001-06-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
ATE451124T1 (de) * 1997-01-21 2009-12-15 Sanofi Pasteur Polysaccharid-peptid-konjugate
AU727593B2 (en) 1997-01-24 2000-12-14 Schweiz. Serum- & Impfinstitut Bern Novel method for the isolation of polysaccharides
US6403306B1 (en) 1997-04-09 2002-06-11 Emory University Serogroup-specific nucleotide sequences in the molecular typing of bacterial isolates and the preparation of vaccines thereto
ES2230687T3 (es) 1997-04-24 2005-05-01 Henry M. Jackson Foundation For The Advancement Of Military Medicine Copulacion de proteinas nomodificadas con polisacaridos derivados de haloacilo o de dihaloacilo para la preparacion de vacunas que incluyen proteinas-polisacaridos.
DE69842010D1 (de) 1997-05-28 2010-12-30 Novartis Vaccines & Diagnostic Verfahren zur Herstellung eines immunogenen Faktors von Corynebacterium diphtheriae unter Verwendung eines Kulturmediums mit Hefeextrakt als Aminosäurenquelle und ohne Proteinkomplexe tierischer Herkunft
EP0994723A1 (fr) * 1997-06-24 2000-04-26 Chiron Corporation Procedes permettant d'immuniser des adultes grace a des compositions de vaccins anti-meningococcique
US5965714A (en) 1997-10-02 1999-10-12 Connaught Laboratories, Inc. Method for the covalent attachment of polysaccharides to protein molecules
JP4435413B2 (ja) 1997-12-23 2010-03-17 バクスター・ヘルスケヤー・ソシエテ・アノニム ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法
US7018637B2 (en) 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
US6146902A (en) 1998-12-29 2000-11-14 Aventis Pasteur, Inc. Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
NZ513259A (en) 1999-02-01 2004-05-28 Eisai Co Ltd Immunological adjuvant compound containing a cardiolipin derivative
TR200102739T2 (tr) 1999-03-19 2001-12-21 Smithkline Beecham Biologicals S.A. Aşı
CN102580072A (zh) 1999-05-19 2012-07-18 诺华疫苗和诊断有限公司 组合式奈瑟球菌组合物
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
GB9925559D0 (en) 1999-10-28 1999-12-29 Smithkline Beecham Biolog Novel method
DE60039450D1 (de) 1999-12-02 2008-08-21 Novartis Vaccines & Diagnostic Zusammensetzungen und methoden zur stabilisierung von biologischen molekülen nach lyophilisierung
US6800455B2 (en) * 2000-03-31 2004-10-05 Scios Inc. Secreted factors
EA006313B1 (ru) 2000-06-29 2005-10-27 Глаксосмитклайн Байолоджикалс С.А. Поливалентные иммуногенные композиции и способы их применения
BRPI0206672B8 (pt) 2001-01-23 2021-05-25 Aventis Pasteur composição imunológica, vacina conjugada tetravalente e vacina meningocócica multivalente
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination

