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AU2001258349A1 - Bisacylguanidine - Google Patents

Bisacylguanidine

Info

Publication number
AU2001258349A1
AU2001258349A1 AU2001258349A AU5834901A AU2001258349A1 AU 2001258349 A1 AU2001258349 A1 AU 2001258349A1 AU 2001258349 A AU2001258349 A AU 2001258349A AU 5834901 A AU5834901 A AU 5834901A AU 2001258349 A1 AU2001258349 A1 AU 2001258349A1
Authority
AU
Australia
Prior art keywords
bisacylguanidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001258349A
Inventor
Dr. Norbert Beier
Rolf Gericke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2001258349A1 publication Critical patent/AU2001258349A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001258349A 2000-05-17 2001-04-19 Bisacylguanidine Abandoned AU2001258349A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10024319 2000-05-17
DE10024319A DE10024319A1 (en) 2000-05-17 2000-05-17 New bis-acylguanidine compounds are subtype-1 cellular sodium ion-proton antiporter inhibitors useful e.g. for treating arrhythmia, angina pectoris, infarction and insulin-independent diabetes mellitus
PCT/EP2001/004425 WO2001087829A1 (en) 2000-05-17 2001-04-19 Bisacylguanidine

Publications (1)

Publication Number Publication Date
AU2001258349A1 true AU2001258349A1 (en) 2001-11-26

Family

ID=7642487

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001258349A Abandoned AU2001258349A1 (en) 2000-05-17 2001-04-19 Bisacylguanidine

Country Status (3)

Country Link
AU (1) AU2001258349A1 (en)
DE (1) DE10024319A1 (en)
WO (1) WO2001087829A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1448515A2 (en) * 2001-11-29 2004-08-25 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
ES2295816T3 (en) 2003-01-14 2008-04-16 Arena Pharmaceuticals, Inc. ARILO AND HETEROARILO 1,2,3-TRISUSTITUTED DERIVATIVES AS METABOLISM MODULATORS, AND PROFILAXIS AND TREATMENT OF DISORDERS RELATED TO THE SAME, SUCH AS DIABETES AND HYPERGLUCEMIA.
US7132426B2 (en) 2003-07-14 2006-11-07 Arena Pharmaceuticals, Inc. Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
US7381841B2 (en) 2003-08-22 2008-06-03 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10338554A1 (en) * 2003-08-22 2005-03-31 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylphenyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
CN1968945A (en) 2004-06-16 2007-05-23 惠氏公司 Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase
CN1997646A (en) 2004-06-16 2007-07-11 惠氏公司 Diphenylimidazopyrimidinamines and diphenylimidazoimidazolamides as β-secretase inhibitors
CN101103034A (en) 2005-01-14 2008-01-09 惠氏公司 Amino-imidazolones that inhibit β-secretase
KR20070107062A (en) 2005-02-01 2007-11-06 와이어쓰 amino-pyridine as inhibitor of β-secretase
WO2006088705A1 (en) 2005-02-14 2006-08-24 Wyeth Terphenyl guanidines as [beta symbol] -secretase inhibitors
JP2008530103A (en) 2005-02-14 2008-08-07 ワイス Azolylacylguanidines as beta-secretase inhibitors
CN101213183A (en) 2005-06-30 2008-07-02 惠氏公司 Amino-5-(6-membered) heteroaryl imidazolone compounds and their use in the regulation of beta-secretase
TW200738683A (en) 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
KR20080050430A (en) 2005-09-26 2008-06-05 와이어쓰 Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as beta-secretase (CAC) inhibitors
WO2007100536A1 (en) 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
US7700606B2 (en) 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
AR065785A1 (en) * 2007-03-19 2009-07-01 Xenon Pharmaceuticals Inc BIARETO AND BIHETEROARILE COMPOUNDS OF UTILITY IN THE TREATMENT OF IRON DISORDERS
CL2008000791A1 (en) 2007-03-23 2008-05-30 Wyeth Corp COMPOUNDS DERIVED FROM 2-AMINO-5- (4-DIFLUOROMETOXI-FENIL) -5-FENIL-IMIDAZOLIDIN-4-ONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH EXCESSIVE BACE ACTIVITY, SUCH AS ILLNESS
EP2619198A1 (en) 2010-09-22 2013-07-31 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
PL3242666T3 (en) 2015-01-06 2025-02-17 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
JP6838744B2 (en) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド (R) -2- (7- (4-cyclopentyl-3- (trifluoromethyl) benzyloxy) -1,2,3,4-tetrahydrocyclopenta [b] indole-for use in S1P1 receptor-related disorders Crystalline L-arginine salt of 3-yl) acetic acid (Compound 1)
AU2018220521A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
KR102859841B1 (en) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. Treatment of conditions associated with the S1P1 receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3420874A (en) * 1962-09-28 1969-01-07 Standard Oil Co Amine addition salts of nitro-carboxyalkali metal phenolates
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4421536A1 (en) * 1994-06-20 1995-12-21 Hoechst Ag Phenyl-substituted alkenylcarboxylic acid guanidines bearing perfluoroalkyl groups, processes for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
DE59603311D1 (en) * 1995-01-30 1999-11-18 Hoechst Ag Basically substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
DE19527305A1 (en) * 1995-07-26 1997-01-30 Hoechst Ag Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament or diagnostic agent and medicament containing them
DE19603425A1 (en) * 1996-01-31 1997-08-07 Hoechst Ag Substituted diaryldicarboxylic acid diguanidides, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Also Published As

Publication number Publication date
WO2001087829A1 (en) 2001-11-22
DE10024319A1 (en) 2001-11-22

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