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AU564556B2 - New p-phenylenediamine peptides and reactance containing themfor the determination of proteases of the blood coagulation system - Google Patents

New p-phenylenediamine peptides and reactance containing themfor the determination of proteases of the blood coagulation system

Info

Publication number
AU564556B2
AU564556B2 AU47238/85A AU4723885A AU564556B2 AU 564556 B2 AU564556 B2 AU 564556B2 AU 47238/85 A AU47238/85 A AU 47238/85A AU 4723885 A AU4723885 A AU 4723885A AU 564556 B2 AU564556 B2 AU 564556B2
Authority
AU
Australia
Prior art keywords
themfor
reactance
phenylenediamine
proteases
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47238/85A
Other versions
AU4723885A (en
Inventor
Knut Bartl
Hans-George Batz
Udo Bekker
Helmut Lill
Herbert Von Der Eltz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU4723885A publication Critical patent/AU4723885A/en
Application granted granted Critical
Publication of AU564556B2 publication Critical patent/AU564556B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU47238/85A 1984-08-02 1985-07-31 New p-phenylenediamine peptides and reactance containing themfor the determination of proteases of the blood coagulation system Ceased AU564556B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3428543 1984-08-02
DE19843428543 DE3428543A1 (en) 1984-08-02 1984-08-02 NEW P-PHENYLENE DIAMINE PEPTIDES AND REAGENTS CONTAINING THESE FOR DETERMINING PROTEASES OF THE BLOOD CLOTHING SYSTEM

Publications (2)

Publication Number Publication Date
AU4723885A AU4723885A (en) 1986-03-07
AU564556B2 true AU564556B2 (en) 1987-08-13

Family

ID=6242223

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47238/85A Ceased AU564556B2 (en) 1984-08-02 1985-07-31 New p-phenylenediamine peptides and reactance containing themfor the determination of proteases of the blood coagulation system

Country Status (6)

Country Link
EP (1) EP0190299A1 (en)
JP (1) JPS61501635A (en)
AU (1) AU564556B2 (en)
DE (1) DE3428543A1 (en)
WO (1) WO1986001209A2 (en)
ZA (1) ZA855814B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
FI860043A7 (en) * 1986-01-06 1987-07-07 Orion Yhtymae Oy Peptide substrates and a method for the quantitative determination of endotoxin.
SE8601327D0 (en) * 1986-03-21 1986-03-21 Kabivitrum Ab NEW PEPTIDE DERIVATIVES
SE461494B (en) * 1986-03-21 1990-02-19 Thorsman & Co Ab MACHINE CONTAINS AN ELECTRIC CLUTCH BOX
FR2644697B1 (en) * 1989-03-24 1992-05-15 Poudres & Explosifs Ste Nale ANESTHETIC COMPOUNDS WITH CONTROLLED DURATION OF ACTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6207399B1 (en) 1995-01-10 2001-03-27 Hendrik Coenraad Hemker Methods of determining endogenous thrombin potential (ETP) and thrombin substrates for use in said methods
IL144839A0 (en) * 1999-02-23 2002-06-30 Pentapharm Ag Oligopeptide derivatives for the electrochemical measurement of protease activity
JP4878031B2 (en) 2004-10-12 2012-02-15 エフ．ホフマン−ラ ロシュ アーゲー Solid phase peptide synthesis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2497798A1 (en) * 1981-01-09 1982-07-16 Pharmindustrie NOVEL PEPTIDES CARRYING A FLUOROPHORE, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION TO FLUORIMETRIC DETERMINATION OF ENDOTOXINS
JPS57176940A (en) * 1981-04-25 1982-10-30 Wako Pure Chem Ind Ltd Novel color-developing peptide derivative
JPS58172354A (en) * 1982-04-05 1983-10-11 Dai Ichi Pure Chem Co Ltd Peptide derivative
GB2118190B (en) * 1982-04-13 1985-05-01 Erba Farmitalia Peptides with sauvagine-like activity
DE3244030A1 (en) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg CHROMOGENIC COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE
JPH08142597A (en) * 1994-11-21 1996-06-04 Dainippon Printing Co Ltd Transfer foil and decorative glass using the same

Also Published As

Publication number Publication date
DE3428543A1 (en) 1986-02-13
WO1986001209A3 (en) 1986-03-27
JPS61501635A (en) 1986-08-07
EP0190299A1 (en) 1986-08-13
AU4723885A (en) 1986-03-07
WO1986001209A2 (en) 1986-02-27
ZA855814B (en) 1986-04-30

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