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AU2003275630B2 - Heterocyclic compounds and antitumor agent comprising the same as effective component - Google Patents

Heterocyclic compounds and antitumor agent comprising the same as effective component Download PDF

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Publication number
AU2003275630B2
AU2003275630B2 AU2003275630A AU2003275630A AU2003275630B2 AU 2003275630 B2 AU2003275630 B2 AU 2003275630B2 AU 2003275630 A AU2003275630 A AU 2003275630A AU 2003275630 A AU2003275630 A AU 2003275630A AU 2003275630 B2 AU2003275630 B2 AU 2003275630B2
Authority
AU
Australia
Prior art keywords
chloro
compound
amino
triazine
morpholino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003275630A
Other languages
English (en)
Other versions
AU2003275630A1 (en
Inventor
Seiichiro Kawashima
Toshiyuki Matsuno
Kenichi Saitoh
Hiroya Sasahara
Yoshio Tsuchida
Tetsuo Watanabe
Shinichi Yaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Publication of AU2003275630A1 publication Critical patent/AU2003275630A1/en
Application granted granted Critical
Publication of AU2003275630B2 publication Critical patent/AU2003275630B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2003275630A 2002-10-25 2003-10-24 Heterocyclic compounds and antitumor agent comprising the same as effective component Ceased AU2003275630B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002-311086 2002-10-25
JP2002311086 2002-10-25
PCT/JP2003/013589 WO2004037812A1 (ja) 2002-10-25 2003-10-24 複素環式化合物及びそれを有効成分とする抗腫瘍剤

Publications (2)

Publication Number Publication Date
AU2003275630A1 AU2003275630A1 (en) 2004-05-13
AU2003275630B2 true AU2003275630B2 (en) 2010-02-18

Family

ID=32171070

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003275630A Ceased AU2003275630B2 (en) 2002-10-25 2003-10-24 Heterocyclic compounds and antitumor agent comprising the same as effective component

Country Status (10)

