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AU2002218029A1 - Modified factor viia - Google Patents

Modified factor viia

Info

Publication number
AU2002218029A1
AU2002218029A1 AU2002218029A AU1802902A AU2002218029A1 AU 2002218029 A1 AU2002218029 A1 AU 2002218029A1 AU 2002218029 A AU2002218029 A AU 2002218029A AU 1802902 A AU1802902 A AU 1802902A AU 2002218029 A1 AU2002218029 A1 AU 2002218029A1
Authority
AU
Australia
Prior art keywords
factor viia
modified factor
modified
viia
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002218029A
Inventor
Ramona J. Petrovan
Wolfram Ruf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of AU2002218029A1 publication Critical patent/AU2002218029A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU2002218029A 2000-11-09 2001-11-09 Modified factor viia Abandoned AU2002218029A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24758900P 2000-11-09 2000-11-09
US60247589 2000-11-09
PCT/US2001/047329 WO2002038162A1 (en) 2000-11-09 2001-11-09 MODIFIED FACTOR VIIa

Publications (1)

Publication Number Publication Date
AU2002218029A1 true AU2002218029A1 (en) 2002-05-21

Family

ID=22935495

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002218029A Abandoned AU2002218029A1 (en) 2000-11-09 2001-11-09 Modified factor viia

Country Status (3)

Country Link
US (1) US7173000B2 (en)
AU (1) AU2002218029A1 (en)
WO (1) WO2002038162A1 (en)

Families Citing this family (52)

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US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
EP1982732A3 (en) 2000-02-11 2011-06-08 Bayer HealthCare LLC Factor VII or VIIA-like conjugates
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6905683B2 (en) * 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
KR100882482B1 (en) 2000-09-13 2009-02-06 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Human Coagulation Factor VII Variants
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
EP1451315B1 (en) * 2001-11-02 2014-05-21 Novo Nordisk Health Care AG Human coagulation factor vii polypeptides
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
KR20040065278A (en) * 2001-12-21 2004-07-21 노보 노르디스크 에이/에스 Liquid composition of modified factor vii polypeptides
PL370652A1 (en) 2001-12-21 2005-05-30 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
NZ536340A (en) 2002-04-30 2006-09-29 Maxygen Holdings Ltd Factor VII or VIIa polypeptide variants with N-glycosylation
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
DK2283856T3 (en) 2002-06-21 2017-11-20 Novo Nordisk Healthcare Ag Stabilized solid compositions of Factor VIIa polypeptides
US6911323B2 (en) * 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
ATE505487T1 (en) 2002-09-30 2011-04-15 Bayer Healthcare Llc FVII OR FVIIA VARIANTS WITH INCREASED COAGULATION EFFECT
AU2004222625A1 (en) * 2003-03-18 2004-09-30 Novo Nordisk Health Care Ag Liquid, aqueous, pharmaceutical compositions of factor VII polypeptides
EP1611236A1 (en) 2003-03-18 2006-01-04 Novo Nordisk Health Care AG Method for the production of gla-residue containing serine proteases
ES2327044T3 (en) 2003-03-20 2009-10-23 Bayer Healthcare Llc VARIATIONS OF FVII OR FVIIA.
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
JP5627832B2 (en) * 2003-05-23 2014-11-19 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Stabilization of proteins in solution
WO2004111242A1 (en) 2003-06-19 2004-12-23 Maxygen Holdings Ltd. FACTOR VII OR VIIa GLA DOMAIN VARIANTS
ES2335994T3 (en) * 2003-07-01 2010-04-07 Novo Nordisk Health Care Ag PHARMACEUTICAL, LIQUID, WATERPROOF POLYPEPTIDE COMPOSITION FACTOR VII.
ES2574581T3 (en) 2003-08-14 2016-06-20 Novo Nordisk Health Care Ag Aqueous liquid pharmaceutical composition of Factor VII polypeptides
EP1664291B1 (en) * 2003-09-09 2012-02-29 Novo Nordisk Health Care AG Coagulation factor vii polypeptides
CN101870729A (en) 2003-09-09 2010-10-27 诺和诺德医疗保健公司 Coagulation factor vii polypeptides
EP2275432A1 (en) 2003-12-01 2011-01-19 Novo Nordisk Health Care AG Nanofiltration of factor VII solutions to remove virus
AU2004298789A1 (en) 2003-12-19 2005-06-30 Novo Nordisk Health Care Ag Stabilised compositions of factor VII polypeptides
ES2397241T3 (en) 2004-01-21 2013-03-05 Novo Nordisk Health Care Ag Conjugation of peptides by transglutaminase
DK1781782T3 (en) 2004-08-17 2010-08-23 Csl Behring Gmbh Modified vitamin K-dependent polypeptides
EP2360171A1 (en) 2004-12-23 2011-08-24 Novo Nordisk Health Care AG Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest
EP1893632B1 (en) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
JP5147692B2 (en) 2005-07-13 2013-02-20 ノボ ノルディスク ヘルス ケア アーゲー Host cell protein knockout cells for the production of therapeutic proteins
WO2007037792A2 (en) * 2005-07-20 2007-04-05 Optimus Services, Llc Robotic floor cleaning with sterile, disposable cartridges
EP1924689B1 (en) 2005-09-01 2014-08-13 Novo Nordisk Health Care AG Hydrophobic interaction chromatography purification of factor vii polypeptides
WO2007031559A2 (en) 2005-09-14 2007-03-22 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
WO2007039475A1 (en) * 2005-09-21 2007-04-12 Novo Nordisk Health Care Ag Human coagulation factor vii polypeptides
EP2046372A2 (en) * 2006-07-17 2009-04-15 Novo Nordisk Health Care AG Factor viia analogues with increased activity for treating thrombocytopenia
ES2531934T3 (en) 2006-09-01 2015-03-20 Novo Nordisk Health Care Ag Modified glycoproteins
CA2683443A1 (en) 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypeptides and uses thereof
FR2917414B1 (en) * 2007-06-15 2012-07-13 Lab Francais Du Fractionnement MODIFIED HUMAN FACTOR VII / VIIA AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
HRP20171375T1 (en) 2007-12-27 2017-12-15 Baxalta GmbH STATION CULTURAL PROCEDURES
TWI538916B (en) 2008-04-11 2016-06-21 介控生化科技公司 Modified Factor VII polypeptide and use thereof
NZ597022A (en) 2009-06-09 2014-05-30 Prolong Pharmaceuticals Llc Hemoglobin compositions
JP2013533871A (en) 2010-06-30 2013-08-29 ノヴォ ノルディスク アー／エス Antibodies capable of specific binding to tissue factor pathway inhibitors
CA2828769A1 (en) 2011-03-02 2012-09-07 Novo Nordisk A/S Coagulation factor-targeting to tlt-1 on activated platelets
CA2838833A1 (en) 2011-06-10 2012-12-13 Biogen Idec Ma Inc. Pro-coagulant compounds and methods of use thereof
EP2906236A1 (en) 2012-10-10 2015-08-19 Novo Nordisk Health Care AG Liquid pharmaceutical composition of factor vii polypeptide
EP3833381B1 (en) 2019-08-15 2022-08-03 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration

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US130191A (en) * 1872-08-06 Improvement in revolving stereoscopes
US170863A (en) * 1875-12-07 Improvement in automatic fans
US96338A (en) * 1869-11-02 Improvement in ovens
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
DK323587D0 (en) 1987-06-25 1987-06-25 Novo Industri As PROTEIN
US5580560A (en) * 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
DE69131292T2 (en) * 1990-01-29 1999-09-30 Zymogenetics, Inc. ANTICOAGULATING PROTEINS
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
WO1994007515A1 (en) 1992-10-06 1994-04-14 The Scripps Research Institute Mutant tissue factor lacking factor vii activation activity
ES2169074T3 (en) 1993-05-21 2002-07-01 Novo Nordisk Healthcare Ag FACTOR VII MODIFIED TO INHIBIT THE VASCULAR RESENOSIS OR THE TANK DEPOSIT.
ES2195025T3 (en) 1995-12-01 2003-12-01 Genentech Inc FUSION PROTEINS OF A KUNITZ TISSULAR-DOMAIN FACTOR DOMAIN AS INHIBITORS OF THE FACTOR VIIA.
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
JPH1058966A (en) 1996-08-20 1998-03-03 Asahi Glass Co Ltd Window glass for vehicles with temporary fastening surface fastener and method of manufacturing the same
PT988056E (en) 1997-01-22 2003-09-30 Univ Texas METHODS AND COMPOSITIONS OF A TUMOR FACTOR FOR THE TREATMENT OF COAGULATION AND TUMORS
US5994296A (en) * 1998-03-05 1999-11-30 The Scripps Research Institute Human mutant tissue factor compositions useful as tissue factor antagonists
JP4451514B2 (en) 1999-08-24 2010-04-14 財団法人化学及血清療法研究所 Blood coagulation factor VII variant
EP1982732A3 (en) * 2000-02-11 2011-06-08 Bayer HealthCare LLC Factor VII or VIIA-like conjugates
WO2001075086A2 (en) 2000-03-31 2001-10-11 Zymogenetics, Inc. Multi-domain proteinase inhibitor
ES2449224T3 (en) 2000-05-03 2014-03-18 Novo Nordisk Health Care Ag Subcutaneous administration of Coagulation Factor VII
US6905683B2 (en) * 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
EP1282693B1 (en) 2000-05-03 2010-10-20 Novo Nordisk Health Care AG Human coagulation factor vii variants
HUP0301868A3 (en) 2000-05-10 2006-11-28 Novo Nordisk Healthcare Ag Pharmaceutical composition comprising a factor viia and a factor xiii
EP2253703A1 (en) 2000-09-13 2010-11-24 Novo Nordisk Health Care AG Human coagulation factor VII variants
KR100882482B1 (en) * 2000-09-13 2009-02-06 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Human Coagulation Factor VII Variants
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
HUP0303130A2 (en) 2001-02-05 2004-01-28 Novo Nordisk Health Care Ag Combined use of factor vii polypeptides and factor viii polypeptides and pharmaceutical compositions containing them
EP1373493B1 (en) 2001-03-22 2013-07-31 Novo Nordisk Health Care AG Coagulation factor vii derivative
EP1432794B1 (en) 2001-09-27 2011-11-09 Novo Nordisk Health Care AG Human coagulation factor vii polypeptides
US6960657B2 (en) * 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides

Also Published As

Publication number Publication date
WO2002038162A1 (en) 2002-05-16
US7173000B2 (en) 2007-02-06
US20040033566A1 (en) 2004-02-19

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