[go: up one dir, main page]

AU1296792A - Mixed pyridine-2,4-and-2,5-dicarboxamides, a process for preparing them, the use thereof and pharmaceuticals based on these compounds - Google Patents

Mixed pyridine-2,4-and-2,5-dicarboxamides, a process for preparing them, the use thereof and pharmaceuticals based on these compounds

Info

Publication number
AU1296792A
AU1296792A AU12967/92A AU1296792A AU1296792A AU 1296792 A AU1296792 A AU 1296792A AU 12967/92 A AU12967/92 A AU 12967/92A AU 1296792 A AU1296792 A AU 1296792A AU 1296792 A AU1296792 A AU 1296792A
Authority
AU
Australia
Prior art keywords
compounds
dicarboxamides
preparing
pharmaceuticals based
mixed pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU12967/92A
Other versions
AU645668B2 (en
Inventor
Ekkehard Baader
Martin Bickel
Volkmar Gunzler-Pukall
Manfred Volz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU1296792A publication Critical patent/AU1296792A/en
Application granted granted Critical
Publication of AU645668B2 publication Critical patent/AU645668B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to mixed pyridine-2,4- and -2,5-dicarboxylic acid diamides, the carboxylic acid amide group in position 2 being a primary acid amide. The said compounds are suitable for the inhibition of proline hydroxylase and lysine hydroxylase and are used as fibrosuppressants and immunosuppressants.
AU12967/92A 1991-03-18 1992-03-17 Mixed pyridine-2,4-and-2,5-dicarboxamides, a process for preparing them, the use thereof and pharmaceuticals based on these compounds Ceased AU645668B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4108824 1991-03-18
DE4108824 1991-03-18

Publications (2)

Publication Number Publication Date
AU1296792A true AU1296792A (en) 1992-09-24
AU645668B2 AU645668B2 (en) 1994-01-20

Family

ID=6427597

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12967/92A Ceased AU645668B2 (en) 1991-03-18 1992-03-17 Mixed pyridine-2,4-and-2,5-dicarboxamides, a process for preparing them, the use thereof and pharmaceuticals based on these compounds

Country Status (22)

Country Link
EP (1) EP0504799B1 (en)
JP (1) JP3121428B2 (en)
KR (1) KR100243959B1 (en)
AT (1) ATE154929T1 (en)
AU (1) AU645668B2 (en)
CA (1) CA2063177A1 (en)
CZ (1) CZ282298B6 (en)
DE (1) DE59208651D1 (en)
DK (1) DK0504799T3 (en)
ES (1) ES2104758T3 (en)
FI (1) FI101701B (en)
GR (1) GR3024309T3 (en)
HR (1) HRP940835A2 (en)
HU (1) HU217809B (en)
IE (1) IE920843A1 (en)
IL (1) IL101257A (en)
MX (1) MX9201156A (en)
NO (1) NO178859C (en)
NZ (1) NZ241968A (en)
TW (1) TW199147B (en)
YU (1) YU48156B (en)
ZA (1) ZA921945B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3703959A1 (en) * 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE58908519D1 (en) * 1988-08-04 1994-11-24 Hoechst Ag Improved process for the preparation of N, N-bis (alkoxyalkyl) pyridine -2,4-dicarboxylic acid diamides.
DE3924093A1 (en) * 1989-07-20 1991-02-07 Hoechst Ag N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3928144A1 (en) * 1989-08-25 1991-02-28 Hoechst Ag CYCLIC PYRIDINE-2,4- AND -2,5-DICARBONIC ACIDEDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3938805A1 (en) * 1989-11-23 1991-05-29 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DIAMOND, METHOD FOR THE PRODUCTION AND USE THEREOF
DE4030999A1 (en) * 1990-10-01 1992-04-09 Hoechst Ag 4- OR 5-SUBSTITUTED PYRIDINE-2-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT

Also Published As

Publication number Publication date
HUT62565A (en) 1993-05-28
AU645668B2 (en) 1994-01-20
FI101701B1 (en) 1998-08-14
TW199147B (en) 1993-02-01
HU217809B (en) 2000-04-28
JPH0586032A (en) 1993-04-06
GR3024309T3 (en) 1997-10-31
HU9200891D0 (en) 1992-05-28
ZA921945B (en) 1992-11-25
FI921119A0 (en) 1992-03-16
IL101257A (en) 1998-03-10
YU48156B (en) 1997-05-28
YU24692A (en) 1994-06-24
IE920843A1 (en) 1992-09-23
CZ282298B6 (en) 1997-06-11
IL101257A0 (en) 1992-11-15
NO178859C (en) 1996-06-19
ES2104758T3 (en) 1997-10-16
NO921025D0 (en) 1992-03-17
CA2063177A1 (en) 1992-09-19
DK0504799T3 (en) 1998-02-02
JP3121428B2 (en) 2000-12-25
ATE154929T1 (en) 1997-07-15
MX9201156A (en) 1992-10-01
FI921119A (en) 1992-09-19
CS80392A3 (en) 1992-10-14
KR920018051A (en) 1992-10-21
EP0504799B1 (en) 1997-07-02
KR100243959B1 (en) 2000-03-02
EP0504799A1 (en) 1992-09-23
NO921025L (en) 1992-09-21
NZ241968A (en) 1994-04-27
HRP940835A2 (en) 1997-06-30
FI101701B (en) 1998-08-14
DE59208651D1 (en) 1997-08-07
NO178859B (en) 1996-03-11

Similar Documents

Publication Publication Date Title
CY2120B1 (en) Substituted heterocyclic carboxylic acid amides their preparation and their use as medicaments
IE870610L (en) Hydroxylamine derivatives.
IL111843A (en) Crystalline 3,4,4-trisubstituted piperidinyl-N-(3-phenylprop-2-YL) carboxylic acid derivatives pharmaceutical compositions containing them and processes for their preparation
AU1145288A (en) Pyridine-2,4- and -2,5-dicarboxylic acid amides, processes for their preparation, the use thereof, and medicaments based on these compounds
AU633142B2 (en) Pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation and the use thereof, and pharmaceuticals based on these compounds
HUT71473A (en) Aromatic carboxylic acid derivatives, pharmaceutical compns. contg. them and process to prepare the said compds.
ZA882449B (en) Dihydropyridinamides,a process for their preparation,and their use in medicaments
AU1296792A (en) Mixed pyridine-2,4-and-2,5-dicarboxamides, a process for preparing them, the use thereof and pharmaceuticals based on these compounds
AU6936691A (en) Di(nitroxyalkyl)amides of pyridine-2,4- and -2,5-dicarboxylic acids, a process for the preparation thereof, and the use thereof
DE59307401D1 (en) Alpha-aryl-alpha-hydroxy-beta-imidazolinyl propionic acid amides
AU627349B2 (en) Cyclic pyridine-2,4 and -2,5-dicarboxylic acid diamides, process for their preparation and their use
HUT56348A (en) Process for producing pyridine-2,4- and 2,5-dicarboxylic acid diamides and pharmaceutical compositions comprising such compounds
ZA92788B (en) 2,4-and 2,5-bistetrazolylpyridines,a process for the preparation thereof and the use thereof as pharmaceuticals

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired