ATE84312T1 - Expression, in eukaryotischen zellen, von biologisch aktiven analoga eines wachstumsfaktors, abstammend von blutplaettchen. - Google Patents

Expression, in eukaryotischen zellen, von biologisch aktiven analoga eines wachstumsfaktors, abstammend von blutplaettchen.

Info

Publication number: ATE84312T1
Authority: AT; Austria
Prior art keywords: pdgf; chain; biologically active; factor; secretion
Prior art date: 1984-10-12

Application number

AT85112852T

Other languages

English (en)

Inventor

Mark Joseph Murray

James Darrel Kelly

Original Assignee

Zymogenetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-12

Filing date

1985-10-10

Publication date

1993-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45478613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE84312(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1984-10-12 Priority claimed from US06/660,496 external-priority patent/US4769328A/en

1985-10-10 Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc

1993-01-15 Application granted granted Critical

1993-01-15 Publication of ATE84312T1 publication Critical patent/ATE84312T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
- C12N2740/11022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/22—Viral peptide or viral protein
- Y10S930/221—Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus related

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Mycology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Virology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Dry Formation Of Fiberboard And The Like (AREA)

AT85112852T 1984-10-12 1985-10-10 Expression, in eukaryotischen zellen, von biologisch aktiven analoga eines wachstumsfaktors, abstammend von blutplaettchen. ATE84312T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US06/660,496 US4769328A (en)	1984-10-12	1984-10-12	Expression of biologically active PDGF analogs in yeast
US06/705,175 US4801542A (en)	1984-10-12	1985-02-25	Expression of biologically active PDGF analogs in eucaryotic cells
CA000492370A CA1340212C (en)	1984-10-12	1985-10-07	Expression of biologically active platelet derived growth factor analogsin eucaryotic cells
EP85112852A EP0177957B2 (de)	1984-10-12	1985-10-10	Expression in Hefezellen, von biologisch aktiven Analoga eines Wachstumsfaktors, abstammend von Blutplättchen
CA 617115 CA1340846E (en)	1984-10-12	1999-06-11	Expression of biologically active platelet derived growth factor analogs in eucaryotic cells

Publications (1)

Publication Number	Publication Date
ATE84312T1 true ATE84312T1 (de)	1993-01-15

Family

ID=45478613

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT85112852T ATE84312T1 (de)	1984-10-12	1985-10-10	Expression, in eukaryotischen zellen, von biologisch aktiven analoga eines wachstumsfaktors, abstammend von blutplaettchen.
AT91121387T ATE188255T1 (de)	1984-10-12	1985-10-10	Von blutplättchen abstammende biologisch aktive analoga eines wachstumsfaktors in eukaryotischen zellen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT91121387T ATE188255T1 (de)	1984-10-12	1985-10-10	Von blutplättchen abstammende biologisch aktive analoga eines wachstumsfaktors in eukaryotischen zellen

Country Status (9)

Country	Link
US (1)	US4801542A (de)
EP (1)	EP0177957B2 (de)
JP (2)	JP2837407B2 (de)
AT (2)	ATE84312T1 (de)
AU (2)	AU4845485A (de)
CA (2)	CA1340212C (de)
DE (4)	DE19975042I2 (de)
LU (1)	LU90408I2 (de)
NL (1)	NL990016I2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE131532T1 (de) *	1986-08-13	1995-12-15	Zymogenetics Inc	Expression von biologisch-aktiven pdgf-analogen in eukaryotischen zellen
US5474982A (en) *	1986-08-13	1995-12-12	Zymogenetics, Inc.	PDGF analogs and methods of use
US5019559A (en) *	1986-11-14	1991-05-28	President And Fellows Of Harvard College	Wound healing using PDGF and IGF-II
AU624789B2 (en) *	1987-02-19	1992-06-25	Amgen, Inc.	Purified platelet-derived growth factor and methods for purification thereof
JPH0198489A (ja) *	1987-04-22	1989-04-17	Chiron Corp	血小板由来成長因子ａ鎖ポリペプチドの組換え生産
US6939849B1 (en)	1987-04-22	2005-09-06	Chiron Corporation	Recombinant PDGF A-chain homodimers and methods of use
US5219759A (en) *	1987-04-22	1993-06-15	Chiron Corporation	Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors
US5094941A (en) *	1987-12-31	1992-03-10	Zymogenetics, Inc.	Monoclonal antibodies to PDGF
US5759815A (en) *	1988-02-11	1998-06-02	Creative Biomolecules, Inc.	Production of platelet derived growth factor (PDGF) an muteins thereof
EP0422125B1 (de) *	1988-06-30	1996-10-23	Cor Therapeutics, Inc.	Plättchen blockierende peptide
US5037743A (en) *	1988-08-05	1991-08-06	Zymogenetics, Inc.	BAR1 secretion signal
DE3900770A1 (de) *	1989-01-12	1990-07-26	Juergen Prof Dr Hoppe	Verfahren zur herstellung von pdgf-a und pdgf-aa
US6899882B1 (en)	1989-03-24	2005-05-31	The Regents Of The University Of California	Endothelial cell growth factor methods of isolation and expression
US5686410A (en) *	1989-07-20	1997-11-11	Novartis Ag	Polypeptide derivatives
US5219739A (en) *	1989-07-27	1993-06-15	Scios Nova Inc.	DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
US5272064A (en) *	1989-12-19	1993-12-21	Amgen Inc.	DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
US6172039B1 (en)	1990-04-16	2001-01-09	Apex Bioscience, Inc.	Expression of recombinant hemoglobin and hemoglobin variants in yeast
DK0547064T3 (da) *	1990-07-23	1995-03-20	Zymogenetics Inc	Proteaseresistent PDGF og anvendelsesfremgangsmåde
US5886141A (en) *	1990-10-26	1999-03-23	Takeda Chemical Industries, Ltd.	Smooth muscle mitogen peptides and DNA coding therefor
GB9101645D0 (en) *	1991-01-25	1991-03-06	British Bio Technology	Compounds
EP0555785B1 (de) *	1992-02-10	1996-12-04	Takeda Chemical Industries, Ltd.	Mitogen für die glatte Muskulatur und dessen kodierende DNS
EP0871730B1 (de) *	1995-10-11	2004-08-18	Chiron Corporation	Kombination pdgf, kgf, igf und igfbp zur wundheilung
ATE253120T1 (de) *	1996-12-13	2003-11-15	Chiron Corp	Verfahren zur expression von heterologen proteinen in hefe
EP2386629A1 (de)	1997-10-14	2011-11-16	Darwin Molecular Corporation	Thymidinkinasemutanten und Fusionsproteine mit Thymidinkinase- und Guanylatkinaseaktivität
US6194169B1 (en) *	1998-06-04	2001-02-27	The University Of Kentucky Research Foundation	Enhanced expression of human platelet-derived growth factor in Pichia pastoris
ES2350454T3 (es)	1998-11-27	2011-01-24	Ucb Pharma S.A.	Composiciones y métodos para incrementar la mineralización de la sustancia ósea.
US20040009535A1 (en)	1998-11-27	2004-01-15	Celltech R&D, Inc.	Compositions and methods for increasing bone mineralization
US7063850B1 (en)	1998-12-22	2006-06-20	University Of Tennessee Research Foundation	Protective antigen of group A Streptococci
US6358733B1 (en) *	2000-05-19	2002-03-19	Apolife, Inc.	Expression of heterologous multi-domain proteins in yeast
EP1967525B1 (de)	2001-05-08	2012-11-14	Darwin Molecular Corporation	Verfahren zur Regulierung der Immunfunktion in Primaten unter Verwendung des foxp3-Proteins
AU2002365223A1 (en) *	2001-10-26	2003-09-02	Id Biomedical Corporation Of Washington	Multivalent streptococcal vaccine compositions and methods for use
EP2399586A1 (de)	2002-01-11	2011-12-28	Jefferies, Dr., Wilfred	Verwendung von P97 als ein Enzymabgabesystem zur Abgabe therapeutischer lyosomaler Enzyme
US20030139333A1 (en) *	2002-01-18	2003-07-24	Genetix Pharmaceuticals, Inc.	Methods and compositions for promoting angiogenesis
US20050048041A1 (en) *	2003-01-13	2005-03-03	Rao Mahendra S.	Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products
US20080119433A1 (en) *	2006-07-06	2008-05-22	Aaron Thomas Tabor	Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
KR20100014290A (ko) *	2006-11-30	2010-02-10	더 유니버시티 오브 브리티쉬 콜럼비아	분자 아주반트로서 ｔａｐ―１ 및/또는 ｔａｐ―２를 포함하는 폭스비리대 치료
BR112012000865A2 (pt)	2009-07-17	2019-09-24	T Tabor Aaron	"composição e método para a modificação genética cosmética de células substancialmente intactas"
US9150846B2 (en)	2011-07-05	2015-10-06	Bioasis Technologies, Inc.	P97-antibody conjugates and methods of use
EP3321281B1 (de)	2011-08-05	2019-11-27	biOasis Technologies Inc	P97-fragmente mit transferaktivität
ES2647082T3 (es)	2012-07-31	2017-12-19	Bioasis Technologies Inc	Proteínas desfosforiladas de la enfermedad de depósito lisosómico y métodos de uso de las mismas
WO2014160438A1 (en)	2013-03-13	2014-10-02	Bioasis Technologies Inc.	Fragments of p97 and uses thereof
ES2703341T3 (es)	2013-03-14	2019-03-08	Genvivo Inc	Ensayo diagnóstico de timidina quinasa para aplicaciones de terapia génica
WO2015117121A1 (en)	2014-02-03	2015-08-06	Bioasis Technologies, Inc.	P97 fusion proteins
US10392605B2 (en)	2014-02-19	2019-08-27	Bioasis Technologies Inc.	P97-IDS fusion proteins
WO2015168521A2 (en)	2014-05-01	2015-11-05	Bioasis Technologies, Inc.	P97-polynucleotide conjugates
EP3206670A4 (de)	2014-10-14	2018-06-20	Samuel Lynch	Zusammensetzung zur behandlung von wunden

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4350687A (en) *	1980-02-10	1982-09-21	Research Corporation	Platelet derived cell growth factor
AU600885B2 (en) *	1984-05-25	1990-08-30	Zymogenetics Inc.	Stable DNA constructs

1985
- 1985-02-25 US US06/705,175 patent/US4801542A/en not_active Expired - Lifetime
- 1985-10-07 CA CA000492370A patent/CA1340212C/en not_active Expired - Lifetime
- 1985-10-10 DE DE1999175042 patent/DE19975042I2/de active Active
- 1985-10-10 DE DE3588218T patent/DE3588218T2/de not_active Expired - Lifetime
- 1985-10-10 AT AT85112852T patent/ATE84312T1/de active
- 1985-10-10 EP EP85112852A patent/EP0177957B2/de not_active Expired - Lifetime
- 1985-10-10 DE DE3586960T patent/DE3586960T3/de not_active Expired - Lifetime
- 1985-10-10 AU AU48454/85A patent/AU4845485A/en not_active Abandoned
- 1985-10-10 DE DE199191121387T patent/DE487116T1/de active Pending
- 1985-10-10 AT AT91121387T patent/ATE188255T1/de not_active IP Right Cessation
- 1985-10-11 JP JP60226637A patent/JP2837407B2/ja not_active Expired - Lifetime
1990
- 1990-05-10 AU AU54885/90A patent/AU638010B2/en not_active Expired
1997
- 1997-10-16 JP JP28366397A patent/JP3145968B2/ja not_active Expired - Lifetime
1999
- 1999-05-28 NL NL990016C patent/NL990016I2/nl unknown
- 1999-06-11 CA CA 617115 patent/CA1340846E/en not_active Expired - Lifetime
- 1999-06-25 LU LU90408C patent/LU90408I2/fr unknown

Also Published As

Publication number	Publication date
DE487116T1 (de)	1992-10-15
ATE188255T1 (de)	2000-01-15
CA1340212C (en)	1998-12-15
EP0177957B1 (de)	1993-01-07
NL990016I2 (nl)	1999-11-01
JPS62278A (ja)	1987-01-06
EP0177957A3 (en)	1988-02-03
AU638010B2 (en)	1993-06-17
DE3588218D1 (de)	2000-02-03
JPH10117790A (ja)	1998-05-12
DE3586960T3 (de)	2005-01-20
AU5488590A (en)	1991-01-31
DE3586960D1 (de)	1993-02-18
DE3588218T2 (de)	2000-05-18
DE3586960T2 (de)	1993-05-13
NL990016I1 (nl)	1999-08-02
EP0177957B2 (de)	2004-08-25
JP2837407B2 (ja)	1998-12-16
JP3145968B2 (ja)	2001-03-12
CA1340846E (en)	1999-12-07
LU90408I2 (fr)	1999-08-25
DE19975042I2 (de)	2004-01-29
US4801542A (en)	1989-01-31
AU4845485A (en)	1986-04-17
EP0177957A2 (de)	1986-04-16

Publication	Publication Date	Title
ATE84312T1 (de)	1993-01-15	Expression, in eukaryotischen zellen, von biologisch aktiven analoga eines wachstumsfaktors, abstammend von blutplaettchen.
KR910015309A (ko)	1991-09-30	종양괴사인자(tnf) 억제제 및 그 제조방법
DE69020335D1 (de)	1995-07-27	B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
NO174965C (no)	1994-08-10	Syntetisk polypeptidanalog av humaninsulinlignende vekstfaktor med redusert binding til bærerproteiner i serum, samt syntetiske gener som koder for slike analoger og preparater som omfatter en slik analog
DE3786321D1 (de)	1993-07-29	Expression von protein-c.
AU7681687A (en)	1988-02-18	Expression of platelet-derived growth factor and analogues
ATE93272T1 (de)	1993-09-15	Expression von protein c.
EP0111814A3 (de)	1985-08-14	Klonierung und Expression von nucleotiden Sequenzen die für Rinderwachstumshormon kodieren
EP0287075A3 (en)	1990-01-24	Process for the construction of an animal cell line for the production of human beta-interferon
JPS6437291A (en)	1989-02-07	Human cytochrome c gene and use thereof
HUP9800520A2 (hu)	1998-06-29	Génexpresszió emlős sejtekben
DK27097A (da)	1997-03-13	Minactivin og fremgangsmåde til fremstilling deraf
Klagsbrun	1990	4882275 Method of purifying endothelial cell growth factors using immobilized heparin
Shaar et al.	1990	4885163 Topical use of IGF-II for wound healing
Rappaport	1990	4889808 Method of enchancing T-PA and SCU-PA production
WO1991009951A3 (en)	1991-08-22	Recombinant protein c with truncated light chain