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ATE88713T1 - Antivirale verbindungen. - Google Patents

Antivirale verbindungen.

Info

Publication number
ATE88713T1
ATE88713T1 AT87310951T AT87310951T ATE88713T1 AT E88713 T1 ATE88713 T1 AT E88713T1 AT 87310951 T AT87310951 T AT 87310951T AT 87310951 T AT87310951 T AT 87310951T AT E88713 T1 ATE88713 T1 AT E88713T1
Authority
AT
Austria
Prior art keywords
antiviral compounds
cytomegalovirus
prophylaxis
pharmaceutically acceptable
processes
Prior art date
Application number
AT87310951T
Other languages
English (en)
Inventor
Saad George Rahim
Dorothy Jane Martin Purifoy
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE88713T1 publication Critical patent/ATE88713T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Silicon Polymers (AREA)
AT87310951T 1986-12-15 1987-12-14 Antivirale verbindungen. ATE88713T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868629892A GB8629892D0 (en) 1986-12-15 1986-12-15 Antiviral compounds
EP87310951A EP0272065B1 (de) 1986-12-15 1987-12-14 Antivirale Verbindungen

Publications (1)

Publication Number Publication Date
ATE88713T1 true ATE88713T1 (de) 1993-05-15

Family

ID=10609013

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87310951T ATE88713T1 (de) 1986-12-15 1987-12-14 Antivirale verbindungen.

Country Status (30)

Country Link
US (1) US5079235A (de)
EP (3) EP0417560A1 (de)
JP (2) JPS63165397A (de)
KR (1) KR880007521A (de)
CN (2) CN87108265A (de)
AT (1) ATE88713T1 (de)
AU (2) AU601529B2 (de)
CA (1) CA1319143C (de)
CS (3) CS275398B2 (de)
DD (2) DD274766A5 (de)
DE (1) DE3785651T2 (de)
DK (2) DK654287A (de)
ES (1) ES2054693T3 (de)
FI (2) FI875487A (de)
GB (1) GB8629892D0 (de)
HU (4) HU200932B (de)
IE (2) IE930471L (de)
IL (3) IL84810A (de)
LT (1) LT2064B (de)
LV (1) LV5273A3 (de)
MC (1) MC1882A1 (de)
MX (1) MX9203216A (de)
NO (1) NO167576C (de)
NZ (1) NZ222898A (de)
PH (2) PH24104A (de)
PL (3) PL158050B1 (de)
PT (1) PT86356B (de)
RU (1) RU2036199C1 (de)
SU (1) SU1731064A3 (de)
ZA (1) ZA879382B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0366685B1 (de) * 1987-06-24 1994-10-19 Howard Florey Institute Of Experimental Physiology And Medicine Nukleosid-derivate
US4954485A (en) * 1987-10-20 1990-09-04 Sanyo-Kokusaku Pulp Co., Ltd. 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
EP0346108A3 (de) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infektiöse Nukleoside
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8827339D0 (en) * 1988-11-23 1988-12-29 Wellcome Found Antiviral compounds
US5006646A (en) * 1989-02-22 1991-04-09 Yuki Gosei Kogyo Co., Ltd. Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
GB9012899D0 (en) * 1990-06-09 1990-08-01 Wellcome Found Anti-hbv pyrimidine nucleoside
GB9014618D0 (en) * 1990-06-30 1990-08-22 Wellcome Found Process for the preparation of pyrimidine nucleosides
JP3094036B2 (ja) 1990-07-19 2000-10-03 ザ ウエルカム ファウンデーション リミテッド 酵素不活性化剤
US5643913A (en) * 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
US5580858A (en) * 1991-06-10 1996-12-03 Alberta Research Council Immunosuppressive and tolerogenic modified Lewisx compounds
HU207524B (en) * 1991-11-22 1993-04-28 Mta Koezponti Kemiai Kutato In Industrial process for producing 5-alkyl-2'-deoxy-beta-uridines with stereoselective synthesis
EP1256589A3 (de) * 1991-11-26 2003-09-17 Isis Pharmaceuticals, Inc. Oligomere, die modifizierte PyrimIdine enthalten
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
JP2823358B2 (ja) * 1992-05-26 1998-11-11 アルバータ リサーチ カウンスル 免疫抑制性および寛容原性修飾ルイス▲上ｃ▼およびＬａｃＮＡｃ化合物
CA2119315A1 (en) * 1993-03-18 1994-09-19 Tsujiaki Hata Nucleoside derivatives and anti-herpes composition
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
WO1997023230A1 (en) * 1995-12-22 1997-07-03 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
WO1997027849A1 (fr) * 1996-02-02 1997-08-07 Showa Shell Sekiyu K.K. Medicaments pour traiter les infections provoquees par le virus de l'herpes et compositions preventives pour empecher un retour de l'infection, contenant tous les deux des derives triterpeniques comme principe actif
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
AU2002360697B2 (en) 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
CN101068549A (zh) 2004-12-03 2007-11-07 阿迪赫里克斯技术公司 与5－fu和5－fu前药组合施用dpd抑制剂的方法
WO2009124150A2 (en) 2008-04-01 2009-10-08 Biosearch Technologies, Inc. Stabilized nucleic acid dark quencher-fluorophore probes
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
CN102811721A (zh) 2009-10-14 2012-12-05 阿迪赫里克斯技术公司 治疗与5-fu或5-fu前药联合的dpd抑制剂给药相关的神经毒性的方法
CA2944155C (en) * 2014-03-30 2023-08-29 Cepheid Modified cytosine polynucleotide oligomers and methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601020A (en) 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4274544A (en) * 1980-03-11 1981-06-23 The Continental Group, Inc. Single-piece plastic closure having integral seal forming means
EP0082667A1 (de) * 1981-12-18 1983-06-29 Beecham Group Plc Pharmazeutische Zusammensetzungen
EP0082668A1 (de) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenvinyl)-2'-Deoxyuridinderivate, Verfahren zu ihrer Herstellung, die sie enthaltende pharmazeutische Präparate und ihre Verwendung bei der Bekämpfung von viralen Infektionen
EP0095294A1 (de) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridin-Derivate, ihre Herstellungsverfahren und ihre medizinische Anwendung
EP0097039A1 (de) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-Halovinyl)-2'-deoxyuridin-Derivate, Verfahren zur Herstellung, sie enthaltende pharmazeutische Zusammensetzungen und ihre Anwendung bei der Behandlung von viralen Infektionen
GB8517402D0 (en) * 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds

