[go: up one dir, main page]

AU2001280767A1 - Peptide-mediated delivery of molecules into cells - Google Patents

Peptide-mediated delivery of molecules into cells

Info

Publication number
AU2001280767A1
AU2001280767A1 AU2001280767A AU8076701A AU2001280767A1 AU 2001280767 A1 AU2001280767 A1 AU 2001280767A1 AU 2001280767 A AU2001280767 A AU 2001280767A AU 8076701 A AU8076701 A AU 8076701A AU 2001280767 A1 AU2001280767 A1 AU 2001280767A1
Authority
AU
Australia
Prior art keywords
peptide
molecules
cells
mediated delivery
mediated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001280767A
Inventor
John Archdeacon
Gilles Divida
Joseph Fernandez
Frederic Heitz
Kyle Horndorp
Jean Mery
May Morris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Active Motif Inc
Original Assignee
Centre National de la Recherche Scientifique CNRS
Active Motif Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Active Motif Inc filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU2001280767A1 publication Critical patent/AU2001280767A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2001280767A 2000-07-31 2001-07-26 Peptide-mediated delivery of molecules into cells Abandoned AU2001280767A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22193200P 2000-07-31 2000-07-31
US60221932 2000-07-31
PCT/US2001/023406 WO2002010201A2 (en) 2000-07-31 2001-07-26 Peptide-mediated delivery of molecules into cells

Publications (1)

Publication Number Publication Date
AU2001280767A1 true AU2001280767A1 (en) 2002-02-13

Family

ID=22830020

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001280767A Abandoned AU2001280767A1 (en) 2000-07-31 2001-07-26 Peptide-mediated delivery of molecules into cells

Country Status (5)