Country Link
US (1) US7153853B2 (da)
EP (1) EP1557415B1 (da)
JP (1) JP4493503B2 (da)
KR (1) KR101046015B1 (da)
CN (1) CN100402523C (da)
AU (1) AU2003275630B2 (da)
CA (1) CA2503451C (da)
DK (1) DK1557415T3 (da)
ES (1) ES2389253T3 (da)
WO (1) WO2004037812A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088112A1 (fr) 2001-04-27 2002-11-07 Zenyaku Kogyo Kabushiki Kaisha Compose heterocyclique et agent antitumoral contenant ce dernier en tant qu'ingredient actif
CN100402523C (zh) 2002-10-25 2008-07-16 全药工业株式会社 杂环化合物及以其为有效成分的抗肿瘤药
KR101130913B1 (ko) * 2004-03-31 2012-03-28 젠야쿠코교가부시키가이샤 헤테로시클릭 화합물 및 이를 활성 성분으로서 포함하는항악성종양제
GB0415364D0 (en) * 2004-07-09 2004-08-11 Astrazeneca Ab Pyrimidine derivatives
PL1864665T3 (pl) * 2005-03-11 2012-10-31 Zenyaku Kogyo Kk Środek immunosupresyjny obejmujący związek heterocykliczny jako składnik aktywny
US20070244110A1 (en) * 2006-04-14 2007-10-18 Zenyaku Kogyo Kabushiki Kaisha Treatment of prostate cancer, melanoma or hepatic cancer
US20080065746A1 (en) * 2006-09-07 2008-03-13 Ace*Comm Corporation Consumer configurable mobile communication web filtering solution
WO2008032060A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders
WO2008032077A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab Pyrimidine derivatives
WO2008032086A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 2-benzimidazolyl-6-morpholino-4-phenylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
WO2008032033A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
WO2008032027A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab Pyrimidine derivatives
WO2008032064A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab Pyrimidine derivatives
EP2069330A1 (en) * 2006-09-14 2009-06-17 AstraZeneca AB 2 -benzimidazolyl- 6 -morpholino-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
AU2008327095B2 (en) * 2007-11-22 2013-07-25 Ohara Pharmaceutical Co., Ltd. Amorphous form of heterocyclic compound, solid dispersion and medicinal preparation each comprising the same, and process for production of the same
JP2011515462A (ja) * 2008-03-27 2011-05-19 アウククランド ウニセルビセス リミテッド 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用
TWI378933B (en) 2008-10-14 2012-12-11 Daiichi Sankyo Co Ltd Morpholinopurine derivatives
HUP0800768A2 (en) 2008-12-18 2012-08-28 Bioblocks Magyarorszag Gyogyszerkemiai Es Fejlesztoe Kft 1,3-heterocycles condensed with monoterpene skeleton, their use and pharmaceutical compositions comprising such compounds
KR20110120286A (ko) 2009-02-12 2011-11-03 아스텔라스세이야쿠 가부시키가이샤 헤테로환 유도체
WO2010110686A1 (en) 2009-03-27 2010-09-30 Pathway Therapeutics Limited Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
AR075974A1 (es) 2009-03-27 2011-05-11 Pathway Therapeutics Ltd Pirimidinil y 1,3,5-triazinilbencimidazolsulfonamidas y su uso en terapia del cancer
ES2706185T3 (es) * 2009-07-07 2019-03-27 Mei Pharma Inc Pirimidinil y 1,3,5-triazinil bencimidazoles y sus usos en la terapia contra el cáncer
KR101759762B1 (ko) 2010-08-10 2017-07-19 아스텔라스세이야쿠 가부시키가이샤 헤테로환 화합물
ES2608967T3 (es) 2011-03-28 2017-04-17 Mei Pharma, Inc. (Aralquilamino sustituido en alfa y heteroarilalquilamino)pirimidinil y 1,3,5-triazinil benzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para usar en el tratamiento de enfermedades proliferativas
JPWO2018131659A1 (ja) * 2017-01-11 2019-12-12 国立研究開発法人国立がん研究センター 免疫療法剤
CN110996959A (zh) 2017-05-23 2020-04-10 梅制药公司 联合疗法
MA49921A (fr) 2017-08-14 2021-05-12 Mei Pharma Inc Polythérapie

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002253619B2 (en) * 2001-04-27 2007-05-17 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same active ingredients

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0629622B1 (en) * 1992-02-28 1998-11-11 Zenyaku Kogyo Kabushikikaisha S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient
DE69821633T2 (de) * 1997-07-24 2004-12-16 Zenyaku Kogyo K.K. Heterozyklische verbindungen und antitumormittel, das diese als aktiven wirkstoff enthält
WO2000043385A1 (fr) 1999-01-25 2000-07-27 Zenyaku Kogyo Kabushiki Kaisha Composes heterocycliques et agents antitumoraux les comprenant en tant que principe actif
CN100402523C (zh) 2002-10-25 2008-07-16 全药工业株式会社 杂环化合物及以其为有效成分的抗肿瘤药

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002253619B2 (en) * 2001-04-27 2007-05-17 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same active ingredients

Also Published As

Publication number Publication date
ES2389253T3 (es) 2012-10-24
WO2004037812A1 (ja) 2004-05-06
KR20050056267A (ko) 2005-06-14
CA2503451C (en) 2011-07-12
CN1708495A (zh) 2005-12-14
US20060009440A1 (en) 2006-01-12
EP1557415A1 (en) 2005-07-27
JP4493503B2 (ja) 2010-06-30
CN100402523C (zh) 2008-07-16
JPWO2004037812A1 (ja) 2006-02-23
AU2003275630A1 (en) 2004-05-13
CA2503451A1 (en) 2004-05-06
KR101046015B1 (ko) 2011-07-01
US7153853B2 (en) 2006-12-26
EP1557415B1 (en) 2012-06-06
EP1557415A4 (en) 2011-02-23
HK1086830A1 (zh) 2006-09-29
DK1557415T3 (da) 2012-09-17

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ HETEROCYCLIC COMPOUNDS AND ANTITUMOR AGENT COMPRISING THE SAME AS EFFECTIVE COMPONENT

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired