SE9503380D0
(en)
*
|
1995-09-29 |
1995-09-29 |
Pharmacia Ab |
Protein derivatives
|
US7125843B2
(en)
|
2001-10-19 |
2006-10-24 |
Neose Technologies, Inc. |
Glycoconjugates including more than one peptide
|
US7265085B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycoconjugation methods and proteins/peptides produced by the methods
|
EP2292271A3
(en)
|
2001-10-10 |
2011-09-14 |
BioGeneriX AG |
Remodelling and glycoconjugation of an antibody
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
US7226903B2
(en)
|
2001-10-10 |
2007-06-05 |
Neose Technologies, Inc. |
Interferon beta: remodeling and glycoconjugation of interferon beta
|
DK2279753T3
(en)
|
2001-10-10 |
2015-11-23 |
Novo Nordisk As |
The conversion of peptides and glycokonjugering
|
US7297511B2
(en)
|
2001-10-10 |
2007-11-20 |
Neose Technologies, Inc. |
Interferon alpha: remodeling and glycoconjugation of interferon alpha
|
US7179617B2
(en)
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7265084B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
US7439043B2
(en)
|
2001-10-10 |
2008-10-21 |
Neose Technologies, Inc. |
Galactosyl nucleotide sugars
|
US7399613B2
(en)
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
US7473680B2
(en)
|
2001-11-28 |
2009-01-06 |
Neose Technologies, Inc. |
Remodeling and glycoconjugation of peptides
|
EP2338523B1
(en)
|
2003-02-26 |
2024-01-17 |
Nektar Therapeutics |
Polymer-factor viii moiety conjugates
|
AU2004221824B2
(en)
|
2003-03-14 |
2009-08-27 |
Ratiopharm Gmbh |
Branched water-soluble polymers and their conjugates
|
US7691603B2
(en)
|
2003-04-09 |
2010-04-06 |
Novo Nordisk A/S |
Intracellular formation of peptide conjugates
|
NZ542586A
(en)
|
2003-04-09 |
2009-11-27 |
Biogenerix Ag |
Method of forming a covalent conjugate between a G-CSF peptide and PEG
|
BRPI0410164A
(en)
|
2003-05-09 |
2006-05-16 |
Neose Technologies Inc |
compositions and methods for preparing human growth hormone glycosylation mutants
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
WO2005051327A2
(en)
|
2003-11-24 |
2005-06-09 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
US7956032B2
(en)
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
ES2560657T3
(en)
|
2004-01-08 |
2016-02-22 |
Ratiopharm Gmbh |
O-linked glycosylation of G-CSF peptides
|
CA2553035A1
(en)
|
2004-02-02 |
2005-08-18 |
Ambrx, Inc. |
Modified human growth hormone polypeptides and their uses
|
EP1745141B2
(en)
|
2004-05-04 |
2019-09-25 |
Novo Nordisk Health Care AG |
O-linked glycoforms of faktor vii and method to manufacture them
|
EP1771205B1
(en)
|
2004-06-18 |
2016-10-26 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
WO2006031811A2
(en)
|
2004-09-10 |
2006-03-23 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
ES2572779T3
(en)
|
2004-10-29 |
2016-06-02 |
Ratiopharm Gmbh |
Remodeling and glucopegilation of Fibroblast Growth Factor (FGF)
|
KR101904630B1
(en)
|
2004-11-12 |
2018-10-04 |
바이엘 헬스케어 엘엘씨 |
Site-directed modification of fviii
|
AU2013203348B2
(en)
*
|
2004-11-12 |
2016-03-03 |
Bayer Healthcare Llc |
Site-directed modification of FVIII
|
AU2012203813B2
(en)
*
|
2004-11-12 |
2013-10-24 |
Bayer Healthcare Llc |
Site-directed modification of FVIII
|
AU2016203693B2
(en)
*
|
2004-11-12 |
2018-08-23 |
Bayer Healthcare Llc |
Site-directed modification of FVIII
|
MX2007007590A
(en)
|
2004-12-22 |
2007-12-10 |
Ambrx Inc |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides.
|
MX2007007591A
(en)
|
2004-12-22 |
2007-07-25 |
Ambrx Inc |
Methods for expression and purification of recombinant human growth hormone.
|
CA2590429C
(en)
|
2004-12-22 |
2014-10-07 |
Ambrx, Inc. |
Compositions of aminoacyl-trna synthetase and uses thereof
|
SG160437A1
(en)
|
2004-12-22 |
2010-04-29 |
Ambrx Inc |
Modified human growth hormone
|
CN103520735B
(en)
|
2004-12-22 |
2015-11-25 |
Ambrx公司 |
Comprise non-naturally encoded amino acid whose formulations of human growth hormone
|
MX2007007877A
(en)
|
2004-12-27 |
2007-08-21 |
Baxter Int |
Polymer-von willebrand factor-conjugates.
|
CA2593682C
(en)
|
2005-01-10 |
2016-03-22 |
Neose Technologies, Inc. |
Glycopegylated granulocyte colony stimulating factor
|
EP2386571B1
(en)
|
2005-04-08 |
2016-06-01 |
ratiopharm GmbH |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
US20080255026A1
(en)
|
2005-05-25 |
2008-10-16 |
Glycopegylated Factor 1X |
Glycopegylated Factor Ix
|
EP1888098A2
(en)
|
2005-05-25 |
2008-02-20 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin formulations
|
MX2007015058A
(en)
|
2005-06-03 |
2008-01-28 |
Ambrx Inc |
Improved human interferon molecules and their uses.