Also Published As

Publication number Publication date
EA200300827A1 (ru) 2004-06-24
LV13128B (en) 2004-07-20
EP2957300A2 (fr) 2015-12-23
US8741314B2 (en) 2014-06-03
HUP0302999A2 (hu) 2003-12-29
NO20033816L (no) 2003-09-11
WO2002058737A3 (fr) 2003-05-22
IS6881A (is) 2003-07-22
EP2332581A1 (fr) 2011-06-15
BR0206672A (pt) 2005-05-10
AU2010219288A1 (en) 2010-09-23
HU230490B1 (hu) 2016-08-29
UA92579C2 (ru) 2010-11-25
PL373710A1 (en) 2005-09-05
EP1355673A2 (fr) 2003-10-29
EP1355673B1 (fr) 2012-05-30
NZ622900A (en) 2015-11-27
CA2435681C (fr) 2011-06-21
FR22C1001I1 (fr) 2022-02-18
BRPI0206672B8 (pt) 2021-05-25
NO20033816D0 (no) 2003-08-27
US20150174259A1 (en) 2015-06-25
IL157060A (en) 2013-04-30
MXPA03006561A (es) 2004-10-15
HUP0302999A3 (en) 2011-05-30
JP5795721B2 (ja) 2015-10-14
HRP20030598A2 (en) 2005-06-30
BRPI0206672B1 (pt) 2018-11-06
US20160000928A1 (en) 2016-01-07
KR100947751B1 (ko) 2010-03-18
EP2957300B1 (fr) 2021-07-14
RO122761B1 (ro) 2010-01-29
CY1113072T1 (el) 2015-08-05
SI21352A (sl) 2004-06-30
IL225522A0 (en) 2013-06-27
US9844601B2 (en) 2017-12-19
ZA200306176B (en) 2005-03-30
HUS1600040I1 (hu) 2019-05-28
CN100556459C (zh) 2009-11-04
US9173955B2 (en) 2015-11-03
ES2388848T3 (es) 2012-10-19
EP2957300A3 (fr) 2016-03-30
WO2002058737A2 (fr) 2002-08-01
US20190060475A1 (en) 2019-02-28
MX341760B (es) 2016-09-02
HRP20030598B1 (hr) 2013-05-31
LT5177B (lt) 2004-11-25
TNSN03041A1 (en) 2005-12-23
US8722062B2 (en) 2014-05-13
US10143757B2 (en) 2018-12-04
LU92108I9 (fr) 2019-01-15
FR22C1001I2 (fr) 2025-02-07
ES2892316T3 (es) 2022-02-03
FR15C0094I1 (fr) 2016-01-22
DK2332581T3 (en) 2015-10-05
JP2014065745A (ja) 2014-04-17
CY2012030I1 (el) 2015-08-05
KR20090029857A (ko) 2009-03-23
FR12C0072I2 (fr) 2013-11-01
EP2332581B1 (fr) 2015-07-01
JP2014043474A (ja) 2014-03-13
JP2014043475A (ja) 2014-03-13
CN1610560A (zh) 2005-04-27
BE2022C502I2 (fr) 2023-04-12
US10617766B2 (en) 2020-04-14
US20130224241A1 (en) 2013-08-29
EA006947B1 (ru) 2006-06-30
CA2435681A1 (fr) 2002-08-01
OA12590A (en) 2006-06-08
YU66103A (sh) 2006-05-25
US20130177588A1 (en) 2013-07-11
US20180154010A1 (en) 2018-06-07
NZ602682A (en) 2014-05-30
GEP20053691B (en) 2005-12-12
PL226184B1 (pl) 2017-06-30
US20130216571A1 (en) 2013-08-22
DK1355673T3 (da) 2012-09-17
IL157060A0 (en) 2004-02-08
AU2007216743A1 (en) 2007-10-04
BE2015C077I2 (fr) 2021-02-04
IL225522A (en) 2016-04-21
US8999354B2 (en) 2015-04-07
US20140308311A1 (en) 2014-10-16
FR12C0072I1 (fr) 2013-01-04
ES2544979T3 (es) 2015-09-07
US20030068336A1 (en) 2003-04-10
LU92108I2 (fr) 2013-01-29
PT1355673E (pt) 2012-08-31
US8734813B2 (en) 2014-05-27
JP2016128526A (ja) 2016-07-14
FR15C0094I2 (fr) 2017-05-19
PT2332581E (pt) 2015-10-16
CY2012030I2 (el) 2016-08-31
LT2003071A (en) 2004-08-25
ECSP034701A (es) 2003-10-28
JP2005504718A (ja) 2005-02-17
CR7035A (es) 2008-11-25
AP1897A (en) 2008-10-10
AP2003002829A0 (en) 2003-09-30
KR20030084913A (ko) 2003-11-01
KR100947757B1 (ko) 2010-03-18
JP2011140522A (ja) 2011-07-21

Similar Documents

Publication Publication Date Title
BE2022C531I2 (fr)
BE2022C502I2 (fr)
BE2022C547I2 (fr)
BE2017C059I2 (fr)
BE2017C057I2 (fr)
BE2017C051I2 (fr)
BE2017C032I2 (fr)
BE2016C051I2 (fr)
BE2015C046I2 (fr)
BE2014C052I2 (fr)
BE2014C036I2 (fr)
BE2014C026I2 (fr)
BE2011C034I2 (fr)
BE2007C047I2 (fr)
AU2002307149A8 (fr)
BE2014C006I2 (fr)
BRPI0209186B1 (fr)
BE2017C050I2 (fr)
BRPI0204884B1 (fr)
BE2014C008I2 (fr)
CH1379220H1 (fr)
BE2016C021I2 (fr)
JP2002230544A5 (fr)
BRPI0101486B8 (fr)
BE2012C051I2 (fr)