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AU2565995A - Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents - Google Patents

Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents

Info

Publication number
AU2565995A
AU2565995A AU25659/95A AU2565995A AU2565995A AU 2565995 A AU2565995 A AU 2565995A AU 25659/95 A AU25659/95 A AU 25659/95A AU 2565995 A AU2565995 A AU 2565995A AU 2565995 A AU2565995 A AU 2565995A
Authority
AU
Australia
Prior art keywords
resistant cells
lactam derivatives
antitumour agents
sensitizing multidrug
polycyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU25659/95A
Inventor
Giorgio Caravatti
Urs Regenass
Oskar Wacker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU2565995A publication Critical patent/AU2565995A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU25659/95A 1994-06-01 1995-05-19 Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents Abandoned AU2565995A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1715/94 1994-06-01
CH171594 1994-06-01
PCT/EP1995/001911 WO1995032976A1 (en) 1994-06-01 1995-05-19 Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents

Publications (1)

Publication Number Publication Date
AU2565995A true AU2565995A (en) 1995-12-21

Family

ID=4216912

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25659/95A Abandoned AU2565995A (en) 1994-06-01 1995-05-19 Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents

Country Status (4)

Country Link
EP (1) EP0763042A1 (en)
JP (1) JPH10500394A (en)
AU (1) AU2565995A (en)
WO (1) WO1995032976A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4940430A1 (en) * 1997-07-07 2000-07-24 Novartis Ag POLYCLIC COMPOUNDS CONTAINING HYDROGENATED STAUROSPORIN WITH CONVENIENT PHARMACOLOGICAL PROPERTIES AND AN INHIBITING EFFECT ON THE GROWTH OF TUMOR CELLS
AU758241B2 (en) * 1998-03-13 2003-03-20 University Of British Columbia, The Granulatimide derivatives for use in cancer treatment
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
CA2379035A1 (en) 1999-07-13 2001-01-18 Shiro Akinaga Staurosporin derivatives
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2462657C (en) 2001-10-30 2011-04-26 Novartis Ag Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
US20070191338A1 (en) 2003-08-08 2007-08-16 Atadja Peter W Combinations comprising staurosporines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383919A4 (en) * 1988-02-04 1992-08-05 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives
ES2171416T3 (en) * 1992-09-21 2002-09-16 Kyowa Hakko Kogyo Kk REMEDY AGAINST THROMBOCITOPENIA.
WO1994020106A1 (en) * 1993-03-03 1994-09-15 Kyowa Hakko Kogyo Co., Ltd. Sensitivity enhancer for antineoplastic agent
WO1995000520A1 (en) * 1993-06-17 1995-01-05 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor

Also Published As

Publication number Publication date
EP0763042A1 (en) 1997-03-19
JPH10500394A (en) 1998-01-13
WO1995032976A1 (en) 1995-12-07

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