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
CA2626522A1
(en)
|
2005-11-16 |
2007-05-24 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
US7985839B2
(en)
|
2006-03-31 |
2011-07-26 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
US7982010B2
(en)
|
2006-03-31 |
2011-07-19 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
NZ572050A
(en)
|
2006-03-31 |
2011-09-30 |
Baxter Int |
Factor VIII conjugated to polyethylene glycol
|
US20080248959A1
(en)
|
2006-07-21 |
2008-10-09 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
WO2008030613A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Hybrid suppressor trna for vertebrate cells
|
WO2008030614A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
DK2615108T3
(en)
|
2006-09-08 |
2017-01-30 |
Ambrx Inc |
Modified human plasma polypeptide or fc scaffolds and their applications
|
US20100075375A1
(en)
|
2006-10-03 |
2010-03-25 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates
|
DK2068907T3
(en)
|
2006-10-04 |
2018-01-15 |
Novo Nordisk As |
GLYCEROL BOND PEGYLED SUGAR AND GLYCOPE Peptides
|
JP5876208B2
(en)
|
2006-12-15 |
2016-03-02 |
バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated |
Factor VIIa- (poly) sialic acid conjugate with extended in vivo half-life
|
AU2007338298B2
(en)
|
2006-12-22 |
2013-02-07 |
Csl Behring Gmbh |
Modified coagulation factors with prolonged in vivo half-life
|
NZ577728A
(en)
*
|
2006-12-27 |
2012-01-12 |
Baxter Int |
Von willebrand factor- and factor viii-polymer conjugates having a releasable linkage
|
CA2682147C
(en)
|
2007-03-30 |
2017-08-08 |
Ambrx, Inc. |
Modified fgf-21 polypeptides and their uses
|
ES2406267T3
(en)
|
2007-04-03 |
2013-06-06 |
Biogenerix Ag |
Treatment methods using glycopegylated G-CSF
|
CA2685596A1
(en)
|
2007-05-02 |
2008-11-13 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
CA2690611C
(en)
|
2007-06-12 |
2015-12-08 |
Novo Nordisk A/S |
Improved process for the production of nucleotide sugars
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
GB2467700A
(en)
*
|
2007-11-09 |
2010-08-11 |
Baxter Int |
Modified recombinant Factor VIII and von Willebrand Factor and methods of use
|
DK2217265T3
(en)
|
2007-11-20 |
2017-07-03 |
Ambrx Inc |
Modified insulin polypeptides and their use
|
NZ586317A
(en)
|
2007-12-27 |
2012-10-26 |
Baxter Int |
Method and compositions for specifically detecting physiologically acceptable polymer molecules
|
MX2010008632A
(en)
|
2008-02-08 |
2010-08-30 |
Ambrx Inc |
Modified leptin polypeptides and their uses.