Country Link
US (1) US6841535B2 (en)
EP (1) EP1305333A4 (en)
AU (1) AU2001280767A1 (en)
CA (1) CA2417454A1 (en)
WO (1) WO2002010201A2 (en)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495518B1 (en) * 1994-06-13 2002-12-17 Vanderbilt University Method for importing biologically active molecules into cells
US5807746A (en) * 1994-06-13 1998-09-15 Vanderbilt University Method for importing biologically active molecules into cells
US7790171B1 (en) * 2000-08-25 2010-09-07 Centre National De La Recherche Scientifique (C.N.R.S.) Antiviral peptides obtained from the tryptophan-rich hydrophobic cluster of the HIV-1 reverse transcriptase
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
EP1502949B1 (en) * 2002-04-25 2010-11-24 Toagosei Co., Ltd. Antimicrobial polypeptide and utilization thereof
AU2003233310A1 (en) * 2002-05-08 2003-11-11 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Agent and method for transporting biologically active molecules in cells
US7105347B2 (en) * 2002-07-30 2006-09-12 Corning Incorporated Method and device for protein delivery into cells
JP3996028B2 (en) * 2002-09-30 2007-10-24 株式会社日本触媒 Method for intracellular introduction of protein or peptide
CA2506714A1 (en) * 2002-11-26 2004-06-10 University Of Massachusetts Delivery of sirnas
FR2849603B1 (en) * 2003-01-07 2006-09-08 Centre Nat Rech Scient COMPOSITION FOR THE INTRACELLULAR TRANSPORT OF MACROMOLECULES OR BIOLOGICAL PARTICLES
JPWO2004078213A1 (en) * 2003-03-06 2006-06-08 千佳子 錦織 Target substance introduction composition and target substance introduction method
US7674771B2 (en) 2003-10-29 2010-03-09 Toagosei Co., Ltd Antimicrobial peptides and utilization of the same
WO2005047531A1 (en) * 2003-11-14 2005-05-26 Garvan Institute Of Medical Research Assay for pkc-beta activation of phosphorylation of myosin heavy chain polypeptide
US7691607B2 (en) * 2004-02-09 2010-04-06 The Regents Of The University Of California Expression system of NELL peptide
US7446099B2 (en) 2004-02-27 2008-11-04 Nitto Denko Corporation Compositions and methods for biodegradable polymer-peptide mediated transfection
US20060014289A1 (en) * 2004-04-20 2006-01-19 Nastech Pharmaceutical Company Inc. Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
US7514530B2 (en) * 2004-04-26 2009-04-07 Centre National De La Recherche Scientifique Peptide carrier for delivering siRNA into mammalian cells
US20060040882A1 (en) * 2004-05-04 2006-02-23 Lishan Chen Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
JP4507080B2 (en) 2004-07-30 2010-07-21 東亞合成株式会社 Antibacterial peptides and their use
JP4730584B2 (en) 2004-12-06 2011-07-20 東亞合成株式会社 Antibacterial peptides and their use
EP1864134A4 (en) * 2005-02-07 2010-10-20 Univ Columbia METHODS OF TREATING OR PREVENTING HORMONE-RESISTANT PROSTATE CANCER USING SMALL INTERFERING RNA SPECIFIC TO PROTOCADHERINE-PC, OR OTHER INHIBITORS OF PROTOCADHERINE-PC EXPRESSION OR ACTIVITY
ES2351942T3 (en) 2005-04-05 2011-02-14 Allergan Inc ANALYSIS OF THE ACTIVITY OF A CLOSTRIDIAL TOXIN.
US7947279B2 (en) 2005-06-30 2011-05-24 The Trustees Of Columbia University In The City Of New York Peptide having hydrolase activity
WO2007054814A1 (en) 2005-11-14 2007-05-18 Centre National De La Recherche Scientifique - Cnrs Inhibitors of parp activity and uses thereof
US8242081B2 (en) 2005-12-06 2012-08-14 Centre National De La Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
EP1964918B8 (en) * 2005-12-06 2012-03-28 Tokyo Metropolitan Institute of Medical Science Protein which can serve as nucleus for polymerization of protein polymer and process for production of cells comprising said nucleus
EP1795539B1 (en) * 2005-12-06 2010-12-01 Centre National de la Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
EP2206778B1 (en) * 2005-12-13 2018-08-01 Kyoto University Nuclear reprogramming factor
US8129187B2 (en) * 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US8273867B2 (en) * 2006-02-10 2012-09-25 The Regents Of The University Of California Transducible delivery of siRNA by dsRNA binding domain fusions to PTD/CPPS
US20070281900A1 (en) * 2006-05-05 2007-12-06 Nastech Pharmaceutical Company Inc. COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
US20070269892A1 (en) * 2006-05-18 2007-11-22 Nastech Pharmaceutical Company Inc. FORMULATIONS FOR INTRACELLULAR DELIVERY dsRNA
EP2046964B1 (en) * 2006-07-12 2018-07-04 The Regents of The University of California Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
US9161696B2 (en) * 2006-09-22 2015-10-20 Masimo Corporation Modular patient monitor
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US8840549B2 (en) 2006-09-22 2014-09-23 Masimo Corporation Modular patient monitor
KR101138930B1 (en) * 2007-02-16 2012-04-25 (주) 에빅스젠 Composition for preventing and treating ???? comprising ??? ?? protein
JP2008307007A (en) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
US9213999B2 (en) * 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
US20090047703A1 (en) * 2007-08-17 2009-02-19 University Of Maryland, Baltimore ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease
GB0724253D0 (en) * 2007-12-12 2008-01-30 Fermentas Uab Transfection reagent
DK2271670T3 (en) 2008-03-14 2014-12-01 Allergan Inc IMMUNE BASED ACTIVITY ASSAYS WITH BOTULINUM TOXIN SEROTYPE A
EP2268809B1 (en) 2008-05-02 2019-02-06 Kyoto University Method of nuclear reprogramming
EP2291544B1 (en) 2008-05-16 2017-10-25 The Children's Hospital of Philadelphia Genetic alterations on chromosomes 21q, 6q and 15q and methods of use thereof for the diagnosis and treatment of type i diabetes
WO2010054326A2 (en) 2008-11-07 2010-05-14 The General Hospital Corporation C-terminal fragments of glucagon-like peptide-1 (glp-1)
US8241623B1 (en) 2009-02-09 2012-08-14 David Bermudes Protease sensitivity expression system
US8361789B2 (en) 2009-03-13 2013-01-29 Allergan, Inc. Cells useful for immuno-based Botulinum toxin serotype A activity assays
PL3281953T3 (en) 2009-03-13 2020-05-18 Allergan, Inc. Immuno-based retargeted endopeptidase activity assays
WO2010108824A1 (en) 2009-03-23 2010-09-30 Vib Vzw L-plastin antibodies and their use
WO2010137012A1 (en) 2009-05-25 2010-12-02 Ramot At Tel-Aviv University Ltd. Peptide therapy for amphiregulin mediated diseases
US8609617B2 (en) 2009-09-04 2013-12-17 University Of Miami KLF family members regulate intrinsic axon regeneration ability
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
US9856456B2 (en) 2009-10-12 2018-01-02 Thermo Fisher Scientific Baltics Uab Delivery agent
GB0917792D0 (en) * 2009-10-12 2009-11-25 Fermentas Uab Delivery agent
AU2010306940A1 (en) 2009-10-12 2012-06-07 Smith, Larry Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
US8409858B2 (en) * 2009-10-22 2013-04-02 The United States Of America, As Represented By The Secretary Of The Navy Modular functional peptides for the intracellular delivery of nanoparticles