Also Published As

Publication number Publication date
DK654287D0 (da) 1987-12-14
PL160321B1 (pl) 1993-02-26
NO875209D0 (no) 1987-12-14
HU200932B (en) 1990-09-28
IL84810A (en) 1992-05-25
JPH0378370B2 (de) 1991-12-13
ZA879382B (en) 1989-08-30
US5079235A (en) 1992-01-07
IE930471L (en) 1988-06-15
DE3785651T2 (de) 1993-11-11
PL158050B1 (pl) 1992-07-31
AU626041B2 (en) 1992-07-23
DK169991A (da) 1991-10-04
IE930470L (en) 1988-06-15
AU601529B2 (en) 1990-09-13
FI941523A (fi) 1994-03-31
PT86356A (en) 1988-01-01
DD264924A5 (de) 1989-02-15
PL277927A1 (en) 1989-08-21
EP0486477A2 (de) 1992-05-20
EP0272065A3 (en) 1988-11-17
KR880007521A (ko) 1988-08-27
EP0272065B1 (de) 1993-04-28
IL95141A0 (en) 1991-06-10
HU903829D0 (en) 1990-11-28
NO167576B (no) 1991-08-12
FI941523A0 (fi) 1994-03-31
GB8629892D0 (en) 1987-01-28
ES2054693T3 (es) 1994-08-16
DK169991D0 (da) 1991-10-04
HU207735B (en) 1993-05-28
CS916187A2 (en) 1991-02-12
FI875487A (fi) 1988-06-16
EP0417560A1 (de) 1991-03-20
MC1882A1 (fr) 1989-01-24
EP0272065A2 (de) 1988-06-22
NO875209L (no) 1988-06-16
JPH03141292A (ja) 1991-06-17
PH24870A (en) 1990-12-26
DD274766A5 (de) 1990-01-03
MX9203216A (es) 1992-07-01
HU199867B (en) 1990-03-28
CS275402B6 (en) 1992-02-19
NZ222898A (en) 1990-12-21
AU8252187A (en) 1988-06-16
IL95141A (en) 1992-05-25
AU5989090A (en) 1990-11-08
CS275398B2 (en) 1992-02-19
CA1319143C (en) 1993-06-15
HUT46336A (en) 1988-10-28
NO167576C (no) 1991-11-20
PL277926A1 (en) 1989-08-21
CN87108265A (zh) 1988-07-13
PH24104A (en) 1990-03-05
PL160322B1 (pl) 1993-02-26
FI875487A0 (fi) 1987-12-14
DE3785651D1 (de) 1993-06-03
LT2064B (lt) 1993-06-15
PT86356B (pt) 1990-11-07
CS342591A3 (en) 1992-04-15
EP0486477A3 (en) 1992-06-17
CN1080292A (zh) 1994-01-05
DK654287A (da) 1988-06-16
IL84810A0 (en) 1988-06-30
HU202112B (en) 1991-02-28
CS767588A3 (en) 1991-02-12
JPS63165397A (ja) 1988-07-08
LV5273A3 (lv) 1993-10-10
SU1731064A3 (ru) 1992-04-30
PL269462A1 (en) 1989-06-26
DK168323B1 (da) 1994-03-14
RU2036199C1 (ru) 1995-05-27

Similar Documents

Publication Publication Date Title
ATE88713T1 (de) Antivirale verbindungen.
DE3679353D1 (de) Antivirale verbindungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee