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ATE554758T1 - Triptolid-lacton-ring-derivate als immunmodulatoren und mittel gegen krebs - Google Patents

Triptolid-lacton-ring-derivate als immunmodulatoren und mittel gegen krebs

Info

Publication number
ATE554758T1
ATE554758T1 AT05724487T AT05724487T ATE554758T1 AT E554758 T1 ATE554758 T1 AT E554758T1 AT 05724487 T AT05724487 T AT 05724487T AT 05724487 T AT05724487 T AT 05724487T AT E554758 T1 ATE554758 T1 AT E554758T1
Authority
AT
Austria
Prior art keywords
triptolide
lactone ring
cancer agent
immune modulators
ring derivatives
Prior art date
Application number
AT05724487T
Other languages
English (en)
Inventor
Hongwei Yuan
John Musser
Dongcheng Dai
Original Assignee
Pharmagenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmagenesis Inc filed Critical Pharmagenesis Inc
Application granted granted Critical
Publication of ATE554758T1 publication Critical patent/ATE554758T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT05724487T 2004-03-02 2005-03-02 Triptolid-lacton-ring-derivate als immunmodulatoren und mittel gegen krebs ATE554758T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54976904P 2004-03-02 2004-03-02
PCT/US2005/006952 WO2005084365A2 (en) 2004-03-02 2005-03-02 Triptolide lactone ring derivatives as immunomodulators and anticancer agents

Publications (1)

Publication Number Publication Date
ATE554758T1 true ATE554758T1 (de) 2012-05-15

Family

ID=34919536

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05724487T ATE554758T1 (de) 2004-03-02 2005-03-02 Triptolid-lacton-ring-derivate als immunmodulatoren und mittel gegen krebs

Country Status (10)

Country Link
US (2) US7863464B2 (de)
EP (1) EP1732536B1 (de)
JP (1) JP5057966B2 (de)
CN (1) CN100558354C (de)
AT (1) ATE554758T1 (de)
AU (1) AU2005218610B2 (de)
CA (1) CA2557260C (de)
DK (1) DK1732536T3 (de)
ES (1) ES2385716T3 (de)
WO (1) WO2005084365A2 (de)

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US7847109B2 (en) 2002-05-31 2010-12-07 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
US7820834B2 (en) 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
WO2005077008A2 (en) 2004-02-09 2005-08-25 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from tripterygium wilfordii
JP5057966B2 (ja) 2004-03-02 2012-10-24 ファーマジェネシス， インコーポレイテッド 免疫調節剤および抗癌剤としてのトリプトライドラクトン環誘導体
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
JP5653939B2 (ja) * 2009-02-05 2015-01-14 ファーマジェネシス， インコーポレイテッド 抗癌剤および免疫調節因子としてのトリプトリドｃ環誘導体
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
SG175885A1 (en) 2009-05-07 2011-12-29 Univ Minnesota Triptolide prodrugs
JP2016515530A (ja) * 2013-03-15 2016-05-30 ファーマジェネシス， インコーポレイテッド 免疫調節薬および抗がん剤としてのトリプトリドの静脈内乳剤
WO2015127011A1 (en) 2014-02-21 2015-08-27 Institute Of Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center C-myc as a biomarker for tumor sensitivity to treatment with rna polymerase ii inhibition
WO2016181312A1 (en) * 2015-05-11 2016-11-17 Versitech Limited Polycyclic epoxides and compositions thereof with anti-cancer activities
CN107663225A (zh) * 2016-07-29 2018-02-06 欣凯医药化工中间体（上海）有限公司 一种氟代雷公藤内酯醇内酯环衍生物
CN106749496A (zh) * 2016-12-05 2017-05-31 张奇军 新型雷公藤甲素衍生物、及其制备和用途
CN108530510A (zh) * 2017-03-02 2018-09-14 欣凯医药化工中间体（上海）有限公司 一种c19-酰基化雷公藤甲素的制备方法
CN108530511B (zh) * 2017-03-02 2021-06-22 欣凯医药化工中间体（上海）有限公司 一种c19-酰基化雷公藤甲素衍生物
WO2018222351A1 (en) * 2017-05-27 2018-12-06 Pharmagenesis, Inc. Triptolide lactone derivatives as immunomodulators and anticancer agents
CN109942665B (zh) * 2018-04-02 2021-04-06 欣凯医药化工中间体（上海）有限公司 雷公藤内酯醇衍生物及其制备方法和应用
CN110551172B (zh) * 2018-05-31 2021-08-27 欣凯医药化工中间体（上海）有限公司 一种c-19位双键化雷公藤内酯醇衍生物的合成方法
CN110551170B (zh) * 2018-05-31 2022-04-22 欣凯医药化工中间体（上海）有限公司 一种c-19位单酰基化雷公藤内酯醇衍生物的合成方法
CN110551171B (zh) * 2018-05-31 2021-07-27 欣凯医药化工中间体（上海）有限公司 一种雷公藤内酯醇衍生物的制备方法
CN111909119B (zh) * 2020-08-25 2023-06-16 上海诗丹德标准技术服务有限公司 雷公藤来源化合物及其应用和制备方法、药物组合物、杀虫剂

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US7847109B2 (en) 2002-05-31 2010-12-07 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
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JP2006513209A (ja) 2002-12-17 2006-04-20 ファーマジェネシス， インコーポレイテッド 免疫調節因子および抗癌剤としてのトリプトライド誘導体
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JP5057966B2 (ja) 2004-03-02 2012-10-24 ファーマジェネシス， インコーポレイテッド 免疫調節剤および抗癌剤としてのトリプトライドラクトン環誘導体
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Also Published As

Publication number Publication date
WO2005084365A2 (en) 2005-09-15
AU2005218610B2 (en) 2011-08-18
US8426616B2 (en) 2013-04-23
CA2557260A1 (en) 2005-09-15
US20100331554A1 (en) 2010-12-30
JP5057966B2 (ja) 2012-10-24
CN100558354C (zh) 2009-11-11
JP2007526331A (ja) 2007-09-13
DK1732536T3 (da) 2012-06-25
EP1732536A2 (de) 2006-12-20
EP1732536A4 (de) 2009-06-10
WO2005084365A3 (en) 2005-11-10
US7863464B2 (en) 2011-01-04
CA2557260C (en) 2013-02-12
ES2385716T3 (es) 2012-07-30
CN1925852A (zh) 2007-03-07
US20080287530A1 (en) 2008-11-20
AU2005218610A1 (en) 2005-09-15
EP1732536B1 (de) 2012-04-25

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