US9153112B1 (en) 2009-12-21 2015-10-06 Masimo Corporation Modular patient monitor
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
EP2563399B1 (en) 2010-04-26 2014-06-11 Université Joseph Fourier Use of peptides as transporters intended for the internalization of molecules of interest into target cells
AU2011312504B2 (en) 2010-09-27 2016-12-22 The Children's Hospital Of Philadelphia Compositions and methods useful for the treatment and diagnosis of inflammatory bowel disease
EP2468303A1 (en) 2010-12-14 2012-06-27 Centre National de la Recherche Scientifique Functionalized nucleic acids and particles comprising them for the treatment of HIV infections
TWI404801B (en) * 2011-06-15 2013-08-11 The method and application of peptide-mediated mitochondrial delivery system
EP2729157B1 (en) 2011-07-06 2019-01-16 The General Hospital Corporation A pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) for use in treatment
US9943269B2 (en) 2011-10-13 2018-04-17 Masimo Corporation System for displaying medical monitoring data
EP3584799B1 (en) 2011-10-13 2022-11-09 Masimo Corporation Medical monitoring hub
US10149616B2 (en) 2012-02-09 2018-12-11 Masimo Corporation Wireless patient monitoring device
US10307111B2 (en) 2012-02-09 2019-06-04 Masimo Corporation Patient position detection system
US10729777B2 (en) 2012-04-09 2020-08-04 Case Western Reserve University Compositions and methods for inhibiting the activity of LAR family phosphatases
WO2013155103A1 (en) 2012-04-09 2013-10-17 Case Western Reserve University Compositions and methods for inhibiting the activity of lar family phosphatases
CA2877384C (en) * 2012-07-02 2023-05-09 Iprogen Biotech Inc. Intracellular protein delivery
CA2880869A1 (en) 2012-08-20 2014-02-27 The Regents Of The University Of California Polynucleotides having bioreversible groups
US9749232B2 (en) 2012-09-20 2017-08-29 Masimo Corporation Intelligent medical network edge router
US9382531B2 (en) 2012-10-22 2016-07-05 Wisconsin Alumni Research Foundation Induction of hemogenic endothelium from pluripotent stem cells
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
US10832818B2 (en) 2013-10-11 2020-11-10 Masimo Corporation Alarm notification system
AU2014369861B2 (en) 2013-12-29 2018-09-13 Curelab Oncology, Inc. Methods and compositions relating to p62/SQSTM1 for the treatment and prevention of inflammation-associated diseases
US9737592B1 (en) 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
WO2015123750A1 (en) 2014-02-20 2015-08-27 Cura Health Inc. Transdermal composition for treating pain
US10029012B2 (en) 2014-09-05 2018-07-24 University Of Pittsuburgh—Of The Commonwealth System Of Higher Education Peptide-mediated intravesical delivery of therapeutic and diagnostic agents
US10201610B2 (en) * 2014-10-20 2019-02-12 The University Of Western Australia Interference peptides and use thereof
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN108472363A (en) 2015-08-21 2018-08-31 费城儿童医院 The method for treating the autoimmune disorder of the patient with the hereditary variation in DCR3 or DCR3 network genes
KR102612874B1 (en) 2015-08-31 2023-12-12 마시모 코오퍼레이션 Wireless patient monitoring systems and methods
AU2017248353A1 (en) 2016-04-07 2018-10-25 Case Western Reserve University TDP-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease
US10617302B2 (en) 2016-07-07 2020-04-14 Masimo Corporation Wearable pulse oximeter and respiration monitor
CN110023321A (en) 2016-08-17 2019-07-16 索尔斯蒂斯生物有限公司 Polynucleotide constructs
EP3525661A1 (en) 2016-10-13 2019-08-21 Masimo Corporation Systems and methods for patient fall detection
KR101797167B1 (en) * 2016-11-09 2017-11-13 주식회사 바이오셀트란 Novel protein transduction domain and the usage thereof
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
US20200230205A1 (en) 2017-07-11 2020-07-23 Case Western Reserve University Compositions and methods for treating myelin disorders
EP3782165A1 (en) 2018-04-19 2021-02-24 Masimo Corporation Mobile patient alarm display
AU2019334965B2 (en) * 2018-09-05 2025-01-23 Case Western Reserve University Methods and compositions for inducing neural plasticity
US11272839B2 (en) 2018-10-12 2022-03-15 Ma Simo Corporation System for transmission of sensor data using dual communication protocol
KR102246906B1 (en) * 2019-04-29 2021-04-30 주식회사 바이오셀트란 Cosmetic composition for anti-wrinkle with high skin or cell penetration capacity
WO2020252298A1 (en) * 2019-06-14 2020-12-17 The University Of North Carolina At Chapel Hill Compositions and methods for targeting the nucleosome remodeling and deacetylase complex
JP2023518303A (en) 2020-03-20 2023-04-28 マシモ・コーポレイション Wearable device for non-invasive body temperature measurement
USD974193S1 (en) 2020-07-27 2023-01-03 Masimo Corporation Wearable temperature measurement device
USD980091S1 (en) 2020-07-27 2023-03-07 Masimo Corporation Wearable temperature measurement device
WO2022025319A1 (en) * 2020-07-30 2022-02-03 주식회사 바이오셀트란 Soluble microneedle patch containing skin-permeable recombinant neuropeptide complex
EP3957721A1 (en) 2020-08-20 2022-02-23 Life & Brain GmbH Rapid production of human neuronal cultures with single cell resolution
CN113214822B (en) * 2021-04-12 2022-07-26 华南理工大学 AIE nanofiber probe for targeted staining of cell membrane and preparation method thereof
WO2023034910A1 (en) 2021-09-01 2023-03-09 Dnovo Inc. Transdifferentiation of non-hair follicle stem cells to non-auditory induced hair follicle stem cells
USD1000975S1 (en) 2021-09-22 2023-10-10 Masimo Corporation Wearable temperature measurement device
AR127419A1 (en) 2021-10-20 2024-01-24 Dnovo Inc TRANSDIFFERENTIATION OF NON-DERMIC PAPILLA CELLS TO DERMAL PAPILLA CELLS
CN113845574A (en) * 2021-11-30 2021-12-28 百益美恒(北京)科技有限公司 Penetrating peptide TDP, fusion penetrating peptide protein, preparation method and application thereof
USD1048908S1 (en) 2022-10-04 2024-10-29 Masimo Corporation Wearable sensor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5747253A (en) 1991-08-23 1998-05-05 Isis Pharmaceuticals, Inc. Combinatorial oligomer immunoabsorbant screening assay for transcription factors and other biomolecule binding
FR2739621B1 (en) * 1995-10-05 1997-12-05 Centre Nat Rech Scient PEPTIDES FOR USE AS VECTORS FOR INTRACELLULAR ADDRESSING OF ACTIVE MOLECULES
WO2000018778A1 (en) 1998-09-29 2000-04-06 Phylos, Inc. Synthesis of codon randomized nucleic acids
US7790171B1 (en) * 2000-08-25 2010-09-07 Centre National De La Recherche Scientifique (C.N.R.S.) Antiviral peptides obtained from the tryptophan-rich hydrophobic cluster of the HIV-1 reverse transcriptase
AU2002240448A1 (en) * 2001-02-15 2002-08-28 Baylor College Of Medicine Use of cell penetrating peptides to generate antitumor immunity

