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AU2003256922A8 - Substituted heterocyclic compounds as modulators of the ccr5 receptor - Google Patents

Substituted heterocyclic compounds as modulators of the ccr5 receptor

Info

Publication number
AU2003256922A8
AU2003256922A8 AU2003256922A AU2003256922A AU2003256922A8 AU 2003256922 A8 AU2003256922 A8 AU 2003256922A8 AU 2003256922 A AU2003256922 A AU 2003256922A AU 2003256922 A AU2003256922 A AU 2003256922A AU 2003256922 A8 AU2003256922 A8 AU 2003256922A8
Authority
AU
Australia
Prior art keywords
modulators
substituted heterocyclic
heterocyclic compounds
ccr5 receptor
ccr5
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003256922A
Other versions
AU2003256922A1 (en
Inventor
William E Bondinell
Michael J Neeb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU2003256922A1 publication Critical patent/AU2003256922A1/en
Publication of AU2003256922A8 publication Critical patent/AU2003256922A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003256922A 2002-07-31 2003-07-28 Substituted heterocyclic compounds as modulators of the ccr5 receptor Abandoned AU2003256922A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40025602P 2002-07-31 2002-07-31
US60/400,256 2002-07-31
PCT/US2003/023523 WO2004010942A2 (en) 2002-07-31 2003-07-28 Substituted heterocyclic compounds as modulators of the ccr5 receptor

Publications (2)

Publication Number Publication Date
AU2003256922A1 AU2003256922A1 (en) 2004-02-16
AU2003256922A8 true AU2003256922A8 (en) 2004-02-16

Family

ID=31188673

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003256922A Abandoned AU2003256922A1 (en) 2002-07-31 2003-07-28 Substituted heterocyclic compounds as modulators of the ccr5 receptor

Country Status (2)

Country Link
AU (1) AU2003256922A1 (en)
WO (1) WO2004010942A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
JP2008501031A (en) 2004-05-28 2008-01-17 バーテックス　ファーマシューティカルズ　インコーポレイテッド Muscarinic receptor modulators
EP2364705A3 (en) 2004-08-19 2012-04-04 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7786141B2 (en) 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
US7863449B2 (en) 2004-11-29 2011-01-04 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP1988892A2 (en) 2006-02-22 2008-11-12 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP2040706A2 (en) 2006-06-29 2009-04-01 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
MY148657A (en) 2007-04-27 2013-05-15 Purdue Pharma Lp Trpv1 antagonists and uses thereof
CN103096893B (en) 2010-06-04 2016-05-04 阿尔巴尼分子研究公司 Glycine transporter-1 inhibitor, Its Preparation Method And Use
WO2012071369A2 (en) 2010-11-24 2012-05-31 The Trustees Of Columbia University In The City Of New York A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease
ES2620528T3 (en) 2011-06-22 2017-06-28 Purdue Pharma Lp TRPV1 antagonists that include a dihydroxy substituent and uses thereof
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
CN104662015B (en) 2012-06-20 2017-03-29 诺华股份有限公司 Complement pathway conditioning agent and application thereof
WO2014151959A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
US9637450B2 (en) 2013-03-14 2017-05-02 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
WO2014151936A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles, their preparation and use
WO2014152013A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York 4-phenylpiperidines, their preparation and use
MX2016014197A (en) 2014-04-30 2017-05-03 Univ Columbia Substituted 4-phenylpiperidines, their preparaiton and use.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002005819A1 (en) * 2000-07-15 2002-01-24 Smithkline Beecham Corporation Compounds and methods
ATE402169T1 (en) * 2000-08-18 2008-08-15 Millennium Pharm Inc QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS

Also Published As

Publication number Publication date
AU2003256922A1 (en) 2004-02-16
WO2004010942A2 (en) 2004-02-05
WO2004010942A3 (en) 2004-07-08

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase