[go: up one dir, main page]

AU2003302740A1 - Methods of diagnosis and treatment of interstitial lung disease - Google Patents

Methods of diagnosis and treatment of interstitial lung disease Download PDF

Info

Publication number
AU2003302740A1
AU2003302740A1 AU2003302740A AU2003302740A AU2003302740A1 AU 2003302740 A1 AU2003302740 A1 AU 2003302740A1 AU 2003302740 A AU2003302740 A AU 2003302740A AU 2003302740 A AU2003302740 A AU 2003302740A AU 2003302740 A1 AU2003302740 A1 AU 2003302740A1
Authority
AU
Australia
Prior art keywords
gene
protein
mammal
nucleic acid
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003302740A
Other languages
English (en)
Inventor
Stephan W. Glasser
Jeffrey A. Whitsett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Original Assignee
Cincinnati Childrens Hospital Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center filed Critical Cincinnati Childrens Hospital Medical Center
Publication of AU2003302740A1 publication Critical patent/AU2003302740A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785Alveolar surfactant peptides; Pulmonary surfactant peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003302740A 2002-12-09 2003-12-09 Methods of diagnosis and treatment of interstitial lung disease Abandoned AU2003302740A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43194902P 2002-12-09 2002-12-09
US60/431,949 2002-12-09
PCT/US2003/038915 WO2004056310A2 (en) 2002-12-09 2003-12-09 Methods of diagnosis and treatment of interstitial lung disease

Publications (1)

Publication Number Publication Date
AU2003302740A1 true AU2003302740A1 (en) 2004-07-14

Family

ID=32681947

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003302740A Abandoned AU2003302740A1 (en) 2002-12-09 2003-12-09 Methods of diagnosis and treatment of interstitial lung disease

Country Status (7)

Country Link
EP (1) EP1589980A4 (pt)
JP (1) JP2006519588A (pt)
CN (1) CN100401896C (pt)
AU (1) AU2003302740A1 (pt)
BR (1) BR0317132A (pt)
CA (1) CA2507613A1 (pt)
WO (1) WO2004056310A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009183176A (ja) * 2008-02-05 2009-08-20 Univ Of Tokyo Il−1タイプiiレセプター遺伝子の欠損変異体マウス
EP2391379B1 (en) 2009-01-30 2017-08-02 Alphabeta AB Compound and method for treatment of alzheimer's disease
WO2011162655A1 (en) 2010-06-24 2011-12-29 Alphabeta Ab Compound and method for treatment of alzheimer's disease and familial dementia
JP6227523B2 (ja) 2011-04-05 2017-11-08 アルファベータ・エービーAlphaBeta AB 治療の方法においておよび化合物のスクリーニングのために有用なアミロドーシスターゲット
US20170296595A1 (en) * 2014-09-18 2017-10-19 North Carolina State University Mammalian Lung Spheroids and Lung Spheroid Cells and Uses Thereof
CN111972354B (zh) * 2019-05-24 2021-11-30 凯斯艾生物科技(苏州)有限公司 一种具有自身免疫特征的间质性肺炎模型的构建方法
CN111296364B (zh) * 2019-10-27 2022-06-24 上海莱士血液制品股份有限公司 一种基因改造的小鼠动物模型基因改造方法及其应用
DK3811777T3 (da) 2019-10-27 2024-09-02 Shanghai Raas Blood Products Co Ltd Genetisk modificerede ikke-humane dyr humaniseret til protein c
AU2021251208A1 (en) * 2020-04-08 2022-11-10 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating and preventing lung disease
CN115772539B (zh) * 2022-11-17 2024-06-21 南京医科大学 一种具有ⅰ型气管发育不全表型的双侧肺脏缺失小鼠模型及其构建方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0164235B1 (ko) * 1993-01-13 1999-01-15 도바 다다스 신규한 세포 표층 단백질
US6020307A (en) * 1997-04-25 2000-02-01 Ony, Inc. Compositions and methods for isolating lung surfactant hydrophobic proteins SP-B and SP-C
US20030221199A1 (en) * 1998-10-20 2003-11-27 Whitsett Jeffrey A. Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
US6838428B2 (en) * 1998-10-20 2005-01-04 Children's Hospital Medical Center Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
IT1308180B1 (it) * 1999-02-12 2001-12-07 Chiesi Farma Spa Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante
EP1189625A1 (en) * 1999-06-11 2002-03-27 Byk Gulden Lomberg Chemische Fabrik GmbH Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)

Also Published As

Publication number Publication date
CN100401896C (zh) 2008-07-16
BR0317132A (pt) 2005-10-25
CN1731932A (zh) 2006-02-08
EP1589980A2 (en) 2005-11-02
WO2004056310A3 (en) 2005-09-01
JP2006519588A (ja) 2006-08-31
CA2507613A1 (en) 2004-07-08
WO2004056310A2 (en) 2004-07-08
EP1589980A4 (en) 2007-04-04

Similar Documents

Publication Publication Date Title
US6187992B1 (en) Transgenic mouse having a disrupted amyloid precursor protein gene
Clark et al. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.
Beers et al. Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene
AU2003302740A1 (en) Methods of diagnosis and treatment of interstitial lung disease
US6437216B1 (en) Transgenic models of inflammatory disease
US6452065B2 (en) Transgenic mouse expressing non-native wild-type and familial Alzheimer's Disease mutant presenilin 1 protein on native presenilin 1 null background
US20060078558A1 (en) Diagnosis, prognosis and treatment of pulmonary diseases
US20130237441A1 (en) Mig-6 Knockout Mice and Elucidation of Association of Mig-6 With Early Onset Degenerative Joint Disease and Role As A Tumor Suppressor
US20050125851A1 (en) Methods of diagnosis and treatment of interstitial lung disease
WO1998019714A1 (en) Mouse lacking heart-muscle adenine nucleotide translocator protein and methods
JP2001523467A (ja) 炎症性疾患のトランスジェニックモデル
US20060064765A1 (en) Obesity gene
Valleix et al. Expression of human F8B, a gene nested within the coagulation factor VIII gene, produces multiple eye defects and developmental alterations in chimeric and transgenic mice
US6448468B1 (en) Transgenetic mouse which comprises an inactive Peg3 gene, and the use thereof
JP5046413B2 (ja) ヒトfadプレセニリン突然変異をもつ標的遺伝子組換え非ヒト哺乳動物および生殖による子孫
JP4749860B2 (ja) 条件的自食作用欠損動物及び疾患モデル動物
Glasser et al. Genetically engineered mice in understanding the basis of neonatal lung disease
US5850002A (en) Animal models for loss and gain of Hox11 function
JP2001017028A (ja) アポeヒト化哺乳動物
WO1996017926A1 (en) Transgenic animal lacking native amyloid precursor protein
JPH10298100A (ja) インスリン抵抗性に起因する疾患の予防及び/又は治療剤
US6028244A (en) Defective platelet activation in Gαq deficient mice
MXPA00004597A (en) Transgenic models of inflammatory disease
Saunders et al. Elizabeth J. Adams, Rami Khoriaty 2, 3, Anna Kiseleva, Audrey CA Cleuren, Kärt Tomberg, Martijn A. van der Ent 3, Peter Gergics 4, K. Sue O’Shea 5, Thomas
WEAVER et al. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failurein newborn mice

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application