ATE69222T1 - 2-amino-oxazoline und verfahren zu ihrer herstellung. - Google Patents
2-amino-oxazoline und verfahren zu ihrer herstellung.Info
- Publication number
- ATE69222T1 ATE69222T1 AT85401360T AT85401360T ATE69222T1 AT E69222 T1 ATE69222 T1 AT E69222T1 AT 85401360 T AT85401360 T AT 85401360T AT 85401360 T AT85401360 T AT 85401360T AT E69222 T1 ATE69222 T1 AT E69222T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- lower alkyl
- hydrogen
- equal
- denotes
- Prior art date
Links
- -1 alkyl radical Chemical class 0.000 abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000007524 organic acids Chemical class 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- YAXGBZDYGZBRBQ-UHFFFAOYSA-N 4,5-dihydro-1,3-oxazol-2-amine Chemical class NC1=NCCO1 YAXGBZDYGZBRBQ-UHFFFAOYSA-N 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH326384 | 1984-07-05 | ||
| EP85401360A EP0167459B1 (de) | 1984-07-05 | 1985-07-04 | 2-Amino-oxazoline und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE69222T1 true ATE69222T1 (de) | 1991-11-15 |
Family
ID=4252197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85401360T ATE69222T1 (de) | 1984-07-05 | 1985-07-04 | 2-amino-oxazoline und verfahren zu ihrer herstellung. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0167459B1 (de) |
| JP (1) | JPS61155375A (de) |
| AT (1) | ATE69222T1 (de) |
| AU (1) | AU579872B2 (de) |
| CA (1) | CA1258040A (de) |
| DD (1) | DD240015A5 (de) |
| DE (1) | DE3584584D1 (de) |
| DK (1) | DK302185A (de) |
| ES (2) | ES8700853A1 (de) |
| HU (1) | HU193333B (de) |
| MA (1) | MA20480A1 (de) |
| OA (1) | OA08166A (de) |
| PL (1) | PL254398A1 (de) |
| PT (1) | PT80779B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2632860A1 (fr) * | 1988-06-21 | 1989-12-22 | Rolland Sa A | Nouveaux medicaments antidepresseurs et les compositions pharmaceutiques en renfermant |
| ES2171191T3 (es) * | 1994-08-22 | 2002-09-01 | Mitsubishi Pharma Corp | Compuesto de benceno y uso medicinal del mismo. |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| SI1471054T1 (sl) | 2002-01-11 | 2009-12-31 | Daiichi Sankyo Co Ltd | Amino alkoholni derivati ali derivati fosfoniäśne kisline in medicinski sestavki, ki vsebujejo le-te |
| CA2557536C (en) | 2004-02-24 | 2010-07-13 | Sankyo Company Limited | Amino alcohol compound |
| EP2114906B1 (de) * | 2007-02-02 | 2014-08-06 | F. Hoffmann-La Roche AG | 2-aminooxazolinverbindungen als taar1-liganden für erkrankungen des zentralen nervensystems |
| KR101335845B1 (ko) * | 2007-02-15 | 2013-12-02 | 에프. 호프만-라 로슈 아게 | Ｔａａｒ1 리간드로서의 2-아미노옥사졸린 |
| ES2398017T3 (es) * | 2008-02-18 | 2013-03-13 | F. Hoffmann-La Roche Ag | Derivados de 4,5-dihidro-oxazol-2-il-amina |
| US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| MX2011000464A (es) * | 2008-07-24 | 2011-03-01 | Hoffmann La Roche | Derivados de 4,5-dihidro-oxazol-2-ilo. |
| US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| US8673950B2 (en) * | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
| MA43706B1 (fr) | 2016-03-17 | 2020-09-30 | Hoffmann La Roche | Dérivé de 5-éthyl-4-méthyl-pyrazole-3-carboxamide ayant une activité en tant qu'agoniste de taar |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2448M (fr) * | 1963-02-27 | 1964-04-06 | Mcneilab Inc | Composé de la classe des 2-amino-5-aryl-oxazolines et compositions pharmaceutiques le contenant. |
| FR2444673A1 (fr) * | 1978-12-20 | 1980-07-18 | Science Union & Cie | Nouvelles trifluoroethylamines, leurs procedes d'obtention et leur emploi comme medicament |
| US4647557A (en) * | 1982-12-28 | 1987-03-03 | Gerard Moinet | Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them |
-
1985
- 1985-07-03 DK DK302185A patent/DK302185A/da not_active Application Discontinuation
- 1985-07-04 AT AT85401360T patent/ATE69222T1/de not_active IP Right Cessation
- 1985-07-04 DE DE8585401360T patent/DE3584584D1/de not_active Expired - Fee Related
- 1985-07-04 MA MA20705A patent/MA20480A1/fr unknown
- 1985-07-04 DD DD85278275A patent/DD240015A5/de unknown
- 1985-07-04 EP EP85401360A patent/EP0167459B1/de not_active Expired - Lifetime
- 1985-07-05 CA CA000486391A patent/CA1258040A/fr not_active Expired
- 1985-07-05 PT PT80779A patent/PT80779B/pt unknown
- 1985-07-05 OA OA58630A patent/OA08166A/xx unknown
- 1985-07-05 HU HU852621A patent/HU193333B/hu unknown
- 1985-07-05 JP JP60148123A patent/JPS61155375A/ja active Pending
- 1985-07-05 ES ES544926A patent/ES8700853A1/es not_active Expired
- 1985-07-05 PL PL25439885A patent/PL254398A1/xx unknown
- 1985-07-08 AU AU44681/85A patent/AU579872B2/en not_active Expired - Fee Related
-
1986
- 1986-03-15 ES ES553058A patent/ES8705364A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU4468185A (en) | 1986-01-30 |
| EP0167459A2 (de) | 1986-01-08 |
| JPS61155375A (ja) | 1986-07-15 |
| CA1258040A (fr) | 1989-08-01 |
| ES553058A0 (es) | 1987-05-01 |
| DK302185D0 (da) | 1985-07-03 |
| AU579872B2 (en) | 1988-12-15 |
| PT80779B (fr) | 1987-01-12 |
| DE3584584D1 (de) | 1991-12-12 |
| DK302185A (da) | 1986-01-06 |
| PT80779A (fr) | 1985-08-01 |
| MA20480A1 (fr) | 1986-04-01 |
| DD240015A5 (de) | 1986-10-15 |
| HUT38918A (en) | 1986-07-28 |
| PL254398A1 (en) | 1986-06-17 |
| HU193333B (en) | 1987-09-28 |
| ES8700853A1 (es) | 1986-10-16 |
| ES544926A0 (es) | 1986-10-16 |
| ES8705364A1 (es) | 1987-05-01 |
| EP0167459A3 (en) | 1987-02-25 |
| EP0167459B1 (de) | 1991-11-06 |
| OA08166A (fr) | 1987-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |