AU3109095A - Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production - Google Patents

Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production

Info

Publication number: AU3109095A
Authority: AU; Australia
Prior art keywords: conjugates; oligonucleotides; production; well; metal complexes
Prior art date: 1994-07-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU31090/95A

Inventor

Dietmar Berndorff

Larry Gold

Andreas Muhler

Ulrich Niedballa

Wolfgang Pieken

Johannes Dr. Platzek

Bernd Dr. Raduchel

Ulrich Speck

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Nexstar Pharmaceuticals Inc

Original Assignee

Schering AG

Nexstar Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-14

Filing date

1995-07-12

Publication date

1996-02-16

1994-07-14 Priority claimed from DE4424923A external-priority patent/DE4424923A1/en

1994-12-05 Priority claimed from DE19944445076 external-priority patent/DE4445076A1/en

1995-07-12 Application filed by Schering AG, Nexstar Pharmaceuticals Inc filed Critical Schering AG

1996-02-16 Publication of AU3109095A publication Critical patent/AU3109095A/en

Status Abandoned legal-status Critical Current

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
238000003745 diagnosis Methods 0.000 title 1
239000002184 metal Substances 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Public Health (AREA)
Radiology & Medical Imaging (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AU31090/95A 1994-07-14 1995-07-12 Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production Abandoned AU3109095A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE4424923A DE4424923A1 (en)	1994-07-14	1994-07-14	Conjugates of nuclease-resistant oligo:nucleotide and metal complexing agent
DE4424923		1994-07-14
DE4445076		1994-12-05
DE19944445076 DE4445076A1 (en)	1994-12-05	1994-12-05	Oligo:nucleotide conjugate with metal chelating residue for NMR diagnosis
PCT/EP1995/002686 WO1996002669A1 (en)	1994-07-14	1995-07-12	Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production

Publications (1)

Publication Number	Publication Date
AU3109095A true AU3109095A (en)	1996-02-16

Family

ID=25938360

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU31090/95A Abandoned AU3109095A (en)	1994-07-14	1995-07-12	Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production

Country Status (5)

Country	Link
EP (1)	EP0770146A1 (en)
JP (1)	JPH10511842A (en)
AU (1)	AU3109095A (en)
IL (1)	IL114235A0 (en)
WO (1)	WO1996002669A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11507027A (en) *	1995-06-07	1999-06-22	シェリングアクチェンゲゼルシャフト	Ferrite and oligonucleotide conjugates that specifically bind to specific target structures
DE19741084A1 (en) *	1997-09-18	1999-03-25	Knoell Hans Forschung Ev	New library of chemically modified nucleic acid molecules
US6906050B2 (en)	2001-05-31	2005-06-14	Miravant Pharmaceuticals, Inc.	Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5057302A (en) *	1987-02-13	1991-10-15	Abbott Laboratories	Bifunctional chelating agents
US4962045A (en) *	1988-05-02	1990-10-09	The Perkin-Elmer Corporation	Time-resolved fluorimetric detection of lanthanide labeled nucleotides
US5559207A (en) *	1989-03-06	1996-09-24	Board Of Regents, University Of Texas	Texaphyrin metal complex mediated ester hydrolysis
EP0531447B1 (en) *	1990-05-23	1999-11-10	Isis Pharmaceuticals, Inc.	Compositions and methods for modulating rna activity through modification of the 5' cap structure of rna
ES2108109T3 (en) *	1991-02-14	1997-12-16	Dade Microscan Inc	NEW OLIGONUCLEOTIDES CONJUGATED WITH LANTANIDES CHELATES.
WO1993012230A1 (en) *	1991-12-13	1993-06-24	Sri International	Triple-helix formation at (punpyn).(punpyn) tracts
FR2697254A1 (en) *	1992-10-22	1994-04-29	Genset Sa	New conjugate of oligo-nucleotide and cationic metallo-porphyrin - can cleave complementary nucleic acid selectively, useful as antitumour, antiviral, antibacterial and antiparasitic agent

1995
- 1995-06-20 IL IL11423595A patent/IL114235A0/en unknown
- 1995-07-12 WO PCT/EP1995/002686 patent/WO1996002669A1/en not_active Application Discontinuation
- 1995-07-12 AU AU31090/95A patent/AU3109095A/en not_active Abandoned
- 1995-07-12 EP EP95926850A patent/EP0770146A1/en not_active Withdrawn
- 1995-07-12 JP JP8504000A patent/JPH10511842A/en active Pending

Also Published As

Publication number	Publication date
IL114235A0 (en)	1995-10-31
JPH10511842A (en)	1998-11-17
EP0770146A1 (en)	1997-05-02
WO1996002669A1 (en)	1996-02-01

Similar Documents

Publication	Publication Date	Title
AU4299496A (en)	1996-06-19	Novel multiple-substituent dtpa derivatives and metal complexes thereof, pharmaceutical compositions containing such complexes, their use in diagnosis and therapy, methods ofpreparing the complexing agents and complexes and methods of preparing the pharmaceutical compositions
UA66857C2 (en)	2004-06-15	PEG-b-INTERFERON CONJUGATE, METHOD FOR ITS SYNTHESIS, METHOD FOR TREATING INFECTIONS, TUMORS, AUTOIMMUNE AND INFLAMMATORY DISEASES
HUP9600596A2 (en)	1997-01-28	Process for producing pharmaceutical compositions containing rapamycin, for treating cardiac inflammatory disease
AU6969796A (en)	1997-04-09	Body wash composition to impart conditioning properties to skin
HUP0100775A3 (en)	2003-07-28	Sulphated hyaluronic acid and sulphated derivatives thereof covalently bound to polyurethanes, and the process for their preparation
PL314252A1 (en)	1996-11-25	Novel fluorophenyl-substituted derivatives of alkenylocarbonyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents as well as pharmaceutic agent containing such derivatives
CA2001765A1 (en)	1990-04-30	Chelants possessing ortho ligating functionality and complexes thereof
PL314253A1 (en)	1996-11-25	Novel substituted derivatives of benzoxycarbonylguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents as well as well as pharmaceutic agent containing such derivatives
HRP960356B1 (en)	2001-02-28	Substituted cinnamic acid guanidides, process for their preparation, their use as medicaments or diagnostic agents, as well as medicaments containing them
HU9302309D0 (en)	1993-12-28	Process for producing conjugates of bicyclo-polyaza-macrocyclo-carboxylic acid complexes and contrast-materials containing them
CA2103556A1 (en)	1993-06-11	Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation
AU3109095A (en)	1996-02-16	Conjugates of metal complexes and oligonucleotides, which specifically bond to specific target structures, agents containing these conjugates, their use in nmr diagnosis as well as process for their production
HK1032534A1 (en)	2001-07-27	L-threonate ferrous, as well as pharmaceutical composition and use for improving and treating human anemia thereof
ZA949604B (en)	1995-08-15	Haloaryl-substituted metal complexes pharmaceutical agents containing these complexes, their use in diagnosis, as well as process for the production of the complexes and agents
ZA955894B (en)	1996-07-30	Conjugates of metal complexes and oligonucleotides which specifically bond to specific target structures agents containing these conjugates their use in nmr diagnosis as well as process for their production
HUP9901247A3 (en)	2000-08-28	Use of naphthimidazole-, naphthoxazole- and naphthothiazole-diones for the preparation of pharmaceutical compositions treating diseases caused by vascular function deficiency
AU3378989A (en)	1989-11-02	Titanium-free activating agents, process for preparing same and use thereof for activating metal surfaces prior to zinc phosphating
PL314278A1 (en)	1997-01-20	Novel 4-fluoroalkyl-substituted derivatives of benzoyloguanidine, method of obtaining them and their application in production of pharmaceutic and diagnostic agents as well as pharmaceutic agent as such
WO1998048844A3 (en)	1999-02-11	Ion paris, method for the production and use thereof as contrast agents
WO2000073274A3 (en)	2001-04-19	Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors
FI933506L (en)	1994-11-07	Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, method for their preparation and use as contrast agents
PL318147A1 (en)	1997-05-12	Conjugates of metal complexes and oligonusleotides, agents containing such conjugates, their application in radiodiagnostics as well as method of obtaining them
AU2886595A (en)	1996-02-16	Technetium-sulphonamide complexes, their use, pharmaceutical agents containing the latter, as well as process for the production of the complexes and agents
EP0302303A3 (en)	1989-05-24	Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
PL316441A1 (en)	1997-05-26	Novel sulphonylamino substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such