Also Published As

Publication number Publication date
EP1305333A2 (en) 2003-05-02
WO2002010201A2 (en) 2002-02-07
CA2417454A1 (en) 2002-02-07
US20030119725A1 (en) 2003-06-26
EP1305333A4 (en) 2006-04-12
US6841535B2 (en) 2005-01-11

Similar Documents

Publication Publication Date Title
AU2001280767A1 (en) Peptide-mediated delivery of molecules into cells
AU2001234567A1 (en) Guaranteed exactly once delivery of messages
AU5090200A (en) Culture chamber
AU2001291859A1 (en) Use of copolycarbonates
AU1803601A (en) Methods and compositions for the introduction of molecules into cells
AU6887401A (en) Delivery of remotely-ordered products
AU2001232020A1 (en) Floating drug delivery composition
AU2001238346A1 (en) Modification of biopolymers for improved drug delivery
AU2001248833A1 (en) Stable liquid preparation
AU2001267428A1 (en) Direct detection of individual molecules
AU2001260270A1 (en) Liposomes containing active substances
AU2001253521A1 (en) Haplotypes of the cxcr4 gene
AU2001253386A1 (en) Haplotypes of the impdh2 gene
AU2001273541A1 (en) Haplotypes of the edg6 gene
AU2001258330A1 (en) New uses of imidazolylmethyl-pyridines
AU2001240017A1 (en) Human enzyme molecules
AU2001266189A1 (en) Materials and methods relating to gene delivery
AU2001255330A1 (en) Haplotypes of the akr1b1 gene
AU5647101A (en) Over expression of the whn protein
AU2001290603A1 (en) Haplotypes of the or11a1 gene
AUPQ985000A0 (en) Partial discharge injector
AU2001270608A1 (en) Peptide-mediated ocular cell transfection
AU2001264800A1 (en) Haplotypes of the aldh5a1 gene
AU2001288868A1 (en) Haplotypes of the gpr68 gene
AU2001266759A1 (en) Haplotypes of the acp2 gene