AU2542501A - Pyrido(2,3-d)pyrimidine-2,7-diamine kinase inhibitors - Google Patents

Pyrido(2,3-d)pyrimidine-2,7-diamine kinase inhibitors Download PDF

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Publication number: AU2542501A
Authority: AU; Australia
Prior art keywords: urea; pyrido; pyrimidin; piperazin; phenylamino
Prior art date: 2000-01-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU25425/01A

Other languages

English (en)

Inventor

Richard John Booth

Ellen Myra Dobrusin

Vara Prasad Venkata Nagendra Josyula

Dennis Joseph Mcnamara

Peter Laurence Toogood

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2001-08-07

2001-01-23 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2001-08-07 Publication of AU2542501A publication Critical patent/AU2542501A/en

Status Abandoned legal-status Critical Current

Links

QRRCMVPZJCHBLQ-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine-2,7-diamine Chemical compound C1=NC(N)=NC2=NC(N)=CC=C21 QRRCMVPZJCHBLQ-UHFFFAOYSA-N 0.000 title description 3
229940043355 kinase inhibitor Drugs 0.000 title description 2
239000003757 phosphotransferase inhibitor Substances 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 148
239000004202 carbamide Substances 0.000 claims description 145
125000000217 alkyl group Chemical group 0.000 claims description 62
229910052736 halogen Inorganic materials 0.000 claims description 48
150000002367 halogens Chemical class 0.000 claims description 48
-1 nitro, carboxy Chemical group 0.000 claims description 45
238000000034 method Methods 0.000 claims description 41
239000001257 hydrogen Substances 0.000 claims description 37
229910052739 hydrogen Inorganic materials 0.000 claims description 37
150000002148 esters Chemical class 0.000 claims description 31
125000004093 cyano group Chemical group *C#N 0.000 claims description 30
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 30
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 29
125000001072 heteroaryl group Chemical group 0.000 claims description 27
125000000623 heterocyclic group Chemical group 0.000 claims description 25
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 25
125000003545 alkoxy group Chemical group 0.000 claims description 24
150000003839 salts Chemical class 0.000 claims description 24
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 23
125000003118 aryl group Chemical group 0.000 claims description 23
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
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125000000304 alkynyl group Chemical group 0.000 claims description 15
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239000000651 prodrug Substances 0.000 claims description 15
229940002612 prodrug Drugs 0.000 claims description 15
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CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 12
125000002837 carbocyclic group Chemical group 0.000 claims description 12
230000002401 inhibitory effect Effects 0.000 claims description 11
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230000001404 mediated effect Effects 0.000 claims description 9
229910052760 oxygen Inorganic materials 0.000 claims description 9
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125000004448 alkyl carbonyl group Chemical group 0.000 claims description 8
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
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125000005143 heteroarylsulfonyl group Chemical group 0.000 claims description 6
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
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NHOWDZOIZKMVAI-UHFFFAOYSA-N (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol Chemical compound C=1N=CN=CC=1C(C=1C(=CC=CC=1)Cl)(O)C1=CC=C(Cl)C=C1 NHOWDZOIZKMVAI-UHFFFAOYSA-N 0.000 claims description 2
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ZOUYYHCVTKXASL-UHFFFAOYSA-N 1-[2-[4-(4-acetylpiperazin-1-yl)-3-chloroanilino]pyrido[2,3-d]pyrimidin-7-yl]-3-(2-hydroxyethyl)urea Chemical compound C1CN(C(=O)C)CCN1C(C(=C1)Cl)=CC=C1NC1=NC=C(C=CC(NC(=O)NCCO)=N2)C2=N1 ZOUYYHCVTKXASL-UHFFFAOYSA-N 0.000 claims description 2
DWKOQXAXRXLTRO-UHFFFAOYSA-N 1-[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-methylpyrido[2,3-d]pyrimidin-7-yl]-3-(2-hydroxyethyl)urea Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1NC1=NC=C(C(C)=CC(NC(=O)NCCO)=N2)C2=N1 DWKOQXAXRXLTRO-UHFFFAOYSA-N 0.000 claims description 2
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KNWWGBNAUNTSRV-UHFFFAOYSA-N 4-methylpiperazine-1-carboxylic acid Chemical compound CN1CCN(C(O)=O)CC1 KNWWGBNAUNTSRV-UHFFFAOYSA-N 0.000 claims description 2
239000003937 drug carrier Substances 0.000 claims description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
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108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
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JYSYXVGVSGEKJX-UHFFFAOYSA-N 1-[2-(3-chloro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-yl]-3-(2-hydroxyethyl)urea Chemical compound N=1C2=NC(NC(=O)NCCO)=CC=C2C=NC=1NC(C=C1Cl)=CC=C1N1CCNCC1 JYSYXVGVSGEKJX-UHFFFAOYSA-N 0.000 claims 1
CSHJWZUPBIECMW-UHFFFAOYSA-N 1-[2-(dimethylamino)ethyl]-3-[2-(4-fluoroanilino)pyrido[2,3-d]pyrimidin-7-yl]urea Chemical compound N=1C2=NC(NC(=O)NCCN(C)C)=CC=C2C=NC=1NC1=CC=C(F)C=C1 CSHJWZUPBIECMW-UHFFFAOYSA-N 0.000 claims 1
MPKZVSBVKJFRCB-UHFFFAOYSA-N 1-[2-[4-(4-acetylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea Chemical compound N=1C2=NC(NC(=O)NCC)=CC=C2C=NC=1NC(C=C1)=CC=C1N1CCN(C(C)=O)CC1 MPKZVSBVKJFRCB-UHFFFAOYSA-N 0.000 claims 1
BMTGASBFAFZLBO-UHFFFAOYSA-N 1-cyclohexyl-3-[2-[4-(3,3-dimethylpiperazin-1-yl)anilino]-6-fluoropyrido[2,3-d]pyrimidin-7-yl]urea Chemical compound C1CNC(C)(C)CN1C(C=C1)=CC=C1NC1=NC=C(C=C(F)C(NC(=O)NC2CCCCC2)=N2)C2=N1 BMTGASBFAFZLBO-UHFFFAOYSA-N 0.000 claims 1
ZTIAGQKFXYSPQF-KDURUIRLSA-N 1-cyclohexyl-3-[2-[4-[(3s,5r)-3,5-dimethylpiperazin-1-yl]anilino]-6-methylpyrido[2,3-d]pyrimidin-7-yl]urea Chemical compound C1[C@@H](C)N[C@@H](C)CN1C(C=C1)=CC=C1NC1=NC=C(C=C(C)C(NC(=O)NC2CCCCC2)=N2)C2=N1 ZTIAGQKFXYSPQF-KDURUIRLSA-N 0.000 claims 1
CZKTXARZWICZDX-IYBDPMFKSA-N 1-cyclopropyl-3-[2-[4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]anilino]-6-methylpyrido[2,3-d]pyrimidin-7-yl]urea Chemical compound C1[C@@H](C)N[C@@H](C)CN1C(C=C1)=CC=C1NC1=NC=C(C=C(C)C(NC(=O)NC2CC2)=N2)C2=N1 CZKTXARZWICZDX-IYBDPMFKSA-N 0.000 claims 1
PMFGZMVIXFORHF-UHFFFAOYSA-N 1-ethyl-3-[2-(4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-yl]urea Chemical compound N=1C2=NC(NC(=O)NCC)=CC=C2C=NC=1NC(C=C1)=CC=C1N1CCNCC1 PMFGZMVIXFORHF-UHFFFAOYSA-N 0.000 claims 1
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230000000699 topical effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
125000006000 trichloroethyl group Chemical group 0.000 description 1
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
231100000588 tumorigenic Toxicity 0.000 description 1
230000000381 tumorigenic effect Effects 0.000 description 1
208000010576 undifferentiated carcinoma Diseases 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
208000010570 urinary bladder carcinoma Diseases 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
229910000166 zirconium phosphate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

