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AU2565895A - Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents - Google Patents

Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents

Info

Publication number
AU2565895A
AU2565895A AU25658/95A AU2565895A AU2565895A AU 2565895 A AU2565895 A AU 2565895A AU 25658/95 A AU25658/95 A AU 25658/95A AU 2565895 A AU2565895 A AU 2565895A AU 2565895 A AU2565895 A AU 2565895A
Authority
AU
Australia
Prior art keywords
antitumor agents
resistant cells
indolocarbazole derivatives
sensitizing multidrug
multidrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU25658/95A
Inventor
Giorgio Caravatti
Andreas Fredenhagen
Urs Regenass
Oskar Wacker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU2565895A publication Critical patent/AU2565895A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU25658/95A 1994-06-01 1995-05-19 Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents Abandoned AU2565895A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH1714/94 1994-06-01
CH171494 1994-06-01
PCT/EP1995/001910 WO1995032975A1 (en) 1994-06-01 1995-05-19 Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents

Publications (1)

Publication Number Publication Date
AU2565895A true AU2565895A (en) 1995-12-21

Family

ID=4216887

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25658/95A Abandoned AU2565895A (en) 1994-06-01 1995-05-19 Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents

Country Status (4)

Country Link
EP (1) EP0763041A1 (en)
JP (1) JPH10501527A (en)
AU (1) AU2565895A (en)
WO (1) WO1995032975A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232299B1 (en) * 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
AU758241B2 (en) * 1998-03-13 2003-03-20 University Of British Columbia, The Granulatimide derivatives for use in cancer treatment
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
GB9903547D0 (en) 1999-02-16 1999-04-07 Novartis Ag Organic compounds
CA2379035A1 (en) 1999-07-13 2001-01-18 Shiro Akinaga Staurosporin derivatives
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
JO2897B1 (en) * 2004-11-05 2015-09-15 نوفارتيس ايه جي Organic compounds
CN101237873A (en) * 2005-08-09 2008-08-06 美因茨约翰内斯古滕贝格大学 Staurosporine derivatives for the treatment of non-small cell lung cancer
ES2611486T3 (en) 2014-05-30 2017-05-09 Entrechem, S.L. Antitumor activity of multiple kinase inhibitors in triple negative breast cancer
CN108299467B (en) * 2018-02-27 2020-04-28 中国海洋大学 Indolecarbazole alkaloids with cytotoxic activity and preparation method and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383919A4 (en) * 1988-02-04 1992-08-05 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives
JPH03220194A (en) * 1989-11-30 1991-09-27 Asahi Chem Ind Co Ltd Staurosporine carboxylic acid derivative
JPH04145085A (en) * 1990-09-25 1992-05-19 Asahi Chem Ind Co Ltd Gamma-lactam ring derivative of staurosporin and ammonium salt thereof
ES2171416T3 (en) * 1992-09-21 2002-09-16 Kyowa Hakko Kogyo Kk REMEDY AGAINST THROMBOCITOPENIA.
WO1994020106A1 (en) * 1993-03-03 1994-09-15 Kyowa Hakko Kogyo Co., Ltd. Sensitivity enhancer for antineoplastic agent
WO1995000520A1 (en) * 1993-06-17 1995-01-05 Ciba-Geigy Ag Indolocarbazole compound useful as proteinkinase c inhibitor

Also Published As

Publication number Publication date
WO1995032975A1 (en) 1995-12-07
JPH10501527A (en) 1998-02-10
EP0763041A1 (en) 1997-03-19

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