ATE550352T1 - Verfahren zur herstellung von hybridantikörper - Google Patents
Verfahren zur herstellung von hybridantikörperInfo
- Publication number
- ATE550352T1 ATE550352T1 AT02794114T AT02794114T ATE550352T1 AT E550352 T1 ATE550352 T1 AT E550352T1 AT 02794114 T AT02794114 T AT 02794114T AT 02794114 T AT02794114 T AT 02794114T AT E550352 T1 ATE550352 T1 AT E550352T1
- Authority
- AT
- Austria
- Prior art keywords
- hybrid
- antibodies
- framework regions
- hybrid antibodies
- antibody fragments
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 3
- 210000004602 germ cell Anatomy 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33659101P | 2001-12-03 | 2001-12-03 | |
PCT/US2002/038450 WO2003048321A2 (en) | 2001-12-03 | 2002-12-03 | Hybrid antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE550352T1 true ATE550352T1 (de) | 2012-04-15 |
Family
ID=23316785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02794114T ATE550352T1 (de) | 2001-12-03 | 2002-12-03 | Verfahren zur herstellung von hybridantikörper |
Country Status (12)
Country | Link |
---|---|
US (1) | US7399594B2 (de) |
EP (2) | EP1461428B1 (de) |
JP (3) | JP4723810B2 (de) |
AT (1) | ATE550352T1 (de) |
AU (1) | AU2002359568B2 (de) |
CA (1) | CA2468744C (de) |
CY (1) | CY1112843T1 (de) |
DK (1) | DK1461428T3 (de) |
ES (1) | ES2384100T3 (de) |
PT (1) | PT1461428E (de) |
SI (1) | SI1461428T1 (de) |
WO (1) | WO2003048321A2 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7393648B2 (en) * | 2001-12-03 | 2008-07-01 | Alexion Pharmaceuticals, Inc. | Hybrid antibodies |
US7772372B2 (en) * | 2002-07-04 | 2010-08-10 | Patrys Limited | Neoplasm specific antibodies and uses thereof |
MXPA06000258A (es) * | 2003-07-15 | 2006-07-03 | Cambridge Antibody Tech | Moleculas de anticuerpo humano para interleucina-13. |
GB0407315D0 (en) * | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
AU2004290085A1 (en) * | 2003-11-07 | 2005-05-26 | Curagen Corporation | Antibodies against secretoryleukocyte protease inhibitor |
DE10353175A1 (de) | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
EP1531162A1 (de) | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Antikörper SAM-6, der spezifisch von Adenocarzinom ist, und dessen Verwendungen |
EP2221315A1 (de) | 2003-12-04 | 2010-08-25 | Xencor, Inc. | Verfahren zur Erzeugung von Proteinvarianten mit erhöhtem Wirtsstranginhalt und Zusammensetzungen davon |
US8354507B2 (en) * | 2003-12-15 | 2013-01-15 | Dendreon Corporation | HLA-DR specific antibodies, compositions and methods |
AU2005230868A1 (en) * | 2004-03-31 | 2005-10-20 | Centocor, Inc. | Method and apparatus for analyzing and generating human antibody amino acid and nucleic acid sequences |
WO2005111081A2 (en) * | 2004-05-10 | 2005-11-24 | Egea Biosciences, Llc | Immunoglobulin-like variable chain binding polypeptides and methods of use |
GB0414886D0 (en) * | 2004-07-02 | 2004-08-04 | Neutec Pharma Plc | Treatment of bacterial infections |
JP5372500B2 (ja) | 2005-06-17 | 2013-12-18 | トレラクス リクイデーティング トラスト | Ilt3結合分子およびその使用 |
FR2892724B1 (fr) * | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
JP5597793B2 (ja) | 2006-06-19 | 2014-10-01 | メルク・シャープ・アンド・ドーム・コーポレーション | Ilt3結合分子およびその使用 |
NO2796466T3 (de) | 2007-12-07 | 2018-04-21 | ||
BRPI0822099A2 (pt) * | 2007-12-21 | 2017-05-23 | Medimmune Ltd | membro de ligação isolado, uso de um membro de ligação isolado, método parav tratar um distúrbio, molécula de ácido nucléico isolada, célula hospedeira, e, método para produzir um membro de ligação |
US20110052565A1 (en) * | 2007-12-21 | 2011-03-03 | National Research Council Of Canada | Non-aggregating human vh domains |
WO2009131605A2 (en) * | 2008-01-28 | 2009-10-29 | Thomas Jefferson University | Fusion partner cell line for preparation of hybrid cells expressing human antibodies |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
AU2009313389A1 (en) * | 2008-11-06 | 2010-05-14 | Alexion Pharmaceuticals, Inc. | Engineered antibodies with reduced immunogenicity and methods of making |
EP2411050A4 (de) * | 2009-03-25 | 2013-07-17 | Vet Therapeutics Inc | Antikörperregionen mit konstanter domäne und ihre verwendung |
CA2791866A1 (en) * | 2010-03-04 | 2011-09-09 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to cd52 |
US9616120B2 (en) * | 2010-03-04 | 2017-04-11 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to CD20 |
NZ603581A (en) * | 2010-06-19 | 2015-05-29 | Sloan Kettering Inst Cancer | Anti-gd2 antibodies |
CN102251013A (zh) * | 2011-02-22 | 2011-11-23 | 北京市肿瘤防治研究所 | 一个识别肿瘤起始细胞的抗体和抗原及其应用 |
CN105102068B (zh) | 2012-10-12 | 2018-06-01 | Adc疗法责任有限公司 | 吡咯并苯并二氮杂卓-抗体结合物 |
JP6392763B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa | ピロロベンゾジアゼピン−抗体結合体 |
EP2766048B1 (de) | 2012-10-12 | 2014-12-10 | Spirogen Sàrl | Pyrrolobenzodiazepine und konjugate davon |
KR102207859B1 (ko) | 2013-03-15 | 2021-01-27 | 메모리얼 슬로안 케터링 캔서 센터 | 고 친화도 항-gd2 항체 |
US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
HUE054689T2 (hu) | 2017-02-08 | 2021-09-28 | Adc Therapeutics Sa | Pirrolobenzodiazepin-antitest konjugátumok |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
WO2018192944A1 (en) | 2017-04-18 | 2018-10-25 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
KR20190141666A (ko) | 2017-04-20 | 2019-12-24 | 에이디씨 테라퓨틱스 에스에이 | 항-axl 항체-약물 접합체로의 병용 요법 |
WO2018229222A1 (en) | 2017-06-14 | 2018-12-20 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-cd19 adc |
SI3668874T1 (sl) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pirolobenzodiazepinski konjugati |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
MX2021010477A (es) | 2019-03-15 | 2021-10-01 | Medimmune Ltd | Dimeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento de cancer. |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4470925A (en) * | 1982-05-05 | 1984-09-11 | E. I. Du Pont De Nemours And Company | Immunoglobulin half-molecules and process for producing hybrid antibodies |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
ES2313867T3 (es) | 1991-12-02 | 2009-03-16 | Medical Research Council | Produccion de anticuerpos anti-auto de repertorios de segmentos de anticuerpo expresados en la superficie de fagos. |
US5643756A (en) | 1992-08-28 | 1997-07-01 | The Public Health Research Institute Of The City Of New York, Inc. | Fusion glycoproteins |
AU689755B2 (en) | 1992-09-22 | 1998-04-09 | Biofocus Discovery Limited | Recombinant viruses displaying a nonviral polypeptide on their external surface |
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
GB9416721D0 (en) | 1994-08-18 | 1994-10-12 | Short Brothers Plc | A bias yarn assembly forming device |
ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
US6254868B1 (en) | 1996-03-20 | 2001-07-03 | Immunomedics, Inc. | Glycosylated humanized B-cell specific antibodies |
US5908925A (en) * | 1996-06-27 | 1999-06-01 | Exocell, Inc. | Genetically engineered immunoglobulins with specificity for glycated albumin |
US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US7117096B2 (en) * | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
US7321026B2 (en) * | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
JP2005512962A (ja) * | 2001-09-20 | 2005-05-12 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 抗pdgf抗体および設計抗体の産生方法 |
US20030190705A1 (en) * | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
-
2002
- 2002-12-03 SI SI200230983T patent/SI1461428T1/sl unknown
- 2002-12-03 DK DK02794114.5T patent/DK1461428T3/da active
- 2002-12-03 PT PT02794114T patent/PT1461428E/pt unknown
- 2002-12-03 AT AT02794114T patent/ATE550352T1/de active
- 2002-12-03 AU AU2002359568A patent/AU2002359568B2/en not_active Ceased
- 2002-12-03 US US10/308,817 patent/US7399594B2/en not_active Expired - Lifetime
- 2002-12-03 ES ES02794114T patent/ES2384100T3/es not_active Expired - Lifetime
- 2002-12-03 EP EP02794114A patent/EP1461428B1/de not_active Expired - Lifetime
- 2002-12-03 CA CA2468744A patent/CA2468744C/en not_active Expired - Fee Related
- 2002-12-03 WO PCT/US2002/038450 patent/WO2003048321A2/en active Application Filing
- 2002-12-03 EP EP10178484A patent/EP2298817A1/de not_active Withdrawn
- 2002-12-03 JP JP2003549500A patent/JP4723810B2/ja not_active Expired - Fee Related
-
2009
- 2009-04-06 JP JP2009092502A patent/JP5054058B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-13 JP JP2012056050A patent/JP2012144551A/ja not_active Withdrawn
- 2012-06-07 CY CY20121100520T patent/CY1112843T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP5054058B2 (ja) | 2012-10-24 |
WO2003048321A3 (en) | 2003-10-16 |
JP2005511706A (ja) | 2005-04-28 |
AU2002359568A1 (en) | 2003-06-17 |
JP4723810B2 (ja) | 2011-07-13 |
CY1112843T1 (el) | 2016-02-10 |
SI1461428T1 (sl) | 2012-07-31 |
AU2002359568B2 (en) | 2008-02-21 |
EP2298817A1 (de) | 2011-03-23 |
CA2468744A1 (en) | 2003-06-12 |
US7399594B2 (en) | 2008-07-15 |
PT1461428E (pt) | 2012-05-29 |
DK1461428T3 (da) | 2012-06-04 |
EP1461428A4 (de) | 2005-05-25 |
US20030219861A1 (en) | 2003-11-27 |
EP1461428B1 (de) | 2012-03-21 |
JP2012144551A (ja) | 2012-08-02 |
WO2003048321A2 (en) | 2003-06-12 |
JP2009153527A (ja) | 2009-07-16 |
CA2468744C (en) | 2013-05-14 |
EP1461428A2 (de) | 2004-09-29 |
ES2384100T3 (es) | 2012-06-29 |
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