|
JP5619630B2
(en)
|
2008-02-27 |
2014-11-05 |
ノボ・ノルデイスク・エー/エス |
Binding factor VIII molecule
|
US20110286988A1
(en)
|
2008-06-04 |
2011-11-24 |
Bayer Healthcare Llc |
FVIII Muteins for Treatment of Von Willebrand Disease
|
US8575104B2
(en)
|
2008-06-24 |
2013-11-05 |
Csl Behring Gmbh |
Factor VIII, von willebrand factor or complexes thereof with prolonged in vivo half-life
|
EA019968B1
(en)
|
2008-07-23 |
2014-07-30 |
Амбркс, Инк. |
Modified bovine g-csf polypeptides and their uses
|
US8575102B2
(en)
|
2008-08-01 |
2013-11-05 |
Nektar Therapeutics |
Conjugates having a releasable linkage
|
CA2737026C
(en)
|
2008-09-26 |
2019-12-24 |
Ambrx, Inc. |
Modified animal erythropoietin polypeptides and their uses
|
ES2660000T3
(en)
|
2008-09-26 |
2018-03-20 |
Ambrx, Inc. |
Vaccines and microorganisms dependent on the replication of unnatural amino acids
|
CA2738064C
(en)
|
2008-10-15 |
2013-03-19 |
Baxter International Inc. |
Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
|
AU2009305612B2
(en)
|
2008-10-17 |
2015-05-21 |
Takeda Pharmaceutical Company Limited |
Modified blood factors comprising a low degree of water soluble polymer
|
PL2356467T3
(en)
|
2008-12-11 |
2013-12-31 |
Baxalta Inc |
Detection of physiologically acceptable polymer molecules using near infrared spectroscopy
|
JP6227870B2
(en)
|
2009-06-09 |
2017-11-08 |
プロロング ファーマシューティカルズ,エルエルシー |
Hemoglobin composition
|
ES2590679T3
(en)
*
|
2009-07-27 |
2016-11-23 |
Lipoxen Technologies Limited |
Glycopolyallylation of proteins other than blood coagulation proteins
|
PT2459224T
(en)
|
2009-07-27 |
2016-09-05 |
Baxalta Inc |
Blood coagulation protein conjugates
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
WO2011017055A2
(en)
*
|
2009-07-27 |
2011-02-10 |
Baxter International Inc. |
Blood coagulation protein conjugates
|
US8642737B2
(en)
*
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
PE20121799A1
(en)
|
2009-12-21 |
2013-01-02 |
Ambrx Inc |
MODIFIED PORCINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
|
US20120283171A1
(en)
|
2009-12-21 |
2012-11-08 |
Ambrx, Inc. |
Modified bovine somatotropin polypeptides and their uses
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
SI3572091T1
(en)
|
2010-08-17 |
2024-07-31 |
Ambrx, Inc., |
Modified relaxin polypeptides and their uses
|
AU2011303916A1
(en)
*
|
2010-09-15 |
2013-03-21 |
Novo Nordisk A/S |
Factor VIII variants having a decreased cellular uptake
|
AR083006A1
(en)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
FORMULATIONS FOR THE STIMULATING FACTOR OF COLONIES OF GRANULOCITS (G-CSF) BOVINE AND VARIANTS OF THE SAME
|
JP6138052B2
(en)
|
2010-12-22 |
2017-05-31 |
バクスアルタ ゲーエムベーハー |
Materials and methods for conjugating water soluble fatty acid derivatives to proteins
|
DK2814502T3
(en)
|
2012-02-15 |
2017-12-18 |
Csl Behring Gmbh |
Von Willebrand Factor variants with improved Factor VIII binding affinity
|
HUE043552T2
(en)
|
2012-06-08 |
2019-09-30 |
Sutro Biopharma Inc |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
WO2014004639A1
(en)
|
2012-06-26 |
2014-01-03 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
US9682934B2
(en)
|
2012-08-31 |
2017-06-20 |
Sutro Biopharma, Inc. |
Modified amino acids
|
ES2657291T3
(en)
|
2013-04-22 |
2018-03-02 |
Csl Ltd. |
A covalent complex of von Willebrand factor and factor VIII associated by a disulfide bridge
|
EP3336103B1
(en)
|
2013-07-10 |
2021-03-17 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
EP3114138B1
(en)
|
2014-03-05 |
2021-11-17 |
Pfizer Inc. |
Improved muteins of clotting factor viii
|
AU2015283822B2
(en)
|
2014-07-02 |
2019-10-03 |
CSL Behring Lengnau AG |
Modified von willebrand factor
|
BR112017008157A2
(en)
|
2014-10-24 |
2017-12-19 |
Bristol Myers Squibb Co |
modified fgf-21 polypeptides and uses thereof
|
AU2016231327B2
(en)
|
2015-03-06 |
2018-08-09 |
CSL Behring Lengnau AG |
Modified von Willebrand factor having improved half-life
|
CN107810194B
(en)
|
2015-05-22 |
2021-10-08 |
康诺贝林伦瑙有限公司 |
Method for preparing modified von willebrand factor
|
EP3297656B1
(en)
|
2015-05-22 |
2020-01-08 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for treating hemophilia
|
US10808023B2
(en)
|
2016-01-07 |
2020-10-20 |
CSL Behring Lengnau AG |
Mutated von Willebrand factor
|
WO2017117631A1
(en)
|
2016-01-07 |
2017-07-13 |
Csl Limited |
Mutated truncated von willebrand factor
|
TW201828975A
(en)
|
2016-11-11 |
2018-08-16 |
瑞士商Csl貝林重組技能公司 |
Truncated von Willebrand factor polypeptides for treating hemophilia
|
AU2017358865A1
(en)
|
2016-11-11 |
2019-05-09 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
|
AU2018219283B2
(en)
|
2017-02-08 |
2022-05-19 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
SG11202102427XA
(en)
|
2018-09-11 |
2021-04-29 |
Ambrx Inc |
Interleukin-2 polypeptide conjugates and their uses
|
KR20220151202A
(en)
|
2020-03-11 |
2022-11-14 |
암브룩스, 인코포레이티드 |
Interleukin-2 polypeptide conjugates and methods of use thereof
|