AU25425/01A 2000-01-25 2001-01-23 Pyrido(2,3-d)pyrimidine-2,7-diamine kinase inhibitors Abandoned AU2542501A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
US60178261		2000-01-25
PCT/IB2001/000069 WO2001055147A1 (en)	2000-01-25	2001-01-23	PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
AU2542501A true AU2542501A (en)	2001-08-07

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU25425/01A Abandoned AU2542501A (en)	2000-01-25	2001-01-23	Pyrido(2,3-d)pyrimidine-2,7-diamine kinase inhibitors

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (es)
JP (1)	JP4047010B2 (es)
KR (1)	KR20020065939A (es)
CN (1)	CN1395578A (es)
AP (1)	AP2002002586A0 (es)
AR (1)	AR030044A1 (es)
AU (1)	AU2542501A (es)
BG (1)	BG106850A (es)
BR (1)	BR0107751A (es)
CA (1)	CA2397961C (es)
CO (1)	CO5261549A1 (es)
CR (1)	CR6706A (es)
CZ (1)	CZ20022475A3 (es)
DZ (1)	DZ3266A1 (es)
EA (1)	EA200200643A1 (es)
EE (1)	EE200200405A (es)
GT (1)	GT200100016A (es)
HN (1)	HN2001000013A (es)
HU (1)	HUP0204141A3 (es)
IL (1)	IL150545A0 (es)
IS (1)	IS6443A (es)
MA (1)	MA26868A1 (es)
MX (1)	MXPA02007221A (es)
NO (1)	NO20023527L (es)
OA (1)	OA12161A (es)
PA (1)	PA8510701A1 (es)
PE (1)	PE20011066A1 (es)
PL (1)	PL356802A1 (es)
SK (1)	SK10632002A3 (es)
SV (1)	SV2002000294A (es)
TN (1)	TNSN01014A1 (es)
WO (1)	WO2001055147A1 (es)
YU (1)	YU50402A (es)
ZA (1)	ZA200205879B (es)

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US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
AU2002246855B2 (en)	2000-10-23	2005-12-22	Smithkline Beecham Corporation	Novel compounds
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
ATE370952T1 (de)	2002-04-19	2007-09-15	Smithkline Beecham Corp	Neue verbindungen
BR0316680A (pt) *	2002-11-28	2005-10-18	Schering Ag	Pirimidinas inibidoras de chk, pdk e akt, sua produção e uso como agentes farmacêuticos
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en) *	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
CN101014600A (zh) *	2004-09-21	2007-08-08	霍夫曼-拉罗奇有限公司	用作蛋白激酶抑制剂的6－(2－烷基－苯基)－吡啶并[2,3－d]嘧啶类
WO2006104917A2 (en)	2005-03-25	2006-10-05	Glaxo Group Limited	Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives
JP2008535822A (ja)	2005-03-25	2008-09-04	グラクソグループリミテッド	新規化合物
AR053346A1 (es)	2005-03-25	2007-05-02	Glaxo Group Ltd	Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
TW200724142A (en)	2005-03-25	2007-07-01	Glaxo Group Ltd	Novel compounds
FR2887882B1 (fr) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
BRPI0613604A2 (pt) *	2005-07-21	2011-01-18	Hoffmann La Roche	compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de ptp-1b, e utilização dos compostos
ES2351939T3 (es) *	2005-08-09	2011-02-14	Irm Llc	Compuestos y composiciones como inhibidores de proteínas cinasas.
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr) *	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
MX2011005720A (es) *	2008-12-01	2011-06-17	Merck Patent Gmbh	Pirido [4,3-d] pirimidinas 2,5-diamino sustituidas como inhibidores de autotaxina contra cancer.
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
WO2014151682A1 (en) *	2013-03-14	2014-09-25	Icahn School Of Medicine At Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

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GEP20012444B (en) *	1994-11-14	2001-05-25	Warner Lambert Company Us	6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
DE69939168D1 (de) *	1998-05-26	2008-09-04	Warner Lambert Co	Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung

2001
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Application Discontinuation
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Application Discontinuation
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CR6706A (es)	2005-04-04
WO2001055147A1 (en)	2001-08-02
PE20011066A1 (es)	2001-10-22
MXPA02007221A (es)	2002-11-29
BR0107751A (pt)	2002-11-12
HUP0204141A3 (en)	2005-03-29
KR20020065939A (ko)	2002-08-14
TNSN01014A1 (fr)	2005-11-10
AP2002002586A0 (en)	2002-09-30
PL356802A1 (en)	2004-07-12
BG106850A (bg)	2003-02-28
OA12161A (en)	2006-05-08
IL150545A0 (en)	2003-02-12
NO20023527L (no)	2002-09-10
EE200200405A (et)	2003-12-15
HN2001000013A (es)	2001-06-18
PA8510701A1 (es)	2002-12-11
IS6443A (is)	2002-06-25
CA2397961C (en)	2008-08-26
DZ3266A1 (fr)	2001-08-02
EP1254137A1 (en)	2002-11-06
EA200200643A1 (ru)	2002-12-26
NO20023527D0 (no)	2002-07-24
CZ20022475A3 (cs)	2003-03-12
CN1395578A (zh)	2003-02-05
GT200100016A (es)	2001-10-19
SV2002000294A (es)	2002-07-16
JP2003523357A (ja)	2003-08-05
CO5261549A1 (es)	2003-03-31
JP4047010B2 (ja)	2008-02-13
AR030044A1 (es)	2003-08-13
HUP0204141A2 (hu)	2003-04-28
ZA200205879B (en)	2003-09-29
MA26868A1 (fr)	2004-12-20
CA2397961A1 (en)	2001-08-02
SK10632002A3 (sk)	2003-06-03
YU50402A (sh)	2005-11-28

Publication	Publication Date	Title
AU2542501A (en)	2001-08-07	Pyrido(2,3-d)pyrimidine-2,7-diamine kinase inhibitors
US7053070B2 (en)	2006-05-30	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
AU777468B2 (en)	2004-10-21	Pteridinones as kinase inhibitors
CA2329703C (en)	2005-12-20	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
EP0964864B1 (en)	2008-04-09	Pyrido 2,3-d pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
US7208489B2 (en)	2007-04-24	2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones
US20090312321A1 (en)	2009-12-17	Compositions and methods for fgf receptor kinases inhibitors
US20040044012A1 (en)	2004-03-04	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
SK141097A3 (en)	1998-07-08	Pyrido[2,3-d]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
KR20020075805A (ko)	2002-10-05	5-알킬피리도[2,3-ｄ]피리미딘 타이로신 카이나제 억제제
MXPA04001191A (es)	2005-02-17	Derivados de 4-amino-6-fenil-pirrolo[2,3-d]pirimidina.
KR20060127947A (ko)	2006-12-13	증식성 질환의 치료에 유용한 피롤로 피리미딘 유도체
OA11554A (en)	2004-06-03	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation.
EP1801112A1 (en)	2007-06-27	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
CZ20004246A3 (cs)	2001-04-11	Bicyklické pyrimidiny a bicyklické 3,4- dihydropyrimidiny jako inhibitory buněčné proliferace

Legal Events

Date	Code	Title	Description
2002-02-28	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
2002-07-18	TH	Corrigenda	Free format text: IN VOL 16, NO 5, PAGE(S) 912-919 UNDER THE HEADING APPLICATIONS LAPSED, REFUSED OR WITHDRAWN PLEASE DELETE ALL REFERENCE TO APPLICATION NO. 18549/00, 25425/01 AND 31890/01